COCP / Cocrystal Pharma, Inc. - Документы SEC, Годовой отчет, Доверенное заявление

Кокристал Фарма, Инк.
US ˙ NasdaqCM ˙ US19188J4094

Основная статистика
LEI 549300QCJ6RBUJKI7S66
CIK 1412486
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Cocrystal Pharma, Inc.
SEC Filings (Chronological Order)
На этой странице представлен полный хронологический список документов SEC, за исключением документов о собственности, которые мы предоставляем в других местах.
August 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA, INC

August 14, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

August 14, 2025 EX-99.1

Cocrystal Pharma Reports Second Quarter 2025 Financial Results and Provides Updates on its Antiviral Drug-Development Programs

Exhibit 99.1 Cocrystal Pharma Reports Second Quarter 2025 Financial Results and Provides Updates on its Antiviral Drug-Development Programs ● Favorable CDI-988 Phase 1 safety and tolerability reported ● Challenge study with CDI-988 as a norovirus preventive and treatment planned later this year BOTHELL, Wash. (August 14, 2025) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”)

August 5, 2025 EX-99.1

Cocrystal Pharma Presents Phase 1 Results for Pan-Viral Inhibitor CDI-988 at Department of Defense Medical Conference

Exhibit 99.1 Cocrystal Pharma Presents Phase 1 Results for Pan-Viral Inhibitor CDI-988 at Department of Defense Medical Conference ● All CDI-988 doses, ranging from 100 mg to 1200 mg, in the Phase 1 study were well tolerated ● Company expects to initiate Phase 1b study with CDI-988 in norovirus-infected healthy subjects later this year ● Lack of approved norovirus treatments or vaccines creates cr

August 5, 2025 EX-99.2

Presentation dated August 5, 2025

Exhibit 99.2

August 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 5, 2025 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 5, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission F

July 10, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 10, 2025 Cocrystal Pharma, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 10, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

July 10, 2025 EX-99.1

Cocrystal Pharma to Presents Data from Phase 1 Study of First-in-Class Norovirus Protease Inhibitor CDI-988 at the 9th International Calicivirus Conference

Exhibit 99.1 Cocrystal Pharma to Presents Data from Phase 1 Study of First-in-Class Norovirus Protease Inhibitor CDI-988 at the 9th International Calicivirus Conference BOTHELL, Wash. (July 10, 2025) – Cocrystal Pharma, Inc. (Nasdaq: COCP) announces that its first-in-class pan-viral protease inhibitor CDI-988 has been selected for an oral presentation at the 9th International Calicivirus Conferenc

July 1, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2025 Cocrystal Pharma, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

June 18, 2025 EX-3.1

Amendment No. 1 to Amended and Restated Bylaws

Exhibit 3.1 Cocrystal Pharma Inc. Amendment No. 1 to Amended and Restated Bylaws Section 7 of the Amended and Restated Bylaws is hereby amended to read in its entirety as follows: Section 7. Stockholder Quorum and Voting. One third of the aggregate voting power of the outstanding shares of all classes or series of voting stock then entitled to vote, represented in person or by proxy, shall constit

June 18, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 17, 2025 Cocrystal Pharma, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 17, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

June 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 5, 2025 Cocrystal Pharma, In

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 5, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

June 5, 2025 EX-99.1

# # #

Exhibit 99.1 Cocrystal Pharma’s Novel Norovirus Antiviral to be Presented at Department of Defense Medical Conference BOTHELL, Wash. (JUNE 5, 2025) – Cocrystal Pharma, Inc. (Nasdaq: COCP) announces that its broad-spectrum protease inhibitor CDI-988 will be featured in an oral presentation at the 2025 Military Health System Research Symposium (MHSRS) being held August 4-7 in Kissimmee, Fla. Cocryst

May 29, 2025 EX-99.1

Cocrystal Pharma’s Investigational Drug Candidate CC-42344 Demonstrates Strong Antiviral Potency Against the 2024 Highly Pathogenic H5N1 Avian Influenza Strain

Exhibit 99.1 Cocrystal Pharma’s Investigational Drug Candidate CC-42344 Demonstrates Strong Antiviral Potency Against the 2024 Highly Pathogenic H5N1 Avian Influenza Strain ● CC-42344 was shown to be highly active against the highly pathogenic 2024 Texas H5N1 avian influenza strain ● The Company’s virology study further confirmed the previous structural and in vitro data that revealed the binding

May 29, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2025 Cocrystal Pharma, In

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 15, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2025 Cocrystal Pharma, In

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 15, 2025 EX-99.1

Cocrystal Pharma Reports First Quarter 2025 Financial Results and Provides Updates on its Antiviral Drug-Development Programs In vitro testing with CDI-988 demonstrated superior broad-spectrum antiviral activity against major norovirus variants

Exhibit 99.1 Cocrystal Pharma Reports First Quarter 2025 Financial Results and Provides Updates on its Antiviral Drug-Development Programs In vitro testing with CDI-988 demonstrated superior broad-spectrum antiviral activity against major norovirus variants BOTHELL, Wash. (May 15, 2025) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) reports financial results for the three m

May 15, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA, IN

May 5, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

May 5, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by Registrant ☒ Filed by Party other than Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Prox

April 25, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by Registrant ☒ Filed by Party other than Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Prox

April 24, 2025 EX-99.1

Cocrystal Pharma’s Norovirus Oral Antiviral Candidate Demonstrates Potent Activity Against the Emerging GII.17 Variants

Exhibit 99.1 Cocrystal Pharma’s Norovirus Oral Antiviral Candidate Demonstrates Potent Activity Against the Emerging GII.17 Variants ○ Norovirus GII.17 variants have overtaken GII.4 as the most prevalent strain and significantly increased norovirus outbreaks in the U.S. and European countries in 2024-2025 ○ Cocrystal Pharma’s pan-viral protease inhibitor CDI-988 shows superior broad-spectrum antiv

April 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2025 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of in

April 23, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 23, 2025 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 23, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of in

April 23, 2025 EX-99.1 CHARTER

Cocrystal Pharma, Inc. Corporate Presentation, dated April 23, 2025

Exhibit 99.1

April 8, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 2, 2025 Cocrystal Pharma, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 2, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

April 8, 2025 EX-10.1

2025 Equity Incentive Plan

Exhibit 10.1 COCRYSTAL PHARMA, INC. 2025 EQUITY INCENTIVE PLAN Adopted: April 2, 2025 1. DEFINITIONS The following terms shall have the following meanings unless the context indicates otherwise: 1.1. “Affiliate” and “Associate” shall have the respective meanings given to such terms under Rule 12b-2 under the Exchange Act. 1.2. “Award” shall mean either a Stock Option, an SAR, a Stock Award, an RSU

April 1, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2025 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission F

March 31, 2025 EX-99.1

Cocrystal Pharma Reports 2024 Financial Results and Provides Updates on its Antiviral Drug-Development Programs

Exhibit 99.1 Cocrystal Pharma Reports 2024 Financial Results and Provides Updates on its Antiviral Drug-Development Programs BOTHELL, Wash. (March 31, 2025) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) reports financial results for the 12 months ended December 31, 2024, and provides updates on its antiviral product pipeline, upcoming milestones and business activities. “O

March 31, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 001-38418 Cocrystal Pharma, Inc. (Exact name of registrant as specif

March 31, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2025 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission F

January 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 Cocrystal Pharma

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of

January 13, 2025 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated January 13, 2025

Exhibit 99.1

January 8, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2025 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2025 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of i

January 8, 2025 EX-99.1

Cocrystal Pharma Reports Phase 1 Results with Oral, Broad-Acting Antiviral Drug CDI-988 for Prophylaxis and Treatment of Norovirus, Coronaviruses and Other Viral Infections

Exhibit 99.1 Cocrystal Pharma Reports Phase 1 Results with Oral, Broad-Acting Antiviral Drug CDI-988 for Prophylaxis and Treatment of Norovirus, Coronaviruses and Other Viral Infections ● Data show favorable safety and tolerability with dosing up to 800 mg for 10 days ● Plans to initiate human challenge study in 2025 in norovirus-infected subjects BOTHELL, Wash. (January 8, 2025) – Cocrystal Pharm

December 31, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 31, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of

December 31, 2024 EX-99.1

Cocrystal Pharma to Extend Phase 2a Influenza Challenge Study with Oral PB2 inhibitor CC-42344

Exhibit 99.1 Cocrystal Pharma to Extend Phase 2a Influenza Challenge Study with Oral PB2 inhibitor CC-42344 ● Data support favorable safety and tolerability profile with no serious adverse events (SAEs) or study-related drug discontinuations ● Enrollment to be extended due to low influenza infection among challenged participants; virology results are uninterpretable BOTHELL, Wash. (December 31, 20

November 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA

November 13, 2024 EX-3.1

Certificate of Incorporation, as amended

Exhibit 3.1 CERTIFICATE OF INCORPORATION OF COCRYSTAL PHARMA, INC. (Conformed copy incorporating all amendments through November 13, 2024) 1. The name of the corporation is Cocrystal Pharma, Inc. (the “Company”). 2. The address of its registered office in the State of Delaware, County of New Castle, is 3411 Silverside Road, Rodney Building #104, Wilmington, Delaware 19810. The name of its register

November 13, 2024 EX-99.1

Cocrystal Pharma Reports Third Quarter 2024 Financial Results and Provides Updates on its Antiviral Drug-Development Programs

Exhibit 99.1 Cocrystal Pharma Reports Third Quarter 2024 Financial Results and Provides Updates on its Antiviral Drug-Development Programs BOTHELL, Wash. (November 13, 2024) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) reports financial results for the three and nine months ended September 30, 2024, and provides updates on its antiviral product pipeline, upcoming mileston

November 13, 2024 8-K

Results of Operations and Financial Condition, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

October 31, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2024 Cocrystal Pharma

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of

October 31, 2024 EX-99.1

Cocrystal Pharma’s Co-CEOs Highlight Pioneering Approach to Antiviral Drug Candidates Targeting Influenza and Coronaviruses as Fall Flu and COVID Season Begins The Company’s antiviral candidate for seasonal and pandemic influenza shows in vitro activ

Exhibit 99.1 Cocrystal Pharma’s Co-CEOs Highlight Pioneering Approach to Antiviral Drug Candidates Targeting Influenza and Coronaviruses as Fall Flu and COVID Season Begins The Company’s antiviral candidate for seasonal and pandemic influenza shows in vitro activity against the avian influenza A PB2 protein, whereas current influenza vaccines offer no protection against pandemic avian influenza BO

October 10, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 9, 2024 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 9, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of i

August 20, 2024 EX-99.1

Cocrystal Pharma to Highlight Near-term Clinical Milestones During Presentations at Two Upcoming Investment Conferences

Exhibit 99.1 Cocrystal Pharma to Highlight Near-term Clinical Milestones During Presentations at Two Upcoming Investment Conferences BOTHELL, Wash. (August 19, 2024) – Cocrystal Pharma, Inc.’s (Nasdaq: COCP) management announces its participation in the upcoming Virtual Investor Summit Microcap Forum in August and the H.C. Wainwright 26th Annual Global Investment Conference in September. “We look

August 20, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 19, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of i

August 14, 2024 EX-99.1

Cocrystal Pharma Reports Second Quarter 2024 Financial Results and Provides Updates on its Antiviral Drug-Development Programs

Exhibit 99.1 Cocrystal Pharma Reports Second Quarter 2024 Financial Results and Provides Updates on its Antiviral Drug-Development Programs ● Expects to report topline results in 2025 from Phase 2a influenza A human challenge study with oral CC-42344, including initial indication of virology ● In vitro testing shows CC-42344 inhibits the avian influenza A (H5N1) PB2 protein recently identified in

August 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2024 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

August 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA, INC

July 18, 2024 EX-99.1

Cocrystal Pharma Reports Favorable Results from Single-Ascending Dose Cohorts of Phase 1 Study with CDI-988, its Oral Pan-Viral Norovirus/Coronavirus Protease Inhibitor

Exhibit 99.1 Cocrystal Pharma Reports Favorable Results from Single-Ascending Dose Cohorts of Phase 1 Study with CDI-988, its Oral Pan-Viral Norovirus/Coronavirus Protease Inhibitor BOTHELL, Wash. (July 18, 2024) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) today reported favorable safety and tolerability results from the single-ascending dose (SAD) cohorts of the Phase 1

July 18, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 18, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of inc

June 28, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2024 Cocrystal Pharma, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction of incorporation) (Commission Fi

June 28, 2024 EX-3.1

Certificate of Amendment to Certificate of Incorporation – reduce number of authorized shares

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO CERTIFICATE OF INCORPORATION OF COCRYSTAL PHARMA, INC. Cocrystal Pharma, Inc. (the “Company”), a corporation organized and existing under the General Corporation Law of the State of Delaware (the “Delaware General Corporation Law”), hereby certifies as follows: 1. The name of the Company is Cocrystal Pharma, Inc. 2. Pursuant to Section 242 of the Delaware Ge

June 20, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 20, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of inc

June 20, 2024 EX-99.1

New Broad-Spectrum Antiviral Currently in a Phase 2a Clinical Trial in Influenza A may be Effective Against the H5N1 Avian Influenza Strain Identified in Humans Exposed to Infected Dairy Cows

Exhibit 99.1 New Broad-Spectrum Antiviral Currently in a Phase 2a Clinical Trial in Influenza A may be Effective Against the H5N1 Avian Influenza Strain Identified in Humans Exposed to Infected Dairy Cows BOTHELL, Wash. (June 20, 2024) – Cocrystal Pharma, Inc.’s (Nasdaq: COCP) novel, broad-spectrum antiviral CC-42344 inhibits activity in the highly pathogenic avian influenza A (H5N1) PB2 protein r

May 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA, IN

May 13, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2024 Cocrystal Pharma, In

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 13, 2024 EX-99.1

Cocrystal Pharma Reports First Quarter 2024 Financial Results and Provides Updates on its Antiviral Drug-Development Programs

Exhibit 99.1 Cocrystal Pharma Reports First Quarter 2024 Financial Results and Provides Updates on its Antiviral Drug-Development Programs ● Topline single ascending dose (SAD) Phase 1 results of oral CDI-988, the first potential pan-coronavirus-pan-norovirus oral antiviral, expected in the second quarter of 2024 ● Enrollment completed in Phase 2a influenza A human challenge study of oral CC-42344

May 7, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by Registrant ☒ Filed by Party other than Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Prox

May 1, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 1, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of incor

May 1, 2024 EX-99.1

Enrollment Completed in Phase 2a Study with Cocrystal Pharma’s Oral Antiviral Candidate CC-42344 for Pandemic and Seasonal Influenza

Exhibit 99.1 Enrollment Completed in Phase 2a Study with Cocrystal Pharma’s Oral Antiviral Candidate CC-42344 for Pandemic and Seasonal Influenza BOTHELL, Wash. (May 1, 2024) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) announces completion of enrollment of 78 subjects who were infected with influenza A in a randomized, double-blind, placebo-controlled Phase 2a human chal

April 26, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by Registrant ☒ Filed by Party other than Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Prox

April 17, 2024 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 001-38418 Cocrystal Pharma, Inc. (Exact name of

March 28, 2024 EX-97.1

Clawback policy

Exhibit 97 COCRYSTAL PHARMA, INC. CLAWBACK POLICY Introduction Cocrystal Pharma, Inc. (the “Company”) adopts this Clawback Policy in accordance with the recently adopted SEC Rule and the Nasdaq Stock Market’s implementation of the Rule. Senior management has acted prior to the next regularly scheduled meeting of the Board of Directors (the “Board”) in reliance upon the advice of counsel that techn

March 28, 2024 8-K

Results of Operations and Financial Condition, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 28, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission F

March 28, 2024 EX-19.1

Insider Trading Policy

Exhibit 19.1 MEMORANDUM TO: All Officer, directors, Employees and Certain Third Parties FROM: Nason, Yeager, Gerson, Harris & Fumero, P.A. DATE: March 23, 2024 RE: Insider Trading Policy We believe that the best way to protect Cocrystal Pharma, Inc. (the “Company”) and its executive officers, directors and employees from potential liability from the insider trading under the federal securities law

March 28, 2024 EX-99.1

Cocrystal Pharma Reports 2023 Financial Results and Provides Updates on its Antiviral Drug-Development Programs

Exhibit 99.1 Cocrystal Pharma Reports 2023 Financial Results and Provides Updates on its Antiviral Drug-Development Programs ● FDA feedback following the Company’s submission of a Pre-IND briefing package improves clarity on regulatory requirements for Phase 2b influenza A clinical trial with oral CC-42344, a broad-spectrum PB2 inhibitor ● Topline data expected in 2024 from Phase 2a influenza A hu

March 28, 2024 EX-14.1

Code of Ethics

Exhibit 14.1 Code of Ethics As Approved March 23, 2024 1 Introduction The reputation of Cocrystal Pharma, Inc. (the “Company”) is built upon basic principles of ethical behavior, individual integrity and personal commitment. This reputation can be retained only if all the Company’s employees establish and adhere to the highest moral and ethical standards in the conduct of the Company’s business. T

March 28, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 001-38418 Cocrystal Pharma, Inc. (Exact name of registrant as specif

March 19, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 19, 2024 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 19, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of in

March 19, 2024 EX-99.1

Cocrystal Pharma Receives Pre-IND Responses from the FDA on Oral CC-42344 for Treating Influenza A Feedback provides greater clarity on regulatory requirements for planned Phase 2b trial

Exhibit 99.1 Cocrystal Pharma Receives Pre-IND Responses from the FDA on Oral CC-42344 for Treating Influenza A Feedback provides greater clarity on regulatory requirements for planned Phase 2b trial BOTHELL, Wash. (March 19, 2024) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) announces it has received Pre-Investigational New Drug (Pre-IND) feedback from the U.S. Food and

March 1, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2024 Cocrystal Pharm

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of

January 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2024 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of i

January 8, 2024 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated January 8, 2024

Exhibit 99.1

January 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 4, 2024 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 4, 2024 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of i

January 4, 2024 EX-99.1

Cocrystal Pharma Provides an Update on the Clinical Development of its Novel, Broad-Spectrum Antiviral Investigational Candidates

Exhibit 99.1 Cocrystal Pharma Provides an Update on the Clinical Development of its Novel, Broad-Spectrum Antiviral Investigational Candidates BOTHELL, Wash. (January 4, 2024) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) provides an update on the clinical development of its oral first-in-class pan-norovirus and pan-coronavirus dual protease inhibitor CDI-988 and its oral

December 21, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 15, 2023 Cocrystal Pharm

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 15, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of

December 6, 2023 EX-99.1

Cocrystal Pharma Announces First-Patient-In for Phase 2a Human Challenge Study Evaluating Oral CC-42344 in Pandemic and Seasonal Influenza A

Exhibit 99.1 Cocrystal Pharma Announces First-Patient-In for Phase 2a Human Challenge Study Evaluating Oral CC-42344 in Pandemic and Seasonal Influenza A BOTHELL, Wash. (December 6, 2023) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) announces the achievement of first-patient-in for the Phase 2a human challenge clinical trial with CC-42344, an investigational new oral anti

December 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 6, 2023 Cocrystal Pharma

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 6, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of

December 4, 2023 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated December 4, 2023

Exhibit 99.1

December 4, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 4, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction of incorporation) (Commission

November 29, 2023 EX-99.2

Cocrystal Pharma Highlights its Novel Inhaled and Oral Influenza A Antiviral CC-42344 at the World Vaccine Congress West Coast

Exhibit 99.2 Cocrystal Pharma Highlights its Novel Inhaled and Oral Influenza A Antiviral CC-42344 at the World Vaccine Congress West Coast BOTHELL, Wash. (November 29, 2023) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”), announces the presentation of favorable data demonstrating activity of its potent broad-spectrum PB2 inhibitor CC-42344 against pandemic and seasonal inf

November 29, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 28, 2023 Cocrystal Pharm

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 28, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction of incorporation) (Commissio

November 29, 2023 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated November 28, 2023

Exhibit 99.1

November 13, 2023 EX-99.1

Cocrystal Pharma Reports Third Quarter 2023 Financial Results and Provides Updates on its Antiviral Drug Development Programs

Exhibit 99.1 Cocrystal Pharma Reports Third Quarter 2023 Financial Results and Provides Updates on its Antiviral Drug Development Programs ● Enrollment underway in Phase 1 trial with novel protease inhibitor CDI-988, the first potential dual coronavirus-norovirus oral antiviral ● Dosing expected to begin later this year in Phase 2a human challenge trial with oral CC-42344 for the treatment of pand

November 13, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA

November 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2023 Cocrystal Pharm

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

October 31, 2023 EX-99.1

Cocrystal Pharma Receives UK MHRA Authorization to Initiate Its Phase 2a Influenza Human Challenge Trial with Oral PB2 Inhibitor CC-42344

Exhibit 99.1 Cocrystal Pharma Receives UK MHRA Authorization to Initiate Its Phase 2a Influenza Human Challenge Trial with Oral PB2 Inhibitor CC-42344 BOTHELL, Wash. (October 31, 2023) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (Cocrystal or the Company) announces receipt of authorization from the United Kingdom Medicines and Healthcare Products Regulatory Agency (MHRA) to initiate a Phase 2a human c

October 31, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2023 Cocrystal Pharma

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other jurisdiction (Commission (IRS Employer of

August 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2023 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

August 16, 2023 EX-99.1

Cocrystal Pharma Reports Second Quarter 2023 Financial Results and Provides Updates on its Antiviral Drug Development Programs

Exhibit 99.1 August 14, 2023 Cocrystal Pharma Reports Second Quarter 2023 Financial Results and Provides Updates on its Antiviral Drug Development Programs ● On track to begin a Phase 2a trial in the second half of 2023 with CC-42344 for the treatment of pandemic and seasonal influenza A ● Selected the novel protease inhibitor CDI-988 as development lead in the oral norovirus program ● CDI-988, th

August 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA, INC

June 15, 2023 424B5

H.C. Wainwright & Co. The date of this prospectus supplement is June 15, 2023

Filed pursuant to Rule 424(b)(5) Registration No. 333-271883 PROSPECTUS SUPPLEMENT (To the Prospectus dated May 24, 2023) Up to $7,250,000 of Common Stock We have entered into an At-The-Market Offering Agreement (the “Offering Agreement”) with H.C. Wainwright & Co., LLC, as sales agent (the “Agent” or “Wainwright”), relating to shares of our Common Stock, par value $0.001 per share (the “Common St

June 15, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2023 Cocrystal Pharma, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

June 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2023 Cocrystal Pharma, In

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 24, 2023 CORRESP

Cocrystal Pharma, Inc. 19805 North Creek Parkway Bothell, Washington 98011 May 24, 2023

Cocrystal Pharma, Inc. 19805 North Creek Parkway Bothell, Washington 98011 May 24, 2023 Via EDGAR Division of Corporation Finance Securities and Exchange Commission 100 F Street, N.E. Washington, D. C. 20549 Attention: Ms. Lauren Hamill Re: Cocrystal Pharma, Inc. Registration Statement on Form S-3 File No. 333-271883 Dear Ms. Hamill: In accordance with Rule 461 promulgated pursuant to the Securiti

May 24, 2023 S-3/A

As filed with the Securities and Exchange Commission on May 24, 2023

As filed with the Securities and Exchange Commission on May 24, 2023 Registration No.

May 15, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA, IN

May 15, 2023 EX-99.1

Financial Tables to follow

Exhibit 99.1 Cocrystal Pharma Reports First Quarter 2023 Financial Results and Provides Updates on its Antiviral Drug Development Programs BOTHELL, Wash. (May 15, 2023) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (Cocrystal or the Company) reports financial results for the three months ended March 31, 2023 and provides updates on its antiviral pipeline, upcoming milestones and business activities. “Re

May 15, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2023 Cocrystal Pharma, In

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 12, 2023 S-3

As filed with the Securities and Exchange Commission on May 12, 2023

As filed with the Securities and Exchange Commission on May 12, 2023 Registration No.

May 12, 2023 EX-FILING FEES

Filing fee table

Exhibit 107 Calculation of Filing Fee Table Form S-3 (Form Type) Cocrystal Pharma, Inc.

April 28, 2023 DEF 14A

Schedule 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by Registrant ☒ Filed by Party other than Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Prox

April 24, 2023 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 20, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission F

April 24, 2023 EX-99.1

Cocrystal Pharma Appoints Pharma Industry Veteran Fred Hassan to its Board of Directors

Exhibit 99.1 Cocrystal Pharma Appoints Pharma Industry Veteran Fred Hassan to its Board of Directors BOTHELL, Wash. (April 24, 2023) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (Cocrystal or the Company) announces the appointment of Fred Hassan to its Board of Directors, increasing its Board membership to six. Mr. Hassan’s distinguished 40-year career includes serving in senior executive and director

April 14, 2023 SC 13D/A

US19188J4094 / COCRYSTAL PHARMA INC / FROST PHILLIP MD ET AL Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 5)* Cocrystal Pharma, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 19188J409 (CUSIP Number) Phillip Frost, M.D. Frost Gamma Investments Trust 4400 Biscayne Boulevard Miami, Florida 33137 (305) 575-6015 (Name

April 12, 2023 SC 13G

US19188J4094 / COCRYSTAL PHARMA INC / Hassan Fred Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Cocrystal Pharma, Inc. (Name of Issuer) Common Stock, $0.001 per share (Title of Class of Securities) 19188J409 (CUSIP Number) April 4, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Sched

April 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 4, 2023 Cocrystal Pharma, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 4, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

April 10, 2023 EX-10.1

Securities Purchase Agreement dated April 1, 2023

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT THIS SECURITIES PURCHASE AGREEMENT (the “Agreement”) entered into as of this 4th day of April, 2023 (the “Effective Date”) by and between the parties on the signature page to this Agreement (each, a “Purchaser”), and Cocrystal Pharma, Inc., a Delaware corporation (“COCP”) (collectively, the Purchasers and COCP are the “Parties”). WHEREAS, this Agreement c

April 10, 2023 EX-99.1

Cocrystal Pharma Completes $4 Million Private Placement Priced At-the-Market Under Nasdaq Rules

Exhibit 99.1 Cocrystal Pharma Completes $4 Million Private Placement Priced At-the-Market Under Nasdaq Rules BOTHELL, Wash. (April 10, 2023) – Cocrystal Pharma, Inc. (Nasdaq: COCP) (Cocrystal or the Company) announces the completion of a private placement of 2,030,458 shares of common stock at a price of $1.97 per share for proceeds of $4.0 million. Investors in the private placement were Cocrysta

April 4, 2023 EX-99.1

Opinion of the United States Court of Appeals for the Third Circuit

Exhibit 99.1

April 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 29, 2023 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 29, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission F

March 29, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 001-38418 Cocrystal Pharma, Inc. (Exact name of registrant as specif

March 15, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 15, 2023 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 15, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission F

March 15, 2023 EX-99.1

Transcript of Interview with Dr. Sam Lee, Co-Chief Executive Officer of Cocrystal Pharma, Inc.

Exhibit 99.1

January 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 9, 2023 Cocrystal Pharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 9, 2023 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

January 9, 2023 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated January 9, 2023

EX-99.1 2 ex99-1.htm Exhibit 99.1

November 14, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA

October 26, 2022 EX-99.1

Enrollment Completed in Phase 1 Influenza A Study with Cocrystal Pharma’s Oral Antiviral Candidate CC-42344

Exhibit 99.1 Enrollment Completed in Phase 1 Influenza A Study with Cocrystal Pharma’s Oral Antiviral Candidate CC-42344 BOTHELL, Wash. (October 26, 2022) – Cocrystal Pharma, Inc. (Nasdaq: COCP) announces the completion of enrollment in a Phase 1 healthy volunteer study to assess the safety, tolerability and pharmacokinetics (PK) of its orally administered, novel, broad-spectrum antiviral candidat

October 26, 2022 EX-99.2

Cocrystal Pharma, Inc. Corporate Presentation, dated October 26, 2022

Exhibit 99.2

October 26, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 25, 2022 Cocrystal Pharma

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 25, 2022 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

October 3, 2022 EX-3.1

Certificate of Amendment to Certificate of Incorporation

Exhibit 3.1

October 3, 2022 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 27, 2022 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissi

September 12, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2022 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissi

September 12, 2022 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated September 12, 2022

Exhibit 99.1

August 15, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA, INC

August 15, 2022 EX-99.1

Cocrystal Pharma Reports Second Quarter 2022 Financial Results and Provides Updates on its Antiviral Development Programs

Exhibit 99.1 Cocrystal Pharma Reports Second Quarter 2022 Financial Results and Provides Updates on its Antiviral Development Programs ? Planned Phase 2a study design with orally administered CC-42344 for the treatment of pandemic and seasonal influenza A ? Reported pharmacokinetic (PK) data from the single ascending dose portion of its Phase 1 study with CC-42344 supporting once-daily dosing ? Co

August 15, 2022 8-K

Results of Operations and Financial Condition, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 15, 2022 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

July 29, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 29, 2022 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

May 20, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 18, 2022 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 19, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 17, 2022 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 11, 2022 EX-99.1

Cocrystal Pharma Reports First Quarter 2022 Financial Results and Provides Updates on its Antiviral Development Programs and Milestones

Exhibit 99.1 Cocrystal Pharma Reports First Quarter 2022 Financial Results and Provides Updates on its Antiviral Development Programs and Milestones ? Reported favorable preliminary data from the two initial cohorts in its Phase 1 study with CC-42344 for the treatment of pandemic and seasonal influenza A ? Announced a collaboration with the National Institute of Allergy and Infectious Diseases (NI

May 11, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA, IN

May 11, 2022 8-K

Results of Operations and Financial Condition, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2022 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

April 11, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEF 14A 1 formdef14a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by Registrant ☒ Filed by Party other than Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6

April 1, 2022 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by Registrant ? Filed by Party other than Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Prox

March 23, 2022 EX-99.1

Cocrystal Pharma Reports 2021 Financial Results and Provides Updates on Development Programs and Milestones

Exhibit 99.1 Cocrystal Pharma Reports 2021 Financial Results and Provides Updates on Development Programs and Milestones ? Commenced enrollment in Phase 1 trial with orally administered, broad-spectrum antiviral agent CC-42344 for the treatment of pandemic and seasonal influenza A ? Advanced COVID-19 programs with the goal of initiating two Phase 1 trials in 2022 with the intranasal/pulmonary anti

March 23, 2022 8-K

Results of Operations and Financial Condition, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 23, 2022 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission F

March 23, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 001-38418 Cocrystal Pharma, Inc. (Exact name of registrant as specif

December 22, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

December 22, 2021 EX-99.1

Antiviral activity now confirmed against SARS-CoV-2 and all variants of concern including Omicron, Delta, Alpha, Beta and Gamma

Exhibit 99.1 Cocrystal Pharma?s COVID-19 Oral and Intranasal/Pulmonary Protease Inhibitors Exhibit Powerful In Vitro Potency Against the SARS-CoV-2 Omicron Variant Antiviral activity now confirmed against SARS-CoV-2 and all variants of concern including Omicron, Delta, Alpha, Beta and Gamma BOTHELL, Wash. (December 22, 2021) ? Cocrystal Pharma, Inc. (Nasdaq: COCP) (?Cocrystal? or the ?Company?) an

November 19, 2021 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 16, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

November 15, 2021 EX-99.1

Cocrystal Pharma Reports Third Quarter Financial Results and Provides an Update on Development Programs and Milestones

Exhibit 99.1 Cocrystal Pharma Reports Third Quarter Financial Results and Provides an Update on Development Programs and Milestones ? Submitted pre-IND briefing package to the FDA for intranasal/pulmonary CDI-45205 for the treatment of COVID-19 and sets goal of initiating IND-enabling study and Phase 1 in 2022 ? Advance oral COVID-19 program with goal of initiating IND-enabling study and Phase 1 i

November 15, 2021 8-K

Results of Operations and Financial Condition, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 15, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

November 15, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA

September 14, 2021 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2021 Cocrystal Phar

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissi

September 14, 2021 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated September 2021

Exhibit 99.1

August 16, 2021 EX-10.1

Consulting and Scientific Advisory Board Agreement, dated April 13, 2021 with Roger Kornberg

Exhibit 10.1 CONSULTING AND SCIENTIFIC ADVISORY BOARD AGREEMENT This Agreement, dated as of April 13, 2021, is made and entered into by and between Cocrystal Discovery, Inc., a Delaware corporation (the ?Company?) and Roger Kornberg, an individual whose principal residence is in California (?Advisor?). 1. Services 1.1 Scope of Services. During the Term (as defined below), Advisor will serve as a c

August 16, 2021 EX-3.1

Certificate of Incorporation, as amended

Exhibit 3.1 CERTIFICATE OF INCORPORATION OF COCRYSTAL PHARMA, INC. (Conformed copy incorporating all amendments through August 6, 2021) 1. The name of the corporation is Cocrystal Pharma, Inc. (the ?Company?). 2. The address of its registered office in the State of Delaware, County of New Castle, is 3411 Silverside Road, Rodney Building #104, Wilmington, Delaware 19810. The name of its registered

August 16, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA, INC

July 20, 2021 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 16, 2021 Cocrystal Pharma, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 16, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

July 12, 2021 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated July 2021

Exhibit 99.1

July 12, 2021 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 12, 2021 Cocrystal Pharma, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 12, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

June 21, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 16, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

June 10, 2021 SC 13D/A

COCP / Cocrystal Pharma Inc / FROST PHILLIP MD ET AL - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 4)* Cocrystal Pharma, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 19188J300 (CUSIP Number) Phillip Frost, M.D. Frost Gamma Investments Trust Steven D. Rubin 4400 Biscayne Boulevard Miami, Florida 33137 (305) 575-6015 (Na

June 7, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

June 1, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

May 28, 2021 EX-99.1

Cocrystal Pharma Announces the Passing of Chairman, CEO and Co-founder Dr. Gary Wilcox

Exhibit 99.1 Cocrystal Pharma Announces the Passing of Chairman, CEO and Co-founder Dr. Gary Wilcox BOTHELL, Wash. (May 28, 2021) ? With great sadness, Cocrystal Pharma, Inc. (Nasdaq: COCP), (?Cocrystal? or the ?Company?) announces that Gary Wilcox, Ph.D., Chairman, CEO and co-founder, suddenly passed away Wednesday, May 26 at the age of 74. The Board of Directors and staff of Cocrystal extend the

May 28, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

May 28, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 27, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 25, 2021 SC 13D

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 COCRYSTAL PHARMA INC (Name of Issuer) Common Shares (Title of Class of Securities) 19188J300 (CUSIP Number) FiveT Investment Management Ltd c/o DMS Corporate Services, Suite 5B201, 2nd Floor, One Nexus Way Camana Bay, Grand Cayman, Cayman Islands KY1-1108 +1 345 749 2552 (

May 17, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. N/A)* Cocrystal Pharma, Inc. (Name of Issuer) Ordinary Shares, $0.001 par value per share (Title of Class of S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

May 17, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q [X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA

May 5, 2021 424B5

26,000,000 Shares of Common Stock

Filed pursuant to Rule 424(b)(5) Registration No. 333-237738 PROSPECTUS SUPPLEMENT (To the Prospectus dated May 13, 2020) 26,000,000 Shares of Common Stock We are offering 26,000,000 shares of our common stock, par value $0.001 per share, at a purchase price of $1.54 per share pursuant to this prospectus supplement and the accompanying prospectus. The offering is being underwritten on a firm commi

May 5, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation

May 5, 2021 EX-99.1

Cocrystal Pharma Announces $40 Million Bought Deal Offering of Common Stock

Exhibit 99.1 Cocrystal Pharma Announces $40 Million Bought Deal Offering of Common Stock BOTHELL, Wash., May 4, 2021 ? Cocrystal Pharma, Inc. (Nasdaq: COCP), (?Cocrystal? or the ?Company?), a clinical-stage biotechnology company discovering and developing novel antiviral therapeutics that target the replication machinery of influenza viruses, coronaviruses, hepatitis C viruses and noroviruses, tod

May 5, 2021 EX-1.1

Underwriting Agreement, dated as of May 4, 2021 by and between Cocrystal Pharma, Inc. and H.C. Wainwright & Co., LLC**

Exhibit 1.1 26,000,000 SHARES of Common Stock Cocrystal Pharma, Inc. UNDERWRITING AGREEMENT May 4, 2021 H.C. Wainwright & Co., LLC As the Representative of the Several underwriters, if any, named in Schedule I hereto c/o H.C. Wainwright & Co., LLC 430 Park Avenue New York, New York 10022 Ladies and Gentlemen: The undersigned, Cocrystal Pharma, Inc.,, a company incorporated under the laws of Delawa

May 5, 2021 8-K

Other Events, Financial Statements and Exhibits

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation

April 26, 2021 DEF 14A

Amendment to 2015 Equity Incentive Plan*

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by Registrant [X] Filed by Party other than Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) [X] Defin

April 26, 2021 DEFA14A

-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

April 16, 2021 PRE 14A

-

PRELIMINARY PROXY STATEMENT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 17, 2021 10-K

Annual Report -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K [X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2020 OR [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 000-38418 Cocrystal Pharma, Inc. (Exact name of registrant as sp

March 9, 2021 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated March 2021

Exhibit 99.1

March 9, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

February 19, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 14, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

February 19, 2021 EX-3.1

Amended and Restated Bylaws

Exhibit 3.1 AMENDED AND RESTATED BYLAWS OF COCRYSTAL PHARMA, INC. Article I. Meeting of Stockholders Section 1. Annual Meeting. The annual meeting of the stockholders of this Company shall be held at the time and place designated by the Board of Directors of the Company. Business transacted at the annual meeting shall include the election of directors of the Company. Section 2. Special Meetings. S

February 16, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. 1)* Cocr

CUSIP No: 19188J300 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. 1)* Cocrystal Pharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 19188J300 (CUSIP Numbe

January 21, 2021 EX-99.1

.

Exhibit 99.1 .

January 21, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 21, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

January 11, 2021 EX-99.1

Cocrystal Pharma, Inc. Investor Presentation, dated January 2021

Exhibit 99.1

January 11, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 11, 2021 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

December 18, 2020 8-K

Other Events -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 10, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

November 19, 2020 SC 13D/A

COCP / Cocrystal Pharma, Inc. / OPKO HEALTH, INC. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* Cocrystal Pharma, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 19188J300 (CUSIP Number) Camielle Green Associate General Counsel, Secretary OPKO Health, Inc. 4400 Biscayne Boulevard Miami, Florida 33137 Telephone: (30

November 13, 2020 10-Q

Quarterly Report -

10-Q 1 form10-q.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q [X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

November 6, 2020 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

8-K 1 form8k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 4, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorpora

October 2, 2020 EX-99.1

United States District Court DISTRICT OF NEW JERSEY

Exhibit 99.1 United States District Court DISTRICT OF NEW JERSEY TRENT NICHOLS and SHARON NICHOLS, derivatively on behalf of COCRYSTAL PHARMA, INC. F/K/A BIOZONE PHARMACEUTICALS, INC., Case No.: 2:19-cv-16751-KM-JBC Plaintiffs, vs. NOTICE OF PROPOSED SETTLEMENT OF DERIVATIVE ACTION TO CURRENT COCRYSTAL STOCKHOLDERS ELLIOTT MAZA, GARY WILCOX, JEFFREY MECKLER, GERALD MCGUIRE, JAMES MARTIN, CURTIS DA

October 2, 2020 8-K

Other Events, Financial Statements and Exhibits -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 22, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissi

October 2, 2020 EX-99.2

United States District Court DISTRICT OF NEW JERSEY

Exhibit 99.2 United States District Court DISTRICT OF NEW JERSEY TRENT NICHOLS and SHARON NICHOLS, derivatively on behalf of COCRYSTAL PHARMA, INC. F/K/A BIOZONE PHARMACEUTICALS, INC., Plaintiffs, vs. ELLIOTT MAZA, GARY WILCOX, JEFFREY MECKLER, GERALD MCGUIRE, JAMES MARTIN, CURTIS DALE, RAYMOND SCHINAZI, DAVID BLOCK, PHILLIP FROST, JANE H. HSIAO, STEVEN RUBIN, BRIAN KELLER, BARRY C. HONIG, JOHN ST

August 27, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 26, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorpora

August 27, 2020 EX-99.1

###

Exhibit 99.1 Cocrystal Pharma Increases Previously Announced Bought Deal to $15.0 Million BOTHELL, WA, August 26, 2020 – Cocrystal Pharma, Inc. (NASDAQ: COCP), (“Cocrystal” or the “Company”), a clinical stage biotechnology company discovering and developing novel antiviral therapeutics, announced today that, due to demand, the underwriter has agreed to increase the size of its previously announced

August 27, 2020 8-K

Other Events, Financial Statements and Exhibits -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 26, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

August 27, 2020 EX-1.1

Amended and Restated Underwriting Agreement, dated as of August 26, 2020, by and between Cocrystal Pharma, Inc. and H.C. Wainwright & Co., LLC *

Exhibit 1.1 14,285,715 SHARES of Common Stock Cocrystal Pharma, Inc. AMENDED AND RESTATED UNDERWRITING AGREEMENT August 26, 2020 H.C. Wainwright & Co., LLC As the Representative of the Several underwriters, if any, named in Schedule I hereto c/o H.C. Wainwright & Co., LLC 430 Park Avenue New York, New York 10022 Ladies and Gentlemen: The undersigned, Cocrystal Pharma, Inc., a company incorporated

August 27, 2020 EX-99.1

Cocrystal Pharma Announces $10.0 Million Bought Deal Offering

Exhibit 99.1 Cocrystal Pharma Announces $10.0 Million Bought Deal Offering BOTHELL, WA, August 26, 2020 – Cocrystal Pharma, Inc. (NASDAQ: COCP), (“Cocrystal” or the “Company”), a clinical stage biotechnology company discovering and developing novel antiviral therapeutics, announced today that it has entered into an underwriting agreement with H.C. Wainwright & Co., LLC under which the underwriter

August 27, 2020 8-K

Financial Statements and Exhibits, Other Events

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 26, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorpora

August 27, 2020 424B5

H.C. Wainwright & Co. The date of this prospectus supplement is August 26, 2020

Filed pursuant to Rule 424(b)(5) Registration No. 333-237738 PROSPECTUS SUPPLEMENT (To the Prospectus dated May 13, 2020) 14,285,715 Shares of Common Stock We are offering 14,285,715 shares of our common stock, par value $0.001 per share, at a purchase price of $1.05 per share pursuant to this prospectus supplement and the accompanying prospectus. The offering is being underwritten on a firm commi

August 26, 2020 424B5

Subject to Completion dated August 26, 2020

Filed pursuant to Rule 424(b)(5) Registration No. 333-237738 The information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are part of an effective registration statement filed with the Securities and Exchange Commission. This preliminary prospectus supplement and the accompanying prospectus are

August 6, 2020 EX-10.1

License Agreement, dated April 19, 2020, between the Company and Kansas State University Research Foundation****

Portions of this document have been omitted as permitted by the rules of the Securities and Exchange Commission.

August 6, 2020 10-Q

Quarterly Report -

10-Q 1 form10-q.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q [X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-384

July 2, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 1, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

July 2, 2020 EX-1.1

At-The-Market Offering Agreement, dated July 1, 2020, by and between the Company and H.C. Wainwright & Co., LLC

Exhibit 1.1 AT THE MARKET OFFERING AGREEMENT July 1, 2020 H.C. Wainwright & Co., LLC 430 Park Avenue New York, NY 10022 Ladies and Gentlemen: Cocrystal Pharma, Inc., a corporation organized under the laws of Delaware (the “Company”), confirms its agreement (this “Agreement”) with H.C. Wainwright & Co., LLC (the “Manager”) as follows: 1. Definitions. The terms that follow, when used in this Agreeme

July 1, 2020 424B5

H.C. Wainwright & Co. The date of this prospectus supplement is July 1, 2020

Filed pursuant to Rule 424(b)(5) Registration No. 333-237738 PROSPECTUS SUPPLEMENT (To the Prospectus dated May 22, 2020) Up to $10,000,000 of Common Stock We have entered into an At-The-Market Offering Agreement (the “Offering Agreement”) with H.C. Wainwright & Co., LLC, as sales agent (the “Agent” or “Wainwright”), relating to shares of our common stock, par value $0.001 per share (the “Common S

June 26, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 22, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

June 15, 2020 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

June 8, 2020 8-K

Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 13, 2020 EX-10.7

License Agreement, dated February 18, 2020, between the Company and Kansas State University Research Foundation****

Portions of this document have been omitted as permitted by the rules of the Securities and Exchange Commission.

May 13, 2020 10-Q

Quarterly Report -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q [X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2020 OR [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38418 COCRYSTAL PHARMA

May 12, 2020 CORRESP

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Cocrystal Pharma, Inc. 9805 North Creek Parkway Bothell, Washington May 12, 2020 Via EDGAR Division of Corporation Finance Securities and Exchange Commission 100 F Street, N.E. Washington, D. C. 20549 Attention: Mr. Tim Buchmiller Re: Cocrystal Pharma, Inc. Registration Statement on Form S-3 File No. 333-237738 Dear Mr. Buchmiller: In accordance with Rule 461 promulgated pursuant to the Securities

May 11, 2020 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated May 2020

Exhibit 99.1

May 11, 2020 CORRESP

-

MICHAEL D. HARRIS DIRECT DIAL: (561) 471-3507 ALSO ADMITTED IN NEW YORK E-MAIL ADDRESS: [email protected] May 11, 2020 VIA EDGAR Division of Corporation Finance U.S. Securities and Exchange Commission Washington, DC 20549 Attention: Mr. Tim Buchmiller Re: Cocrystal Pharma, Inc. Registration Statement on Form S-3 Filed April 17, 2020 File No. 333-237738 Dear Mr. Buchmiller: Confirming our tel

May 11, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fil

May 4, 2020 CORRESP

-

CORRESP 1 filename1.htm Cocrystal Pharma, Inc. 9805 North Creek Parkway Bothell, Washington May 4, 2020 Via EDGAR Division of Corporation Finance U.S. Securities and Exchange Commission Washington, DC 20549 Re: Cocrystal Pharma, Inc. Registration Statement on Form S-3 Filed April 17, 2020 File No. 333-237738 Dear Mr. Buchmiller: Please find our response to the comments received from you in your le

May 4, 2020 S-3/A

-

As filed with the Securities and Exchange Commission on May 4, 2020 Registration No.

April 28, 2020 DEFA14A

-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

April 28, 2020 DEF 14A

-

DEF 14A 1 def14a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by Registrant [X] Filed by Party other than Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule 1

April 22, 2020 EX-99.1

Cocrystal Pharma Expands Exclusive License Agreement with Kansas State University Research Foundation to New Coronavirus Antiviral Compounds with Novel Mechanism of Action - Expanded license agreement with KSURF further broadens and advances Cocrysta

Exhibit 99.1 Cocrystal Pharma Expands Exclusive License Agreement with Kansas State University Research Foundation to New Coronavirus Antiviral Compounds with Novel Mechanism of Action - Expanded license agreement with KSURF further broadens and advances Cocrystal’s COVID-19 program - - Small molecule therapeutic inhibitors against coronaviruses included in agreement have demonstrated strong proof

April 22, 2020 8-K

Entry into a Material Definitive Agreement, Regulation FD Disclosure, Financial Statements and Exhibits

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 19, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporat

April 20, 2020 EX-99.1

Cocrystal Pharma Announces Appointment of Nobel Laureate and Scientific Advisor, Roger D. Kornberg, Ph.D., to Board of Directors - Work completed over decades of renowned biochemist’s career serves as basis for Company’s structure-based technology wh

EX-99.1 2 ex99-1.htm Exhibit 99.1 Cocrystal Pharma Announces Appointment of Nobel Laureate and Scientific Advisor, Roger D. Kornberg, Ph.D., to Board of Directors - Work completed over decades of renowned biochemist’s career serves as basis for Company’s structure-based technology which has demonstrated broad utility in development of proprietary antivirals - BOTHELL, WA, April 20, 2020 – Cocrysta

April 20, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission F

April 17, 2020 S-3

COCP / Cocrystal Pharma, Inc. S-3 - -

As filed with the Securities and Exchange Commission on April 17, 2020 Registration No.

March 30, 2020 EX-99.1

Cocrystal Pharma Reports 2019 Financial Results and Outlines Expected Value-Driving Milestones for 2020

Exhibit 99.1 Cocrystal Pharma Reports 2019 Financial Results and Outlines Expected Value-Driving Milestones for 2020 ● Advancing preclinical COVID-19 Coronavirus program leveraging patent rights recently acquired from Kansas State University Research Foundation (“KSURF”) ● Continuing collaboration with Merck to discover and develop certain proprietary influenza A/B antiviral agents ● Expecting to

March 30, 2020 8-K

Results of Operations and Financial Condition, Other Events, Financial Statements and Exhibits

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 30, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporat

March 27, 2020 EX-21.1

Subsidiaries of Cocrystal Pharma, Inc. Name of Subsidiary Jurisdiction of Incorporation Cocrystal Discovery, Inc. Delaware Cocrystal Merger Sub, Inc. Delaware

Exhibit 21.1 Subsidiaries of Cocrystal Pharma, Inc. Name of Subsidiary Jurisdiction of Incorporation Cocrystal Discovery, Inc. Delaware Cocrystal Merger Sub, Inc. Delaware

March 27, 2020 10-K

COCP / Cocrystal Pharma, Inc. 10-K - Annual Report -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K [X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2019 OR [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number: 000-38418 Cocrystal Pharma, Inc. (Exact name of registrant as sp

March 27, 2020 EX-4.1

Description of Capital Stock

Exhibit 4.1 DESCRIPTION OF CAPITAL STOCK The following is a summary of our capital stock and provisions of our amended and restated articles of incorporation and amended and restated by-laws. For more detailed information, please refer to our certificate of incorporation and by-laws, which are filed, or incorporated by reference, as exhibits to the Annual Report on Form 10-K for the year ended Dec

March 13, 2020 EX-99.1

Cocrystal Pharma Announces Closing of $6.8 Million Registered Direct Offering Priced At-the-Market

Exhibit 99.1 Cocrystal Pharma Announces Closing of $6.8 Million Registered Direct Offering Priced At-the-Market BOTHELL, WA, March 11, 2020 — COCRYSTAL PHARMA, INC. (NASDAQ: COCP) (“Cocrystal” or the “Company”), a clinical stage biotechnology company discovering and developing novel antiviral therapeutics, announced today the closing of its previously announced registered direct offering with seve

March 13, 2020 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Other Events, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Regulation FD Disclosure, Financial Statements and Exhibits

8-K 1 form8k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporatio

March 13, 2020 EX-10.1

Form of Securities Purchase Agreement, dated March 9, 2020**

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of March 9, 2020, and is between Cocrystal Pharma, Inc., a corporation incorporated under the laws of the state of Delaware (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchaser

March 10, 2020 424B5

H.C. Wainwright & Co. The date of this prospectus supplement is March 9, 2020

Filed pursuant to Rule 424(b)(5) Registration No. 333-220632 PROSPECTUS SUPPLEMENT (To the Prospectus dated October 10, 2017) 5,037,038 Shares of Common Stock We are offering up to 5,037,038 shares of our common stock, par value $0.001 per share at a purchase price of $1.35 per share of common stock to certain institutional investors pursuant to this prospectus supplement and the accompanying pros

March 10, 2020 SC 13D/A

COCP / Cocrystal Pharma, Inc. / Opko Health, Inc. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Cocrystal Pharma, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 19188J300 (CUSIP Number) Kate Inman General Counsel, Secretary OPKO Health, Inc. 4400 Biscayne Boulevard Miami, Florida 33137 Telephone: (305) 575-4100 Ph

March 9, 2020 EX-99.1

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EX-99.1 2 ex99-1.htm Exhibit 99.1 Cocrystal Pharma Announces Plans to Advance Coronavirus Program ● Company has immediately initiated Coronavirus program ● Leveraging patent rights recently acquired from Kansas State University Research Foundation (“KSURF”) ● Strong financial position bolsters Company’s ongoing research and development efforts BOTHELL, WA, March 6, 2020 – Cocrystal Pharma, Inc. (N

March 9, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 6, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporati

March 6, 2020 SC 13G

COCP / Cocrystal Pharma, Inc. / CVI Investments, Inc. - SC 13G Passive Investment

CUSIP No: 19188J300 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. )* Cocrystal Pharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 19188J300 (CUSIP Number

March 4, 2020 EX-10.2

Engagement Letter, dated February 26, 2020

Exhibit 10.2 H.C.WAINWRIGHT&CO. February 26, 2020 Cocrystal Pharma, Inc. 19805 N. Creek Parkway Bothell, WA 98011 Attn: Gary Wilcox, Chief Executive Officer Dear Mr. Wilcox: This letter agreement (this “Agreement”) constitutes the agreement between Cocrystal Pharma, Inc. (the “Company”) and H.C. Wainwright & Co., LLC (“Wainwright”), that Wainwright shall serve as the exclusive agent, advisor or un

March 4, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 4, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission Fi

March 4, 2020 EX-99.1

Cocrystal Pharma Announces Closing of $11.0 Million Registered Direct Offering Priced At-the-Market

Exhibit 99.1 Cocrystal Pharma Announces Closing of $11.0 Million Registered Direct Offering Priced At-the-Market FEBRUARY 28, 2020 BOTHELL, WA, Feb. 28, 2020 (GLOBE NEWSWIRE) — COCRYSTAL PHARMA, INC. (NASDAQ: COCP) (“Cocrystal” or the “Company”), a clinical stage biotechnology company discovering and developing novel antiviral therapeutics, announced today the closing of its previously announced r

March 4, 2020 8-K

Entry into a Material Definitive Agreement, Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

March 4, 2020 EX-99.1

Investor Presentation dated March 2020

Exhibit 99.1

March 4, 2020 EX-10.1

Form of Securities Purchase Agreement, dated February 27, 2020**

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of February 27, 2020, and is between Cocrystal Pharma, Inc., a corporation incorporated under the laws of the state of Delaware (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purch

February 28, 2020 424B5

H.C. Wainwright & Co. The date of this prospectus supplement is February 27, 2020

Filed pursuant to Rule 424(b)(5) Registration No. 333-220632 PROSPECTUS SUPPLEMENT (To the Prospectus dated October 10, 2017) 8,461,540 Shares of Common Stock We are offering up to 8,461,540 shares of our common stock, par value $0.001 per share at a purchase price of $1.30 per share of common stock to certain institutional investors pursuant to this prospectus supplement and the accompanying pros

February 28, 2020 SC 13G/A

COCP / Cocrystal Pharma, Inc. / LSP Advisory B.V. - SC 13G/A Passive Investment

SC 13G/A United States Securities and Exchange Commission Washington, D.C. 20549 Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3)* Cocrystal Pharma, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 19188J

February 24, 2020 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 18, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

February 18, 2020 EX-99.1

Cocrystal Pharma, Inc. Corporate Presentation, dated February 2020

EX-99.1 2 ex99-1.htm

February 18, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 18, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commissio

February 10, 2020 SC 13G/A

COCP / Cocrystal Pharma, Inc. / LSP Advisory B.V. - SC 13G/A Passive Investment

SC 13G/A 1 d881293dsc13ga.htm SC 13G/A United States Securities and Exchange Commission Washington, D.C. 20549 Schedule 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* Cocrystal Pharma, Inc. (Name of Issuer) Common Stock (Title

January 31, 2020 424B5

The date of this prospectus supplement is January 29, 2020

Filed pursuant to Rule 424(b)(5) Registration No. 333-220632 PROSPECTUS SUPPLEMENT (To the Prospectus dated October 10, 2017) Up to $200,000 maximum aggregate offering price of Common Stock We have entered into an amendment to the amended and restated equity distribution agreement with A.G.P./Alliance Global Partners (the “Agent”), relating to shares of our common stock, par value $0.001 per share

January 31, 2020 EX-10.1

Form of Securities Purchase Agreement**

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of January , 2020, and is between Cocrystal Pharma, Inc., a corporation incorporated under the laws of the state of Delaware (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchase

January 31, 2020 EX-1.1

Placement Agency Agreement, dated January 29, 2020

Exhibit 1.1 January 28, 2020 Cocrystal Pharma, Inc. 19805 N. Creek Parkway Bothell, WA 98011 Attention: Gary Wilcox Chief Executive Officer Dear Mr. Wilcox: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as placement agent (“A.G.P.” or the “Placement Agent”) and Cocrystal Pharma, Inc., a company organized under the laws of the state of Delaware (th

January 31, 2020 424B5

A.G.P. The date of this prospectus supplement is January 29, 2020

Filed pursuant to Rule 424(b)(5) Registration No. 333-220632 PROSPECTUS SUPPLEMENT (To the Prospectus dated October 10, 2017) 3,492,063 Shares of Common Stock We are offering up to 3,492,063 shares of our common stock, par value $0.001 per share at a purchase price of $0.63 per share of common stock to institutional investors pursuant to this prospectus supplement and the accompanying prospectus a

January 31, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 29, 2020 Cocrystal Pharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-38418 35-2528215 (State or other Jurisdiction of Incorporation) (Commission

January 29, 2020 EX-1.1

Amendment No. 1 to the Amended and Restated Equity Distribution Agreement

Cocrystal Pharma, Inc. 19805 N. Creek Parkway Bothell, WA 98011 January 29, 2020 A.G.P./Alliance Global Partners 590 Madison Avenue, 36th Floor New York, New York 10022 Ladies and Gentlemen: This letter agreement documents our understanding regarding amending that certain Amended and Restated Equity Distribution Agreement between Cocrystal Pharma, Inc. (the “Company”) and A.G.P./Alliance Global Pa

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