DICE / DICE Therapeutics Inc - Документы SEC, Годовой отчет, Доверенное заявление

DICE Therapeutics Inc.
US ˙ NASDAQ ˙ US23345J1043
ЭТОТ СИМВОЛ БОЛЬШЕ НЕ АКТИВЕН

Основная статистика
CIK 1645569
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to DICE Therapeutics Inc
SEC Filings (Chronological Order)
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August 21, 2023 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-40794 DICE THERAPEUTICS, INC. (Exact name of registrant as specified in

August 9, 2023 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF DICE THERAPEUTICS, INC.

EX-3.1 Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF DICE THERAPEUTICS, INC. 1. The name of the corporation is: DICE Therapeutics, Inc. (the “Corporation”). 2. The address of the Corporation’s registered office in the State of Delaware is 1209 Orange Street, Wilmington, New Castle County, Delaware 19801. The name of its registered agent at such address is: National Registered Ag

August 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2023 DICE THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2023 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commission

August 9, 2023 S-8 POS

As filed with the Securities and Exchange Commission on August 9, 2023

As filed with the Securities and Exchange Commission on August 9, 2023 Registration No.

August 9, 2023 EX-3.2

AMENDED AND RESTATED BYLAWS DICE THERAPEUTICS, INC. (a Delaware corporation) ARTICLE I

EX-3.2 Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF DICE THERAPEUTICS, INC. (a Delaware corporation) ARTICLE I STOCKHOLDERS Section 1. Annual Meetings. The annual meeting of the stockholders of Dice Therapeutics, Inc. (the “Corporation”) for the election of directors and for the transaction of such other business as may properly come before the meeting shall be held each year at such date and time,

August 9, 2023 POS AM

As filed with the Securities and Exchange Commission on August 9, 2023

As filed with the Securities and Exchange Commission on August 9, 2023 Registration No.

August 9, 2023 EX-99.(A)(5)(C)

Lilly Completes Acquisition of DICE Therapeutics

EX-99.(a)(5)(C) Exhibit (a)(5)(C) For Release: Aug. 9, 2023 Refer to: Jordan Bishop; [email protected]; 317-473-5712 (Media) Joe Fletcher; [email protected]; 317-296-2884 (Investors) Lilly Completes Acquisition of DICE Therapeutics INDIANAPOLIS, Aug. 9, 2023 — Eli Lilly and Company (NYSE: LLY) today announced the successful completion of its acquisition of DICE Therapeutics, Inc. (NASDAQ:

August 9, 2023 SC 13D/A

DICE / DICE Therapeutics Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 4)* DICE THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 23345J104 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617.778.2500 (Na

August 9, 2023 S-8 POS

As filed with the Securities and Exchange Commission on August 9, 2023

As filed with the Securities and Exchange Commission on August 9, 2023 Registration No.

August 9, 2023 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 3) DICE THERAPEUTICS, INC. (Name of Subject Company (i

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 3) DICE THERAPEUTICS, INC. (Name of Subject Company (issuer)) DURNING ACQUISITION CORPORATION (Offeror) a wholly-owned subsidiary of ELI LILLY AND COMPANY (Parent of Offeror) (Names of Filing Persons (ide

August 9, 2023 SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 3) DICE Therapeutics, Inc. (Name

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 3) DICE Therapeutics, Inc. (Name of Subject Company) DICE Therapeutics, Inc. (Name of Person(s) Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securiti

August 9, 2023 S-8 POS

As filed with the Securities and Exchange Commission on August 9, 2023

As filed with the Securities and Exchange Commission on August 9, 2023 Registration No.

August 9, 2023 POSASR

As filed with the Securities and Exchange Commission on August 9, 2023

As filed with the Securities and Exchange Commission on August 9, 2023 Registration No.

August 8, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40794 DICE THERA

July 25, 2023 EX-99.(A)(5)(B)

Lilly Announces Extension of Tender Offer to Acquire DICE

EX-99.(a)(5)(B) Exhibit (a)(5)(B) For Release: July 25, 2023 @ 6:55 a.m. ET Refer to: Jordan Bishop; [email protected]; 317-473-5712 (Media) Joe Fletcher; [email protected]; 317-296-2884 (Investors) Lilly Announces Extension of Tender Offer to Acquire DICE INDIANAPOLIS, July 25, 2023 – Eli Lilly and Company (NYSE: LLY) today announced the extension of the expiration of the tender offer to

July 25, 2023 SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 2) DICE Therapeutics, Inc. (Name

SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 2) DICE Therapeutics, Inc. (Name of Subject Company) DICE Therapeutics, Inc. (Name of Person(s) Filing Statement) Common Stock, par value $0.0001 per share (Title of Class o

July 25, 2023 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No.2) DICE THERAPEUTICS, INC. (Name of Subject Company (is

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No.2) DICE THERAPEUTICS, INC. (Name of Subject Company (issuer)) DURNING ACQUISITION CORPORATION (Offeror) a wholly-owned subsidiary of ELI LILLY AND COMPANY (Parent of Offeror) (Names of Filing Per

July 17, 2023 SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 1) DICE Therapeutics, Inc. (Name

SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 1) DICE Therapeutics, Inc. (Name of Subject Company) DICE Therapeutics, Inc. (Name of Person(s) Filing Statement) Common Stock, par value $0.0001 per share (Title of Class o

July 17, 2023 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No.1) DICE THERAPEUTICS, INC. (Name of Subject Company (is

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No.1) DICE THERAPEUTICS, INC. (Name of Subject Company (issuer)) DURNING ACQUISITION CORPORATION (Offeror) a wholly-owned subsidiary of ELI LILLY AND COMPANY (Parent of Offeror) (Names of Filing Per

June 30, 2023 EX-99.(A)(1)(E)

This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below). The Offer (as defined below) is being made only by the Offer to Purchase, dated June 30, 2023 (the “Offer to Purchase”) and the relate

EX-99.(a)(1)(E) Exhibit (a)(1)(E) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below). The Offer (as defined below) is being made only by the Offer to Purchase, dated June 30, 2023 (the “Offer to Purchase”) and the related Letter of Transmittal, as each may be amended or supplemented from time to time, and is being made to all holders

June 30, 2023 SC 14D9

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 DICE Therapeutics, Inc. (Name of Subject Company

SC 14D9 Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

June 30, 2023 EX-99.(A)(1)(D)

Offer to Purchase All Outstanding Shares of Common Stock DICE THERAPEUTICS, INC. $48.00 per share, net in cash, without interest and less any applicable tax withholding Pursuant to the Offer to Purchase dated June 30, 2023 DURNING ACQUISITION CORPORA

EX-99.(a)(1)(D) Exhibit (a)(1)(D) Offer to Purchase All Outstanding Shares of Common Stock of DICE THERAPEUTICS, INC. at $48.00 per share, net in cash, without interest and less any applicable tax withholding Pursuant to the Offer to Purchase dated June 30, 2023 by DURNING ACQUISITION CORPORATION a wholly-owned subsidiary of ELI LILLY AND COMPANY THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT ONE

June 30, 2023 EX-99.(A)(1)(A)

Offer to Purchase All Outstanding Shares of Common Stock DICE THERAPEUTICS, INC. $48.00 per share, net in cash, without interest and less any applicable tax withholding DURNING ACQUISITION CORPORATION a wholly-owned subsidiary of ELI LILLY AND COMPAN

EX-99.(a)(1)(A) Table of Contents Exhibit (a)(1)(A) Offer to Purchase All Outstanding Shares of Common Stock of DICE THERAPEUTICS, INC. at $48.00 per share, net in cash, without interest and less any applicable tax withholding by DURNING ACQUISITION CORPORATION a wholly-owned subsidiary of ELI LILLY AND COMPANY THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT ONE MINUTE PAST 11:59 P.M., EASTERN TIME

June 30, 2023 SC TO-T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 DICE THERAPEUTICS, INC. (Name of Subject Company (issuer)) DURNING AC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 DICE THERAPEUTICS, INC. (Name of Subject Company (issuer)) DURNING ACQUISITION CORPORATION (Offeror) a wholly-owned subsidiary of ELI LILLY AND COMPANY (Parent of Offeror) (Names of Filing Persons (identifying status as

June 30, 2023 EX-99.(A)(1)(C)

Offer to Purchase All Outstanding Shares of Common Stock DICE THERAPEUTICS, INC. $48.00 per share, net in cash, without interest and less any applicable tax withholding Pursuant to the Offer to Purchase dated June 30, 2023 DURNING ACQUISITION CORPORA

EX-99.(a)(1)(C) Exhibit (a)(1)(C) Offer to Purchase All Outstanding Shares of Common Stock of DICE THERAPEUTICS, INC. at $48.00 per share, net in cash, without interest and less any applicable tax withholding Pursuant to the Offer to Purchase dated June 30, 2023 by DURNING ACQUISITION CORPORATION a wholly-owned subsidiary of ELI LILLY AND COMPANY THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT ONE

June 30, 2023 EX-99.(A)(1)(B)

LETTER OF TRANSMITTAL to Tender Shares of Common Stock DICE THERAPEUTICS, INC. $48.00 per share, net in cash, without interest and less any applicable tax withholding Pursuant to the Offer to Purchase dated June 30, 2023 DURNING ACQUISITION CORPORATI

EX-99.(a)(1)(B) Exhibit (a)(1)(B) LETTER OF TRANSMITTAL to Tender Shares of Common Stock of DICE THERAPEUTICS, INC. at $48.00 per share, net in cash, without interest and less any applicable tax withholding Pursuant to the Offer to Purchase dated June 30, 2023 by DURNING ACQUISITION CORPORATION a wholly-owned subsidiary of ELI LILLY AND COMPANY THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT ONE MI

June 30, 2023 EX-99.(D)(4)

CONFIDENTIALITY AGREEMENT

EX-99.(d)(4) Exhibit (d)(4) Contract No.: ICMConfidentialityAgreement6334 CONFIDENTIALITY AGREEMENT THIS CONFIDENTIALITY AGREEMENT (the “Agreement”) is made on the last date signed below, (the “Effective Date”), between Eli Lilly And Company, having its principal place of business at Lilly Corporate Center, Indianapolis, Indiana 46285, United States (“Lilly”), and DiCE Therapeutics, Inc. having it

June 30, 2023 EX-99.(D)(5)

FIRST AMENDMENT TO CONFIDENTIALITY AGREEMENT

EX-99.(d)(5) Exhibit (d)(5) FIRST AMENDMENT TO CONFIDENTIALITY AGREEMENT Eli Lilly And Company and DICE Therapeutics, Inc. entered into a Confidentiality Agreement effective April 21, 2022 (the “Agreement”). This amendment (“Amendment”) forms part of and is hereby incorporated by reference into the Agreement. By this Amendment, the parties agree to, and hereby: (a) extend the term of the Agreement

June 30, 2023 EX-FILING FEES

Calculation of Filing Fee Tables Schedule TO DICE THERAPEUTICS, INC. (Name of Subject Company (issuer)) DURNING ACQUISITION CORPORATION a wholly-owned subsidiary of ELI LILLY AND COMPANY (Parent of Offeror) (Names of Filing Persons (identifying statu

EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables Schedule TO DICE THERAPEUTICS, INC.

June 23, 2023 SC 13D/A

DICE / DICE Therapeutics Inc / Northpond Ventures, LP - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* DICE Therapeutics, Inc. (Name of Issuer) Common stock, par value $0.0001 per share (Title of Class of Securities) 23345J104 (CUSIP Number) Paul Hodgdon c/o Northpond Ventures, LLC 7500 Old Georgetown Road, Suite 800 Bethesda, MD 20814 240-800-12

June 22, 2023 SC 13D/A

DICE / DICE Therapeutics Inc / Sands Capital Life Sciences Pulse Fund II, L.P. - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) DICE Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 23345J104 (CUSIP Number) Jonathan Goodman Sands Capital Ventures, LLC 1000 Wilson Blvd., Suite 3000, Arlington VA 22209 Telephone: (703) 562-4000 (Name, Address

June 21, 2023 SC 13D/A

DICE / DICE Therapeutics Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* DICE THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 23345J104 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617.778.2500 (Na

June 20, 2023 EX-10.1

Tender and Support Agreement, dated June 18, 2023, by and among Eli Lilly and Company, Durning Acquisition Corporation, RA Capital Healthcare Fund, L.P. and RA Capital Nexus Fund II, L.P. (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed by DICE Therapeutics, Inc. with the Securities and Exchange Commission on June 20, 2023 (File No. 001-40794)).

EX-10.1 Exhibit 10.1 TENDER AND SUPPORT AGREEMENT This TENDER AND SUPPORT AGREEMENT (this “Agreement”), dated as of June 18, 2023, is entered into by and among Eli Lilly and Company, an Indiana corporation (“Parent”), Durning Acquisition Corporation, a Delaware corporation and a wholly-owned subsidiary of Parent (“Merger Sub”), and the stockholders of DICE Therapeutics, Inc., a Delaware corporatio

June 20, 2023 EX-10.2

Tender and Support Agreement, dated June 18, 2023, by and among Eli Lilly and Company, Durning Acquisition Corporation and J. Kevin Judice, PhD. (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed by DICE Therapeutics, Inc. with the Securities and Exchange Commission on June 20, 2023 (File No. 001-40794)).

EX-10.2 Exhibit 10.2 TENDER AND SUPPORT AGREEMENT This TENDER AND SUPPORT AGREEMENT (this “Agreement”), dated as of June 18, 2023, is entered into by and among Eli Lilly and Company, an Indiana corporation (“Parent”), Durning Acquisition Corporation, a Delaware corporation and a wholly-owned subsidiary of Parent (“Merger Sub”), and the stockholders of DICE Therapeutics, Inc., a Delaware corporatio

June 20, 2023 EX-99.2

Email to Service Providers

EX-99.2 Exhibit 99.2 Email to Service Providers Colleagues, Earlier today, we announced that DICE Therapeutics has entered into a definitive agreement to be acquired by Eli Lilly and Company. Below is the email Kevin sent to employees announcing this news. As a key member of the DICE team, we wanted to confirm that our work at DICE continues as usual. Between the signing and closing, DICE Therapeu

June 20, 2023 EX-99.3

Employee FAQ

EX-99.3 Exhibit 99.3 Employee FAQ 1. What was announced today? Eli Lilly and Company and DICE Therapeutics, Inc. (“DICE” or “DICE Therapeutics”) announced an agreement for the acquisition of DICE Therapeutics for $48 per share, or approximately $2.4 billion. 2. Why does Lilly want to acquire DICE? Lilly was looking for opportunities to expand the breadth of its immunology portfolio and recognized

June 20, 2023 SC14D9C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 DICE Therapeutics, Inc. (Name of Subject Company

SC14D9C UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement under Section 14(d)(4) of the Securities Exchange Act of 1934 DICE Therapeutics, Inc. (Name of Subject Company) DICE Therapeutics, Inc. (Name of Person(s) Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securities) 2345J

June 20, 2023 EX-99.1

Lilly to Acquire DICE Therapeutics to Advance Innovation in Immunology

EX-99.1 Exhibit 99.1 June 20, 2023 For Release: June 20, 2023 @ 6:45 a.m. ET Refer to: Jordan Bishop; [email protected]; 317-473-5712 (Media) Joe Fletcher; [email protected]; 317-296-2884 (Investors) Dan Budwick; [email protected] (DICE Media and Investors) Lilly to Acquire DICE Therapeutics to Advance Innovation in Immunology INDIANAPOLIS and SOUTH SAN FRANCISCO, Calif., June 20, 2023 – El

June 20, 2023 SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 DICE THERAPEUTICS, INC. (Name of Subject Company (issuer)) DURNING AC

SC TO-C UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 DICE THERAPEUTICS, INC. (Name of Subject Company (issuer)) DURNING ACQUISITION CORPORATION (Offeror) a wholly-owned subsidiary of ELI LILLY AND COMPANY (Parent of Offeror) (Names of Filing Persons (identifying s

June 20, 2023 EX-99.4

Investor FAQ

EX-99.4 EXHIBIT 99.4 Investor FAQ 1. When will more information about the transaction and negotiations be available? Eli Lilly and Company will initiate the tender offer process with a public filing of a tender offer document, and DICE Therapeutics, Inc. (“DICE”) will make its own public filing at the same time. Please review these documents for additional background to the transaction. 2. Why sel

June 20, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2023 DICE THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2023 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commission F

June 20, 2023 EX-99.1

Lilly to Acquire DICE Therapeutics to Advance Innovation in Immunology

EX-99.1 Exhibit 99.1 June 20, 2023 For Release: June 20, 2023 @ 6:45 a.m. ET Refer to: Jordan Bishop; [email protected]; 317-473-5712 (Media) Joe Fletcher; [email protected]; 317-296-2884 (Investors) Dan Budwick; [email protected] (DICE Media and Investors) Lilly to Acquire DICE Therapeutics to Advance Innovation in Immunology INDIANAPOLIS and SOUTH SAN FRANCISCO, Calif., June 20, 2023 – El

June 20, 2023 EX-99.1

Lilly to Acquire DICE Therapeutics to Advance Innovation in Immunology

EX-99.1 Exhibit 99.1 June 20, 2023 For Release: June 20, 2023 @ 6:45 a.m. ET Refer to: Jordan Bishop; [email protected]; 317-473-5712 (Media) Joe Fletcher; [email protected]; 317-296-2884 (Investors) Dan Budwick; [email protected] (DICE Media and Investors) Lilly to Acquire DICE Therapeutics to Advance Innovation in Immunology INDIANAPOLIS and SOUTH SAN FRANCISCO, Calif., June 20, 2023 – El

June 20, 2023 EX-2.1

Agreement and Plan of Merger, dated June 18, 2023, by and among Eli Lilly and Company, Durning Acquisition Corporation and DICE Therapeutics, Inc. (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed by DICE Therapeutics, Inc. with the Securities and Exchange Commission on June 20, 2023 (File No. 001-40794)).

EX-2.1 Exhibit 2.1 AGREEMENT AND PLAN OF MERGER DATED AS OF JUNE 18, 2023, AMONG ELI LILLY AND COMPANY, DURNING ACQUISITION CORPORATION AND DICE THERAPEUTICS, INC. Table of Contents Page ARTICLE I DEFINITIONS 2 SECTION 1.01 Definitions 2 SECTION 1.02 Interpretation and Rules of Construction 11 ARTICLE II THE OFFER 12 SECTION 2.01 The Offer 12 SECTION 2.02 Company Actions 14 ARTICLE III THE MERGER

June 7, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 07, 2023 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commission F

June 7, 2023 EX-3.1

DICE THERAPEUTICS, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

Exhibt 3.1 DICE THERAPEUTICS, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION DICE Therapeutics, Inc., a Delaware corporation, hereby certifies as follows: 1. The name of this corporation is “DICE Therapeutics, Inc.” The date of the filing of its original Certificate of Incorporation with the Secretary of State of the State of Delaware was September 14, 2021 under the name DICE Therapeutics

May 11, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2023 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 11, 2023 EX-99.1

DICE Therapeutics Reports First Quarter 2023 Financial Results and Recent Highlights

Exhibit 99.1 DICE Therapeutics Reports First Quarter 2023 Financial Results and Recent Highlights • First patient dosed in global Phase 2b clinical trial of lead oral IL-17 inhibitor, DC-806, in moderate-to-severe psoriasis • Topline data from Phase 1 clinical trial of second oral IL-17 inhibitor, DC-853, in healthy volunteers expected in 2H 2023 • Strong financial position with $554.5 million in

May 11, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40794 DICE THER

April 26, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

April 26, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 14, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

March 29, 2023 SC 13D/A

DICE / DICE Therapeutics Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* DICE THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 23345J104 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617.778.2500 (Na

March 15, 2023 EX-4.4

Form of Debt Security

EX-4.4 Exhibit 4.4 FORM OF DEBT SECURITY [Face of Security] DICE THERAPEUTICS, INC. [If applicable, insert—FOR PURPOSES OF THE ORIGINAL ISSUE DISCOUNT PROVISIONS OF THE INTERNAL REVENUE CODE OF 1986, THE ISSUE PRICE OF THIS SECURITY IS % OF ITS PRINCIPAL AMOUNT AT STATED MATURITY SET FORTH BELOW (ITS “PRINCIPAL AMOUNT”), THE AMOUNT OF ORIGINAL ISSUE DISCOUNT IS % OF ITS PRINCIPAL AMOUNT, THE YIELD

March 15, 2023 10-K

Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40794 DICE THERAPEUTICS, INC. (

March 15, 2023 EX-99

Press release issued by DICE Therapeutics, Inc. on March 15, 2023.

Exhibit 99.1 DICE Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Recent Highlights • IND application for DICE’s lead oral IL-17 antagonist, DC-806, cleared by FDA; global Phase 2b clinical trial in patients with moderate-to-severe psoriasis on track to initiate in 1H 2023 • First participants dosed in Phase 1 clinical trial of second oral IL-17 antagonist DC-853; topl

March 15, 2023 S-3ASR

As filed with the Securities and Exchange Commission on March 15, 2023

S-3ASR Table of Contents As filed with the Securities and Exchange Commission on March 15, 2023 Registration No.

March 15, 2023 S-8

As filed with the Securities and Exchange Commission on March 15, 2023

As filed with the Securities and Exchange Commission on March 15, 2023 Registration No.

March 15, 2023 EX-10

Offer Letter, dated September 7, 2021, by and between the Registrant and Timothy Lu, M.D., Ph.D.

Exhibit 10.9 279 E. Grand Avenue South San Francisco, CA 94080 (ph) 650.566.1402 (fx) 650.566.1429 www.dicemolecules.com September 24, 2021 Timothy Lu, PhD, MD Via Email Dear Dr. Lu: This letter agreement amends and restates the offer letter between you and DICE Therapeutics, Inc. (the “Company”)1, dated July 23, 2020 (the “Prior Agreement”) effective [ ]2, 2021. You will continue to work in the r

March 15, 2023 EX-21

Subsidiaries of the Registrant.

Exhibit 21.1 Subsidiaries of the Registrant DiCE Molecules SV, Inc. DiCE Alpha, Inc.

March 15, 2023 EX-1.2

ATM Equity OfferingTM Sales Agreement, dated March 15, 2023, by and among DICE Therapeutics, Inc., BofA Securities, Inc. and Stifel, Nicolaus & Company, Incorporated

EX-1.2 Exhibit 1.2 DICE Therapeutics, Inc. Common Stock ($0.0001 par value) ATM EQUITY OFFERINGSM SALES AGREEMENT March 15, 2023 BofA Securities, Inc. Stifel, Nicolaus & Company, Incorporated c/o BofA Securities, Inc. One Bryant Park New York, New York 10036 Stifel, Nicolaus & Company, Incorporated 787 7th Avenue New York, New York 10019 Ladies and Gentlemen: DICE Therapeutics, Inc., a Delaware co

March 15, 2023 EX-FILING FEES

Filing Fee Table

EX-FILING FEES Exhibit 107 Calculation of Fee Filing Tables Form S-3 (Form Type) DICE Therapeutics, Inc.

March 15, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 15, 2023 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commission

March 15, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) DICE Therapeutics, Inc.

March 15, 2023 EX-4.5

Form of Indenture

EX-4.5 Exhibit 4.5 DICE THERAPEUTICS, INC. And , as Trustee INDENTURE Dated as of , TABLE OF CONTENTS ARTICLE 1 – DEFINITIONS AND INCORPORATION BY REFERENCE 1 1.1 DEFINITIONS 1 1.2. OTHER DEFINITIONS 4 1.3. INCORPORATION BY REFERENCE OF TRUST INDENTURE ACT 4 1.4. RULES OF CONSTRUCTION 4 ARTICLE 2 – THE SECURITIES 5 2.1. ISSUABLE IN SERIES 5 2.2. ESTABLISHMENT OF TERMS OF SERIES OF SECURITIES 5 2.3

February 14, 2023 SC 13G

DICE / DICE Therapeutics Inc / Avoro Capital Advisors LLC - DICE THERAPEUTICS, INC. Passive Investment

SC 13G 1 p23-0584sc13g.htm DICE THERAPEUTICS, INC. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Dice Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 23345J104 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of This Statement) Check

February 10, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 07, 2023 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commissi

November 17, 2022 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2022 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commissi

November 17, 2022 EX-3.1

Restated Bylaws.

Exhibit 3.1 DICE THERAPEUTICS, INC. (a Delaware corporation) RESTATED BYLAWS As Amended and Restated on November 14, 2022 DICE THERAPEUTICS, INC. (a Delaware corporation) RESTATED BYLAWS TABLE OF CONTENTS Page Article I: STOCKHOLDERS 1 Section 1.1: Annual Meetings 1 Section 1.2: Special Meetings 1 Section 1.3: Notice of Meetings 1 Section 1.4: Adjournments 1 Section 1.5: Quorum 2 Section 1.6: Orga

November 10, 2022 SC 13G/A

DICE / DICE Therapeutics Inc / DRIEHAUS CAPITAL MANAGEMENT LLC - NONE Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* DICE Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 23345J104 (CUSIP Number) October 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

November 10, 2022 SC 13D/A

DICE / DICE Therapeutics Inc / Northpond Ventures, LP - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* DICE Therapeutics, Inc. (Name of Issuer) Common stock, par value $0.0001 per share (Title of Class of Securities) 23345J104 (CUSIP Number) Paul Hodgdon c/o Northpond Ventures, LLC 7500 Old Georgetown Road, Suite 850 Bethesda, MD 20814 240-800-1200 (Name,

November 9, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 09, 2022 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commissi

November 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40794 DICE

November 9, 2022 EX-99.1

DICE Therapeutics Reports Third Quarter 2022 Financial Results and Recent Highlights

Exhibit 99.1 DICE Therapeutics Reports Third Quarter 2022 Financial Results and Recent Highlights • Reported positive Phase 1 proof-of-concept data supporting the further development of lead oral IL-17 antagonist, DC-806, as potential best-in-class oral agent for psoriasis • Demonstrated direct inhibition of a cytokine with a small molecule in psoriasis patients, which we believe validates the DEL

October 19, 2022 SC 13D/A

DICE / DICE Therapeutics Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* DICE THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 23345J104 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617.778.2500 (Na

October 13, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 12, 2022 DICE THERAPEUTIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 12, 2022 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commissio

October 13, 2022 EX-1.1

Underwriting Agreement, dated October 12, 2022.

EX-1.1 Exhibit 1.1 Execution Version DICE THERAPEUTICS, INC. (a Delaware corporation) 8,219,178 Shares of Common Stock UNDERWRITING AGREEMENT Dated: October 12, 2022 DICE THERAPEUTICS, INC. (a Delaware corporation) 8,219,178 Shares of Common Stock UNDERWRITING AGREEMENT October 12, 2022 BofA Securities, Inc. SVB Securities LLC Evercore Group L.L.C. Guggenheim Securities, LLC as Representatives of

October 13, 2022 424B5

8,219,178 Shares Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-267702 P R O S P E C T U S S U P P L E M E N T (To prospectus dated October 7, 2022) 8,219,178 Shares Common Stock We are offering 8,219,178 shares of our common stock. Our common stock is listed on The Nasdaq Global Market under the symbol “DICE.” The last reported sale price of our common stock on The Nasdaq Global Mar

October 13, 2022 EX-99.1

DICE Announces Pricing of Upsized Public Offering of Common Stock

EX-99.1 Exhibit 99.1 DICE Announces Pricing of Upsized Public Offering of Common Stock SOUTH SAN FRANCISCO, Calif., October 12, 2022 (GLOBE NEWSWIRE) — DICE Therapeutics, Inc. (Nasdaq: DICE), a biopharmaceutical company leveraging its proprietary technology platform to build a pipeline of novel oral therapeutic candidates to treat chronic diseases in immunology and other therapeutic areas, today a

October 11, 2022 EX-99.1

DICE Therapeutics Announces Positive Topline Data from Phase 1 Clinical Trial of Lead Oral IL-17 Antagonist, DC-806, for Psoriasis Clinical proof-of-concept in psoriasis patients achieved with a mean percentage reduction in PASI from baseline at 4 we

EX-99.1 Exhibit 99.1 DICE Therapeutics Announces Positive Topline Data from Phase 1 Clinical Trial of Lead Oral IL-17 Antagonist, DC-806, for Psoriasis Clinical proof-of-concept in psoriasis patients achieved with a mean percentage reduction in PASI from baseline at 4 weeks of 43.7% in the high dose group compared to 13.3% in the placebo group, with an exploratory p-value of 0.0008 DC-806 was well

October 11, 2022 EX-99.2

Disclaimer This presentation and the accompanying oral commentary contain forward-looking statements and information relating to DICE Therapeutics, Inc. within the meaning of, and made pursuant to the safe harbor provisions of, the Private Securities

EX-99.2 Exhibit 99.2 DC-806: Phase 1 Topline Results October 11, 2022 Disclaimer This presentation and the accompanying oral commentary contain forward-looking statements and information relating to DICE Therapeutics, Inc. within the meaning of, and made pursuant to the safe harbor provisions of, the Private Securities Litigation Reform Act of 1995. You should not place undue reliance on forward-l

October 11, 2022 424B5

Subject to Completion, Preliminary Prospectus Supplement, dated October 11, 2022

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-267702 The information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are part of an effective registration statement filed with the Securities and Exchange Commission. This preliminary prospectus supplement and the accompanyi

October 11, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 11, 2022 DICE THERAPEUTIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 11, 2022 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commissio

October 5, 2022 CORRESP

DICE THERAPEUTICS, INC. 400 East Jamie Court, Suite 300 South San Francisco, California 94080 October 5, 2022

CORRESP 1 filename1.htm DICE THERAPEUTICS, INC. 400 East Jamie Court, Suite 300 South San Francisco, California 94080 October 5, 2022 United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Office of Life Sciences Re: DICE Therapeutics, Inc. Registration Statement on Form S-3 Filed October 3, 2022 File No. 333-267702 Via E

October 3, 2022 S-3

As filed with the Securities and Exchange Commission on October 3, 2022

Table of Contents As filed with the Securities and Exchange Commission on October 3, 2022 Registration No.

October 3, 2022 EX-FILING FEES

Filing Fee Table

EX-FILING FEES 6 d324236dexfilingfees.htm EX-FILING FEES Exhibit 107 Calculation of Fee Filing Tables Form S-3 (Form Type) DICE Therapeutics, Inc. (Exact name of Registration as Specified in its Charter) Table 1 – Newly Registered Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering

October 3, 2022 EX-4.5

Form of Indenture

Exhibit 4.5 DICE THERAPEUTICS, INC. And , as Trustee INDENTURE Dated as of , TABLE OF CONTENTS ARTICLE 1 ? DEFINITIONS AND INCORPORATION BY REFERENCE 1 1.1 DEFINITIONS 1 1.2. OTHER DEFINITIONS 4 1.3. INCORPORATION BY REFERENCE OF TRUST INDENTURE ACT 4 1.4. RULES OF CONSTRUCTION 4 ARTICLE 2 ? THE SECURITIES 5 2.1. ISSUABLE IN SERIES 5 2.2. ESTABLISHMENT OF TERMS OF SERIES OF SECURITIES 5 2.3. EXECU

October 3, 2022 EX-4.4

Form of Debt Security

Exhibit 4.4 FORM OF DEBT SECURITY [Face of Security] DICE THERAPEUTICS, INC. [If applicable, insert?FOR PURPOSES OF THE ORIGINAL ISSUE DISCOUNT PROVISIONS OF THE INTERNAL REVENUE CODE OF 1986, THE ISSUE PRICE OF THIS SECURITY IS % OF ITS PRINCIPAL AMOUNT AT STATED MATURITY SET FORTH BELOW (ITS ?PRINCIPAL AMOUNT?), THE AMOUNT OF ORIGINAL ISSUE DISCOUNT IS % OF ITS PRINCIPAL AMOUNT, THE YIELD TO MAT

August 11, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2022 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commission

August 11, 2022 EX-10.1

Joinder and First Amendment to Loan and Security Agreement, by and between the Registrant and Silicon Valley Bank, dated as of June 27, 2022

Exhibit 10.1 JOINDER AND FIRST AMENDMENT to Loan and security agreement This Joinder and First Amendment to Loan and Security Agreement (this ?Amendment?) is entered into this 27th day of June, 2022, by and among (a) Silicon Valley Bank (?Bank?) and (b) (i) DICE MOLECULES SV, INC., a Delaware corporation (?SV?), (ii) DICE ALPHA, INC., a Delaware corporation (?Alpha?, and together with SV, ?Existin

August 11, 2022 EX-99.1

DICE Therapeutics Reports Second Quarter 2022 Financial Results and Recent Highlights

Exhibit 99.1 DICE Therapeutics Reports Second Quarter 2022 Financial Results and Recent Highlights ? Completed enrollment in Phase 1 clinical trial of lead oral IL-17 antagonist DC-806; topline proof-of-concept data in healthy volunteers and psoriasis patients expected in 2H 2022 SOUTH SAN FRANCISCO, CA, August 11, 2022 ? DICE Therapeutics, Inc. (Nasdaq: DICE), a biopharmaceutical company leveragi

August 11, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40794 DICE THERA

August 11, 2022 EX-4.1

Warrant to Purchase Stock, by and between DICE Therapeutics, Inc. and Silicon Valley Bank, dated as of June 27, 2022

Exhibit 4.1 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?ACT?), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 6.3 AND 6.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTAN

June 28, 2022 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 27, 2022 DICE THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40794 47-2286244 (State or Other Jurisdiction of Incorporation) (Commission F

June 8, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2022 DICE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-40794 47-2286244 (State or other jurisdiction of incorporation) (Commission Fi

May 12, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40794 DICE THER

May 12, 2022 EX-99.1

DICE Therapeutics Reports First Quarter 2022 Financial Results and Recent Highlights

Exhibit 99.1 DICE Therapeutics Reports First Quarter 2022 Financial Results and Recent Highlights ? Topline proof-of-concept data from Phase 1 clinical trial of oral IL-17 antagonist DC-806 in healthy volunteers and psoriasis patients expected in mid-2022 ? Current cash provides runway through mid-2024 and multiple expected key clinical milestones SOUTH SAN FRANCISCO, CA, May 12, 2022 ? DICE Thera

May 12, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2022 DICE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-40794 47-2286244 (State or other jurisdiction of incorporation) (Commission Fi

May 3, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 3, 2022 DICE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-40794 47-2286244 (State or other jurisdiction of incorporation) (Commission Fil

May 3, 2022 EX-99.1

Forward Looking Statements These slides contain forward-looking statements and information relating to DICE Therapeutics, Inc. within the meaning of, and made pursuant to the safe harbor provisions of, the Private Securities Litigation Reform Act of

Corporate Presentation May 2022 Exhibit 99.1 Forward Looking Statements These slides contain forward-looking statements and information relating to DICE Therapeutics, Inc. within the meaning of, and made pursuant to the safe harbor provisions of, the Private Securities Litigation Reform Act of 1995. You should not place undue reliance on forward-looking statements, as these statements are based up

April 26, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defin

April 26, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defin

March 28, 2022 S-8

As filed with the Securities and Exchange Commission on March 28, 2022

As filed with the Securities and Exchange Commission on March 28, 2022 Registration No.

March 28, 2022 EX-4.3

Exhibit 4.3

Exhibit 4.3 DESCRIPTION OF THE REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 The following description summarizes the most important terms of our capital stock. Because it is only a summary, it does not contain all the information that may be important to you. For a complete description, you should refer to our restated certificate of incorporatio

March 28, 2022 EX-21.1

Subsidiaries of the Registrant.

Exhibit 21.1 Subsidiaries of the Registrant DiCE Molecules SV, Inc. DiCE Alpha, Inc.

March 28, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number: 001-40794 DICE THERAPEUT

March 28, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) DICE Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Share Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, par value $0.000

March 28, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 24, 2022 DICE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-40794 47-2286244 (State or other jurisdiction of incorporation) (Commission

March 21, 2022 EX-99.1

DICE Therapeutics Reports Fourth Quarter and Full Year 2021 Financial Results and Recent Highlights

Exhibit 99.1 DICE Therapeutics Reports Fourth Quarter and Full Year 2021 Financial Results and Recent Highlights ? On track to deliver topline proof-of-concept data from Phase 1 clinical trial of oral IL-17 antagonist DC-806 in healthy volunteers and psoriasis patients in mid-2022 ? Named development candidate DC-853 from the novel scaffold program 1 series of oral IL-17 franchise ? Current cash p

March 21, 2022 8-K

Termination of a Material Definitive Agreement, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 15, 2022 DICE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-40794 47-2286244 (State or other jurisdiction of incorporation) (Commission

February 17, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 17, 2022 DICE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-40794 47-2286244 (State or other jurisdiction of incorporation) (Commissi

February 17, 2022 EX-99.1

Forward Looking Statements These slides contain forward-looking statements and information relating to DICE Therapeutics, Inc. within the meaning of, and made pursuant to the safe harbor provisions of, the Private Securities Litigation Reform Act of

Corporate Presentation February 2022 Exhibit 99.1 Forward Looking Statements These slides contain forward-looking statements and information relating to DICE Therapeutics, Inc. within the meaning of, and made pursuant to the safe harbor provisions of, the Private Securities Litigation Reform Act of 1995. You should not place undue reliance on forward-looking statements, as these statements are bas

February 14, 2022 SC 13G

DICE / DICE Therapeutics Inc / DRIEHAUS CAPITAL MANAGEMENT LLC - NONE Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. n/a )* DICE Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 23345J104 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which t

November 12, 2021 EX-3.1

Restated Certificate of Incorporation.

Exhibit 3.1 DICE THERAPEUTICS, INC. RESTATED CERTIFICATE OF INCORPORATION DICE Therapeutics, Inc., a Delaware corporation, hereby certifies as follows: 1.The name of this corporation is ?DICE Therapeutics, Inc.? The date of the filing of its original Certificate of Incorporation with the Secretary of State of the State of Delaware was September 14, 2021 under the name DICE Therapeutics, Inc. 2.The

November 12, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40794 DICE THERAPEUTICS, INC.

November 12, 2021 EX-3.2

Restated Bylaws.

Exhibit 3.2 DICE THERAPEUTICS, INC. (a Delaware corporation) RESTATED BYLAWS As Adopted September 14, 2021 and As Effective September 17, 2021 DICE THERAPEUTICS, INC. (a Delaware corporation) RESTATED BYLAWS TABLE OF CONTENTS Page Article I: STOCKHOLDERS1 Section 1.1: Annual Meetings1 Section 1.2: Special Meetings1 Section 1.3: Notice of Meetings1 Section 1.4: Adjournments1 Section 1.5: Quorum2 Se

November 12, 2021 EX-99.1

DICE Therapeutics Reports Third Quarter 2021 Financial Results and Recent Highlights

Exhibit 99.1 DICE Therapeutics Reports Third Quarter 2021 Financial Results and Recent Highlights ? Dosed first healthy volunteers in Phase 1 clinical trial of oral IL-17 antagonist S011806 ? Successfully completed $234.6 million upsized initial public offering SOUTH SAN FRANCISCO, CA, November 12, 2021 ? DICE Therapeutics, Inc. (Nasdaq: DICE), a biopharmaceutical company leveraging its proprietar

November 12, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2021 DICE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-40794 47-2286244 (State or other jurisdiction of incorporation) (Commissi

September 28, 2021 SC 13D

DICE / DICE Therapeutics Inc / Northpond Ventures, LP - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* DICE Therapeutics, Inc. (Name of Issuer) Common stock, par value $0.0001 per share (Title of Class of Securities) 23345J104 (CUSIP Number) Paul Hodgdon c/o Northpond Ventures, LLC 7500 Old Georgetown Road, Suite 850 Bethesda, MD 20814 240-800-1200 (Name,

September 28, 2021 EX-99.A

Joint Filing Agreement

Exhibit A Joint Filing Agreement In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13D.

September 27, 2021 SC 13D

DICE / DICE Therapeutics Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13D Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment )* DICE Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 23345J104 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617.778.2500 (Name, Add

September 27, 2021 EX-99.C

AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13D

EXHIBIT C AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13D The undersigned being duly authorized thereunto, hereby execute this agreement as an exhibit to this Schedule 13D to evidence the agreement of the below-named parties, in accordance with the rules promulgated pursuant to the Securities Exchange Act of 1934, as amended, to file this Schedule 13D (including amendments thereto) jointly on behalf of each such party.

September 27, 2021 SC 13D

DICE / DICE Therapeutics Inc / Sands Capital Life Sciences Pulse Fund II, L.P. - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* DICE Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 23345J104 (CUSIP Number) Jonathan Goodman Sands Capital Ventures, LLC 1000 Wilson Blvd., Suite 3000, Arlington VA 22209 Telephone: (703) 562-4000 (Name, Address and Telep

September 16, 2021 424B4

12,000,000 Shares Common Stock

Table of Contents Filed pursuant to Rule 424(b)(4) Registration No. 333-259061 Registration No. 333-259528 PROSPECTUS 12,000,000 Shares Common Stock This is an initial public offering of shares of common stock of DICE Therapeutics, Inc. We are selling 12,000,000 shares of our common stock. Prior to this offering, there has been no public market for our common stock. The initial offering price is $

September 15, 2021 S-8

As filed with the Securities and Exchange Commission on September 15, 2021

As filed with the Securities and Exchange Commission on September 15, 2021 Registration No.

September 14, 2021 S-1MEF

As Filed with the Securities and Exchange Commission on September 14, 2021.

S-1MEF 1 d234015ds1mef.htm S-1MEF As Filed with the Securities and Exchange Commission on September 14, 2021. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 DICE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 2834 47-2286244 (State or other jurisdictio

September 10, 2021 CORRESP

[signature page follows]

September 10, 2021 United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

September 10, 2021 CORRESP

* * *

CORRESP 1 filename1.htm DiCE Molecules Holdings, LLC 279 E. Grand Avenue, Suite 300, Lobby B South San Francisco, CA 94080 September 10, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, DC 20549 Attention: Gary Newberry Angela Connell Ada D. Sarmento Laura Crotty Re: DiCE Molecules Holdings, LLC Registration Statement on F

September 10, 2021 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF l934 DiCE Molecules Holdings, LLC* (Exact name of Registrant as specified in its charter) Delaware 47-2286244 (State of incorporation or organization) (I.R.S. Employer Identification No.) 279 E. Grand A

September 9, 2021 S-1/A

As filed with the Securities and Exchange Commission on September 9, 2021.

S-1/A Table of Contents As filed with the Securities and Exchange Commission on September 9, 2021.

September 9, 2021 EX-10.14

Form of Change in Control and Severance Agreement.

Exhibit 10.14 CHANGE IN CONTROL AND SEVERANCE AGREEMENT This Change in Control and Severance Agreement (the ?Agreement?) is entered into by and between [Name] (the ?Executive?) and DICE Therapeutics, Inc., a Delaware corporation (the ?Company?), effective as of (the ?Effective Date?). 1. Qualifying Termination. If the Executive is subject to a Qualifying Termination, then, subject to Sections 3, 7

September 9, 2021 EX-10.3

2021 Equity Incentive Plan and forms of award agreements.

Exhibit 10.3 DICE THERAPEUTICS, INC. 2021 EQUITY INCENTIVE PLAN 1. PURPOSE. The purpose of this Plan is to provide incentives to attract, retain, and motivate eligible persons whose present and potential contributions are important to the success of the Company, and any Parents, Subsidiaries, and Affiliates that exist now or in the future, by offering them an opportunity to participate in the Comp

September 9, 2021 EX-10.11

Offer Letter by and between the Registrant and J. Kevin Judice, Ph.D.

EX-10.11 8 d134346dex1011.htm EX-10.11 Exhibit 10.11 279 E. Grand Avenue South San Francisco, CA 94080 (ph) 650.566.1402 (fx) 650.566.1429 www.dicemolecules.com September 7, 2021 J. Kevin Judice, Ph.D. via email Dear Dr. Judice: This letter agreement amends and restates the offer letter between you and DICE Therapeutics, Inc. (the “Company”)1, dated January 26, 2015 (the “Prior Agreement”) effecti

September 9, 2021 EX-10.4

2021 Employee Stock Purchase Plan and forms of award agreements.

Exhibit 10.4 DICE THERAPEUTICS, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN 1. PURPOSE. DICE Therapeutics, Inc. adopted the Plan effective as of the Effective Date. The purpose of this Plan is to provide eligible employees of the Company and the Participating Corporations with a means of acquiring an equity interest in the Company, to enhance such employees? sense of participation in the affairs of the

September 9, 2021 FWP

DiCE Molecules Holdings, LLC

Filed Pursuant to Rule 433 of the Securities Act of 1933 Issuer Free Writing Prospectus dated September 9, 2021 Relating to Preliminary Prospectus dated September 9, 2021 Registration No.

September 9, 2021 EX-3.2

Form of Certificate of Incorporation of the Registrant (to be effective upon completion of the Registrant’s conversion from a limited liability company to a corporation).

Exhibit 3.2 CERTIFICATE OF INCORPORATION OF DICE THERAPEUTICS, INC. FIRST: The name of this corporation is DICE Therapeutics, Inc. (the ?Corporation?). SECOND: The address of the registered office of the Corporation in the State of Delaware is 251 Little Falls Drive in the City of Wilmington, County of New Castle, 19808, and the name of the registered agent of this Corporation in the State of Dela

September 9, 2021 EX-1.1

Form of Lock-up Agreement (incorporated by reference to Exhibit A to Exhibit 1.1 to the Issuer’s Registration Statement on Form S-1 (SEC File No. 333- 259061), filed with the SEC on September 9, 2021).

Exhibit 1.1 DICE THERAPEUTICS, INC. (a Delaware corporation) [?] Shares of Common Stock UNDERWRITING AGREEMENT Dated: [?], 2021 DICE THERAPEUTICS, INC. (a Delaware corporation) [?] Shares of Common Stock UNDERWRITING AGREEMENT [?], 2021 BofA Securities, Inc. SVB Leerink LLC Evercore Group L.L.C. as Representatives of the several Underwriters c/o BofA Securities, Inc. One Bryant Park New York, New

September 9, 2021 EX-10.12

Offer Letter by and between the Registrant and John Jacobsen, Ph.D.

Exhibit 10.12 279 E. Grand Avenue South San Francisco, CA 94080 (ph) 650.566.1402 (fx) 650.566.1429 www.dicemolecules.com September 7, 2021 John Jacobsen, Ph.D. via email Dear Dr. Jacobsen: This letter agreement amends and restates the offer letter between you and DICE Therapeutics, Inc. (the ?Company?)1, dated October 13, 2015 (the ?Prior Agreement?) effective [ ]2, 2021. You will continue to wor

September 9, 2021 EX-10.13

Offer Letter by and between the Registrant and Scott Robertson.

Exhibit 10.13 279 E. Grand Avenue South San Francisco, CA 94080 (ph) 650.566.1402 (fx) 650.566.1429 www.dicemolecules.com September 7, 2021 Scott Robertson via email Dear Scott: This letter agreement amends and restates the offer letter between you and DICE Therapeutics, Inc. (the ?Company?)1, dated March 26, 2016 (the ?Prior Agreement?) effective [ ]2, 2021. You will continue to work in the role

September 9, 2021 EX-3.1

Fifth Amended and Restated Operating Agreement of the Registrant, dated August 20, 2021, as amended.

Exhibit 3.1 FIFTH AMENDED AND RESTATED LIMITED LIABILITY COMPANY AGREEMENT OF DICE MOLECULES HOLDINGS, LLC (a Delaware limited liability company) This Fifth Amended and Restated Limited Liability Company Agreement (this ?Agreement?) of DiCE Molecules Holdings, LLC, a Delaware limited liability company (the ?Company?), is entered into effective as of August 20, 2021 (the ?Effective Date?) by and be

August 27, 2021 S-1/A

As filed with the Securities and Exchange Commission on August 27, 2021.

S-1/A Table of Contents As filed with the Securities and Exchange Commission on August 27, 2021.

August 27, 2021 CORRESP

555 California Street

555 California Street San Francisco, CA 94104 (415) 875-2300 Fenwick.com Robert A. Freedman [email protected] | 650.335.7292 August 27, 2021 VIA EDGAR U.S. Securities and Exchange Commission Washington, D.C. 20549 Attention: Gary Newberry Angela Connell Ada D. Sarmento Laura Crotty Re: DiCE Molecules Holdings, LLC Amendment No. 1 to Draft Registration Statement on Form S-1 Submitted August 6,

August 27, 2021 EX-4.2

Amended and Restated Investors’ Rights Agreement, dated August 20, 2021, by and among DICE Therapeutics, Inc. and certain of its stockholders

Exhibit 4.2 DICE MOLECULES HOLDINGS, LLC AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT(the ?Agreement?) is entered into as of the 20 day of August, 2021, by and among DiCE Molecules Holdings, LLC, a Delaware limited liability company (the ?Company?), the investors listed on Exhibit A hereto, referred to hereinafter as the ?Investors? and each in

August 25, 2021 EX-4.3

Warrant to Purchase Series B Preferred Units, dated as of November 13, 2018, by and between the Registrant and JMP Securities LLC.

Exhibit 4.3 NEITHER THIS WARRANT NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?ACT?), OR UNDER THE SECURITIES LAWS OF APPLICABLE STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD (I) EXCEPT AS PERMITTED UNDER THE ACT AND THE APPLICABLE STATE SECU

August 25, 2021 EX-4.4

Warrant to Purchase Limited Liability Company Interests, dated as of April 13, 2021, by and between the Registrant and Silicon Valley Bank.

Exhibit 4.4 THIS WARRANT AND THE UNITS ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?ACT?), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANC

August 25, 2021 EX-2.1

Form of Plan of Conversion.

Exhibit 2.1 PLAN OF CONVERSION Converting DiCE Molecules Holdings, LLC (a Delaware limited liability company) into DiCE Therapeutics, Inc. (a Delaware corporation) THIS PLAN OF CONVERSION (this ?Plan?), dated as of [ ], 2021, is hereby adopted and approved by DiCE Molecules Holdings, LLC, a Delaware limited liability company (the ?LLC?), in order to set forth the terms, conditions and procedures g

August 25, 2021 EX-10.9

Amended and Restated License and Collaboration Agreement, by and between the Registrant and Aventis Inc., dated as of December 17, 2015, as amended and restated as of August 16, 2017.

Exhibit 10.9 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE AND CONFIDENTIAL. CONFIDENTIAL AMENDED AND RESTATED LICENSE AND COLLABORATION AGREEMENT between AVENTIS INC. and DICE MOLECULES SV, LLC Dated as of December 17, 2015 Amended and Restated August 16, 2017 CONFIDENTI

August 25, 2021 EX-10.10

Loan and Security Agreement, by and between the Registrant and Silicon Valley Bank, dated as of April 13, 2021.

Exhibit 10.10 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (this ?Agreement?) dated as of April 13, 2021 (the ?Effective Date?) by and among (a) SILICON VALLEY BANK, a California corporation with a loan production office located at 505 Howard Street, 3rd Floor, San Francisco, California 94103 (?Bank?), and (b) (i) DICE MOLECULES SV, INC., a Delaware corporation (?SV?) and (ii) DICE

August 25, 2021 EX-10.1

Form of Indemnification Agreement with directors and officers.

Exhibit 10.1 INDEMNITY AGREEMENT This Indemnity Agreement, dated as of , 2021 is made by and between DICE Therapeutics, Inc., a Delaware corporation (the ?Company?), and , a director, officer or key employee of the Company or one of the Company?s Subsidiaries or Affiliates (as those terms are defined below) or other service provider who satisfies the definition of Indemnifiable Person set forth be

August 25, 2021 EX-10.2

2014 Equity Incentive Plan and forms of award agreements.

Exhibit 10.2 DICE MOLECULES HOLDINGS, LLC 2014 EQUITY INCENTIVE PLAN ADOPTED ON DECEMBER 1, 2014 AS AMENDED ON JUNE 30, 2016, JULY 7 ,2018, JULY 9, 2018 AND DECEMBER 18, 2020. TABLE OF CONTENTS Page SECTION 1. ESTABLISHMENT AND PURPOSE 1 SECTION 2. ADMINISTRATION 1 (a) Committees of the Managers 1 (b) Authority of the Managers 1 SECTION 3. ELIGIBILITY 1 SECTION 4. UNITS SUBJECT TO PLAN 1 (a) Basic

August 25, 2021 EX-10.5

Sublease, dated March 1, 2019, by and between Insitro, Inc. and the Registrant.

Exhibit 10.5 SUBLEASE (279 East Grand Avenue?Suite 330) THIS SUBLEASE (this ?Sublease?), dated for reference purposes only as of March 1, 2019 (the ?Execution Date?), is made by and between INSITRO, INC., a Delaware corporation (?Sublandlord?), and DICE MOLECULES SV, INC., a Delaware corporation (?Subtenant?). RECITALS WHEREAS, ARE-SAN FRANCISCO No. 12, LLC, a Delaware limited liability company (?

August 25, 2021 EX-10.8

Lease Agreement, dated June 25, 2021, by and between ARE-EAST JAMIE COURT, LLC and the Registrant.

Exhibit 10.8 LEASE AGREEMENT THIS LEASE AGREEMENT (this ?Lease?) is made this 25 day of June, 2021, between ARE-EAST JAMIE COURT, LLC, a Delaware limited liability company (?Landlord?), and DiCE MOLECULES SV, INC., a Delaware corporation (?Tenant?). Building: 400 East Jamie Court, South San Francisco, California Premises: The entire 3rd floor of the Building, known as Suite 300, containing approxi

August 25, 2021 EX-3.3

Form of Bylaws of the Registrant. (to be effective upon completion of the Registrant’s conversion from a limited liability company to a corporation).

Exhibit 3.3 DICE THERAPEUTICS, INC. a Delaware corporation BYLAWS As Adopted [?], 2021 DICE THERAPEUTICS, INC. a Delaware corporation BYLAWS As Adopted [?], 2021 ARTICLE I: STOCKHOLDERS Section 1.1: Annual Meetings. Unless members of the Board of Directors of the Corporation (the ?Board?) are elected by written consent in lieu of an annual meeting, as permitted by Section 211 of the Delaware Gener

August 25, 2021 EX-4.1

Form of Common Stock Certificate

Exhibit 4.1 DICE Therapeutics Number Shares DELAWARE SEAL DICE THERAPEUTICS, INC. CORPORATE DT FULLY PAID AND NONASSESSABLE SHARES OF COMMON STOCK, $0.0001 PAR VALUE PER SHARE, OF DICE Therapeutics, Inc. transferable on the books of the Corporation in person or by duly authorized attorney upon surrender of this Certificate properly endorsed. This Certificate is not valid until countersigned by the

August 25, 2021 S-1

Power of Attorney (included in the signature page to this Registration Statement on Form S-1).

S-1 Table of Contents As filed with the Securities and Exchange Commission on August 25, 2021.

August 25, 2021 EX-3.4

Form of Restated Certificate of Incorporation of the Registrant (to be effective upon the closing of this offering).

Exhibit 3.4 DICE THERAPEUTICS, INC. RESTATED CERTIFICATE OF INCORPORATION DICE Therapeutics, Inc., a Delaware corporation, hereby certifies as follows: 1. The name of this corporation is ?DICE Therapeutics, Inc.? The date of the filing of its original Certificate of Incorporation with the Secretary of State of the State of Delaware was [ ], 2021 under the name DICE Therapeutics, Inc. 2. The Restat

August 25, 2021 EX-21.1

Subsidiaries of the Registrant.

Exhibit 21.1 SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction of Organization % Ownership* DiCE Molecules SV, Inc. Delaware 100.00 % DiCE Alpha, Inc. Delaware 100.00 %

August 25, 2021 EX-10.6

Sublease Commencement Agreement, dated August 29, 2019, by and between Insitro, Inc. and the Registrant.

Exhibit 10.6 SUBLEASE COMMENCEMENT AGREEMENT August 29, 2019 Scott Robertson DiCE Molecules SV, Inc. 220 Penobscot Drive Redwood City, CA 94063 Re: Commencement Agreement with respect to that certain Sublease dated as of March 1, 2019, by and between INSITRO, INC., a Delaware corporation, as Sublandlord, and DiCE Molecules SV, Inc., a Delaware corporation, as Subtenant, for approximately 19,532 re

August 25, 2021 EX-10.7

First Amendment to Sublease, dated June 18, 2021, by and between Insitro, Inc. and the Registrant.

Exhibit 10.7 FIRST AMENDMENT TO SUBLEASE THIS FIRST AMENDMENT TO SUBLEASE (this ?Amendment?) is made as of the 18th day of June 2021, by and between INSITRO, INC., a Delaware corporation (?Sublandlord?) and DICE MOLECULES SV, INC., a Delaware corporation (?Subtenant?), with reference to the following facts and objectives: RECITALS A. ARE-SAN FRANCISCO No. 12, LLC, a Delaware limited liability comp

August 25, 2021 EX-3.5

Form of Amended and Restated Bylaws of the Registrant (to be effective upon the closing of this offering).

Exhibit 3.5 DICE THERAPEUTICS, INC. (a Delaware corporation) RESTATED BYLAWS As Adopted [?], 2021 and As Effective [?], 2021 DICE THERAPEUTICS, INC. (a Delaware corporation) RESTATED BYLAWS TABLE OF CONTENTS Page Article I: STOCKHOLDERS 1 Section 1.1: Annual Meetings 1 Section 1.2: Special Meetings 1 Section 1.3: Notice of Meetings 1 Section 1.4: Adjournments 1 Section 1.5: Quorum 2 Section 1.6: O

August 6, 2021 DRS/A

Confidential draft no. 2 submitted to the Securities and Exchange Commission on August 6, 2021. This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains confidential.

Table of Contents Confidential draft no. 2 submitted to the Securities and Exchange Commission on August 6, 2021. This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains confidential. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under

August 6, 2021 EX-10.7

FIRST AMENDMENT TO SUBLEASE

Exhibit 10.7 FIRST AMENDMENT TO SUBLEASE THIS FIRST AMENDMENT TO SUBLEASE (this ?Amendment?) is made as of the 18th day of June 2021, by and between INSITRO, INC., a Delaware corporation (?Sublandlord?) and DICE MOLECULES SV, INC., a Delaware corporation (?Subtenant?), with reference to the following facts and objectives: RECITALS A. ARE-SAN FRANCISCO No. 12, LLC, a Delaware limited liability comp

August 6, 2021 EX-10.8

LEASE AGREEMENT

Exhibit 10.8 LEASE AGREEMENT THIS LEASE AGREEMENT (this ?Lease?) is made this 25 day of June, 2021, between ARE-EAST JAMIE COURT, LLC, a Delaware limited liability company (?Landlord?), and DiCE MOLECULES SV, INC., a Delaware corporation (?Tenant?). Building: 400 East Jamie Court, South San Francisco, California Premises: The entire 3rd floor of the Building, known as Suite 300, containing approxi

August 6, 2021 EX-3.5

DICE THERAPEUTICS, INC. (a Delaware corporation) RESTATED BYLAWS As Adopted [•], 2021 and As Effective [•], 2021

Exhibit 3.5 DICE THERAPEUTICS, INC. (a Delaware corporation) RESTATED BYLAWS As Adopted [?], 2021 and As Effective [?], 2021 DICE THERAPEUTICS, INC. (a Delaware corporation) RESTATED BYLAWS TABLE OF CONTENTS Page Article I: STOCKHOLDERS 1 Section 1.1: Annual Meetings 1 Section 1.2: Special Meetings 1 Section 1.3: Notice of Meetings 1 Section 1.4: Adjournments 1 Section 1.5: Quorum 2 Section 1.6: O

August 6, 2021 EX-10.9

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE AND CONFIDENTIAL.

Exhibit 10.9 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE AND CONFIDENTIAL. CONFIDENTIAL AMENDED AND RESTATED LICENSE AND COLLABORATION AGREEMENT between AVENTIS INC. and DICE MOLECULES SV, LLC Dated as of December 17, 2015 Amended and Restated August 16, 2017 CONFIDENTI

August 6, 2021 EX-3.4

DICE THERAPEUTICS, INC. RESTATED CERTIFICATE OF INCORPORATION

Exhibit 3.4 DICE THERAPEUTICS, INC. RESTATED CERTIFICATE OF INCORPORATION DICE Therapeutics, Inc., a Delaware corporation, hereby certifies as follows: 1. The name of this corporation is ?DICE Therapeutics, Inc.? The date of the filing of its original Certificate of Incorporation with the Secretary of State of the State of Delaware was [ ], 2021 under the name DICE Therapeutics, Inc. 2. The Restat

August 6, 2021 EX-4.2

DICE MOLECULES HOLDINGS, LLC AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

Exhibit 4.2 DICE MOLECULES HOLDINGS, LLC AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the ?Agreement?) is entered into as of the 18th day of December, 2020, by and among DiCE Molecules Holdings, LLC, a Delaware limited liability company (the ?Company?), the investors listed on Exhibit A hereto, referred to hereinafter as the ?Investors? and ea

August 6, 2021 EX-10.10

LOAN AND SECURITY AGREEMENT

Exhibit 10.10 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (this ?Agreement?) dated as of April 13, 2021 (the ?Effective Date?) by and among (a) SILICON VALLEY BANK, a California corporation with a loan production office located at 505 Howard Street, 3rd Floor, San Francisco, California 94103 (?Bank?), and (b) (i) DICE MOLECULES SV, INC., a Delaware corporation (?SV?) and (ii) DICE

August 6, 2021 EX-10.5

SUBLEASE (279 East Grand Avenue—Suite 330)

Exhibit 10.5 SUBLEASE (279 East Grand Avenue?Suite 330) THIS SUBLEASE (this ?Sublease?), dated for reference purposes only as of March 1, 2019 (the ?Execution Date?), is made by and between INSITRO, INC., a Delaware corporation (?Sublandlord?), and DICE MOLECULES SV, INC., a Delaware corporation (?Subtenant?). RECITALS WHEREAS, ARE-SAN FRANCISCO No. 12, LLC, a Delaware limited liability company (?

August 6, 2021 EX-10.1

INDEMNITY AGREEMENT

Exhibit 10.1 INDEMNITY AGREEMENT This Indemnity Agreement, dated as of , 2021 is made by and between DICE Therapeutics, Inc., a Delaware corporation (the ?Company?), and , a director, officer or key employee of the Company or one of the Company?s Subsidiaries or Affiliates (as those terms are defined below) or other service provider who satisfies the definition of Indemnifiable Person set forth be

August 6, 2021 EX-3.1

FOURTH AMENDED AND RESTATED LIMITED LIABILITY COMPANY AGREEMENT DICE MOLECULES HOLDINGS, LLC (a Delaware limited liability company)

Exhibit 3.1 FOURTH AMENDED AND RESTATED LIMITED LIABILITY COMPANY AGREEMENT OF DICE MOLECULES HOLDINGS, LLC (a Delaware limited liability company) This Fourth Amended and Restated Limited Liability Company Agreement (this ?Agreement?) of DiCE Molecules Holdings, LLC, a Delaware limited liability company (the ?Company?), is entered into effective as of December 18, 2020 (the ?Effective Date?) by an

August 6, 2021 EX-21.1

SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction of Organization % Ownership* DiCE Molecules SV, Inc. Delaware 100.00 % DiCE Alpha, Inc. Delaware 100.00 %

Exhibit 21.1 SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction of Organization % Ownership* DiCE Molecules SV, Inc. Delaware 100.00 % DiCE Alpha, Inc. Delaware 100.00 %

August 6, 2021 EX-10.6

SUBLEASE COMMENCEMENT AGREEMENT

Exhibit 10.6 SUBLEASE COMMENCEMENT AGREEMENT August 29, 2019 Scott Robertson DiCE Molecules SV, Inc. 220 Penobscot Drive Redwood City, CA 94063 Re: Commencement Agreement with respect to that certain Sublease dated as of March 1, 2019, by and between INSITRO, INC., a Delaware corporation, as Sublandlord, and DiCE Molecules SV, Inc., a Delaware corporation, as Subtenant, for approximately 19,532 re

August 6, 2021 DRSLTR

801 California Street

DRSLTR 1 filename1.htm 801 California Street Mountain View, CA 94041 650.988.8500 Fenwick.com Amanda L. Rose [email protected] | 206.389.4553 August 6, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, NE Washington, DC 20549 Attention: Gary Newberry Angela Connell Ada D. Sarmento Laura Crotty Re: DiCE Molecules Holdings, L

July 2, 2021 DRS

As confidentially submitted to the Securities and Exchange Commission on July 2, 2021. This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains confidential.

DRS 1 filename1.htm Table of Contents As confidentially submitted to the Securities and Exchange Commission on July 2, 2021. This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains confidential. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STAT

July 2, 2021 EX-4.4

DICE MOLECULES HOLDINGS, LLC WARRANT TO PURCHASE SERIES B PREFERRED UNITS

Exhibit 4.4 NEITHER THIS WARRANT NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?ACT?), OR UNDER THE SECURITIES LAWS OF APPLICABLE STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD (I) EXCEPT AS PERMITTED UNDER THE ACT AND THE APPLICABLE STATE SECU

July 2, 2021 EX-4.5

WARRANT TO PURCHASE LIMITED LIABILITY COMPANY INTERESTS

Exhibit 4.5 THIS WARRANT AND THE UNITS ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?ACT?), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANC

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