JANX / Janux Therapeutics, Inc. - Документы SEC, Годовой отчет, Доверенное заявление

Джанукс Терапевтикс, Инк.
US ˙ NasdaqGM ˙ US47103J1051

Основная статистика
CIK 1817713
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Janux Therapeutics, Inc.
SEC Filings (Chronological Order)
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August 7, 2025 EX-10.1

Employment Agreement, by and between the Registrant and Janeen Doyle, dated May 14, 2025.

Exhibit 10.1 April 8, 2025 Janeen Doyle Re: Employment Terms Dear Janeen: Janux Therapeutics, Inc. (the "Company") is pleased to offer you employment anticipated to begin on or around May 12, 2025 (the "Start Date"). Position Your initial position will be Chief Corporate and Business Development Officer, responsible for performing such duties as are assigned to you from time to time, reporting to

August 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2025 Janux Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2025 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

August 7, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

August 7, 2025 EX-99.1

Janux Therapeutics, Inc. Condensed Balance Sheets (in thousands)

Exhibit 99.1 Janux Therapeutics Reports Second Quarter 2025 Financial Results and Business Highlights • R&D Day highlighted TRACTr, TRACIr, and ARM pipeline progress and best-in-class potential of novel bispecific ARM platform for autoimmune diseases • Enrollment ongoing for JANX007 and JANX008 • Updates on JANX007 and JANX008 expected in the second half of 2025 • First patient dosed in lead colla

June 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 11, 2025 Janux Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 11, 2025 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

May 8, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2025 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 8, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

May 8, 2025 EX-99.1

Janux Therapeutics, Inc. Condensed Balance Sheets (in thousands)

Exhibit 99.1 Janux Therapeutics Reports First Quarter 2025 Financial Results and Business Highlights • Phase 1b expansion study initiated with JANX007 in taxane-naïve mCRPC patients • Updated JANX007 data from Phase 1a dose escalation support initiation of Phase 1b dose expansion • Enrollment ongoing for JANX007 and JANX008 • Updates on JANX007 and JANX008 expected in the second half of 2025 • $1.

May 8, 2025 EX-10.1

Amended and Restated Non-Employee Director Compensation Policy.

Exhibit 10.1 Janux Therapeutics, Inc. Amended and Restated Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) who is not also serving as an employee of or consultant to Janux Therapeutics, Inc. (the “Company”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compens

April 25, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 25, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents 90 c UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

February 27, 2025 S-8

As filed with the Securities and Exchange Commission on February 27, 2025

As filed with the Securities and Exchange Commission on February 27, 2025 Registration No.

February 27, 2025 EX-19.1

Janux Therapeutics, Inc. Insider Trading Policy

Exhibit 19.1 JANUX THERAPEUTICS, INC. INSIDER TRADING POLICY Persons Covered This Insider Trading Policy of Janux Therapeutics, Inc. (the “Company”) applies to all directors, officers, other employees and consultants of the Company and any subsidiaries. It also applies to their family members who reside with them, anyone else who lives in their households and any family members who do not live in

February 27, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-404

February 27, 2025 EX-10.12

Employment Agreement, by and between the Registrant and Zachariah McIver, D.O., Ph.D., dated April 24, 2023.

Exhibit 10.12 April 24, 2023 Zachariah McIver Re: Employment Terms Dear Zachariah: Janux Therapeutics, Inc. (the “Company”) is pleased to offer you employment anticipated to begin on or around June 5, 2023 (the “Start Date”). Position Your initial position will be Vice President of Clinical Development, PSMA Global Clinical Lead, responsible for performing such duties as are assigned to you from t

February 27, 2025 EX-99.1

Janux Therapeutics, Inc. Condensed Balance Sheets (in thousands)

Exhibit 99.1 Janux Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Business Highlights • Recently presented positive Phase 1 clinical trial data for PSMA-TRACTr JANX007 in mCRPC • Enrollment ongoing for JANX007 and JANX008 • Update on JANX007 and JANX008 data is anticipated in 2025 • R&D Day is anticipated in 2025 to disclose new programs moving toward the clinic • $1.

February 27, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2025 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commiss

February 27, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Janux Therapeutics, Inc.

February 12, 2025 EX-99

JOINT ACQUISITION STATEMENT PURSUANT TO RULE 13d-1(k)

EXHIBIT 99.1 JOINT ACQUISITION STATEMENT PURSUANT TO RULE 13d-1(k) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements. The unders

December 5, 2024 EX-4.1

Form of Pre-Funded Warrant.

Exhibit 4.1 JANUX THERAPEUTICS, INC. FORM OF PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK   Number of Shares: [     ] (subject to adjustment) Original Issue Date: [ ], 2024 Warrant No. [        ] Janux Therapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [    ] or its reg

December 5, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 4, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commissi

December 5, 2024 EX-99.2

Janux Therapeutics Announces Pricing of $350.0 Million Underwritten Public Offering of Common Stock and Pre-Funded Warrants

Exhibit 99.2 Janux Therapeutics Announces Pricing of $350.0 Million Underwritten Public Offering of Common Stock and Pre-Funded Warrants December 4, 2024 SAN DIEGO – Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and

December 5, 2024 424B5

5,317,460 Shares of Common Stock Pre-Funded Warrants to Purchase 238,095 Shares of Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-279196 PROSPECTUS SUPPLEMENT (to Prospectus dated May 8, 2024) 5,317,460 Shares of Common Stock Pre-Funded Warrants to Purchase 238,095 Shares of Common Stock We are offering 5,317,460 shares of our common stock at a purchase price of $63.00 per share, and in lieu of offering shares of our common stock to certain investors tha

December 5, 2024 EX-99.1

Janux Therapeutics Announces Proposed Public Offering

Exhibit 99.1 Janux Therapeutics Announces Proposed Public Offering December 3, 2024 SAN DIEGO – Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms, today announced t

December 5, 2024 EX-FILING FEES

Calculation of Filing Fee Table (Form Type) Janux Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type  Security Class Title Fee Calculation Rule Amount Registered Proposed Maxim

Exhibit 107 Calculation of Filing Fee Table 424(b)(5) (Form Type) Janux Therapeutics, Inc.

December 5, 2024 EX-1.1

Underwriting Agreement, dated December 4, 2024, by and among Janux Therapeutics, Inc. and BofA Securities, Inc., TD Securities (USA) LLC, Stifel, Nicolaus & Company, Incorporated, Cantor Fitzgerald & Co. and William Blair & Company, L.L.C. as representatives of the several underwriters named therein.

Exhibit 1.1 JANUX THERAPEUTICS, INC. (a Delaware corporation) 5,317,460 Shares of Common Stock and Pre-Funded Warrants to Purchase 238,095 Shares of Common Stock UNDERWRITING AGREEMENT Dated: December 4, 2024 JANUX THERAPEUTICS, INC. (a Delaware corporation) 5,317,460 Shares of Common Stock and Pre-Funded Warrants to Purchase 238,095 Shares of Common Stock UNDERWRITING AGREEMENT December 4, 2024 B

December 3, 2024 424B5

Subject to Completion, dated December 3, 2024

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-279196 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been filed with the Securities and Exchange Commission and is effective. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell

December 2, 2024 EX-99.1

Janux Announces Doses Selected for Phase 1b Expansion Trials Supported by Encouraging Efficacy and Safety Profile Observed in Phase 1a Dose Escalation for JANX007 in mCRPC

Exhibit 99.1 Janux Announces Doses Selected for Phase 1b Expansion Trials Supported by Encouraging Efficacy and Safety Profile Observed in Phase 1a Dose Escalation for JANX007 in mCRPC • Emerging JANX007 data demonstrated substantial clinical activity in 5L mCRPC patients, supporting clinical development plan directed at pre-PLUVICTO® 2L / 3L patients • In 16 patients JANX007 displayed: o High PSA

December 2, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 2, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commissi

December 2, 2024 EX-99.2

Forward-Looking Statements and Disclaimers This presentation includes certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future result

Creating Transformative Medicines to Improve Patients’ Lives Program Updates December 2, 2024 Exhibit 99.

November 14, 2024 SC 13G/A

JANX / Janux Therapeutics, Inc. / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 2 TO SCHEDULE 13G Passive Investment

SC 13G/A 1 sc13ga207422janx11142024.htm AMENDMENT NO. 2 TO SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 2)1 Janux Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par

November 14, 2024 SC 13G/A

JANX / Janux Therapeutics, Inc. / Campbell David Alan - SC 13G/A Passive Investment

SC 13G/A 1 d846761dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. 3) Janux Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 47103J 105 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the ru

November 14, 2024 SC 13G/A

JANX / Janux Therapeutics, Inc. / CITADEL ADVISORS LLC - SC 13G/A Passive Investment

SC 13G/A 1 tm2427061d12sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. 2)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (the “Shares”

November 8, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / Avalon Ventures XI, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm2427977d2sc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 7)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 47103J 105 (CUSIP Number) Jay Lichter, Ph.D. Avalon Ventures 1134 Kline Street La Jolla, California 92037 (858) 348-2180 (Na

November 6, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 6, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commissi

November 6, 2024 EX-10.1

Transition and Consulting Agreement, by and between the Registrant and Tighe Reardon, dated August 2, 2024.

Exhibit 10.1 August 2, 2024 Tighe Reardon Re: Transition and Consulting Agreement Dear Tighe: This letter sets forth the substance of the transition and consulting agreement (the “Agreement”) that Janux Therapeutics, Inc. (the “Company”) is offering to you. 1. Resignation Date. Pursuant to your voluntary resignation, which the Company hereby accepts, your last day of engagement as the Company’s Ac

November 6, 2024 EX-99.1

Janux Therapeutics, Inc. Condensed Balance Sheets (in thousands)

Exhibit 99.1 Janux Therapeutics Reports Third Quarter 2024 Financial Results and Business Highlights • Enrollment ongoing for PSMA-TRACTr (JANX007) in prostate cancer and EGFR-TRACTr (JANX008) in solid tumors • Update on JANX007 data and doses selected for expansion cohorts is anticipated in 2024 • $658.0 million in cash and cash equivalents and short-term investments at end of third quarter 2024

November 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

November 4, 2024 SC 13G/A

JANX / Janux Therapeutics, Inc. / Bregua Corp - SC 13G/A Passive Investment

SC 13G/A 1 d832507dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. 2) Janux Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 47103J 105 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the ru

October 25, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / Avalon Ventures XI, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm2426876d1sc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 6)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 47103J 105 (CUSIP Number) Jay Lichter, Ph.D. Avalon Ventures 1134 Kline Street La Jolla, California 92037 (858) 348-2180 (Na

October 25, 2024 EX-99.A

Joint Filing Agreement

EX-99.A 2 tm2426876d1ex99a.htm EXHIBIT 99.A EXHIBIT A JOINT FILING AGREEMENT The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Janux Therapeutics, Inc. shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13D. Dated: October 25, 2024 AVALON VENTURES XI, L.P. AVALON

October 23, 2024 EX-99.1

Joint Filing Agreement

EX-99.1 2 tm2426437d1ex1.htm EXHIBIT 1 Exhibit 1 JOINT FILING AGREEMENT In accordance with Rule 13d - 1 (k) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock, $0.001 par value per share, of Janux Therapeutics, Inc., and furt

October 23, 2024 SC 13G

JANX / Janux Therapeutics, Inc. / Paradigm Biocapital Advisors LP - SC 13G Passive Investment

SC 13G 1 tm2426437d1sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 47103J105 (CUSIP Number) October 16, 2024 (Date of Event Which Requires Filing of this statement) Check

October 22, 2024 EX-99.A

Joint Filing Agreement

EXHIBIT A JOINT FILING AGREEMENT The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Janux Therapeutics, Inc.

October 22, 2024 EX-99.1

Exhibit 1 Joint Filing Agreement

EX-99.1 2 tm2426608d1ex1.htm EXHIBIT 1 Exhibit 1 JOINT FILING AGREEMENT This Joint Filing Agreement, dated as of October 22, 2024, is by and among RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P. (the foregoing are collectively referred to herein as the “Filers”). Each of the Filers may be required to file with the United States Securities and Exchan

October 22, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm2426608d1sc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment 3)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 47103J105 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Ko

October 22, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / Avalon Ventures XI, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.

September 16, 2024 EX-99.A

Joint Filing Agreement

EX-99.A 2 tm2424212d1ex99a.htm EXHIBIT 99.A EXHIBIT A JOINT FILING AGREEMENT The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Janux Therapeutics, Inc. shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13D. Dated: September 16, 2024 AVALON VENTURES XI, L.P. AVALO

September 16, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / Avalon Ventures XI, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm2424212d1sc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 4)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 47103J 105 (CUSIP Number) Jay Lichter, Ph.D. Avalon Ventures 1134 Kline Street La Jolla, California 92037 (858) 348-2180 (Na

September 16, 2024 EX-99.B

Stock Purchase Agreement

EX-99.B 3 tm2424212d1ex99b.htm EXHIBIT 99.B Exhibit B STOCK PURCHASE AGREEMENT This STOCK PURCHASE AGREEMENT (the “Agreement”) is made as of September 12, 2024 (the “Effective Date”), by and among RA Capital Healthcare Fund, L.P., a Delaware limited partnership (the “Purchaser”), on the one hand, and Avalon Ventures XI, L.P., a Delaware limited partnership (“Avalon XI”), Avalon BioVentures I, LP,

September 16, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm2424209d1sc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment 2)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 47103J105 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Ko

September 16, 2024 EX-7

Stock Purchase Agreement

EX-7 2 tm2424209d1ex7.htm EXHIBIT 7 Exhibit 7 STOCK PURCHASE AGREEMENT This STOCK PURCHASE AGREEMENT (the “Agreement”) is made as of September 12, 2024 (the “Effective Date”), by and among RA Capital Healthcare Fund, L.P., a Delaware limited partnership (the “Purchaser”), on the one hand, and Avalon Ventures XI, L.P., a Delaware limited partnership (“Avalon XI”), Avalon BioVentures I, LP, a Delawa

August 9, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 2 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 47103J105 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP VIII LLC OrbiMed Genesis GP LLC OrbiMed Capital LLC 601 Lexington Avenue, 54th Floor New York, NY 10022

August 9, 2024 EX-99.2

JOINT FILING AGREEMENT

Exhibit 2 JOINT FILING AGREEMENT The undersigned hereby agree that Amendment No. 2 to the Statement on Schedule 13D, dated July 31. 2024, with respect to the common stock of Janux Therapeutics, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended. Each of the undersigned agrees to be responsib

August 9, 2024 EX-99.1

The Reporting Persons undertake, upon request by the staff of the Securities and Exchange Commission or the Issuer to provide full information regarding the number of Shares sold at each separate price.

Exhibit 1 Seller Date of Transaction Transaction Number of Shares Weighted Average Price Per Share BIOG June 3, 2024 Sold 118,683 $55.

August 7, 2024 EX-99.1

Janux Therapeutics, Inc. Condensed Balance Sheets (in thousands)

Exhibit 99.1 Janux Therapeutics Reports Second Quarter 2024 Financial Results and Business Highlights • Enrollment ongoing for PSMA-TRACTr (JANX007) in prostate cancer and EGFR-TRACTr (JANX008) in solid tumors • Update on JANX007 data and doses selected for expansion cohorts is anticipated in 2H 2024 • Appointed Eric Dobmeier and Natasha Hernday to the Board of Directors • Received $7.5 million de

August 7, 2024 EX-10.1

Janux Therapeutics, Inc. 2021 Equity Incentive Plan, Forms of Option Grant Notice, Option Agreement and Notice of Exercise thereunder, and Forms of RSU Award Grant Notice and RSU Award Agreement. (incorporated by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q, filed with the SEC on August 7, 2024).

Exhibit 10.1 Janux Therapeutics, Inc. 2021 Equity Incentive Plan Adopted by the Board of Directors: June 3, 2021 Approved by the Stockholders: June 4, 2021 Table of Contents Page 1. General. 1 2. Shares Subject to the Plan. 1 3. Eligibility and Limitations. 2 4. Options and Stock Appreciation Rights. 3 5. Awards Other Than Options and Stock Appreciation Rights. 7 6. Adjustments upon Changes in Com

August 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

August 7, 2024 EX-10.2

Amended and Restated Non-Employee Director Compensation Policy.

Exhibit 10.2 Janux Therapeutics, Inc. Amended and Restated Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) who is not also serving as an employee of or consultant to Janux Therapeutics, Inc. (the “Company”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compens

August 7, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

July 22, 2024 EX-99.1

Janux Therapeutics Announces Updates to Board of Directors

Exhibit 99.1 Janux Therapeutics Announces Updates to Board of Directors • The appointment of Eric Dobmeier and Natasha Hernday to the Board brings extensive operational and business development experience to support corporate and pipeline strategy • Janux also announced the resignation of Jay Lichter, Ph.D., from the Board, and the appointment of current Board member Ronald W. Barrett, Ph.D., as C

July 22, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 19, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

June 28, 2024 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 26, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

June 17, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.     )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.     ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-

June 5, 2024 EX-99.A

Joint Filing Agreement

EX-99.A 2 tm2416571d1ex99a.htm EXHIBIT 99.A EXHIBIT A JOINT FILING AGREEMENT The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Janux Therapeutics, Inc. shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13D. Dated: June 5, 2024 AVALON VENTURES XI, L.P. AVALON VENT

June 5, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / Avalon Ventures XI, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 tm2416571d1sc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 47103J 105 (CUSIP Number) Jay Lichter, Ph.D. Avalon Ventures 1134 Kline Street La Jolla, California 92037 (858) 348-2180 (Na

May 8, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

May 8, 2024 EX-4.12

Form of Debt Securities Warrant Agreement and Warrant Certificate.

Exhibit 4.12 JANUX THERAPEUTICS, INC. AND        , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OF        JANUX THERAPEUTICS, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT THIS DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of [●], between JANUX THERAPEUTICS, INC., a Delaware corporation (the “Company”), and [●], a [corporation] [national banking association

May 8, 2024 S-3ASR

As filed with the Securities and Exchange Commission on May 8, 2024

Table of Contents As filed with the Securities and Exchange Commission on May 8, 2024 Registration No.

May 8, 2024 EX-99.1

Janux Therapeutics, Inc. Condensed Balance Sheets (in thousands)

Exhibit 99.1 Janux Therapeutics Reports First Quarter 2024 Financial Results and Business Highlights • Enrollment ongoing for PSMA-TRACTr (JANX007) in prostate cancer • Enrollment ongoing for EGFR-TRACTr (JANX008) in solid tumors • Update on JANX007 data and doses selected for expansion cohorts is anticipated in 2H 2024 • $651.8 million in cash and cash equivalents and short-term investments at en

May 8, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Table Form S-3 (Form Type) Janux Therapeutics, Inc.

May 8, 2024 EX-4.8

Form of Indenture, between the registrant and one or more trustees to be named.

Exhibit 4.8 JANUX THERAPEUTICS, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [●], 20[●] Debt Securities TABLE OF CONTENTS  PAGE  ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee’s Certificate

May 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2024 Janux Therapeutics, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 8, 2024 EX-4.11

Form of Preferred Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.11 JANUX THERAPEUTICS, INC. AND       , AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF       JANUX THERAPEUTICS, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT THIS PREFERRED STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [●], between JANUX THERAPEUTICS, INC., a Delaware corporation (the “Company”), and [●], a [corporation] [national banking association]

May 8, 2024 EX-4.10

Form of Common Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.10 JANUX THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF JANUX THERAPEUTICS, INC. FORM OF COMMON STOCK WARRANT AGREEMENT THIS COMMON STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [●], between JANUX THERAPEUTICS, INC., a Delaware corporation (the “Company”), and [●], a [corporation] [national banking association] organized and existin

April 29, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

90 c UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒

April 29, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

March 8, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Janux Therapeutics, Inc.

March 8, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-404

March 8, 2024 EX-10.14

Employment Agreement, by and between the Registrant and Tommy DiRaimondo, Ph.D., dated January 1, 2021.

Exhibit 10.14 January 1, 2021 Thomas DiRaimondo Re: Employment Terms Dear Tommy: Janux Therapeutics, Inc. (the "Company") is pleased to offer you employment beginning on January 1, 2021 (the "Start Date"). Position Your initial position will be Director, Research, responsible for performing such duties as are assigned to you from time to time, reporting to the Company's President & CEO. You will p

March 8, 2024 S-8

As filed with the Securities and Exchange Commission on March 8, 2024

As filed with the Securities and Exchange Commission on March 8, 2024 Registration No.

March 8, 2024 EX-99.1

Janux Therapeutics, Inc. Condensed Balance Sheets (in thousands)

Exhibit 99.1 Janux Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Business Highlights • Recently presented positive Phase 1 clinical trial data for PSMA-TRACTr JANX007 in mCRPC and for EGFR-TRACTr JANX008 in solid tumors • Enrollment ongoing for JANX007 and JANX008 • Update on JANX007 data and doses selected for expansion cohorts is anticipated in 2H 2024 • $344.0 mil

March 8, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 8, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

March 8, 2024 EX-10.5

Amended and Restated Non-Employee Director Compensation Policy.

Exhibit 10.5 Janux Therapeutics, Inc. Amended and Restated Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) who is not also serving as an employee of or consultant to Janux Therapeutics, Inc. (the “Company”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compens

March 8, 2024 EX-10.22

Janux Therapeutics, Inc. Incentive Compensation Recoupment Policy.

Exhibit 10.22 Janux Therapeutics, Inc. Incentive Compensation Recoupment Policy 1. Introduction The Compensation Committee (the “Compensation Committee”) of the Board of Directors (the “Board”) of Janux Therapeutics, Inc., a Delaware corporation (the “Company”), has determined that it is in the best interests of the Company and its stockholders to adopt this Incentive Compensation Recoupment Polic

March 6, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment 1)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 47103J105 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617.778.2500 (Name, Ad

March 4, 2024 EX-99.A

Joint Filing Agreement

EXHIBIT A JOINT FILING AGREEMENT The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Janux Therapeutics, Inc.

March 4, 2024 SC 13D/A

JANX / Janux Therapeutics, Inc. / Avalon Ventures XI, L.P. - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.

February 29, 2024 EX-1.1

Underwriting Agreement, dated February 28, 2024, by and among Janux Therapeutics, Inc. and BofA Securities, Inc., Cowen and Company, LLC, Cantor Fitzgerald & Co. and William Blair & Company, L.L.C. as representatives of the several underwriters named therein (incorporated by reference to Exhibit 1.1 of the Registrant’s Current Report on Form 8-K, filed February 29, 2024).

Exhibit 1.1 JANUX THERAPEUTICS, INC. (a Delaware corporation) 4,440,851 Shares of Common Stock and Pre-Funded Warrants to Purchase 1,935,483 Shares of Common Stock UNDERWRITING AGREEMENT Dated: February 28, 2024 JANUX THERAPEUTICS, INC. (a Delaware corporation) 4,440,851 Shares of Common Stock and Pre-Funded Warrants to Purchase 1,935,483 Shares of Common Stock UNDERWRITING AGREEMENT February 28,

February 29, 2024 424B5

4,440,851 Shares of Common Stock Pre-Funded Warrants to Purchase 1,935,483 Shares of Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-266720 PROSPECTUS SUPPLEMENT (to Prospectus dated September 19, 2022) 4,440,851 Shares of Common Stock Pre-Funded Warrants to Purchase 1,935,483 Shares of Common Stock We are offering 4,440,851 shares of our common stock at a purchase price of $46.50 per share, and in lieu of offering shares of our common stock to certain inve

February 29, 2024 FWP

JANUX THERAPEUTICS, INC. Common Stock Pre-funded Warrants to Purchase Shares of Common Stock

Issuer Free Writing Prospectus Filed Pursuant to Rule 433 Dated February 28, 2024 Relating to Preliminary Prospectus Supplement Dated February 27, 2024 Registration Statement No.

February 29, 2024 EX-99.1

Janux Therapeutics Announces Proposed Public Offering of Common Stock

Exhibit 99.1 Janux Therapeutics Announces Proposed Public Offering of Common Stock SAN DIEGO, Feb. 27, 2024 - Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms, tod

February 29, 2024 EX-99.2

Janux Therapeutics Announces Pricing of $296.5 Million Underwritten Public Offering of Common Stock and Pre-Funded Warrants

Exhibit 99.2 Janux Therapeutics Announces Pricing of $296.5 Million Underwritten Public Offering of Common Stock and Pre-Funded Warrants SAN DIEGO, Feb. 29, 2024 - Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and T

February 29, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commiss

February 29, 2024 EX-4.1

Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K, filed February 29, 2024).

Exhibit 4.1 JANUX THERAPEUTICS, INC. FORM OF PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK Number of Shares: [ ] (subject to adjustment) Original Issue Date: [ ], 2024 Warrant No. [ ] Janux Therapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [ ] or its registered assigns

February 28, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2024 Janux Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commiss

February 28, 2024 424B5

SUBJECT TO COMPLETION, DATED FEBRUARY 27, 2024

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-266720 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been filed with the Securities and Exchange Commission and is effective. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell

February 27, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2024 Janux Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commiss

February 26, 2024 EX-99.1

Janux Announces Encouraging Safety and Efficacy Data in Ongoing Dose Escalation Trials for PSMAxCD3-TRACTr JANX007 in mCRPC and EGFRxCD3-TRACTr JANX008 in Solid Tumors

Exhibit 99.1 Janux Announces Encouraging Safety and Efficacy Data in Ongoing Dose Escalation Trials for PSMAxCD3-TRACTr JANX007 in mCRPC and EGFRxCD3-TRACTr JANX008 in Solid Tumors • Emerging JANX007 data illustrate a potential best-in-class profile: promising efficacy with favorable safety profile in heavily pretreated subjects with late-stage mCRPC - 83% (5/6) of subjects achieved PSA50 declines

February 26, 2024 EX-99.2

Forward-looking statements and disclaimers This presentation includes certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future result

Tumor Activated Cancer Therapeutics Restoring anti-tumor immune responses to treat cancer patients February 26, 2024 Exhibit 99.

February 26, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 26, 2024 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commiss

February 14, 2024 SC 13G/A

JANX / Janux Therapeutics, Inc. / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 1 TO SCHEDULE 13G Passive Investment

SC 13G/A 1 sc13ga107422janx02142024.htm AMENDMENT NO. 1 TO SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1)1 Janux Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par

February 14, 2024 SC 13G/A

JANX / Janux Therapeutics, Inc. / EcoR1 Capital, LLC Passive Investment

SC 13G/A 1 janx13ga.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 47103J105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropri

February 14, 2024 SC 13G/A

JANX / Janux Therapeutics, Inc. / CITADEL ADVISORS LLC - SC 13G/A Passive Investment

SC 13G/A 1 tm243953d8sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. 1)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (the “Shares”)

February 9, 2024 SC 13G/A

JANX / Janux Therapeutics, Inc. / Campbell David Alan - SC 13G/A Passive Investment

SC 13G/A 1 d736647dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2) Janux Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 47103J 105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rul

February 1, 2024 SC 13G/A

JANX / Janux Therapeutics, Inc. / Bregua Corp - SC 13G/A Passive Investment

SC 13G/A 1 d724857dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. 1) Janux Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 47103J 105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rul

November 16, 2023 SC 13D/A

JANX / Janux Therapeutics Inc / Avalon Ventures XI, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 d943966dsc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 47103J 105 (CUSIP Number) Jay Lichter, Ph.D. Avalon Ventures 1134 Kline Street La Jolla, California 92037 (858) 348-2180 (Name,

November 16, 2023 EX-99.C

JOINT FILING AGREEMENT

EX-99.C 2 d943966dex99c.htm EX-99.C EXHIBIT C JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13D (including amendments thereto) with respect to the Common Stock of Janux Therapeutics, Inc. and further agree that this agreement be included as

November 7, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commissi

November 7, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

November 7, 2023 EX-99.1

Janux Therapeutics, Inc. Condensed Balance Sheets (in thousands)

Exhibit 99.1 Janux Therapeutics Reports Third Quarter 2023 Financial Results and Business Highlights • Enrollment ongoing for PSMA-TRACTr (JANX007) in prostate cancer • Enrollment ongoing for EGFR-TRACTr (JANX008) in solid tumors • Update on clinical programs expected in 2024 • $349.7 million in cash, cash equivalents, and short-term investments at end of third quarter 2023 • Cash and investments

August 8, 2023 EX-99.1

Janux Therapeutics, Inc. Condensed Balance Sheets (in thousands)

Exhibit 99.1 Janux Therapeutics Reports Second Quarter 2023 Financial Results and Business Highlights - Presented positive interim Phase 1 clinical trial data for PSMA-TRACTr JANX007 in prostate cancer - Management team bolstered with key appointment - $303.3 million in cash, cash equivalents, and short-term investments at end of second quarter 2023 - In July, further strengthened balance sheet wi

August 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 8, 2023 Janux Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 8, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

August 8, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

July 18, 2023 EX-99.1

Janux Therapeutics Announces Pricing of $60 Million Underwritten Offering of Common Stock and

EX-99.1 Exhibit 99.1 Janux Therapeutics Announces Pricing of $60 Million Underwritten Offering of Common Stock and Pre-Funded Warrants SAN DIEGO, July 17, 2023 – Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and Tum

July 18, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 17, 2023 Janux Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 17, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

July 18, 2023 EX-1.1

Underwriting Agreement, between the Company and BofA Securities, Inc., dated as of July 17, 2023 (incorporated by reference to Exhibit 1.1 of the Registrant’s Current Report on Form 8-K, filed with the SEC on July 18, 2023).

EX-1.1 Exhibit 1.1 JANUX THERAPEUTICS, INC. (a Delaware corporation) 4,153,717 Shares of Common Stock and Pre-Funded Warrants to Purchase 583,483 Shares of Common Stock UNDERWRITING AGREEMENT Dated: July 17, 2023 JANUX THERAPEUTICS, INC. (a Delaware corporation) 4,153,717 Shares of Common Stock and Pre-Funded Warrants to Purchase 583,483 Shares of Common Stock UNDERWRITING AGREEMENT July 17, 2023

July 18, 2023 EX-4.1

Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K, filed July 18, 2023).

EX-4.1 Exhibit 4.1 JANUX THERAPEUTICS, INC. PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK Number of Shares: [] Original Issue Date: [] Warrant No. [] Janux Therapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [] or its permitted registered assigns (the “Holder”), is entitl

July 18, 2023 424B5

4,153,717 Shares of Common Stock Pre-Funded Warrants to Purchase 583,483 Shares of Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-266720 P R O S P E C T U S S U P P L E M E N T (To Prospectus dated September 19, 2022) 4,153,717 Shares of Common Stock Pre-Funded Warrants to Purchase 583,483 Shares of Common Stock We are offering 4,153,717 shares of our common stock at a purchase price of $12.46 per share and, in lieu of offering shares of our common

July 17, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 17, 2023 Janux Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 17, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

July 17, 2023 FWP

1

FWP Issuer Free Writing Prospectus Filed Pursuant to Rule 433 Dated July 17, 2023 Relating to Prospectus Dated September 19, 2022 Registration Statement No.

July 17, 2023 EX-99.2

Forward-looking statements and disclaimers This presentation includes certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future result

EX-99.2 Program Updates July 2023 Exhibit 99.2 Forward-looking statements and disclaimers This presentation includes certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements regarding Janux Therapeutics, Inc. (the “Comp

July 17, 2023 EX-99.1

Janux Therapeutics Announces Positive Interim Clinical Data from Phase 1a Dose Escalation for PSMA-TRACTr JANX007 and an Update on Pipeline Programs

EX-99.1 Exhibit 99.1 Janux Therapeutics Announces Positive Interim Clinical Data from Phase 1a Dose Escalation for PSMA-TRACTr JANX007 and an Update on Pipeline Programs • Multiple patients treated with PSMA-TRACTr JANX007 have achieved meaningful PSA drops coupled with manageable safety and CRS • PSMA-TRACTr JANX007 and EGFR-TRACTr JANX008 have been generally well tolerated at levels above the pr

July 10, 2023 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the Shares of Janux Therapeutics, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(c) under the Securities Exchange Act of 1934, as amended, on behalf of each of the unders

July 10, 2023 SC 13G

JANX / Janux Therapeutics Inc / CITADEL ADVISORS LLC - SC 13G Passive Investment

SC 13G 1 tm2320955-1sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. )* Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (the “Shares”) (Titl

June 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 21, 2023 Janux Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 21, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

June 20, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2023 Janux Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

May 30, 2023 SC 13G

JANX / Janux Therapeutics Inc / BIOTECHNOLOGY VALUE FUND L P - SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. )1 Janux Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 47103J105 (CUSIP Number)

May 30, 2023 EX-99.1

Joint Filing Agreement

Exhibit 99.1 Joint Filing Agreement The undersigned hereby agree that the Statement on Schedule 13G dated May 30, 2023 with respect to the Common Stock, $0.001 par value per share, of Janux Therapeutics, Inc., a Delaware corporation, and any further amendments thereto executed by each and any of the undersigned shall be filed on behalf of each of the undersigned pursuant to and in accordance with

May 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

May 9, 2023 EX-99

-First patient dosed with EGFR-TRACTr (JANX008) in first-in-human Phase 1 clinical trial in patients with solid tumors- -Interim clinical update from Phase 1 trial of JANX007 expected in 2H 2023- -$316.9 million in cash and cash equivalents and short

Exhibit 99.1 Janux Therapeutics Reports First Quarter 2023 Financial Results and Business Highlights -First patient dosed with EGFR-TRACTr (JANX008) in first-in-human Phase 1 clinical trial in patients with solid tumors- -Interim clinical update from Phase 1 trial of JANX007 expected in 2H 2023- -$316.9 million in cash and cash equivalents and short-term investments at end of first quarter 2023- S

May 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2023 Janux Therapeutics, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 9, 2023 424B5

Up to $150,000,000 Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-266720 P R O S P E C T U S S U P P L E M E N T (To Prospectus dated September 19, 2022) Up to $150,000,000 Common Stock We have entered into an ATM Equity OfferingSM Sales Agreement (the “Sales Agreement”) with BofA Securities, Inc. (“BofA”) relating to the sale of shares of our common stock, $0.001 par value per share,

May 9, 2023 EX-1

ATM Equity OfferingSM Sales Agreement, dated May 9, 2023, by and between the Registrant and BofA Securities, Inc. (incorporated by reference to Exhibit 1.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on May 9, 2023).

Exhibit 1.1 ATM EQUITY OFFERINGSM SALES AGREEMENT May 9, 2023 BOFA SECURITIES, INC. One Bryant Park New York, New York 10036 Ladies and Gentlemen: Janux Therapeutics, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through BofA Securities, Inc., as sales agent and/or principal (the “Agent”), shares of th

May 9, 2023 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission Fi

April 28, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 28, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

March 31, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 27, 2023 Janux Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 27, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

March 10, 2023 EX-99

Janux Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Business Highlights -Interim clinical update from Phase 1 trial of JANX007 expected in 2H 2023- -FDA clearance granted for Investigational New Drug (IND) application f

Exhibit 99.1 Janux Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Business Highlights -Interim clinical update from Phase 1 trial of JANX007 expected in 2H 2023- -FDA clearance granted for Investigational New Drug (IND) application for EGFR-TRACTr (JANX008)- -$327.0 million in year-end cash and cash equivalents and short-term investments- SAN DIEGO, March 10, 2023 – J

March 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Janux Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

March 10, 2023 EX-10

Employment Agreement, by and between the Registrant and Charles Winter, dated February 12, 2021 (incorporated by reference to Exhibit 10.20 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 10, 2023).

Exhibit 10.20 February 8, 2021 Charles Winter VIA ELECTRONIC MAIL CONFIDENTIAL Dear Charles, We are very pleased to extend to you the offer of employment for the exempt position of Senior Vice President, CMC reporting to me, the company’s President and Chief Executive Officer. The following outlines your offer of Employment: Start Date: March 22, 2021. Compensation: Your semi-monthly salary in the

March 10, 2023 S-8

As filed with the Securities and Exchange Commission on March 10, 2023

As filed with the Securities and Exchange Commission on March 10, 2023 Registration No.

March 10, 2023 EX-10

Transition and Consulting Agreement, by and between the Registrant and Shahram Salek-Ardakani, Ph.D., dated November 10, 2022.

Exhibit 10.19 November 8, 2022 Shahram Salek-Ardakani, Ph.D. Re: Transition and Consulting Agreement Dear Shahram: This letter sets forth the substance of the transition and consulting agreement (the “Agreement”) that Janux Therapeutics, Inc. (the “Company”) is offering to you to aid in your employment transition. 1. Resignation Date. Pursuant to your voluntary resignation, which the Company hereb

March 10, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Janux Therapeutics, Inc.

March 10, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-404

February 10, 2023 SC 13G/A

JANX / Janux Therapeutics, Inc. / Campbell David Alan - SC 13G/A Passive Investment

SC 13G/A 1 d430237dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) Janux Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 47103J 105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rul

January 23, 2023 SC 13G

JANX / Janux Therapeutics, Inc. / EcoR1 Capital, LLC Passive Investment

SC 13G 1 janx13g.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. ) Janux Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 47103J105 (CUSIP Number) January 10, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate b

November 10, 2022 EX-99.1

Janux Therapeutics Reports Third Quarter 2022 Financial Results and Business Highlights -First patient dosed with JANX007 in first-in-human Phase 1 clinical trial in prostate cancer patients- -Interim clinical update from Phase 1 trial of JANX007 exp

Exhibit 99.1 Janux Therapeutics Reports Third Quarter 2022 Financial Results and Business Highlights -First patient dosed with JANX007 in first-in-human Phase 1 clinical trial in prostate cancer patients- -Interim clinical update from Phase 1 trial of JANX007 expected in 2H 2023- -IND application for EGFR-TRACTr (JANX008) remains on-track to be submitted in 2H 2022- -Management team and Board stre

November 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

November 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commiss

September 22, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 21, 2022 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commis

September 22, 2022 EX-99.1

Janux Therapeutics Appoints Winston Kung to Board of Directors

Exhibit 99.1 Janux Therapeutics Appoints Winston Kung to Board of Directors SAN DIEGO, September 22, 2022 ? Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr) and Tumor Activated Immunomodulator (TRACIr) platforms, today announced the

September 15, 2022 CORRESP

Janux Therapeutics, Inc. 10955 Vista Sorrento Parkway, Suite 200 San Diego, California 92130

Janux Therapeutics, Inc. 10955 Vista Sorrento Parkway, Suite 200 San Diego, California 92130 September 15, 2022 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Jason Drory Re: Janux Therapeutics, Inc. Registration Statement on Form S-3 File No. 333-266720 Request for Acceleration of Effective Date Requested Date: Sep

August 9, 2022 EX-99.1

Janux Therapeutics Reports Second Quarter 2022 Financial Results and Business Highlights -IND application cleared for lead product candidate JANX007 (PSMA-TRACTr)- -Phase 1 clinical trial evaluating JANX007 for metastatic castration-resistant prostat

Exhibit 99.1 Janux Therapeutics Reports Second Quarter 2022 Financial Results and Business Highlights -IND application cleared for lead product candidate JANX007 (PSMA-TRACTr)- -Phase 1 clinical trial evaluating JANX007 for metastatic castration-resistant prostate cancer remains on-track to initiate in 2H 2022- -IND application for EGFR-TRACTr (JANX008) remains on-track to be submitted in 2H 2022-

August 9, 2022 EX-1.2

Open Market Sale AgreementSM, dated August 9, 2022, by and between the Registrant and Jefferies LLC (incorporated by reference to Exhibit 1.2 to the Registrant’s Registration Statement on Form S-3 (File No. 333-266720), filed August 9, 2022).

Exhibit 1.2 OPEN MARKET SALE AGREEMENTSM August 9, 2022 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Janux Therapeutics, Inc., a Delaware corporation (the ?Company?), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the ?Agent?), shares of the Company?s common

August 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

August 9, 2022 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Janux Therapeutics, Inc.

August 9, 2022 EX-4.6

Form of Indenture, between the registrant and one or more trustees to be named.

Exhibit 4.6 JANUX THERAPEUTICS, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [?], 20[?] Debt Securities TABLE OF CONTENTS PAGE ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee?s Certificate 8

August 9, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2022 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

August 9, 2022 EX-4.10

Form of Debt Securities Warrant Agreement and Warrant Certificate.

EX-4.10 6 d403660dex410.htm EX-4.10 Exhibit 4.10 JANUX THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OF JANUX THERAPEUTICS, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT THIS DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of [●], between JANUX THERAPEUTICS, INC., a Delaware corporation (the “Company”), and [●], a [corporation] [nation

August 9, 2022 EX-4.9

Form of Preferred Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.9 JANUX THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF JANUX THERAPEUTICS, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT THIS PREFERRED STOCK WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between JANUX THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking association] organized and

August 9, 2022 S-3

As filed with the Securities and Exchange Commission on August 9, 2022

Table of Contents As filed with the Securities and Exchange Commission on August 9, 2022 Registration No.

August 9, 2022 EX-4.8

Form of Common Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.8 JANUX THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF JANUX THERAPEUTICS, INC. FORM OF COMMON STOCK WARRANT AGREEMENT THIS COMMON STOCK WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between JANUX THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking association] organized and existing

June 15, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2022 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

May 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

May 10, 2022 EX-99.1

Janux Therapeutics Reports First Quarter 2022 Financial Results and Business Highlights -IND application recently submitted for PSMA-TRACTr (JANX007)- -Company remains on-track to submit IND application for EGFR-TRACTr (JANX008) in 2H 2022- -Merck no

Exhibit 99.1 Janux Therapeutics Reports First Quarter 2022 Financial Results and Business Highlights -IND application recently submitted for PSMA-TRACTr (JANX007)- -Company remains on-track to submit IND application for EGFR-TRACTr (JANX008) in 2H 2022- -Merck nominates second target as part of strategic collaboration and license agreement- -Presented preclinical data for JANX007 and JANX008 at th

May 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2022 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission F

May 2, 2022 EX-99.2

JANX008 Poster, dated May 2-5, 2022

Exhibit 99.2 Exhibit 99.2 Exhibit 99.2 Exhibit 99.2 Exhibit 99.2

May 2, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 2, 2022 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 2, 2022 EX-99.1

JANX007 Poster, dated May 2-5, 2022

Exhibit 99.1 Exhibit 99.1 Exhibit 99.1 Exhibit 99.1 Exhibit 99.1

April 29, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEF 14A 1 janxdef14a2022.htm DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as p

April 29, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defin

March 18, 2022 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Janux Therapeutics, Inc.

March 18, 2022 EX-10.15

Employment Agreement, by and between the Registrant and Byron Robinson, Ph.D., dated January 20, 2022 (incorporated by reference to Exhibit 10.15 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 18, 2022).

Exhibit 10.15 January 20, 2022 Byron Robinson, Ph.D. Re: Employment Terms Dear Byron: Janux Therapeutics, Inc. (the "Company?) is pleased to offer you employment anticipated to begin on or around March 1, 2022 (the ?Start Date?). Position Your initial position will be Chief Strategy Officer, responsible for performing such duties as are assigned to you from time to time, reporting to the Company?s

March 18, 2022 EX-10.14

Employment Agreement, by and between the registrant and Shahram Salek-Ardakani, Ph.D., dated May 11, 2021.

Exhibit 10.14 May 4, 2021 Shahram Salek-Ardakani, Ph.D. Re: Offer of Employment Dear Shahram: Janux Therapeutics, Inc. (the ?Company?) is pleased to offer you at-will employment in the position of Chief Scientific Officer on the terms and conditions set forth in this letter agreement (the ?Agreement?). 1. Employment by the Company. Your employment with the Company shall begin on July 12, 2021 or s

March 18, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-404

March 18, 2022 EX-10.17

Lease, by and between the Registrant and Pacific Plaza Owner LLC, dated October 1, 2021 (incorporated by reference to Exhibit 10.17 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 18, 2022).

Exhibit 10.17 TORREY PLAZA LEASE PACIFIC PLAZA OWNER, L.L.C., a Delaware limited liability company, as Landlord, and JANUX THERAPEUTICS, INC., a Delaware corporation, as Tenant SUMMARY OF BASIC LEASE INFORMATION This Summary of Basic Lease Information ("Summary") is hereby incorporated into and made a part of the attached Lease. Each reference in the Lease to any term of this Summary shall have th

March 18, 2022 S-8

As filed with the Securities and Exchange Commission on March 18, 2022

As filed with the Securities and Exchange Commission on March 18, 2022 Registration No.

March 18, 2022 EX-99.1

Janux Therapeutics Provides Business Update and Reports Fourth Quarter and Full Year 2021 Financial Results -Company remains on-track to submit IND filings for two programs in 2022- -Company nominated its first TRACIr development candidate, a PD-L1 x

Exhibit 99.1 Janux Therapeutics Provides Business Update and Reports Fourth Quarter and Full Year 2021 Financial Results -Company remains on-track to submit IND filings for two programs in 2022- -Company nominated its first TRACIr development candidate, a PD-L1 x CD28 costimulatory bispecific- -Management team strengthened with key appointment- ? $375.0 million in year-end 2021 cash, cash equivale

March 18, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2022 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commission

March 18, 2022 EX-4.4

(incorporated by reference to Exhibit 4.4 to the Registrant’s Annual Report on Form 10-K, filed with the SEC on March 18, 2022).

Exhibit 4.4 DESCRIPTION OF COMMON STOCK The following summary description of the common stock of Janux Therapeutics, Inc. (we, our or us) is based on the provisions of our amended and restated certificate of incorporation (Restated Certificate), as well as our amended and restated bylaws (Restated Bylaws), and the applicable provisions of the Delaware General Corporation Law. This information is q

February 11, 2022 SC 13G

JANX / Janux Therapeutics, Inc. / Campbell David Alan - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 Janux Therapeutics, Inc.

December 17, 2021 SC 13D/A

JANX / Janux Therapeutics, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 1 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Janux Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 47103J105 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP VIII LLC OrbiMed Genesis GP LLC OrbiMed Capital LLC 601 Lexington Avenue, 54th Floor New York, NY 10022

December 17, 2021 EX-99.1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13D, dated December 17, 2021, with respect to the common stock of Janux Therapeutics, Inc.

November 9, 2021 EX-10.1

Lease, by and between the Registrant and UTC Properties LLC, dated August 25, 2021.

Exhibit 10.1 LEASE BETWEEN UTC PROPERTIES LLC AND JANUX THERAPEUTICS, INC. LEASE (Short Form) THIS LEASE is made as of August 25, 2021, by and between UTC PROPERTIES LLC, a Delaware limited liability company, hereafter called ?Landlord,? and JANUX THERAPEUTICS, INC., a Delaware corporation hereafter called ?Tenant.? Article 1. BASIC LEASE PROVISIONS Each reference in this Lease to the ?Basic Lease

November 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

November 9, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2021 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commissi

November 9, 2021 EX-99.1

Janux Therapeutics Reports Business Highlights and Third Quarter 2021 Financial Results -Company remains on-track to submit IND filings for two programs in 2022- -Board of Directors strengthened with key appointments- -$387.5 million in cash and cash

Exhibit 99.1 Janux Therapeutics Reports Business Highlights and Third Quarter 2021 Financial Results -Company remains on-track to submit IND filings for two programs in 2022- -Board of Directors strengthened with key appointments- -$387.5 million in cash and cash equivalents and short-term investments at end of third quarter 2021- SAN DIEGO, November 9, 2021 ? Janux Therapeutics, Inc. (Nasdaq: JAN

October 1, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 1, 2021 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commissio

September 9, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 7, 2021 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commiss

August 27, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 25, 2021 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commissio

August 10, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40475 Janux Therapeutics, Inc.

August 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2021 Janux Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40475 82-2289112 (State or Other Jurisdiction of Incorporation) (Commissio

August 10, 2021 EX-99.1

Janux Therapeutics Reports Second Quarter 2021 Financial Results -Successful $222.9 million IPO in June brings total funds raised in the quarter to $347.9 million- -Company on-track to submit IND filings for multiple programs in 2022- -Management tea

Exhibit 99.1 Janux Therapeutics Reports Second Quarter 2021 Financial Results -Successful $222.9 million IPO in June brings total funds raised in the quarter to $347.9 million- -Company on-track to submit IND filings for multiple programs in 2022- -Management team strengthened with key appointments- SAN DIEGO, August 10, 2021 ? Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a biopharmaceutical c

July 16, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 15, 2021 Janux Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40475 82-2289112 (State or other jurisdiction of incorporation) (Commission

June 25, 2021 EX-99.C

Agreement regarding joint filing of Schedule 13D.

EXHIBIT C JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13D (including amendments thereto) with respect to the Common Stock of Janux Therapeutics, Inc.

June 25, 2021 SC 13G

JANX / Janux Therapeutics, Inc. / Bregua Corp - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 Janux Therapeutics, Inc.

June 25, 2021 SC 13D

JANX / Janux Therapeutics, Inc. / Avalon Ventures XI, L.P. - SC 13D Activist Investment

SC 13D SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.

June 25, 2021 EX-99.B

Form of Lock-up Agreement

EXHIBIT B FORM OF LOCK-UP AGREEMENT , 2021 BofA Securities, Inc. Cowen and Company, LLC Evercore Group L.L.C. as Representatives of the several Underwriters to be named in the within-mentioned Underwriting Agreement c/o BofA Securities, Inc. One Bryant Park New York, New York 10036 c/o Cowen and Company LLC 599 Lexington Avenue New York, New York 10022 c/o Evercore Group L.L.C. 55 East 52nd Street

June 22, 2021 SC 13D

EWTX / Edgewise Therapeutics, Inc. / ORBIMED ADVISORS LLC - SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 Janux Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 47103J105 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP VIII LLC OrbiMed Genesis GP LLC OrbiMed Capital LLC 601 Lexington Avenue, 54th Floor New York, NY 10022 Telephone: (212) 7

June 22, 2021 EX-99.1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13D, dated June 21, 2021, with respect to the common stock of Janux Therapeutics, Inc.

June 16, 2021 SC 13D

JANX / Janux Therapeutics, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13D Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment )* Janux Therapetuics, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 47103J105 (CUSIP Number) RA Capital Management, L.P. 200 Berkeley Street, 18th Floor Boston, MA 02116 Attn: Peter Kolchinsky Telephone: 617.778.2500 (Name, Add

June 15, 2021 EX-3.1

Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K, filed June 15, 2021).

EX-3.1 2 d177137dex31.htm EX-3.1 Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF JANUX THERAPEUTICS, INC. David Campbell, Ph.D., hereby certifies that: ONE: He is the duly elected Chief Executive Officer of Janux Therapeutics, Inc., a Delaware corporation. TWO: The date of filing the original Certificate of Incorporation of the Company with the Secretary of State of the State of D

June 15, 2021 EX-99.1

Janux Therapeutics Announces Closing of Initial Public Offering and Full Exercise of Underwriters’ Option to Purchase Additional Shares

Exhibit 99.1 Janux Therapeutics Announces Closing of Initial Public Offering and Full Exercise of Underwriters? Option to Purchase Additional Shares La Jolla, CA, June 15, 2021 ? Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a biopharmaceutical company developing novel T cell engager immunotherapies, today announced the closing of its previously announced initial public offering of 13,110,000 s

June 15, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2021 Janux Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40475 82-2289112 (State or other jurisdiction of incorporation) (Commission

June 15, 2021 EX-3.2

Amended and Restated Bylaws (incorporated by reference to Exhibit 3.2 to the Registrant’s Current Report on Form 8-K, filed June 15, 2021).

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF JANUX THERAPEUTICS, INC. ARTICLE I OFFICES Section 1. Registered Office. The registered office of the corporation in the State of Delaware shall be in the City of Wilmington, County of New Castle. Section 2. Other Offices. The corporation shall also have and maintain an office or principal place of business at such place as may be fixed by the corporation

June 11, 2021 424B4

11,400,000 Shares Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(4) Registration Nos. 333-256297 and 333-257003 PROSPECTUS 11,400,000 Shares Common Stock This is the initial public offering of shares of common stock of Janux Therapeutics, Inc. We are selling 11,400,000 shares of our common stock. Prior to this offering, there has been no public market for our common stock. The initial public offering price is 17.0

June 11, 2021 S-8

As filed with the Securities and Exchange Commission on June 11, 2021

As filed with the Securities and Exchange Commission on June 11, 2021 Registration No.

June 10, 2021 S-1MEF

As filed with the Securities and Exchange Commission on June 10, 2021

As filed with the Securities and Exchange Commission on June 10, 2021 Registration No.

June 9, 2021 CORRESP

JANUX THERAPEUTICS, INC. 11099 N. Torrey Pines Road, Suite 290 La Jolla, California 92037

JANUX THERAPEUTICS, INC. 11099 N. Torrey Pines Road, Suite 290 La Jolla, California 92037 June 9, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Tracie Mariner Al Pavot Deanna Virginio Irene Paik Re: Janux Therapeutics, Inc. Registration Statement on Form S-1, as amended (File No. 333-256297) Request for Accele

June 9, 2021 CORRESP

[Signature Page Follows]

June 9, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attn: Tracie Mariner Al Pavot Deanna Virginio Irene Paik Re: Janux Therapeutics, Inc. Registration Statement on Form S-1, as amended File No. 333-256297 Acceleration Request Requested Date: Thursday, June 10, 2021 Requested Time: 4:00 P.M.

June 9, 2021 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Janux Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 82-2289112 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification No

June 7, 2021 EX-4.1

Form of Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registrant’s Registration Statement on Form S-1, as amended, filed June 7, 2021).

Exhibit 4.1

June 7, 2021 EX-4.2

Amended and Restated Investors’ Rights Agreement, by and between the Registrant and certain of its stockholders, dated April 15, 2021, as amended (incorporated by reference to Exhibit 4.2 to the Registrant’s Registration Statement on Form S-1, filed June 7, 2021).

Exhibit 4.2 AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT (this ?Agreement?) is made and entered into as of April 15, 2021, by and among Janux Therapeutics, Inc., a Delaware corporation (the ?Company?), and the investors set forth on the Schedule of Investors attached hereto as Schedule A (each, an ?Investor? and collectively, the ?Investors

June 7, 2021 EX-10.3

Janux Therapeutics, Inc. 2021 Equity Incentive Plan, and Forms of Option Grant Notice, Option Agreement and Notice of Exercise thereunder.

Exhibit 10.3 JANUX THERAPEUTICS, INC. 2021 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: JUNE 3, 2021 APPROVED BY THE STOCKHOLDERS: JUNE 4, 2021 TABLE OF CONTENTS Page 1 GENERAL. 1 2. SHARES SUBJECT TO THE PLAN. 1 3. ELIGIBILITY AND LIMITATIONS. 2 4. OPTIONS AND STOCK APPRECIATION RIGHTS. 3 5. AWARDS OTHER THAN OPTIONS AND STOCK APPRECIATION RIGHTS. 7 6. ADJUSTMENTS UPON CHANGES IN COMM

June 7, 2021 EX-3.1

Amended and Restated Certificate of Incorporation, as currently in effect.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF JANUX THERAPEUTICS, INC. David Campbell hereby certifies that: ONE: The original Certificate of Incorporation of this corporation was filed with the Secretary of State of the State of Delaware on June 27, 2017. TWO: He is the duly elected and acting President and Chief Executive Officer of this corporation. THREE: The Amended and Res

June 7, 2021 EX-10.5

Non-Employee Director Compensation Policy.

Exhibit 10.5 JANUX THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY Each member of the Board of Directors (the ?Board?) who is not also serving as an employee of or consultant to Janux Therapeutics, Inc. (the ?Company?) or any of its subsidiaries (each such member, an ?Eligible Director?) will receive the compensation described in this Non-Employee Director Compensation Policy for his

June 7, 2021 EX-3.2

Form of Amended and Restated Certificate of Incorporation of the Registrant, to be in effect immediately prior to the closing of the Registrant’s initial public offering of Common Stock (incorporated by reference to Exhibit 3.2 to the Registrant’s Registration Statement on Form S-1, as amended (File No. 333-256297), filed with the SEC on June 7, 2021).

Exhibit 3.2 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF JANUX THERAPEUTICS, INC. David Campbell, Ph.D., hereby certifies that: ONE: He is the duly elected Chief Executive Officer of Janux Therapeutics, Inc., a Delaware corporation. TWO: The date of filing the original Certificate of Incorporation of the Company with the Secretary of State of the State of Delaware was June 27, 2017. THREE:

June 7, 2021 EX-10.4

Janux Therapeutics, Inc. 2021 Employee Stock Purchase Plan.

Exhibit 10.4 JANUX THERAPEUTICS, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN ADOPTED BY THE BOARD OF DIRECTORS: JUNE 3, 2021 APPROVED BY THE STOCKHOLDERS: JUNE 4, 2021 1. GENERAL; PURPOSE. (a) The Plan provides a means by which Eligible Employees of the Company and certain designated Related Corporations may be given an opportunity to purchase shares of Common Stock. The Plan permits the Company to gra

June 7, 2021 S-1/A

As filed with the Securities and Exchange Commission on June 7, 2021.

Table of Contents As filed with the Securities and Exchange Commission on June 7, 2021.

June 7, 2021 EX-1.1

Form of Underwriting Agreement.

Exhibit 1.1 JANUX THERAPEUTICS, INC. (a Delaware corporation) [?] Shares of Common Stock UNDERWRITING AGREEMENT Dated: [?], 2021 JANUX THERAPEUTICS, INC. (a Delaware corporation) [?] Shares of Common Stock UNDERWRITING AGREEMENT [?], 2021 BofA Securities, Inc. Cowen and Company, LLC Evercore Group L.L.C. as Representatives of the several Underwriters c/o BofA Securities, Inc. One Bryant Park New Y

June 7, 2021 CORRESP

Cooley LLP 4401 Eastgate Mall San Diego, CA 92121-1909 t: (858) 550-6000 f: (858) 550-6420 cooley.com

Kenneth J. Rollins +1 858 550 6136 [email protected] June 7, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Tracie Mariner, Al Pavot, Deanna Virginio and Irene Paik Re: Janux Therapeutics, Inc. Registration Statement on Form S-1 Filed May 19, 2021 File No. 333-256297 Ladies and Gentlemen: On behalf of Janux Therapeutic

June 7, 2021 EX-10.13

Employment Agreement, by and between the registrant and Wayne Godfrey, M.D., dated May 4, 2021.

Exhibit 10.13 May 4, 2021 Dr. Wayne Godfrey, MD VIA ELECTRONIC MAIL CONFIDENTIAL Dear Dr. Wayne Godfrey, We are very pleased to extend to you the offer of employment for the exempt position of Chief Medical Officer, reporting to me, the company?s Chief Executive Officer. The following outlines your offer of Employment: Start Date: May 28, 2021 Compensation: Your semi-monthly salary in the amount o

May 19, 2021 CORRESP

Cooley LLP 4401 Eastgate Mall San Diego, CA 92121-1909 t: (858) 550-6000 f: (858) 550-6420 cooley.com

Kenneth J. Rollins +1 858 550 6136 [email protected] May 19, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Tracie Mariner, Al Pavot, Deanna Virginio and Irene Paik Re: Janux Therapeutics, Inc. Draft Registration Statement on Form S-1 Submitted April 16, 2021 CIK No. 0001817713 Ladies and Gentlemen: On behalf of Janux

May 19, 2021 EX-10.9

Support Services Agreement by and between the registrant and COI Pharmaceuticals, Inc., dated January 1, 2021.

Exhibit 10.9 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. SUPPORT SERVICES AGREEMENT THIS SUPPORT SERVICES AGREEMENT (this ?Agreement?) is made and entered into as of January 1, 2021 (the ?Effective Date?), by and between JANUX THERAPEUTICS, INC., a D

May 19, 2021 EX-10.7

Employment Agreement by and between the registrant and Andy Meyer, dated February 17, 2021.

Exhibit 10.7 February 17, 2021 Andy Meyer VIA ELECTRONIC MAIL CONFIDENTIAL Dear Andy, We are very pleased to extend to you the offer of employment for the exempt position of Chief Business Officer reporting to me, the company?s President & Chief Executive Officer. The following outlines your offer of Employment: Start Date: March 9, 2021. Compensation: Your semi-monthly salary in the amount of $11

May 19, 2021 EX-10.6

Employment Agreement, by and between the registrant and David Campbell, Ph.D., dated January 1, 2021.

Exhibit 10.6 January 1, 2021 David Campbell Re: Offer of Employment Dear David: Janux Therapeutics, Inc. (the ?Company?) is pleased to offer you at-will employment in the position of President and Chief Executive Officer on the terms and conditions set forth in this letter agreement (the ?Agreement?). 1. Employment by the Company. Your employment with the Company shall begin on January 1, 2021 or

May 19, 2021 EX-10.1

Form of Indemnity Agreement, by and between the registrant and its directors and officers.

Exhibit 10.1 INDEMNITY AGREEMENT THIS INDEMNITY AGREEMENT (this ?Agreement?) dated as of , 20, is made by and between JANUX THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and (?Indemnitee?). RECITALS A. The Company desires to attract and retain the services of highly qualified individuals as directors, officers, employees and agents. B. The Company?s Amended and Restated Bylaws (the ?

May 19, 2021 EX-4.2

Amended and Restated Investors’ Rights Agreement, by and between the registrant and certain of its stockholders, dated April 15, 2021.

Exhibit 4.2 AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT (this ?Agreement?) is made and entered into as of April 15, 2021, by and among Janux Therapeutics, Inc., a Delaware corporation (the ?Company?), and the investors set forth on the Schedule of Investors attached hereto as Schedule A (each, an ?Investor? and collectively, the ?Investors

May 19, 2021 EX-10.8

Research Collaboration and Exclusive License Agreement by and between the registrant and Merck Sharp & Dohme Corp., dated December 17, 2020.

Exhibit 10.8 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED EXECUTION COPY RESEARCH COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT by and between JANUX THERAPEUTICS, INC. and MERCK SHARP & DOHME CORP. ***Certain Confidential Information Omitted CERTAIN CO

May 19, 2021 EX-3.2

Form of Amended and Restated Certificate of Incorporation to become effective immediately prior to the closing of this offering.

Exhibit 3.2 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF JANUX THERAPEUTICS, INC. David Campbell, Ph.D., hereby certifies that: ONE: He is the duly elected Chief Executive Officer of Janux Therapeutics, Inc., a Delaware corporation. TWO: The date of filing the original Certificate of Incorporation of the Company with the Secretary of State of the State of Delaware was June 27, 2017. THREE:

May 19, 2021 EX-10.12

Janux Therapeutics, Inc. 2021 Change in Control and Severance Benefit Plan.

Exhibit 10.12 JANUX THERAPEUTICS, INC. CHANGE IN CONTROL AND SEVERANCE BENEFIT PLAN APPROVED BY THE BOARD OF DIRECTORS: MAY 14, 2021 Section 1. INTRODUCTION. The Janux Therapeutics, Inc. Change in Control and Severance Benefit Plan (the ?Plan?) is hereby established effective upon the IPO Date. The purpose of the Plan is to provide for the payment of severance and/or change in control benefits to

May 19, 2021 EX-10.2

Janux Therapeutics, Inc. 2017 Equity Incentive Plan, as amended, and Forms of Option Agreement, Notice of Exercise and Early Exercise Stock Purchase Agreement thereunder.

Exhibit 10.2 JANUX THERAPEUTICS, INC. 2017 EQUITY INCENTIVE PLAN Approved by the Board of Directors: August 14, 2017 Approved by the Stockholders: August 14, 2017 Amended by the Board of Directors: October 19, 2018 Approved by the Stockholders: October 19, 2018 Amended by the Board of Directors: March 1, 2021 Approved by the Stockholders: March 1, 2021 Amended by the Board of Directors: April 15,

May 19, 2021 S-1

Form S-1

Table of Contents As filed with the Securities and Exchange Commission on May 19, 2021.

May 19, 2021 EX-3.4

Form of Amended and Restated Bylaws of the Registrant, to be in effect upon the closing of the Registrant’s initial public offering of Common Stock (incorporated by reference to Exhibit 3.4 to the Registrant’s Registration Statement on Form S-1, as amended (File No. 333-256297), filed with the SEC on May 19, 2021).

Exhibit 3.4 AMENDED AND RESTATED BYLAWS OF JANUX THERAPEUTICS, INC. ARTICLE I OFFICES Section 1. Registered Office. The registered office of the corporation in the State of Delaware shall be in the City of Wilmington, County of New Castle. Section 2. Other Offices. The corporation shall also have and maintain an office or principal place of business at such place as may be fixed by the corporation

May 19, 2021 EX-3.3

Bylaws, as currently in effect.

Exhibit 3.3 BYLAWS OF JANUX THERAPEUTICS, INC. (A DELAWARE CORPORATION) TABLE OF CONTENTS Page ARTICLE I OFFICES 1 Section 1. Registered Office 1 Section 2. Other Offices 1 ARTICLE II CORPORATE SEAL 1 Section 3. Corporate Seal 1 ARTICLE III STOCKHOLDERS? MEETINGS 1 Section 4. Place of Meetings 1 Section 5. Annual Meeting 1 Section 6. Special Meetings 3 Section 7. Notice of Meetings 4 Section 8. Qu

May 19, 2021 EX-3.1

Amended and Restated Certificate of Incorporation, as currently in effect.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF JANUX THERAPEUTICS, INC. David Campbell hereby certifies that: ONE: The original Certificate of Incorporation of this corporation was filed with the Secretary of State of the State of Delaware on June 27, 2017. TWO: He is the duly elected and acting President and Chief Executive Officer of this corporation. THREE: The Amended and Res

May 19, 2021 EX-10.11

Consulting Agreement by and between the registrant and Sheila Gujrathi, M.D., dated March 10, 2021.

Exhibit 10.11 CONSULTING AGREEMENT THIS CONSULTING AGREEMENT (this ?Agreement?) is made as of March 10, 2021 (the ?Effective Date?) by and between JANUX THERAPEUTICS, INC., a Delaware corporation (?Janux? or the ?Company?), and SHEILA GUJRATHI, M.D. (?Consultant?). Janux desires to benefit from Consultant?s expertise by retaining Consultant as a consultant, and Consultant wishes to perform consult

May 19, 2021 EX-10.10

Cell Line License Agreement by and between the registrant and WuXi Biologics (Hong Kong) Limited, dated April 19, 2021.

Exhibit 10.10 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. CELL LINE LICENSE AGREEMENT This Cell Line License Agreement (?Agreement?), effective as of April 19, 2021 (?EFFECTIVE DATE?), is entered and made by and between WuXi Biologics (Hong Kong) Lim

April 16, 2021 EX-4.2

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

Exhibit 4.2 AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT (this ?Agreement?) is made and entered into as of April 15, 2021, by and among Janux Therapeutics, Inc., a Delaware corporation (the ?Company?), and the investors set forth on the Schedule of Investors attached hereto as Schedule A (each, an ?Investor? and collectively, the ?Investors

April 16, 2021 EX-10.2

JANUX THERAPEUTICS, INC. 2017 EQUITY INCENTIVE PLAN Approved by the Board of Directors: August 14, 2017 Approved by the Stockholders: August 14, 2017 Amended by the Board of Directors: March 1, 2021 Approved by the Stockholders: March 1, 2021 Amended

Exhibit 10.2 JANUX THERAPEUTICS, INC. 2017 EQUITY INCENTIVE PLAN Approved by the Board of Directors: August 14, 2017 Approved by the Stockholders: August 14, 2017 Amended by the Board of Directors: March 1, 2021 Approved by the Stockholders: March 1, 2021 Amended by the Board of Directors: April 15, 2021 Approved by the Stockholders: April 15, 2021 1. DEFINED TERMS. Capitalized terms in this Janux

April 16, 2021 EX-10.6

11099 N Torrey Pines Road, Suite 290, La Jolla, CA 92037 Main: (858) 750-4700 Fax: (858) 750-4701

Exhibit 10.6 January 1, 2021 David Campbell Re: Offer of Employment Dear David: Janux Therapeutics, Inc. (the ?Company?) is pleased to offer you at-will employment in the position of President and Chief Executive Officer on the terms and conditions set forth in this letter agreement (the ?Agreement?). 1. Employment by the Company. Your employment with the Company shall begin on January 1, 2021 or

April 16, 2021 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION JANUX THERAPEUTICS, INC.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF JANUX THERAPEUTICS, INC. David Campbell hereby certifies that: ONE: The original Certificate of Incorporation of this corporation was filed with the Secretary of State of the State of Delaware on June 27, 2017. TWO: He is the duly elected and acting President and Chief Executive Officer of this corporation. THREE: The Amended and Res

April 16, 2021 DRS

As confidentially submitted to the Securities and Exchange Commission on April 16, 2021. This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains strictly confidentia

Table of Contents As confidentially submitted to the Securities and Exchange Commission on April 16, 2021.

April 16, 2021 EX-10.8

RESEARCH COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT by and between JANUX THERAPEUTICS, INC. MERCK SHARP & DOHME CORP. ***Certain Confidential Information Omitted

Exhibit 10.8 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED EXECUTION COPY RESEARCH COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT by and between JANUX THERAPEUTICS, INC. and MERCK SHARP & DOHME CORP. ***Certain Confidential Information Omitted CERTAIN CO

April 16, 2021 EX-3.3

BYLAWS OF JANUX THERAPEUTICS, INC. (A DELAWARE CORPORATION)

Exhibit 3.3 BYLAWS OF JANUX THERAPEUTICS, INC. (A DELAWARE CORPORATION) TABLE OF CONTENTS Page ARTICLE I OFFICES 1 Section 1. Registered Office 1 Section 2. Other Offices 1 ARTICLE II CORPORATE SEAL 1 Section 3. Corporate Seal 1 ARTICLE III STOCKHOLDERS? MEETINGS 1 Section 4. Place of Meetings 1 Section 5. Annual Meeting 1 Section 6. Special Meetings 3 Section 7. Notice of Meetings 4 Section 8. Qu

April 16, 2021 EX-10.7

11099 N. Torrey Pines Road, Suite 290, La Jolla, CA 92037 Main: (858) 750-4700 Fax: (858) 750-4701

Exhibit 10.7 February 17, 2021 Andy Meyer VIA ELECTRONIC MAIL CONFIDENTIAL Dear Andy, We are very pleased to extend to you the offer of employment for the exempt position of Chief Business Officer reporting to me, the company?s President & Chief Executive Officer. The following outlines your offer of Employment: Start Date: March 9, 2021. Compensation: Your semi-monthly salary in the amount of $11

April 16, 2021 EX-10.9

SUPPORT SERVICES AGREEMENT

Exhibit 10.9 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. SUPPORT SERVICES AGREEMENT THIS SUPPORT SERVICES AGREEMENT (this ?Agreement?) is made and entered into as of January 1, 2021 (the ?Effective Date?), by and between JANUX THERAPEUTICS, INC., a D

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