KYTH / Kythera Biopharma - Документы SEC, Годовой отчет, Доверенное заявление

Китера Биофарма
US ˙ NASDAQ
ЭТОТ СИМВОЛ БОЛЬШЕ НЕ АКТИВЕН

Основная статистика
CIK 1436304
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Kythera Biopharma
SEC Filings (Chronological Order)
На этой странице представлен полный хронологический список документов SEC, за исключением документов о собственности, которые мы предоставляем в других местах.
February 11, 2016 SC 13G/A

KYTH / Kythera Biopharma / ARCH VENTURE FUND VI LP - KYTHERA BIOPHARMACEUTICALS - AMEND. #3 Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* KYTHERA Biopharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 501570105 (CUSIP Number) December 31, 2015 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to w

February 8, 2016 SC 13G/A

KYTH / Kythera Biopharma / PRUDENTIAL FINANCIAL INC Passive Investment

13G HTML File DOCUMENT TYPE SC 13G/A TEXT SECURITIES AND EXCHANGE COMMISSION Washington, D.

January 26, 2016 EX-99.1

AGREEMENT

EX-99.1 2 d15947dex991.htm EX-99.1 CUSIP No. 501570 10 5 13G Exhibit A AGREEMENT Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of the shares of Common Stock of KYTHERA Biopharmaceuticals

January 26, 2016 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* KYTHERA Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.00001 per share (Title of Class of Securiti

SC 13G/A 1 d15947dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* KYTHERA Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.00001 per share (Title of Class of Securities) 501570 10 5 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing of This Statement) Check t

October 13, 2015 15-12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-35663 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as spec

October 2, 2015 SC 13D/A

KYTH / Kythera Biopharma / GAMCO INVESTORS, INC. ET AL Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 KYTHERA Biopharmaceuticals, Inc. (Amendment No. 1) (Name of Issuer) Common Stock, par value $0.00001 per share (Title of Class of Securities) 501570105 (CUSIP Number) David Goldman GAMCO Investors, Inc. One Corporate Center Rye, New York 10580-1435 (914) 921-5000 (Name, Address and Tele

October 1, 2015 S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-194735 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-198512 Post

October 1, 2015 S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-194735 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-198512 Post

October 1, 2015 S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-194735 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-198512 Post

October 1, 2015 EX-3.1

KYTHERA BIOPHARMACEUTICALS, INC. a Delaware Corporation (hereinafter referred to as the “Corporation”) ARTICLE I

EX-3.1 2 a15-205701ex3d1.htm EX-3.1 Exhibit 3.1 BYLAWS OF KYTHERA BIOPHARMACEUTICALS, INC. a Delaware Corporation (hereinafter referred to as the “Corporation”) ARTICLE I OFFICES Section 1. Registered Office. The registered office and the registered agent of the Corporation are as set forth in the Certificate of Incorporation. Section 2. Other Offices. The Corporation may also have offices at such

October 1, 2015 POS AM

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-3 Registration Statement No. 333-198511 UNDER THE SECURITIES ACT OF 1933 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as sp

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-3 Registration Statement No. 333-198511 UNDER THE SECURITIES ACT OF 1933 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 03-0552903 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification Number) 309

October 1, 2015 S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-194735 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-198512 Post

October 1, 2015 S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-184439 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-187538 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-194735 Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-198512 Post

October 1, 2015 8-K

Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Termination of a Material Definitive Agreement, Material Modification to Rights of Security Holders, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 1, 2015 KYTHERA BIOPHARMACEUTICALS, INC.

September 28, 2015 8-K

Submission of Matters to a Vote of Security Holders

8-K 1 a15-2031518k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 September 28, 2015 (September 28, 2015) Date of Report (date of earliest event reported) KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of Registrant as specified in its charter) Delaware 001-35663 03-0552903

August 21, 2015 DEFM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFM14A 1 a2225753zdefm14a.htm DEFM14A Use these links to rapidly review the document TABLE OF CONTENTS TABLE OF CONTENTS Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ý Filed by a Party other than the Registrant o Check

August 20, 2015 SC 13D

KYTH / Kythera Biopharma / GAMCO INVESTORS, INC. ET AL Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 KYTHERA Biopharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.00001 per share (Title of Class of Securities) 501570105 (CUSIP Number) David Goldman GAMCO Investors, Inc. One Corporate Center Rye, New York 10580-1435 (914) 921-5000 (Name, Address and Telephone Number of Pe

August 18, 2015 EX-99.1

KYTHERA® Biopharmaceuticals Submits Marketing Authorization Application in the European Union for ATX-101 as First-in-Class Treatment for the Reduction of Submental Fat Submission supported by four pivotal Phase III trials conducted in Europe and Nor

Exhibit 99.1 KYTHERA? Biopharmaceuticals Submits Marketing Authorization Application in the European Union for ATX-101 as First-in-Class Treatment for the Reduction of Submental Fat Submission supported by four pivotal Phase III trials conducted in Europe and North America with more than 1,500 patients Westlake Village, Calif., U.S., August 18, 2015 - KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH

August 18, 2015 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a15-1817718k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 18, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisd

August 10, 2015 SC 13D/A

KYTH / Kythera Biopharma / Allergan plc - SCHEDULE 13D (AMENDMENT NO. 2) Activist Investment

Schedule 13D (Amendment No. 2) UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 2)* Under the Securities Exchange Act of 1934 KYTHERA BIOPHARMACEUTICALS, INC. (Name of Issuer) Common Stock, $0.00001 par value (Title of Class of Securities) 501570105 (CUSIP Number) A. Robert D. Bailey Allergan plc Chief Legal Officer and Corporate Secretary Clonsha

August 6, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 a15-1669318k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 6, 2015 KYTHERA Biopharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdi

August 6, 2015 EX-10.1

KYTHERA BIOPHARMACEUTICALS, INC. EXECUTIVE CHANGE IN CONTROL AND SEPARATION BENEFITS PLAN (AND SUMMARY PLAN DESCRIPTION) EFFECTIVE MAY 26, 2015

EX-10.1 2 kyth-20150630ex1015bd088.htm EX-10.1 Exhibit 10.1 KYTHERA BIOPHARMACEUTICALS, INC. EXECUTIVE CHANGE IN CONTROL AND SEPARATION BENEFITS PLAN (AND SUMMARY PLAN DESCRIPTION) EFFECTIVE MAY 26, 2015 This KYTHERA Biopharmaceuticals, Inc. Executive Change in Control and Separation Benefits Plan (this “Plan”) was established effective as of May 26, 2015 (the “Effective Date”). The purpose of thi

August 6, 2015 10-Q

KYTH / Kythera Biopharma 10-Q - Quarterly Report - 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2015 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

August 6, 2015 EX-99.1

KYTHERA Biopharmaceuticals Releases Second Quarter 2015 Operating Results and Progress Update Company Executing on Commercial Launch of KYBELLA™ (deoxycholic acid) Injection

EX-99.1 2 a15-166931ex99d1.htm EX-99.1 Exhibit 99.1 KYTHERA Biopharmaceuticals Releases Second Quarter 2015 Operating Results and Progress Update Company Executing on Commercial Launch of KYBELLA™ (deoxycholic acid) Injection Westlake Village, Calif., Aug. 6, 2015 – KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for the second quarter of 2015, and provided an upda

August 5, 2015 EX-99.1

CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: Mark Marmur (862) 261-7558 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143

EX-99.1 3 a2225617zex-991.htm EX-99.1 QuickLinks - Click here to rapidly navigate through this document Exhibit 99.1 NEWS RELEASE CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: Mark Marmur (862) 261-7558 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143 Allergan and KYTHERA Announce that Pending Transaction will now be for All-Cash Considerat

August 5, 2015 EX-2.1

AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. KYTHERA BIOPHARMACEUTICALS, INC. dated as of August 4, 2015 TABLE OF CONTENTS

EX-2.1 2 a2225617zex-21.htm EX-2.1 Use these links to rapidly review the document TABLE OF CONTENTS Exhibit 2.1 AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. and KYTHERA BIOPHARMACEUTICALS, INC. dated as of August 4, 2015 TABLE OF CONTENTS Page ARTICLE I. THE MERGER 2 Section 1.1 The Merger 2 Section 1.2 Closing 2 Section 1.3 Effective Time 2 Se

August 5, 2015 EX-99.1

Allergan and KYTHERA Announce that Pending Transaction will now be for All-Cash Consideration

EX-99.1 4 d35780dex991.htm EX-99.1 Exhibit 99.1 NEWS RELEASE CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: Mark Marmur (862) 261-7558 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143 Allergan and KYTHERA Announce that Pending Transaction will now be for All-Cash Consideration DUBLIN, IRELAND and WESTLAKE VILLAGE, CALIF. – August 5, 2015 – A

August 5, 2015 425

Allergan + Kythera Frequently Asked Questions

Filed by Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Pursuant to Rule 425 Under the Securities Act of 1933 And Deemed Filed Pursuant to Rule 14a-12 Under the Securities Exchange Act of 1934 Subject Company: Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Allergan + Kythera Frequently Asked Questions This FAQ contains responses to common questions related to employ

August 5, 2015 EX-10.1

AMENDED AND RESTATED STOCKHOLDER VOTING AGREEMENT

EX-10.1 Exhibit 10.1 AMENDED AND RESTATED STOCKHOLDER VOTING AGREEMENT THIS AMENDED AND RESTATED STOCKHOLDER VOTING AGREEMENT, dated as of August 4, 2015 (as amended, modified or supplemented from time to time in accordance with its terms, this “Agreement”), is entered into by and between Allergan plc, a company incorporated under the laws of Ireland (“Parent”), and each of the individuals or enti

August 5, 2015 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

8-K 1 a2225617z8-k.htm 8-K QuickLinks - Click here to rapidly navigate through this document SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 4, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in Charter) Delawar

August 5, 2015 EX-2.1

AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. KYTHERA BIOPHARMACEUTICALS, INC. dated as of August 4, 2015 TABLE OF CONTENTS

EX-2.1 2 a2225617zex-21.htm EX-2.1 Use these links to rapidly review the document TABLE OF CONTENTS Exhibit 2.1 AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. and KYTHERA BIOPHARMACEUTICALS, INC. dated as of August 4, 2015 TABLE OF CONTENTS Page ARTICLE I. THE MERGER 2 Section 1.1 The Merger 2 Section 1.2 Closing 2 Section 1.3 Effective Time 2 Se

August 5, 2015 EX-2.1

AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. KYTHERA BIOPHARMACEUTICALS, INC. dated as of August 4, 2015 TABLE OF CONTENTS Page ARTICLE I. THE MERGER 2 Section 1.1 The Merger 2 Section 1.2 Closing

EX-2.1 Exhibit 2.1 AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. and KYTHERA BIOPHARMACEUTICALS, INC. dated as of August 4, 2015 TABLE OF CONTENTS Page ARTICLE I. THE MERGER 2 Section 1.1 The Merger 2 Section 1.2 Closing 2 Section 1.3 Effective Time 2 Section 1.4 Governing Documents 3 Section 1.5 Officers and Directors of the Surviving Corporati

August 5, 2015 EX-99.1

CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: Mark Marmur (862) 261-7558 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143

QuickLinks - Click here to rapidly navigate through this document Exhibit 99.1 NEWS RELEASE CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: Mark Marmur (862) 261-7558 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143 Allergan and KYTHERA Announce that Pending Transaction will now be for All-Cash Consideration DUBLIN, IRELAND and WESTLAKE VILLA

August 5, 2015 425

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 4, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (

QuickLinks - Click here to rapidly navigate through this document SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 4, 2015 KYTHERA BIOPHARMACEUTICALS, INC.

August 5, 2015 PREM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Use these links to rapidly review the document TABLE OF CONTENTS TABLE OF CONTENTS Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

August 5, 2015 425

Allergan FORM 8-K (Prospectus)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 4, 2015 ALLERGAN PLC (Exact name of registrant as specified in its charter) Ireland 001-36867 98-1114402 (State or other jurisdiction of incorporation) (Commission Fil

July 27, 2015 425

Allergan FORM 8-K (Prospectus)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 27, 2015 ALLERGAN PLC (Exact name of registrant as specified in its charter) Ireland 001-36867 98-1114402 (State or other jurisdiction of incorporation) (Commission File

July 27, 2015 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a15-1636618k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 July 27, 2015 Date of Report (Date of Earliest Event Reported) KYTHERA BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 001-35663 03-0552903 (State or Other of Incorp

July 27, 2015 EX-99.1

Allergan and KYTHERA Announce Early Termination of Hart-Scott-Rodino Waiting Period for Allergan’s Pending Acquisition of KYTHERA

EX-99.1 2 a15-163661ex99d1.htm EX-99.1 Exhibit 99.1 NEWS RELEASE CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: David Belian (862) 261-8141 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143 Allergan and KYTHERA Announce Early Termination of Hart-Scott-Rodino Waiting Period for Allergan’s Pending Acquisition of KYTHERA DUBLIN, IRELAND and WEST

July 27, 2015 EX-99.1

Allergan and KYTHERA Announce Early Termination of Hart-Scott-Rodino Waiting Period for Allergan’s Pending Acquisition of KYTHERA

EX-99.1 2 d51188dex991.htm EX-99.1 Exhibit 99.1 NEWS RELEASE CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: David Belian (862) 261-8141 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143 Allergan and KYTHERA Announce Early Termination of Hart-Scott-Rodino Waiting Period for Allergan’s Pending Acquisition of KYTHERA DUBLIN, IRELAND and WESTLAKE

July 27, 2015 EX-99.1

Allergan and KYTHERA Announce Early Termination of Hart-Scott-Rodino Waiting Period for Allergan’s Pending Acquisition of KYTHERA

Exhibit 99.1 NEWS RELEASE CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: David Belian (862) 261-8141 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143 Allergan and KYTHERA Announce Early Termination of Hart-Scott-Rodino Waiting Period for Allergan?s Pending Acquisition of KYTHERA DUBLIN, IRELAND and WESTLAKE VILLAGE, CALIF. ? July 27, 2015 ?

July 27, 2015 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 July 27, 2015 Date of Report (Date of Earliest Event Reported) KYTHERA BIOPHARMACEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 July 27, 2015 Date of Report (Date of Earliest Event Reported) KYTHERA BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 001-35663 03-0552903 (State or Other of Incorporation) (Commission File N

July 7, 2015 425

Dear KYTHERA Colleagues,

Filed by Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Pursuant to Rule 425 Under the Securities Act of 1933 And Deemed Filed Pursuant to Rule 14a-12 Under the Securities Exchange Act of 1934 Subject Company: Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Dear KYTHERA Colleagues, I want to share some important details regarding the pre-integration planning activiti

July 2, 2015 EX-2.1

AMENDMENT NO. 1 AGREEMENT AND PLAN OF MERGER

Exhibit 2.1 AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER This AMENDMENT NO. 1 (this ?Amendment?), dated as of July 1, 2015, to the Agreement and Plan of Merger (the ?Merger Agreement?), dated as of June 17, 2015, is by and among Allergan plc, a company incorporated under the laws of Ireland (formerly known as Actavis plc) (?Parent?), Keto Merger Sub, Inc., a Delaware corporation and an indirect

July 2, 2015 8-K

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 1, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Ex

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 1, 2015 KYTHERA BIOPHARMACEUTICALS, INC.

July 2, 2015 425

Allergan FORM 8-K (Prospectus)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 1, 2015 ALLERGAN PLC (Exact name of registrant as specified in its charter) Ireland 001-36867 98-1114402 (State or other jurisdiction of incorporation) (Commission File

July 2, 2015 EX-2.1

AMENDMENT NO. 1 AGREEMENT AND PLAN OF MERGER

Exhibit 2.1 AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER This AMENDMENT NO. 1 (this ?Amendment?), dated as of July 1, 2015, to the Agreement and Plan of Merger (the ?Merger Agreement?), dated as of June 17, 2015, is by and among Allergan plc, a company incorporated under the laws of Ireland (formerly known as Actavis plc) (?Parent?), Keto Merger Sub, Inc., a Delaware corporation and an indirect

July 2, 2015 425

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 1, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Ex

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 1, 2015 KYTHERA BIOPHARMACEUTICALS, INC.

July 2, 2015 EX-2.1

AMENDMENT NO. 1 AGREEMENT AND PLAN OF MERGER

EX-2.1 2 d78450dex21.htm EX-2.1 Exhibit 2.1 Execution Version AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER This AMENDMENT NO. 1 (this “Amendment”), dated as of July 1, 2015, to the Agreement and Plan of Merger (the “Merger Agreement”), dated as of June 17, 2015, is by and among Allergan plc, a company incorporated under the laws of Ireland (formerly known as Actavis plc) (“Parent”), Keto Merger

July 2, 2015 SC 13D/A

KYTH / Kythera Biopharma / Allergan plc - SCHEDULE 13D (AMENDMENT NO. 1) Activist Investment

Schedule 13D (Amendment No. 1) UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 1)* Under the Securities Exchange Act of 1934 KYTHERA BIOPHARMACEUTICALS, INC. (Name of Issuer) Common Stock, $0.00001 par value (Title of Class of Securities) 501570105 (CUSIP Number) A. Robert D. Bailey Allergan plc Chief Legal Officer and Corporate Secretary 1 Grand

June 29, 2015 SC 13D

KYTH / Kythera Biopharma / Allergan plc - SCHEDULE 13D Activist Investment

Schedule 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 KYTHERA BIOPHARMACEUTICALS, INC. (Name of Issuer) Common Stock, $0.00001 par value (Title of Class of Securities) 501570105 (CUSIP Number) A. Robert D. Bailey Allergan plc Chief Legal Officer and Corporate Secretary 1 Grand Canal Square, Docklands Dublin 2, Ir

June 25, 2015 425

Number of Options

Filed by Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Pursuant to Rule 425 Under the Securities Act of 1933 And Deemed Filed Pursuant to Rule 14a-12 Under the Securities Exchange Act of 1934 Subject Company: Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 The following memorandum was sent to employees of Kythera Biopharmaceuticals, Inc. on June 24, 2015: June 24, 2

June 25, 2015 425

Number of Options/RSUs

425 1 a15-140755425.htm 425 Filed by Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Pursuant to Rule 425 Under the Securities Act of 1933 And Deemed Filed Pursuant to Rule 14a-12 Under the Securities Exchange Act of 1934 Subject Company: Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 The following memorandum was sent to employees of Kythera Biopharmaceuticals, Inc.

June 25, 2015 425

Dear Dr [Last Name]:

Filed by Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Pursuant to Rule 425 Under the Securities Act of 1933 And Deemed Filed Pursuant to Rule 14a-12 Under the Securities Exchange Act of 1934 Subject Company: Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Dear Dr [Last Name]: We are looking forward to seeing you at the KYBELLA? Educational Congress (KEC) Product Tr

June 17, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. KYTHERA BIOPHARMACEUTICALS, INC. dated as of June 17, 2015 TABLE OF CONTENTS Page ARTICLE I. THE MERGER 1 Section 1.1 The Merger 1 Section 1.2 Closing 2 Section 1.3 Effecti

EX-2.1 2 d943390dex21.htm EX-2.1 Exhibit 2.1 Execution Version AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. and KYTHERA BIOPHARMACEUTICALS, INC. dated as of June 17, 2015 TABLE OF CONTENTS Page ARTICLE I. THE MERGER 1 Section 1.1 The Merger 1 Section 1.2 Closing 2 Section 1.3 Effective Time 2 Section 1.4 Governing Documents 2 Section 1.5 Officers and Directors of t

June 17, 2015 425

Allergan 425 (Prospectus)

425 Filing pursuant to Rule 425 under the Securities Act of 1933, as amended Deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934, as amended Filer: Allergan plc Subject Company: KYTHERA Biopharmaceuticals, Inc.

June 17, 2015 425

Allergan 425 (Prospectus)

425 Filing pursuant to Rule 425 under the Securities Act of 1933, as amended Deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934, as amended Filer: Allergan plc Subject Company: KYTHERA Biopharmaceuticals, Inc.

June 17, 2015 EX-10.1

KYTHERA BIOPHARMACEUTICALS, INC. RETENTION PLAN Effective as of June 16, 2015

EX-10.1 3 a15-140751ex10d1.htm EX-10.1 Exhibit 10.1 KYTHERA BIOPHARMACEUTICALS, INC. RETENTION PLAN Effective as of June 16, 2015 1. Introduction and Purpose. This KYTHERA Biopharmaceuticals, Inc. Retention Plan (the “Plan”) has been adopted effective as of June 16, 2015 (the “Effective Date”) in connection with the transaction contemplated under that certain Agreement and Plan of Merger, dated Ju

June 17, 2015 425

Allergan 425 (Prospectus)

425 Filing pursuant to Rule 425 under the Securities Act of 1933, as amended Deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934, as amended Filer: Allergan plc Subject Company: KYTHERA Biopharmaceuticals, Inc.

June 17, 2015 EX-99.1

Allergan to Acquire KYTHERA Biopharmaceuticals — Complements Allergan’s Existing Position in Facial Aesthetics — — Lead Product KYBELLA™ the First and Only Approved Non-surgical Treatment for Reduction of Submental Fullness — — Enhances Allergan’s Lo

EX-99.1 4 a15-140751ex99d1.htm EX-99.1 Exhibit 99.1 NEWS RELEASE CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: David Belian (862) 261-8141 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143 Allergan to Acquire KYTHERA Biopharmaceuticals — Complements Allergan’s Existing Position in Facial Aesthetics — — Lead Product KYBELLA™ the First and Onl

June 17, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. KYTHERA BIOPHARMACEUTICALS, INC. dated as of June 17, 2015

EX-2.1 2 a15-140751ex2d1.htm EX-2.1 Exhibit 2.1 AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. and KYTHERA BIOPHARMACEUTICALS, INC. dated as of June 17, 2015 TABLE OF CONTENTS Page ARTICLE I. THE MERGER 1 Section 1.1 The Merger 1 Section 1.2 Closing 2 Section 1.3 Effective Time 2 Section 1.4 Governing Documents 2 Section 1.5 Officers and Directors of the Surviving Co

June 17, 2015 425

Allergan and KYTHERA Combine to Enhance Facial Aesthetics Industry-Leading Portfolio

Filed by Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Pursuant to Rule 425 Under the Securities Act of 1933 And Deemed Filed Pursuant to Rule 14a-12 Under the Securities Exchange Act of 1934 Subject Company: Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 The following letter to customers of Kythera Biopharmaceuticals, Inc. was sent on June 17, 2015: June 17,2015 A

June 17, 2015 425

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 17, 2015 (June 16, 2015) KYTHERA BIOPHARMACE

425 1 a15-1407518k.htm 8-K SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 17, 2015 (June 16, 2015) KYTHERA BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35663 03-0552903 (State or Other Jurisdiction

June 17, 2015 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

8-K 1 a15-1407518k.htm 8-K SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 17, 2015 (June 16, 2015) KYTHERA BIOPHARMACEUTICALS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35663 03-0552903 (State or Other Jurisdiction

June 17, 2015 425

The following question and answer document was sent to employees of Kythera Biopharmaceuticals, Inc. on June 17, 2015:

Filed by Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Pursuant to Rule 425 Under the Securities Act of 1933 And Deemed Filed Pursuant to Rule 14a-12 Under the Securities Exchange Act of 1934 Subject Company: Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 The following question and answer document was sent to employees of Kythera Biopharmaceuticals, Inc. on June 17

June 17, 2015 EX-99.1

Allergan to Acquire KYTHERA Biopharmaceuticals – Complements Allergan’s Existing Position in Facial Aesthetics – – Lead Product KYBELLA™ the First and Only Approved Non-surgical Treatment for Reduction of Submental Fullness – – Enhances Allergan’s Lo

EX-99.1 4 d943390dex991.htm EX-99.1 Exhibit 99.1 NEWS RELEASE CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: David Belian (862) 261-8141 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143 Allergan to Acquire KYTHERA Biopharmaceuticals – Complements Allergan’s Existing Position in Facial Aesthetics – – Lead Product KYBELLA™ the First and Only A

June 17, 2015 EX-10.1

KYTHERA BIOPHARMACEUTICALS, INC. RETENTION PLAN Effective as of June 16, 2015

Exhibit 10.1 KYTHERA BIOPHARMACEUTICALS, INC. RETENTION PLAN Effective as of June 16, 2015 1. Introduction and Purpose. This KYTHERA Biopharmaceuticals, Inc. Retention Plan (the ?Plan?) has been adopted effective as of June 16, 2015 (the ?Effective Date?) in connection with the transaction contemplated under that certain Agreement and Plan of Merger, dated June 17, 2015 (the ?Merger Agreement?), b

June 17, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. KYTHERA BIOPHARMACEUTICALS, INC. dated as of June 17, 2015

EX-2.1 2 a15-140751ex2d1.htm EX-2.1 Exhibit 2.1 AGREEMENT AND PLAN OF MERGER by and among ALLERGAN PLC, KETO MERGER SUB, INC. and KYTHERA BIOPHARMACEUTICALS, INC. dated as of June 17, 2015 TABLE OF CONTENTS Page ARTICLE I. THE MERGER 1 Section 1.1 The Merger 1 Section 1.2 Closing 2 Section 1.3 Effective Time 2 Section 1.4 Governing Documents 2 Section 1.5 Officers and Directors of the Surviving Co

June 17, 2015 425

Allergan Announces Acquisition of Kythera Biopharmaceuticals; Combination Enhances Industry-Leading Facial Aesthetics Portfolio and Expands KYBELLATM Commercialization

Filed by Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 Pursuant to Rule 425 Under the Securities Act of 1933 And Deemed Filed Pursuant to Rule 14a-12 Under the Securities Exchange Act of 1934 Subject Company: Kythera Biopharmaceuticals, Inc. Commission File No. 001-35663 The following memorandum was sent to employees of Kythera Biopharmaceuticals, Inc. on June 17, 2015: Allergan A

June 17, 2015 EX-99.1

Allergan to Acquire KYTHERA Biopharmaceuticals — Complements Allergan’s Existing Position in Facial Aesthetics — — Lead Product KYBELLA™ the First and Only Approved Non-surgical Treatment for Reduction of Submental Fullness — — Enhances Allergan’s Lo

EX-99.1 4 a15-140751ex99d1.htm EX-99.1 Exhibit 99.1 NEWS RELEASE CONTACTS: Allergan: Investors: Lisa DeFrancesco (862) 261-7152 Media: David Belian (862) 261-8141 KYTHERA: Investors: Heather Rowe (818) 587-4559 Media: Ashley Cadle (310) 463-0143 Allergan to Acquire KYTHERA Biopharmaceuticals — Complements Allergan’s Existing Position in Facial Aesthetics — — Lead Product KYBELLA™ the First and Onl

June 17, 2015 EX-10.1

STOCKHOLDER VOTING AGREEMENT

EX-10.1 Exhibit 10.1 STOCKHOLDER VOTING AGREEMENT THIS STOCKHOLDER VOTING AGREEMENT, dated as of June 17, 2015 (this ?Agreement?), is entered into by and between Allergan plc, a company incorporated under the laws of Ireland (?Parent?), and each of the individuals or entities listed on the signature pages hereto (each, a ?Stockholder? and, together, the ?Stockholders?). RECITALS A. Concurrently wi

June 17, 2015 425

Allergan FORM 8-K (Prospectus)

425 1 d943390d8k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 17, 2015 ALLERGAN PLC (Exact name of registrant as specified in its charter) Ireland 001-36867 98-1114402 (State or other jurisdiction of incorporat

June 4, 2015 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Comm

June 2, 2015 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 26, 2015 KYTHERA Biopharmaceu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 26, 2015 KYTHERA Biopharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Comm

May 7, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2015 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 0

May 7, 2015 EX-99.1

KYTHERA Biopharmaceuticals Releases First Quarter 2015 Operating Results and Progress Update Company Well Positioned for Commercial Launch of KYBELLA™ (deoxycholic acid) Injection

Exhibit 99.1 KYTHERA Biopharmaceuticals Releases First Quarter 2015 Operating Results and Progress Update Company Well Positioned for Commercial Launch of KYBELLA? (deoxycholic acid) Injection Westlake Village, Calif., May 7, 2015 ? KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for the first quarter of 2015, and provided an update on recent accomplishments. ?KYTH

May 7, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2015 KYTHERA Biopharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Commi

May 4, 2015 EX-99.1

KYTHERA Biopharmaceuticals Announces FDA Approval of KYBELLA™ (also known as ATX-101) — First and Only Submental Contouring Injectable Drug KYBELLA™ (deoxycholic acid) Injection Significantly Improves Submental Fullnesss, or “Double Chin”

Exhibit 99.1 KYTHERA Biopharmaceuticals Announces FDA Approval of KYBELLA? (also known as ATX-101) ? First and Only Submental Contouring Injectable Drug KYBELLA? (deoxycholic acid) Injection Significantly Improves Submental Fullnesss, or ?Double Chin? Westlake Village, Calif., April 29, 2015 ? KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) announced today that the U.S. Food and Drug Administratio

May 4, 2015 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 29, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Co

April 23, 2015 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 23, 2015 DEFA14A

UNITED STATES

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Defin

March 16, 2015 EX-1.1

UNDERWRITING AGREEMENT KYTHERA Biopharmaceuticals, Inc. 2,604,168 Shares of Common Stock Underwriting Agreement

Exhibit 1.1 EXECUTION VERSION UNDERWRITING AGREEMENT KYTHERA Biopharmaceuticals, Inc. 2,604,168 Shares of Common Stock Underwriting Agreement March 10, 2015 Goldman, Sachs & Co. Merrill Lynch, Pierce, Fenner & Smith Incorporated Leerink Partners LLC As Representatives of the several Underwriters listed in Schedule 1 hereto c/o Goldman, Sachs & Co. 200 West Street New York, NY 10282-2198 c/o Merril

March 16, 2015 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2015 KYTHERA BIOPHARMAC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Co

March 11, 2015 424B5

Prospectus Supplement (to Prospectus dated November 6, 2014) 2,604,168 Shares KYTHERA Biopharmaceuticals, Inc. Common Stock

Use these links to rapidly review the document Table of Contents Table of Contents Filed pursuant to Rule 424(b)(5) Registration Statement No.

March 9, 2015 424B5

Preliminary Prospectus Supplement (to Prospectus dated November 6, 2014) Subject to Completion. Dated March 9, 2015 KYTHERA Biopharmaceuticals, Inc. Common Stock

Use these links to rapidly review the document Table of Contents Table of Contents Filed pursuant to Rule 424(b)(5) Registration Statement No.

March 2, 2015 EX-10.21

LICENSE AGREEMENT DATED AS OF FEBRUARY , 2015 BY AND BETWEEN THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA KYTHERA HOLDINGS, LTD. KYTHERA BIOPHARMACEUTICALS, INC.

Exhibit 10.21 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. LICENSE AGREEMENT DATED AS OF FEBRUARY , 2015 BY AND BETWEEN THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA AND KYTHERA HOLDINGS, LTD. AND KYTHERA BIOPHARMACEUTICALS, INC. CONFIDEN

March 2, 2015 EX-10.20

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. CONFIDENTIAL INFORMATION

Exhibit 10.20 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. CONFIDENTIAL INFORMATION EXECUTION COPY LICENSE AGREEMENT This license agreement (the “Agreement”) is effective as of February , 2015 (the “Effective Date”) by and among ACTELION P

March 2, 2015 EX-21.1

List of Subsidiaries of KYTHERA Biopharmaceuticals, Inc.

QuickLinks - Click here to rapidly navigate through this document Exhibit 21.1 List of Subsidiaries of KYTHERA Biopharmaceuticals, Inc. Jurisdiction of Incorporation or Organization Kythera Biopharmaceuticals (Europe) Ltd. United Kingdom Kythera Biopharmaceuticals Australia Pty. Ltd. Australia Kythera Holdings Ltd. Bermuda QuickLinks Exhibit 21.1 List of Subsidiaries of KYTHERA Biopharmaceuticals,

March 2, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 2, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Com

March 2, 2015 EX-10.8(C)

Second Amendment to Manufacturing and Supply Agreement

Exhibit 10.8(c) Second Amendment to Manufacturing and Supply Agreement This Second Amendment to the Manufacturing and Supply Agreement (this ?Second Amendment?) is made as of October 17, 2014 (the ?Effective Date of this Second Amendment?) by and between Pfizer, Inc., a corporation organized and existing under the laws of the State of Delaware, with offices at 235 E. 42nd Street, New York, NY 1001

March 2, 2015 EX-99.1

KYTHERA Biopharmaceuticals Announces 2014 Operating Results

Exhibit 99.1 KYTHERA Biopharmaceuticals Announces 2014 Operating Results Westlake Village, Calif., March 2, 2015 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for its quarter and year ended December 31, 2014, and provided an update on recent accomplishments. “Last year KYTHERA achieved many milestones and this year we continue our upward momentum. Most notably,

March 2, 2015 EX-10.22

DISTRIBUTION SERVICES AGREEMENT

Exhibit 10.22 DISTRIBUTION SERVICES AGREEMENT This Distribution Services Agreement (?Agreement?) dated as of January 16, 2015 (?Effective Date?), is made by and between KYTHERA Biopharmaceuticals, Inc. (?Company?) and Besse Medical, a division of ASD Specialty Healthcare, Inc. (?Distributor?). RECITALS A. The Company is a manufacturer and supplier of biological therapeutic products including the p

March 2, 2015 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

Use these links to rapidly review the document TABLE OF CONTENTS PART IV KYTHERA BIOPHARMACEUTICALS, INC.

February 13, 2015 EX-99.1

KYTHERA BIOPHARMACEUTICALS, INC. 2015 EMPLOYEE STOCK PURCHASE PLAN ARTICLE I. PURPOSE, SCOPE AND ADMINISTRATION OF THE PLAN

Exhibit 99.1 KYTHERA BIOPHARMACEUTICALS, INC. 2015 EMPLOYEE STOCK PURCHASE PLAN ARTICLE I. PURPOSE, SCOPE AND ADMINISTRATION OF THE PLAN 1.1 Purpose and Scope. The purpose of the Kythera Biopharmaceuticals, Inc. 2015 Employee Stock Purchase Plan, as it may be amended from time to time, (the “Plan”) is to assist employees of Kythera Biopharmaceuticals, Inc., a Delaware corporation, (the “Company”)

February 13, 2015 SC 13G/A

KYTH / Kythera Biopharma / WADDELL & REED FINANCIAL INC - KYTHERA BIOPHARMACEUTICALS, INC. Passive Investment

Kythera Biopharmaceuticals, Inc. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment No. 1* Kythera Biopharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 501570105 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to d

February 13, 2015 S-8

KYTH / Kythera Biopharma S-8 - - S-8

As filed with the Securities and Exchange Commission on February 13, 2015 Registration No.

February 13, 2015 EX-2

EXHIBIT 2

Identification and Classification of the Subsidiary Which Acquired the Security EXHIBIT 2 Waddell & Reed Investment Management Company - Tax ID No. 48-1106973 Investment Advisor registered under Section 203 of the Investment Advisors Act of 1940

February 13, 2015 EX-1

JOINT FILING AGREEMENT

Joint Filing Agreement EXHIBIT 1 JOINT FILING AGREEMENT Waddell & Reed Financial, Inc.

February 13, 2015 EX-3

POWER OF ATTORNEY

Power of Attorney EXHIBIT 3 POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENTS, THAT: The undersigned, Waddell & Reed Financial, Inc.

February 13, 2015 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 10, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

February 11, 2015 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 16, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (

February 11, 2015 SC 13G/A

KYTH / Kythera Biopharma / ARCH VENTURE FUND VI LP - KYTHERA BIOPHARMACEUTICALS Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* KYTHERA Biopharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 501570105 (CUSIP Number) December 31, 2014 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to w

January 30, 2015 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 29, 2015 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (

January 27, 2015 SC 13G/A

KYTH / Kythera Biopharma / PRUDENTIAL FINANCIAL INC Passive Investment

13G HTML File DOCUMENT TYPE SC 13G/A TEXT SECURITIES AND EXCHANGE COMMISSION Washington, D.

January 6, 2015 EX-99.1

KYTHERA Biopharmaceuticals Appoints Hollings C. Renton to Board of Directors Former Onyx CEO Brings Additional Company Building Experience to KYTHERA Board

Exhibit 99.1 KYTHERA Biopharmaceuticals Appoints Hollings C. Renton to Board of Directors Former Onyx CEO Brings Additional Company Building Experience to KYTHERA Board Westlake Village, Calif., January 5, 2015 – KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today announced that it has named Hollings C. Renton to its Board of Directors. Mr. Renton brings extensive biotechnology leadership experi

January 6, 2015 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 31, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

November 10, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2014 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 10, 2014 EX-99.1

# # # (Tables follow)

Exhibit 99.1 PRESS RELEASE KYTHERA Biopharmaceuticals Releases Third Quarter 2014 Operating Results Westlake Village, Calif., November 10, 2014 – KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for its third quarter 2014 and provided an update on recent accomplishments. “We’ve demonstrated good progress in advancing our ATX-101 program. Of note, we continue to incr

November 10, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2014 KYTHERA Biopharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

November 6, 2014 S-3/A

KYTH / Kythera Biopharma S-3/A - - S-3/A

Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents As filed with the Securities and Exchange Commission on November 6, 2014 Registration No.

November 5, 2014 8-K

Termination of a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (

November 5, 2014 EX-10.1

TERMINATION AND WAIVER AGREEMENT

Exhibit 10.1 TERMINATION AND WAIVER AGREEMENT This Termination and Waiver Agreement (this “Agreement”) is dated as of November 5, 2014, by and among KYTHERA Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), KYTHERA Holdings Ltd., a company incorporated under the laws of Bermuda (“KHL”) (solely for purposes of Article II hereof), and Bayer Consumer Care AG, a company organized under

September 17, 2014 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1) (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2014 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number:

September 17, 2014 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No.1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No.1) (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2014 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number:

September 17, 2014 CORRESP

KYTH / Kythera Biopharma CORRESP - -

KYTHERA Biopharmaceuticals, Inc. 30930 Russell Ranch Road, Suite 300 Westlake Village, CA 91362 September 17, 2014 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-6010 Attention: Jim B. Rosenberg, Senior Assistant Chief Accountant Joel Parker, Accounting Branch Chief Vanessa Robertson, Staff Accountant Re: KYTHERA

September 2, 2014 S-8

KYTH / Kythera Biopharma S-8 - - S-8

As filed with the Securities and Exchange Commission on September 2, 2014 Registration No.

September 2, 2014 EX-99.1

KYTHERA BIOPHARMACEUTICALS, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN ARTICLE 1.

Exhibit 99.1 KYTHERA BIOPHARMACEUTICALS, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN ARTICLE 1. PURPOSE The purpose of the Kythera Biopharmaceuticals, Inc. 2014 Employment Commencement Incentive Plan (the “Plan”) is to promote the success and enhance the value of Kythera Biopharmaceuticals, Inc. (the “Company”) by linking the individual interests of the Eligible Participants to those of the C

September 2, 2014 EX-99.3

KYTHERA BIOPHARMACEUTICALS, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN RESTRICTED STOCK UNIT AWARD GRANT NOTICE

Exhibit 99.3 KYTHERA BIOPHARMACEUTICALS, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN RESTRICTED STOCK UNIT AWARD GRANT NOTICE Kythera Biopharmaceuticals, Inc., a Delaware corporation, (the “Company”), pursuant to its 2014 Employment Commencement Incentive Plan, as amended from time to time (the “Plan”), hereby grants to the holder listed below (the “Participant”), an award of restricted stock

September 2, 2014 S-3

KYTH / Kythera Biopharma S-3 - - S-3

Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents As filed with the Securities and Exchange Commission on September 2, 2014 Registration No.

September 2, 2014 EX-12.1

Statement Regarding the Computation of Ratios

Exhibit 12.1 Statement Regarding the Computation of Ratios Our earnings are inadequate to cover combined fixed charges and preferred stock dividends. The following table sets forth the dollar amount of the coverage deficiency (in thousands) for the periods indicated. Six Months Ended Year Ended December 31, June 30, 2013 2012 2011 2010 2009 2014 EARNINGS: Net loss $ (51,911 ) $ (36,799 ) $ (11,152

September 2, 2014 EX-99.2

KYTHERA BIOPHARMACEUTICALS, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN STOCK OPTION GRANT NOTICE AND STOCK OPTION AGREEMENT

Exhibit 99.2 KYTHERA BIOPHARMACEUTICALS, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN STOCK OPTION GRANT NOTICE AND STOCK OPTION AGREEMENT Kythera Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), pursuant to its 2014 Employment Commencement Incentive Plan (the “Plan”), hereby grants to the individual listed below (the “Optionee”), an option to purchase the number of shares of

September 2, 2014 EX-25.1

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE x CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT T

Exhibit 25.1 File No. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE x CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO SECTION 305(b)(2) WILMINGTON TRUST, NATIONAL ASSOCIATION (Exact name of trustee as specified in its charter) 16-1486454 (I.R.S

September 2, 2014 EX-4.3

KYTHERA Biopharmaceuticals, Inc. Dated as of , 20 Wilmington Trust, National Association

Exhibit 4.3 KYTHERA Biopharmaceuticals, Inc. INDENTURE Dated as of , 20 Wilmington Trust, National Association Trustee TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions 1 Section 1.2. Other Definitions 4 Section 1.3. Incorporation by Reference of Trust Indenture Act 5 Section 1.4. Rules of Construction 5 ARTICLE II. THE SECURITIES 5 Section 2.1

August 11, 2014 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (C

August 11, 2014 EX-99.1

KYTHERA Biopharmaceuticals Submits New Drug Submission to Health Canada for ATX-101 as First-in-Class Treatment for the Reduction of Submental Fat

Exhibit 99.1 KYTHERA Biopharmaceuticals Submits New Drug Submission to Health Canada for ATX-101 as First-in-Class Treatment for the Reduction of Submental Fat Westlake Village, Calif., Aug. 11, 2014 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today announced it submitted a New Drug Submission (NDS) to Health Canada seeking approval for the company’s investigational drug, ATX-101 (deoxycholi

August 7, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2014 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

August 7, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Co

August 7, 2014 EX-99.1

# # # (Tables follow)

Exhibit 99.1 PRESS RELEASE KYTHERA Biopharmaceuticals Releases Second Quarter 2014 Operating Results Westlake Village, Calif., August 7, 2014 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for its second quarter 2014 and provided an update on recent accomplishments. “We made significant progress during the second quarter, including the submission of our New Drug

July 11, 2014 EX-99.1

KYTHERA Biopharmaceuticals Announces FDA Acceptance of ATX-101 New Drug Application

Exhibit 99.1 PRESS RELEASE KYTHERA Biopharmaceuticals Announces FDA Acceptance of ATX-101 New Drug Application Calabasas, Calif., July 10, 2014 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today announced that its New Drug Application (NDA) for ATX-101 (deoxycholic acid) has been accepted for filing by the U.S. Food and Drug Administration (FDA). The acceptance of the NDA reflects the FDA’s d

July 11, 2014 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 10, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Com

June 9, 2014 8-K

Submission of Matters to a Vote of Security Holders - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 5, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Comm

May 13, 2014 8-K

Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Comm

May 8, 2014 EX-99.1

KYTHERA Biopharmaceuticals Releases First Quarter 2014 Operating Results

Exhibit 99.1 PRESS RELEASE KYTHERA Biopharmaceuticals Releases First Quarter 2014 Operating Results Calabasas, Calif., May 8, 2014 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for its first quarter 2014, and provided an update on recent accomplishments. “We made significant progress in the first quarter and we remain on track to file our New Drug Application w

May 8, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2014 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 0

May 8, 2014 EX-10.3

ASSIGNMENT AND NOVATION AGREEMENT BAYER CONSUMER CARE AG KYTHERA HOLDINGS LTD.

Exhibit 10.3 [*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. ASSIGNMENT AND NOVATION AGREEMENT BETWEEN BAYER CONSUMER CARE AG AND KYTHERA HOLDINGS LTD. ASSIGNMENT AND NOVATION AGREEMENT THIS ASSIGNMENT AND NOVATION AGREEMENT (this ?Agreement?),

May 8, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Commi

May 8, 2014 EX-10.2

RESTRUCTURING AGREEMENT BAYER CONSUMER CARE AG KYTHERA BIOPHARMACEUTICALS, INC.

Exhibit 10.2 RESTRUCTURING AGREEMENT BETWEEN BAYER CONSUMER CARE AG AND KYTHERA BIOPHARMACEUTICALS, INC. RESTRUCTURING AGREEMENT THIS RESTRUCTURING AGREEMENT (this ?Restructuring Agreement?), is entered into as of March 7, 2014 (the ?Effective Date?), by and among Bayer Consumer Care AG, a company organized under the laws of Switzerland (?Bayer?) and KYTHERA Biopharmaceuticals, Inc., a Delaware co

April 17, 2014 DEF 14A

- DEF 14A

DEF 14A 1 a2219689zdef14a.htm DEF 14A Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box

April 17, 2014 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Defin

March 31, 2014 8-K/A

Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 7, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (C

March 21, 2014 S-8

- S-8

As filed with the Securities and Exchange Commission on March 21, 2014 Registration No.

March 17, 2014 EX-10.4(F)

FIFTH AMENDMENT TO OFICE LEASE

Exhibit 10.4(f) FIFTH AMENDMENT TO OFICE LEASE THIS FIFTH AMENDMENT TO OFFICE LEASE (this ?Amendment?) is entered into as of the 29 day of January 2014 by and between 27200 Associates, LLC, a California limited liability company (?Lessor?), and Kythera Biopharmaceuticals, Inc., a Delaware corporation, (?Lessee?). WITNESSETH WHEREAS, Lessor and Lessee, entered into that certain Standard Multi-Lesse

March 17, 2014 EX-21.1

List of Subsidiaries of KYTHERA Biopharmaceuticals, Inc.

QuickLinks - Click here to rapidly navigate through this document Exhibit 21.1 List of Subsidiaries of KYTHERA Biopharmaceuticals, Inc. Jurisdiction of Incorporation or Organization Kythera Biopharmaceuticals (Europe) Ltd. United Kingdom Kythera Biopharmaceuticals Australia Pty. Ltd. Australia Kythera Holdings Ltd. Bermuda QuickLinks Exhibit 21.1 List of Subsidiaries of KYTHERA Biopharmaceuticals,

March 17, 2014 EX-10.20

OFFICE LEASE (30930 RUSSELL RANCH ROAD) RUSSELL RANCH ROAD, LLC, a Delaware limited liability company AS LANDLORD KYTHERA BIOPHARMACEUTICALS, INC., a Delaware corporation AS TENANT

Exhibit 10.20 OFFICE LEASE (30930 RUSSELL RANCH ROAD) BETWEEN RUSSELL RANCH ROAD, LLC, a Delaware limited liability company AS LANDLORD AND KYTHERA BIOPHARMACEUTICALS, INC., a Delaware corporation AS TENANT OFFICE LEASE (30930 RUSSELL RANCH ROAD) THIS OFFICE LEASE (this “Lease”) is made and entered into as of March 12, 2014 (the “Effective Date”), by and between “Landlord” RUSSELL RANCH ROAD, LLC,

March 17, 2014 EX-99.1

KYTHERA BIOPHARMACEUTICALS ANNOUNCES 2013 OPERATING RESULTS

Exhibit 99.1 PRESS RELEASE KYTHERA BIOPHARMACEUTICALS ANNOUNCES 2013 OPERATING RESULTS Calabasas, Calif., March 17 2014 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for its quarter and year ended December 31, 2013, and provided an update on recent accomplishments. “2013 was a productive year for KYTHERA. Most notably, we announced positive results from our piv

March 17, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 17, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Co

March 17, 2014 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

Use these links to rapidly review the document TABLE OF CONTENTS ITEM 7A. Quantitative and Qualitative Disclosures About Market Risk. KYTHERA BIOPHARMACEUTICALS, INC. Index to Financial Statements Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For t

March 10, 2014 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of March 7, 2014, by and between KYTHERA Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), KYTHERA Holdings Ltd., a company incorporated under the laws of Bermuda (“KHL”) and Bayer Consumer Care AG, a company organized under the laws of Switzerland (“Bayer”). RECITALS A. The

March 10, 2014 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Completion of Acquisition or Disposition of Assets - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 7, 2014 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Com

March 10, 2014 EX-4.1

[Signature page follows]

Exhibit 4.1 NOTE $51,000,000.00 March 7, 2014 FOR VALUE RECEIVED, KYTHERA BIOPHARMACEUTICALS, INC., a Delaware corporation (“Borrower”), located at 27200 West Agoura Road, Suite 200, Calabasas, CA 91301, promises to pay to the order of KYTHERA HOLDINGS LTD., a wholly-owned subsidiary of Borrower and a company incorporated under the laws of Bermuda (“Lender”), the principal amount of Fifty One Mill

March 10, 2014 EX-4.2

REGISTRATION RIGHTS AGREEMENT

Exhibit 4.2 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this “Agreement”) is made and entered into as of March 7, 2014, by and between KYTHERA Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), and Bayer Consumer Care AG, a company organized under the laws of Switzerland (the “Investor”). This Agreement is made pursuant to the Securities Purchase Agreement, dat

February 14, 2014 SC 13G/A

KYTH / Kythera Biopharma / Partner Fund Management, L.P. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) Information Statement Pursuant to Rules 13d-1 and 13d-2 Under the Securities Exchange Act of 1934 (Amendment No. 2 )* Kythera Biopharmaceuticals, Inc. (Name of Issuer) Common stock, par value $0.00001 per share (Title of Class of Securities) 501570105 (CUSIP Number) December 31, 2013 Date of Event W

February 10, 2014 EX-99.1

Page 9

EX-A Exhibit A CUSIP No. 501570 10 5 13G AGREEMENT Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of the shares of Common Stock of KYTHERA Biopharmaceuticals, Inc. Dated: February 7, 2014

February 10, 2014 SC 13G/A

KYTH / Kythera Biopharma / Prospect Venture Partners III L P - SC 13G/A Passive Investment

SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.

February 7, 2014 EX-2

EXHIBIT 2

Identification and Classification of the Subsidiary Which Acquired the Security EXHIBIT 2 Waddell & Reed Investment Management Company - Tax ID No. 48-1106973 Investment Advisor registered under Section 203 of the Investment Advisors Act of 1940 Ivy Investment Management Company - Tax ID No. 03-0481447 Investment Advisor registered under Section 203 of the Investment Advisors Act of 1940

February 7, 2014 SC 13G

KYTH / Kythera Biopharma / WADDELL & REED FINANCIAL INC - KYTHERA BIOPHARMACEUTICALS, INC. Passive Investment

Kythera Biopharmaceuticals, Inc. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Kythera Biopharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 501570105 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule

February 7, 2014 EX-3

POWER OF ATTORNEY

Power of Attorney EXHIBIT 3 POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENTS, THAT: The undersigned, Waddell & Reed Financial, Inc.

February 7, 2014 EX-1

JOINT FILING AGREEMENT

EX-1 2 d662990dex1.htm JOINT FILING AGREEMENT EXHIBIT 1 JOINT FILING AGREEMENT Waddell & Reed Financial, Inc., Waddell & Reed Financial Services, Inc., Waddell & Reed, Inc., Waddell & Reed Investment Management Company and Ivy Investment Management Company (the “Filing Persons”), hereby agree to file jointly a Schedule 13G and any amendments thereto relating to the aggregate ownership by each of t

February 6, 2014 SC 13G/A

KYTH / Kythera Biopharma / ARCH VENTURE FUND VI LP - KYTHERA BIOPHARMACEUTICALS Passive Investment

SC 13G/A 1 kythera-sch13g17609.htm KYTHERA BIOPHARMACEUTICALS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Kythera Biopharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 501570105 (CUSIP Number) December 31, 2013 (Date of Event which Requires Filing of this Statement)

February 5, 2014 SC 13G

KYTH / Kythera Biopharma / PRUDENTIAL FINANCIAL INC Passive Investment

SC 13G 1 kbio.htm DOCUMENT TYPE SC 13G TEXT SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Name of Issuer: KYTHERA BIOPHARMACEUTICALS INC Title of Class of Securities: Common Stock CUSIP Number: 501570105 1) NAME AND I.R.S. IDENTIFICATION NO. OF REPORTING PERSON Prudential Financial, Inc. 22-3703799 2.) MEMBER OF A GROUP: (a) N/A (b

November 14, 2013 EX-99.1

KYTHERA Biopharmaceuticals Announces Third Quarter 2013 Operating Results

EX-99.1 2 a13-243121ex99d1.htm EX-99.1 Exhibit 99.1 PRESS RELEASE KYTHERA Biopharmaceuticals Announces Third Quarter 2013 Operating Results LOS ANGELES, November 14, 2013 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for its third quarter 2013, and provided an update on recent accomplishments. Summary Financial Results Cash and cash equivalents, marketable secu

November 14, 2013 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2013 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 14, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

October 9, 2013 424B4

2,622,950 Shares Common Stock

Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC.

October 8, 2013 S-1MEF

- S-1MEF

QuickLinks - Click here to rapidly navigate through this document As filed with the Securities and Exchange Commission on October 8, 2013 Registration No.

October 7, 2013 EX-1.1

UNDERWRITING AGREEMENT KYTHERA Biopharmaceuticals, Inc. Shares of Common Stock Underwriting Agreement

Exhibit 1.1 UNDERWRITING AGREEMENT KYTHERA Biopharmaceuticals, Inc. Shares of Common Stock Underwriting Agreement , 2013 J.P. Morgan Securities LLC Merrill Lynch, Pierce, Fenner & Smith Incorporated Leerink Swann LLC As Representatives of the several Underwriters listed in Schedule 1 hereto c/o J.P. Morgan Securities LLC 383 Madison Avenue New York, New York 10179 c/o Merrill Lynch, Pierce, Fenner

October 7, 2013 S-1/A

- S-1/A

Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC.

October 7, 2013 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 7, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (C

September 30, 2013 S-1

Registration Statement - S-1

Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC.

September 27, 2013 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1) (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2013 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commi

September 27, 2013 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1) (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2013 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commis

September 27, 2013 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K/A Amendment No. 1

Use these links to rapidly review the document TABLE OF CONTENTS PART IV Index to Financial Statements Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

September 25, 2013 8-K

Non-Reliance on Previously Issued Financial Statements or a Related Audit Report or Completed Interim Review - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 23, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

September 19, 2013 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 September 17, 2013 Date of Report (date of earliest event reported) KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of Registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of (Commission Fil

September 19, 2013 EX-99.1

KYTHERA Appoints F. Michael Ball to Board of Directors Hospira Chief Executive Officer and Former Allergan President Brings Extensive Healthcare and Aesthetics Experience

Exhibit 99.1 Investor Contact: Heather Rowe Associate Director, Investor Relations Tel: (818) 587- 4559 [email protected] PRESS RELEASE KYTHERA Appoints F. Michael Ball to Board of Directors Hospira Chief Executive Officer and Former Allergan President Brings Extensive Healthcare and Aesthetics Experience Calabasas, Calif., September 19, 2013 – KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KY

September 17, 2013 EX-99.1

The beauty of science. September 17, 2013

Exhibit 99.1 The beauty of science. September 17, 2013 Forward Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. In some cases, you can identify forward-looking statements by the following words: “may,” “will,” “could,” “would,” “should,” “expect,” “intend,” “plan,” “anticipate,” “contemplate,” “believe,” “estimate,” “predict

September 17, 2013 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 16, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

September 9, 2013 8-K

Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 9, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

September 9, 2013 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 9, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

August 6, 2013 EX-99.1

KYTHERA Biopharmaceuticals Announces Second Quarter 2013 Operating Results

Exhibit 99.1 Contact: Heather Rowe Associate Director, Investor Relations Tel: (818) 587- 4559 [email protected] PRESS RELEASE KYTHERA Biopharmaceuticals Announces Second Quarter 2013 Operating Results LOS ANGELES, August 6, 2013 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for its second quarter 2013, and provided an update on recent accomplishments.

August 6, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 6, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Co

August 6, 2013 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2013 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

June 7, 2013 8-K

Submission of Matters to a Vote of Security Holders - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 4, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Comm

May 13, 2013 EX-10.4

COMMERCIAL DEVELOPMENT AND SUPPLY AGREEMENT BY AND BETWEEN KYTHERA BIOPHARMACEUTICALS, INC. CAMBRIDGE MAJOR LABORATORIES, INC.

Exhibit 10.4 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. COMMERCIAL DEVELOPMENT AND SUPPLY AGREEMENT BY AND BETWEEN KYTHERA BIOPHARMACEUTICALS, INC. AND CAMBRIDGE MAJOR LABORATORIES, INC. COMMERCIAL DEVELOPMENT AND SUPPLY AGREEMENT This C

May 13, 2013 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2013 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 0

May 13, 2013 EX-10.5

FOURTH AMENDMENT TO OFFICE LEASE

Exhibit 10.5 FOURTH AMENDMENT TO OFFICE LEASE THIS FOURTH AMENDMENT TO OFFICE LEASE (this ?Amendment?) is entered into as of the 28th day of March 2013 by and between 27200 Associates, LLC, a California limited liability company (?Lessor?), and Kythera Biopharmaceuticals, Inc., a Delaware corporation (?Lessee?). WITNESSETH: WHEREAS, Lessor and Lessee, entered into that certain Standard Multi-Lesse

May 13, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Comm

May 13, 2013 EX-99.1

KYTHERA Biopharmaceuticals Announces First Quarter 2013 Operating Results

EX-99.1 2 a13-120931ex99d1.htm EX-99.1 Exhibit 99.1 Contact: Heather Rowe Associate Director, Investor Relations Tel: (818) 587- 4559 [email protected] PRESS RELEASE KYTHERA Biopharmaceuticals Announces First Quarter 2013 Operating Results LOS ANGELES, May 13, 2013 – KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for its first quarter 2013, and provided a

April 26, 2013 DEF 14A

- DEF 14A

Use these links to rapidly review the document TABLE OF CONTENTS Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 25, 2013 8-K

Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 25, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Co

April 5, 2013 8-K

Entry into a Material Definitive Agreement - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Com

April 2, 2013 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 27, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Co

April 2, 2013 EX-10.1

SEPARATION AGREEMENT AND RELEASE

Exhibit 10.1 SEPARATION AGREEMENT AND RELEASE This Separation Agreement and Release (“Agreement”) is made by and between Patricia Walker, M.D., Ph.D. (“Employee”) and KYTHERA Biopharmaceuticals, Inc. (the “Company”) (collectively referred to as the “Parties” or individually referred to as a “Party”). RECITALS WHEREAS, Employee was employed by the Company; WHEREAS, Employee signed an Amended and Re

April 2, 2013 EX-10.2

SENIOR ADVISOR TO THE BOARD OF DIRECTORS AGREEMENT

Exhibit 10.2 SENIOR ADVISOR TO THE BOARD OF DIRECTORS AGREEMENT This Sr. Advisor to the Board of Directors Agreement (“Agreement”) is entered into as of March 28, 2013 (the “Effective Date”) by and between KYTHERA Biopharmaceuticals, Inc. (the “Company”) and Patricia Walker, MD, PhD (“Sr. Advisor”). The Company desires to retain Sr. Advisor as an independent contractor to perform consulting servic

March 26, 2013 S-8

- S-8

As filed with the Securities and Exchange Commission on March 26, 2013 Registration No.

March 26, 2013 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

10-K 1 a2213914z10-k.htm 10-K Use these links to rapidly review the document TABLE OF CONTENTS PART IV Index to Financial Statements Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2012 OR o TRANSITION REPORT PU

March 26, 2013 EX-10.18

KYTHERA BIOPHARMACEUTICALS, INC. EMPLOYMENT AGREEMENT

Exhibit 10.18 KYTHERA BIOPHARMACEUTICALS, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into as of March 23, 2013 (the “Effective Date”) by and between Kythera Biopharmaceuticals, Inc. (the “Company”) and Frederick Beddingfield, III, MD, PhD (“Employee”). 1. Duties and Scope of Employment. (a) Positions and Duties. As of the Effective Date, Employee will serve as

March 21, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Co

March 21, 2013 EX-99.1

KYTHERA BIOPHARMACEUTICALS ANNOUNCES 2012 OPERATING RESULTS

EX-99.1 2 a13-81211ex99d1.htm EX-99.1 Exhibit 99.1 Contact: Heather Rowe Associate Director, Investor Relations Tel: (818) 587- 4559 [email protected] PRESS RELEASE KYTHERA BIOPHARMACEUTICALS ANNOUNCES 2012 OPERATING RESULTS LOS ANGELES, March 21, 2013 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for its quarter and year ended December 31, 2012. “2012

March 12, 2013 EX-99.1

MEDICAL AESTHETICS VETERAN FREDERICK BEDDINGFIELD, III, MD, PHD APPOINTED NEW CHIEF MEDICAL OFFICER OF KYTHERA BIOPHARMACEUTICALS

Exhibit 99.1 Investor Contact: Heather Rowe Tel: (818) 587-4559 [email protected] MEDICAL AESTHETICS VETERAN FREDERICK BEDDINGFIELD, III, MD, PHD APPOINTED NEW CHIEF MEDICAL OFFICER OF KYTHERA BIOPHARMACEUTICALS LOS ANGELES, March 12, 2013 — KYTHERA Biopharmaceuticals, Inc. (KYTHERA), a biotechnology company focused on the development and commercialization of prescription products in aest

March 12, 2013 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 6, 2013 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (Com

February 14, 2013 SC 13G/A

KYTH / Kythera Biopharma / Partner Fund Management, L.P. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) Information Statement Pursuant to Rules 13d-1 and 13d-2 Under the Securities Exchange Act of 1934 (Amendment No. 1 )* Kythera Biopharmaceuticals, Inc. (Name of Issuer) Common stock, par value $0.00001 per share (Title of Class of Securities) 501570105 (CUSIP Number) December 31, 2012 Date of Event W

February 11, 2013 SC 13G

KYTH / Kythera Biopharma / Versant Affiliates Fund II-A, LP - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b) (Amendment No. )* Kythera Biopharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 501570 10 5 (CUSIP Number) December 31, 2012 (Dat

February 8, 2013 SC 13G

KYTH / Kythera Biopharma / ARCH VENTURE FUND VI LP - KYTHERA BIOPHARMACEUTICALS Passive Investment

SC 13G 1 kythera-sch13g17466.htm KYTHERA BIOPHARMACEUTICALS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Kythera Biopharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 501570105 (CUSIP Number) December 31, 2012 (Date of Event which Requires Filing of this Statement) Check the appropriat

January 28, 2013 EX-99.1

AGREEMENT

EX-99.1 2 d475324dex991.htm JOINT FILING STATEMENT CUSIP No. 501570 10 5 13G Exhibit A AGREEMENT Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of the shares of Common Stock of KYTHERA Bi

January 28, 2013 SC 13G

KYTH / Kythera Biopharma / Prospect Venture Partners III L P - SCHEDULE 13G Passive Investment

Schedule 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.

December 14, 2012 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 11, 2012 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

December 5, 2012 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 30, 2012 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

December 5, 2012 EX-10.1

AMENDMENT NO. 03 Dated November 30, 2012 that certain Loan and Security Agreement No. 1991 dated as of March 21, 2011, as amended (“Agreement”), by and between LIGHTHOUSE CAPITAL PARTNERS VI, L.P. (“Lender”) and KYTHERA BIOPHARMACEUTICALS, INC. (“Bor

Exhibit 10.1 AMENDMENT NO. 03 Dated November 30, 2012 TO that certain Loan and Security Agreement No. 1991 dated as of March 21, 2011, as amended (“Agreement”), by and between LIGHTHOUSE CAPITAL PARTNERS VI, L.P. (“Lender”) and KYTHERA BIOPHARMACEUTICALS, INC. (“Borrower”). WHEREAS, Borrower and Lender have previously entered into the Agreement; WHEREAS, Borrower has requested that Lender modify c

December 3, 2012 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1) (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2012 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file num

November 13, 2012 EX-99.1

KYTHERA BIOPHARMACEUTICALS ANNOUNCES THIRD QUARTER 2012 FINANCIAL RESULTS

Exhibit 99.1 Investor & Media Contact: Heather Rowe Tel: (818) 587-4559 [email protected] KYTHERA BIOPHARMACEUTICALS ANNOUNCES THIRD QUARTER 2012 FINANCIAL RESULTS LOS ANGELES, November 13, 2012 – KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today reported financial results for the three and nine months ended September 30, 2012, and provided an update on recent accomplishments. “We hav

November 13, 2012 EX-10.3(A)

KYTHERA BIOPHARMACEUTICALS, INC. 2012 EQUITY INCENTIVE AWARD PLAN ARTICLE 1.

EX-10.3(A) 2 a12-227401ex10d3a.htm EX-10.3(A) Exhibit 10.3(a) KYTHERA BIOPHARMACEUTICALS, INC. 2012 EQUITY INCENTIVE AWARD PLAN ARTICLE 1. PURPOSE The purpose of the Kythera Biopharmaceuticals, Inc. 2012 Equity Incentive Award Plan (the “Plan”) is to promote the success and enhance the value of Kythera Biopharmaceuticals, Inc. (the “Company”) by linking the individual interests of the Employees, C

November 13, 2012 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2012 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 13, 2012 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2012 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation)

October 19, 2012 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the Common Stock of Kythera Biopharmaceuticals, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(c) under the Securities Exchange Act of 1934, as amended, on behalf of each

October 19, 2012 SC 13G

KYTH / Kythera Biopharma / Partner Fund Management, L.P. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) Information Statement Pursuant to Rules 13d-1 and 13d-2 Under the Securities Exchange Act of 1934 (Amendment No. )* Kythera Biopharmaceuticals, Inc. (Name of Issuer) Common stock, par value $0.00001 per share (Title of Class of Securities) 501570105 (CUSIP Number) October 11, 2012 Date of Event Whic

October 16, 2012 EX-3.2

AMENDED AND RESTATED BYLAWS OF KYTHERA BIOPHARMACEUTICALS, INC. (a Delaware corporation)

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF KYTHERA BIOPHARMACEUTICALS, INC. (a Delaware corporation) TABLE OF CONTENTS Page ARTICLE I - CORPORATE OFFICES 1 1.1 REGISTERED OFFICE 1 1.2 OTHER OFFICES 1 ARTICLE II - MEETINGS OF STOCKHOLDERS 1 2.1 PLACE OF MEETINGS 1 2.2 ANNUAL MEETING 1 2.3 SPECIAL MEETING 1 2.4 ADVANCE NOTICE PROCEDURES FOR BUSINESS BROUGHT BEFORE A MEETING 2 2.5 ADVANCE NOTICE PROC

October 16, 2012 S-8

- S-8

As filed with the Securities and Exchange Commission on October 16, 2012 Registration No.

October 16, 2012 EX-99.3

KYTHERA BIOPHARMACEUTICALS, INC. 2012 EQUITY INCENTIVE AWARD PLAN ARTICLE 1.

Exhibit 99.3 KYTHERA BIOPHARMACEUTICALS, INC. 2012 EQUITY INCENTIVE AWARD PLAN ARTICLE 1. PURPOSE The purpose of the Kythera Biopharmaceuticals, Inc. 2012 Equity Incentive Award Plan (the “Plan”) is to promote the success and enhance the value of Kythera Biopharmaceuticals, Inc. (the “Company”) by linking the individual interests of the Employees, Consultants and members of the Board to those of t

October 16, 2012 EX-99.1

KYTHERA BIOPHARMACEUTICALS ANNOUNCES CLOSING OF INITIAL PUBLIC OFFERING AND EXERCISE OF UNDERWRITERS’ OVER-ALLOTMENT OPTION

Exhibit 99.1 27200 West Agoura Road 818.587.4500 Phone Suite 200 818.587.4591 Fax Calabasas, CA 91301 Investor Contact: Heather Rowe Tel: (818) 587-4559 [email protected] KYTHERA BIOPHARMACEUTICALS ANNOUNCES CLOSING OF INITIAL PUBLIC OFFERING AND EXERCISE OF UNDERWRITERS’ OVER-ALLOTMENT OPTION LOS ANGELES, October 16, 2012 — KYTHERA Biopharmaceuticals, Inc. (NASDAQ: KYTH) today announced

October 16, 2012 EX-3.1

SEVENTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION KYTHERA BIOPHARMACEUTICALS, INC.

Exhibit 3.1 SEVENTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF KYTHERA BIOPHARMACEUTICALS, INC. Keith Leonard and Keith Klein, hereby certifies that: ONE: The name of this corporation is Kythera Biopharmaceuticals, Inc. The corporation was incorporated on June 3, 2004 under the name Dermion, Inc. pursuant to the General Corporation Law of the State of Delaware (the “Delaware General Corp

October 16, 2012 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 16, 2012 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35663 03-0552903 (State or other jurisdiction of incorporation) (

October 11, 2012 424B4

4,400,000 Shares Common Stock

Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC.

October 10, 2012 S-1MEF

- S-1MEF

As filed with the Securities and Exchange Commission on October 10, 2012 Registration No.

October 9, 2012 EX-3.1

SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF KYTHERA BIOPHARMACEUTICALS, INC.

Exhibit 3.1 SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF KYTHERA BIOPHARMACEUTICALS, INC. Kythera Biopharmaceuticals, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), certifies that: A. The name of the Corporation is Kythera Biopharmaceuticals, Inc. The Corporation’s original Certificate of Incorporation was filed with the Secret

October 9, 2012 S-1/A

- S-1/A#6

Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC.

October 4, 2012 CORRESP

-

KYTHERA Biopharmaceuticals, Inc. 27200 West Agoura Road, Suite 200 Calabasas, CA 91301 October 4, 2012 VIA FACSIMILE AND EDGAR TRANSMISSION United States Securities and Exchange Commission Division of Corporate Finance 100 F Street, N.E. Washington, D.C. 20549-6010 Attention: Jeffrey Riedler, Assistant Director Rose Zukin Daniel Greenspan Re: KYTHERA Biopharmaceuticals, Inc. Registration Statement

October 4, 2012 CORRESP

-

J.P. Morgan Securities LLC 383 Madison Avenue New York, New York 10179 Goldman, Sachs & Co. 200 West Street New York, NY 10282 October 4, 2012 Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-7010 Re: KYTHERA Biopharmaceuticals, Inc. Registration Statement on Form S-1 Registration File No. 333- 181476 Dear Ladies and Gentlemen: In accorda

September 24, 2012 S-1/A

- S-1/A#5

Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC.

September 24, 2012 8-A12B

- 8-A12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 KYTHERA BIOPHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Delaware 03-0552903 (State of incorporation or organization) (I.R.S. Employer Identification No.) 27200 West

September 24, 2012 EX-3.2

SEVENTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION KYTHERA BIOPHARMACEUTICALS, INC.

Exhibit 3.2 SEVENTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF KYTHERA BIOPHARMACEUTICALS, INC. Keith Leonard and Keith Klein, hereby certifies that: ONE: The name of this corporation is Kythera Biopharmaceuticals, Inc. The corporation was incorporated on June 3, 2004 under the name Dermion, Inc. pursuant to the General Corporation Law of the State of Delaware (the “Delaware General Corp

September 24, 2012 EX-3.1(B)

SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF KYTHERA BIOPHARMACEUTICALS, INC.

EX-3.1(B) 2 a2211119zex-31b.htm EX-3.1(B) Exhibit 3.1(b) SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF KYTHERA BIOPHARMACEUTICALS, INC. Kythera Biopharmaceuticals, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), certifies that: A. The name of the Corporation is Kythera Biopharmaceuticals, Inc. The Corporation’s original Certifica

September 20, 2012 S-1/A

- S-1/A#4

S-1/A 1 a2210175zs-1a.htm S-1/A#4 Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC. Index to Financial Statements Table of Contents As filed with the Securities and Exchange Commission on September 20, 2012 Registration No. 333-181476 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 4 TO FORM S-1 REGISTRATION STAT

September 20, 2012 CORRESP

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September 19, 2012 File No. 048370-0008 VIA EDGAR AND HAND DELIVERY United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-6010 Attention: Jeffrey Riedler, Assistant Director Rose Zukin Daniel Greenspan Re: KYTHERA Biopharmaceuticals, Inc. Amendment No. 4 to Registration Statement on Form S-1 File No. 333-181476 Ladies and Gentlem

September 12, 2012 CORRESP

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[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission.

August 31, 2012 EX-1.1

UNDERWRITING AGREEMENT KYTHERA Biopharmaceuticals, Inc. [·] Shares of Common Stock Underwriting Agreement

Exhibit 1.1 UNDERWRITING AGREEMENT KYTHERA Biopharmaceuticals, Inc. [·] Shares of Common Stock Underwriting Agreement [·] , 2012 J. P. Morgan Securities LLC Goldman, Sachs & Co. As Representatives of the several Underwriters listed in Schedule 1 hereto c/o J. P. Morgan Securities LLC 383 Madison Avenue New York, New York 10179 c/o Goldman, Sachs & Co. 200 West Street New York, NY 10282 Ladies and

August 31, 2012 S-1/A

- S-1/A

Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC.

August 31, 2012 EX-4.5(B)

AMENDMENT NO. 01 Dated July 23, 2012 that certain Preferred Stock Warrant Agreement dated as of December 30, 2011, (the “Warrant”) by and between LIGHTHOUSE CAPITAL PARTNERS VI, L.P. (“Holder”) and KYTHERA BIOPHARMACEUTICALS, INC. (“Company”).

Exhibit 4.5(b) AMENDMENT NO. 01 Dated July 23, 2012 TO that certain Preferred Stock Warrant Agreement dated as of December 30, 2011, (the “Warrant”) by and between LIGHTHOUSE CAPITAL PARTNERS VI, L.P. (“Holder”) and KYTHERA BIOPHARMACEUTICALS, INC. (“Company”). (All capitalized terms not otherwise defined herein shall have the meanings given to such terms in the Warrant.) Without limiting or amend

August 31, 2012 EX-4.2

DELAWARE JUNE 2004 SEAL KYTHERA BIOPHARMACEUTICALS, INC. CORPORATE This certifies that is the record holder of Dated: KB INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE FULLY PAID AND NONASSESSABLE SHARES OF COMMON STOCK, $.00001 PAR VALUE, OF K

Exhibit 4.2 DELAWARE JUNE 2004 SEAL KYTHERA BIOPHARMACEUTICALS, INC. CORPORATE This certifies that is the record holder of Dated: KB INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE FULLY PAID AND NONASSESSABLE SHARES OF COMMON STOCK, $.00001 PAR VALUE, OF KYTHERA Biopharmaceuticals, Inc. transferable on the books of the corporation in person or by duly authorized attorney upon surrender of th

August 31, 2012 EX-10.3(C)

AMENDMENT NO. 02 Dated July 23, 2012 that certain Loan and Security Agreement No. 1991 dated as of March 21, 2011, (“Agreement”), by and between LIGHTHOUSE CAPITAL PARTNERS VI, L.P. (“Lender”) and KYTHERA BIOPHARMACEUTICALS, INC. (“Borrower”).

Exhibit 10.3(c) AMENDMENT NO. 02 Dated July 23, 2012 TO that certain Loan and Security Agreement No. 1991 dated as of March 21, 2011, (“Agreement”), by and between LIGHTHOUSE CAPITAL PARTNERS VI, L.P. (“Lender”) and KYTHERA BIOPHARMACEUTICALS, INC. (“Borrower”). WHEREAS, Borrower and Lender have previously entered into the Agreement; WHEREAS, Borrower has requested that Lender modify certain terms

July 11, 2012 S-1/A

- S-1/A

Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC.

July 11, 2012 CORRESP

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July 11, 2012 File No. 048370-0008 VIA EDGAR AND HAND DELIVERY United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-6010 Attention: Jeffrey Riedler, Assistant Director Rose Zukin Daniel Greenspan Re: KYTHERA Biopharmaceuticals, Inc. Amendment No. 2 to Registration Statement on Form S-1 File No. 333-181476 Ladies and Gentleman: O

June 11, 2012 EX-10.8(A)

MANUFACTURING AND SUPPLY AGREEMENT

Exhibit 10.8(a) [*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. MANUFACTURING AND SUPPLY AGREEMENT THIS MANUFACTURING AND SUPPLY AGREEMENT dated as of July 7, 2009 (the “Effective Date”) is made by and between Pfizer Inc., a corporation organiz

June 11, 2012 EX-10.8(B)

First Amendment to Manufacturing and Supply Agreement

Exhibit 10.8(b) [*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. First Amendment to Manufacturing and Supply Agreement This First Amendment to the Manufacturing and Supply Agreement (this “Amendment”) is made as of the 21 of May, 2012 (the “Effe

June 11, 2012 CORRESP

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June 11, 2012 File No. 048370-0008 VIA EDGAR AND HAND DELIVERY United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-6010 Attention: Jeffrey Riedler, Assistant Director Rose Zukin Daniel Greenspan Re: KYTHERA Biopharmaceuticals, Inc. Amendment No. 1 to Registration Statement on Form S-1 File No. 333-181476 Ladies and Gentleman: O

June 11, 2012 S-1/A

- S-1/A

S-1/A 1 a2209812zs-1a.htm S-1/A Use these links to rapidly review the document Table of Contents KYTHERA BIOPHARMACEUTICALS, INC. Index to Financial Statements Table of Contents As filed with the Securities and Exchange Commission on June 11, 2012 Registration No. 333-181476 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-1 REGISTRATION STATEMENT U

May 17, 2012 EX-10.5(B)

FIRST AMENDMENT TO LICENSE AGREEMENT

Exhibit 10.5(b) [*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. FIRST AMENDMENT TO LICENSE AGREEMENT This FIRST AMENDMENT TO LICENSE AGREEMENT (“First Amendment”) is entered into as of March 21, 2011 (“First Amendment Effective Date”) by and be

May 17, 2012 EX-10.12

KYTHERA BIOPHARMACEUTICALS, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT

Exhibit 10.12 KYTHERA BIOPHARMACEUTICALS, INC. AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is entered into as of April 2, 2012 (the “Effective Date”) by and between Kythera Biopharmaceuticals, Inc. (the “Company”) and Keith Leonard (“Employee”), and amends and restates in its entirety that certain Employment Agreement (the “Prior Agree

May 17, 2012 EX-99.1

Confidential Submission Pursuant to Title I, Section 106 under the Jumpstart Our Business Startups Act and Section 24(b)(2) of the Securities Exchange Act of 1934

QuickLinks - Click here to rapidly navigate through this document Exhibit 99.1 140 Scott Drive Menlo Park, California 94025 Tel: +1.650.328.4600 Fax: +1.650.463.2600 www.lw.com FIRM / AFFILIATE OFFICES Abu Dhabi Moscow Barcelona Munich Beijing New Jersey Boston New York Brussels Orange County Chicago Paris April 6, 2012 Doha Riyadh Dubai Rome Frankfurt San Diego Hamburg San Francisco Hong Kong Sha

May 17, 2012 EX-10.6(A)

SERVICES, RESEARCH, DEVELOPMENT AND COLLABORATION AGREEMENT

Exhibit 10.6(a) [*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. SERVICES, RESEARCH, DEVELOPMENT AND COLLABORATION AGREEMENT THIS SERVICES, RESEARCH, DEVELOPMENT AND COLLABORATION AGREEMENT (this “Collaboration Agreement”) is entered into as of

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