LABP / Landos Biopharma, Inc. - Документы SEC, Годовой отчет, Доверенное заявление

Ландос Биофарма, Инк.
US ˙ NasdaqCM ˙ US5150692011
ЭТОТ СИМВОЛ БОЛЬШЕ НЕ АКТИВЕН

Основная статистика
CIK 1785345
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Landos Biopharma, Inc.
SEC Filings (Chronological Order)
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June 3, 2024 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-39971 LANDOS BIOPHARMA, INC. (Exact name of registrant as specified in i

May 23, 2024 S-8 POS

As filed with the Securities and Exchange Commission on May 23, 2024

As filed with the Securities and Exchange Commission on May 23, 2024 Registration No.

May 23, 2024 S-8 POS

As filed with the Securities and Exchange Commission on May 23, 2024

As filed with the Securities and Exchange Commission on May 23, 2024 Registration No.

May 23, 2024 EX-3.1

FIFTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION LANDOS BIOPHARMA, INC.

Exhibit 3.1 FIFTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF LANDOS BIOPHARMA, INC. FIRST: The name of the corporation is Landos BioPharma, Inc. (hereinafter, the “Corporation”). SECOND: The address of the Corporation’s registered office in the State of Delaware is c/o Corporate Creations Network Inc., 1521 Concord Pike Suite 201, Wilmington, DE 19803, New Castle County, USA, and the nam

May 23, 2024 8-K

Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2024 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 23, 2024 S-8 POS

As filed with the Securities and Exchange Commission on May 23, 2024

As filed with the Securities and Exchange Commission on May 23, 2024 Registration No.

May 23, 2024 S-8 POS

As filed with the Securities and Exchange Commission on May 23, 2024

As filed with the Securities and Exchange Commission on May 23, 2024 Registration No.

May 23, 2024 EX-99.1

### Media: Lindsay Cangemi [email protected]    Investors: Liz Shea [email protected]

Exhibit 99.1 PRESS RELEASE AbbVie Completes Acquisition of Landos Biopharma - Adds first-in-class investigational asset, NX-13, to AbbVie’s pipeline with the potential to offer a novel approach to the treatment of ulcerative colitis (UC) and Crohn’s disease (CD) NORTH CHICAGO, Ill., May 23, 2024 – AbbVie (NYSE: ABBV) announced today that it has completed its acquisition of Landos Biopharma, Inc. (

May 23, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2024 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 23, 2024 EX-3.2

LANDOS BIOPHARMA, INC. AMENDED AND RESTATED BYLAWS DATED AS OF MAY 23, 2024 ARTICLE I

Exhibit 3.2 LANDOS BIOPHARMA, INC. AMENDED AND RESTATED BYLAWS DATED AS OF MAY 23, 2024 ARTICLE I STOCKHOLDERS Section 1. Annual Meeting. An annual meeting of the stockholders, for the election of the directors to succeed those whose terms expire and for the transaction of such other business as may properly come before the meeting, shall be held at such place, on such date, and at such time as th

May 23, 2024 RW

Landos Biopharma, Inc. P.O. Box 11239 Blacksburg, VA 24062

Landos Biopharma, Inc. P.O. Box 11239 Blacksburg, VA 24062 May 23, 2024 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 RE: Landos Biopharma, Inc. Withdrawal of Registration Statement on Form S-3 File No. 333-263836 Ladies and Gentlemen: Pursuant to Rule 477 promulgated under the Securities Act of 1933, as amended (the “Se

May 9, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

April 25, 2024 DEFM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒   Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ De

April 16, 2024 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K/A (Amendment No. 1) (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRA

Table of Contents Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K/A (Amendment No.

April 15, 2024 EX-FILING FEES

CALCULATION OF FILING FEE TABLES Schedule 14A (Form Type) Landos Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Transaction Valuation  Proposed Maximum  Aggregate Value of Transaction Fee  Rate   Amount of  Filing Fee

EX-FILING FEES Exhibit 107 CALCULATION OF FILING FEE TABLES Schedule 14A (Form Type) Landos Biopharma, Inc.

April 15, 2024 PREM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒   Filed by a party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

April 10, 2024 SC 13D/A

LABP / Landos Biopharma, Inc. / PERCEPTIVE ADVISORS LLC - SC 13D/A Activist Investment

SC 13D/A 1 d770327dsc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 5)* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 515069201 (CUSIP Number) Alexander Rakitin Perceptive Advisors LLC 51 Astor Place, 10th Floor New York, NY 10003 (646) 205-534

April 10, 2024 SC 13D/A

LABP / Landos Biopharma, Inc. / Xontogeny, LLC - SC 13D/A Activist Investment

SC 13D/A 1 d773582dsc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 4)* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 515069201 (CUSIP Number) Christopher Garabedian Xontogeny, LLC 361 Newbury Street, Suite 501 Boston, MA 02115 (857) 891-0017 (

March 26, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant  ☒        Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Pr

March 25, 2024 EX-2.1

Agreement and Plan of Merger, dated as of March 24, 2024, by and among Landos Biopharma, Inc., AbbVie Inc., Bespin Subsidiary, LLC and Bespin Merger Sub, Inc.

Exhibit 2.1 AGREEMENT AND PLAN OF MERGER among: BESPIN SUBSIDIARY, LLC, BESPIN MERGER SUB, INC., LANDOS BIOPHARMA, INC., and ABBVIE INC., solely for the limited purposes set forth herein. Dated as of March 24, 2024 TABLE OF CONTENTS Page ARTICLE I THE MERGER 2 Section 1.1 The Merger 2 Section 1.2 Closing 2 Section 1.3 Effective Time 2 Section 1.4 Effects of the Merger 2 Section 1.5 Organizational

March 25, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant  ☒        Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Pr

March 25, 2024 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 24, 2024 Landos Biopharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39971 81-5085535 (State or other jurisdiction of incorporation) (Commission F

March 25, 2024 EX-99.1

AbbVie to Acquire Landos Biopharma, Further Strengthening its Portfolio in Inflammatory and Autoimmune Diseases

Exhibit 99.1 PRESS RELEASE AbbVie to Acquire Landos Biopharma, Further Strengthening its Portfolio in Inflammatory and Autoimmune Diseases – Landos’ lead asset, NX-13, is a first-in-class, oral NLRX1 agonist in Phase 2 for the treatment of ulcerative colitis (UC) NORTH CHICAGO, Ill. and NEW YORK, N.Y. March 25, 2024 – AbbVie Inc. (NYSE: ABBV) (“AbbVie”) and Landos Biopharma, Inc. (NASDAQ: LABP) (“

March 25, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 24, 2024 Landos Biopharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 24, 2024 Landos Biopharma, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39971 81-5085535 (State or other jurisdiction of incorporation) (Commission F

March 25, 2024 EX-10.1

Voting Agreement, dated as of March 24, 2024, by and among Landos Biopharma, Inc., Xontogeny, LLC and Perceptive Advisors LLC.

Exhibit 10.1 VOTING AGREEMENT This VOTING AGREEMENT (this “Agreement”) is being executed and delivered as of March 24, 2024 by and among Xontogeny, LLC, a Delaware limited liability company (together with its Affiliates, including those set forth on Schedule A, “Xontogeny”), Perceptive Advisors LLC, a Delaware limited liability company (together with its Affiliates, including those set forth on Sc

March 21, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2024 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission F

March 21, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Registration Statement on Form S-8 LANDOS BIOPHARMA, INC.

March 21, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

March 21, 2024 EX-99.1

Landos Biopharma Provides Business Update and Reports Fourth Quarter and Full Year 2023 Results Top-line Results from the NEXUS Phase 2 Clinical Trial of NX-13 for Ulcerative Colitis Planned for Q4 2024 Sufficient Cash to Fund Planned Operations into

Exhibit 99.1 Landos Biopharma Provides Business Update and Reports Fourth Quarter and Full Year 2023 Results Top-line Results from the NEXUS Phase 2 Clinical Trial of NX-13 for Ulcerative Colitis Planned for Q4 2024 Sufficient Cash to Fund Planned Operations into mid-2025 NEW YORK, March 21, 2024 –– Landos Biopharma, Inc. (NASDAQ: LABP) (“Landos” or “the Company”), a clinical-stage biopharmaceutic

March 21, 2024 EX-97.1

Landos Biopharma, Inc. Incentive Compensation Recoupment Policy

Exhibit 97.1 Landos Biopharma, Inc. Incentive Compensation Recoupment Policy 1. Introduction The Board of Directors (the “Board”) of Landos Biopharma, Inc., a Delaware corporation (the “Company”), has determined that it is in the best interests of the Company and its stockholders to adopt this Incentive Compensation Recoupment Policy (this “Policy”) providing for the Company’s recoupment of Recove

March 21, 2024 S-8

As filed with the Securities and Exchange Commission on March 21, 2024

As filed with the Securities and Exchange Commission on March 21, 2024 Registration Statement No.

February 14, 2024 SC 13G/A

LABP / Landos Biopharma, Inc. / Bassaganya-Riera Josep Passive Investment

SC 13G/A 1 formsc13ga.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Landos Biopharma, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 515069102 (CUSIP Number) December 31, 2023 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the

January 4, 2024 EX-99.1

Forward Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation, including statements regardi

January 2024 Clinical stage biopharmaceutical company focused on developing first-in-class, oral therapeutics for autoimmune disease Corporate Overview Exhibit 99.

January 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 04, 2024 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

November 21, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 21, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissio

November 21, 2023 EX-99.1

Landos Biopharma Publishes Results of NX-13 Phase 1b Study in Ulcerative Colitis in Journal of Crohn’s and Colitis NX-13, a Novel, Oral, NLRX1 Agonist, was Observed to be Well Tolerated and Demonstrated Early Signs of Rapid Symptomatic Relief and End

Exhibit 99.1 Landos Biopharma Publishes Results of NX-13 Phase 1b Study in Ulcerative Colitis in Journal of Crohn’s and Colitis NX-13, a Novel, Oral, NLRX1 Agonist, was Observed to be Well Tolerated and Demonstrated Early Signs of Rapid Symptomatic Relief and Endoscopic Improvement in Patients with Ulcerative Colitis NEXUS Phase 2 Proof-of-Concept Study is Ongoing, with Top-Line Readout Expected i

November 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

November 9, 2023 EX-99.1

Landos Biopharma Provides Company Update and Reports Third Quarter 2023 Results NEXUS Phase 2 Clinical Trial of NX-13 for Ulcerative Colitis Remains On Track with Top-line Results Planned for Q4 2024 Sufficient Cash to Fund Planned Operations into Fi

Exhibit 99.1 Landos Biopharma Provides Company Update and Reports Third Quarter 2023 Results NEXUS Phase 2 Clinical Trial of NX-13 for Ulcerative Colitis Remains On Track with Top-line Results Planned for Q4 2024 Sufficient Cash to Fund Planned Operations into First Half of 2025 NEW YORK, November 9, 2023 –– Landos Biopharma, Inc. (NASDAQ: LABP), a clinical-stage biopharmaceutical company developi

November 9, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 09, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissio

September 21, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 18, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissi

September 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 14, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissi

September 14, 2023 EX-99.1

Landos Biopharma Announces Strategic Research Collaboration with KU Leuven and University Hospitals Leuven to Further Characterize the Effects of NX-13 on Epithelial Cells Collaboration Will Focus on Defining the Effects Of NX-13 in Ulcerative Coliti

Exhibit 99.1 Landos Biopharma Announces Strategic Research Collaboration with KU Leuven and University Hospitals Leuven to Further Characterize the Effects of NX-13 on Epithelial Cells Collaboration Will Focus on Defining the Effects Of NX-13 in Ulcerative Colitis Patient Derived Organoid Models NEW YORK, September 14, 2023 –– Landos Biopharma, Inc. (NASDAQ: LABP), a clinical-stage biopharmaceutic

August 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

August 9, 2023 EX-99.1

Landos Biopharma Provides Business Update & Reports Second Quarter 2023 Results Initiated NEXUS Phase 2 Clinical Trial of NX-13 for Ulcerative Colitis NEXUS Remains On Track With Top-line Results Planned for Q4 2024 Sufficient Cash to Fund Planned Op

Exhibit 99.1 Landos Biopharma Provides Business Update & Reports Second Quarter 2023 Results Initiated NEXUS Phase 2 Clinical Trial of NX-13 for Ulcerative Colitis NEXUS Remains On Track With Top-line Results Planned for Q4 2024 Sufficient Cash to Fund Planned Operations into First Half of 2025 NEW YORK, August 9, 2023 –– Landos Biopharma, Inc. (NASDAQ: LABP), a clinical-stage biopharmaceutical co

August 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 09, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

May 30, 2023 EX-99.1

Landos Biopharma Expands Board of Directors with Appointment of Alka Batycky, Ph.D.

Exhibit 99.1 Landos Biopharma Expands Board of Directors with Appointment of Alka Batycky, Ph.D. NEW YORK, May 30, 2023 –– Landos Biopharma, Inc. (NASDAQ: LABP), a clinical-stage biopharmaceutical company developing novel, oral medicines for patients with autoimmune diseases, today announced the appointment of Alka Batycky, Ph.D. to its Board of Directors and Audit Committee. “Dr. Batycky is an ac

May 30, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 24, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 30, 2023 EX-3.1

Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K (File No. 001-39971), filed with the Securities and Exchange Commission on May 30, 2023).

Exhibit 3.1 LANDOS BIOPHARMA, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION Landos Biopharma, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Company”), does hereby certify as follows: FIRST: The name of the Company is Landos Biopharma, Inc. SECOND: The Company was originally formed as a corporation organized under the jurisdiction of the State of

May 25, 2023 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant, as currently in effect

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF LANDOS BIOPHARMA, INC. Landos Biopharma, Inc. (the “Company”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify that: First: The name of this corporation is Landos Biopharma, Inc., and the date on which the Ce

May 25, 2023 EX-99.1

Landos Biopharma Announces 1-for-10 Reverse Stock Split

Exhibit 99.1 Landos Biopharma Announces 1-for-10 Reverse Stock Split NEW YORK, May 25, 2023 –– Landos Biopharma, Inc. (NASDAQ: LABP), a clinical-stage biopharmaceutical company developing novel, oral medicines for patients with autoimmune diseases, today announced that it will effect a reverse stock split of its outstanding shares of common stock at a ratio of 1-for-10, to be effective as of 5:00

May 25, 2023 8-K

Regulation FD Disclosure, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2023 Landos Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware (State or Other Jurisdiction of Incorporation) 001-39971 (Commission File Number) 8

May 12, 2023 EX-10.1

Severance Agreement by and between the Company and Fabio Cataldi, effective as of September 5, 2022.

Exhibit 10.1 SEVERANCE AGREEMENT This Severance Agreement (the “Agreement”) is entered into effective September 5, 2022 (the “Effective Date”), by and between Landos Biopharma, Inc. (the “Company”), and Fabio Cataldi (the “Executive”). Whereas, the Company considers it important to foster the continuous employment of its key management personnel; and Whereas, the Company desires to provide the Exe

May 12, 2023 EX-99.2

Forward Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation, including statements regardi

May 2023 Clinical stage biopharmaceutical company focused on developing first-in-class, oral therapeutics for autoimmune disease Corporate Overview Exhibit 99.

May 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 12, 2023 EX-99.1

Landos Biopharma Provides Business Update and Reports First Quarter 2023 Results NEXUS Phase 2 Clinical Trial of NX-13 for Ulcerative Colitis Initiated NEXUS Top-line Results Planned for Q4 2024 Sufficient Cash to Fund Planned Operations into First H

Exhibit 99.1 Landos Biopharma Provides Business Update and Reports First Quarter 2023 Results NEXUS Phase 2 Clinical Trial of NX-13 for Ulcerative Colitis Initiated NEXUS Top-line Results Planned for Q4 2024 Sufficient Cash to Fund Planned Operations into First Half of 2025 NEW YORK, May 12, 2023 –– Landos Biopharma, Inc. (NASDAQ: LABP), a clinical-stage biopharmaceutical company developing novel,

May 12, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

April 19, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

April 10, 2023 PRE 14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

March 30, 2023 SC 13D/A

LABP / Landos Biopharma Inc / PERCEPTIVE ADVISORS LLC - SC 13D/A Activist Investment

SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 4)* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 515069 102 (CUSIP Number) Alexander Rakitin Perceptive Advisors LLC 51 Astor Place, 10th Floor New York, NY 10003 (646) 205-5340 (Name, Address and Telephon

March 30, 2023 SC 13D/A

LABP / Landos Biopharma Inc / Xontogeny, LLC - SC 13D/A Activist Investment

SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 515069 102 (CUSIP Number) Christopher Garabedian Xontogeny, LLC 240 Newbury Street, Suite 201 Boston, MA 02116 (857) 891-0017 (Name, Address and Telephone N

March 23, 2023 EX-10

First Amendment to License and Collaboration Agreement, by and between the Company and LianBio Respiratory Limited, dated February 28, 2023 (incorporated by reference to Exhibit 10.19 to the Company’s Annual Report on Form 10-K (File No. 001-39971), filed with the Securities and Exchange Commission on March 23, 2023).

Exhibit 10.19 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED FIRST AMENDMENT TO LICENSE AND COLLABORATION AGREEMENT THIS FIRST AMENDMENT TO THE LICENSE AND COLLABORATION AGREEMENT (this “Amendment”) is made as of February 28, 2023 (the “Amendment E

March 23, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Registration Statement on Form S-8 LANDOS BIOPHARMA, INC.

March 23, 2023 EX-10

Severance Agreement (pursuant to employment agreement) by and between the Company and Patrick Truesdell, effective as of December 8, 2022.

Exhibit 10.17 SEVERANCE AGREEMENT This Severance Agreement (the “Agreement”) is entered into effective December 8, 2022 (the “Effective Date”), by and between Landos Biopharma, Inc. (the “Company”), and Patrick Truesdell (the “Employee”). Whereas, the Company considers it important to foster the continuous employment of its key management personnel; and Whereas, the Company desires to provide the

March 23, 2023 EX-10

Offer Letter by and between the Company and Patrick Truesdell, effective as of May 3, 2022.

Exhibit 10.16 April 7th, 2022 Dear Patrick, I am pleased to confirm the offer of employment to you with Landos Biopharma (“Landos”) in the full-time position of Vice President, Controller. You are tentatively scheduled for a start date of May 3rd, 2022. Base Salary The initial annualized base salary for this position will be $300,000.00 which on a semi-monthly basis will be $12,500.00 (less applic

March 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 23, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission F

March 23, 2023 10-K

Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

March 23, 2023 EX-99

Landos Biopharma Provides Business Update and Reports Fourth Quarter and Full Year 2022 Results On Track to Initiate Phase 2 Proof-of-Concept Trial in Ulcerative Colitis for NX-13 in the Second Quarter of 2023 and Report Topline Results by the Fourth

Exhibit 99.1 Landos Biopharma Provides Business Update and Reports Fourth Quarter and Full Year 2022 Results On Track to Initiate Phase 2 Proof-of-Concept Trial in Ulcerative Colitis for NX-13 in the Second Quarter of 2023 and Report Topline Results by the Fourth Quarter of 2024 Projected Cash Runway into First Half of 2025 NEW YORK, March 23, 2023 –– Landos Biopharma, Inc. (NASDAQ: LABP), a clini

March 23, 2023 S-8

As filed with the Securities and Exchange Commission on March 23, 2023

As filed with the Securities and Exchange Commission on March 23, 2023 Registration Statement No.

March 23, 2023 EX-10

Offer Letter by and between the Company and Fabio Cataldi, effective as of September 5, 2022.

Exhibit 10.15 July 26, 2022 Fabio Cataldi 53 Preston Pl. Beverly, MA 01915 Re: Offer of Employment Dear Fabio, We are pleased to offer you employment with Landos Biopharma, Inc. (the “Company”), beginning on September 5, 2022. Position Your initial position will be Executive Vice President & Chief Medical Officer, performing such duties as are normally associated with this position and such duties

March 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Landos Biopharma,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission F

February 28, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissio

February 28, 2023 EX-99

This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation, including statements regarding our strategy, future ope

Corporate Overview February 28, 2023 Clinical stage biopharmaceutical company focused on the development of first-in-class therapeutics for patients with autoimmune disease.

February 28, 2023 EX-99

Landos Biopharma Announces Transfer of LANCL Portfolio, including Omilancor, LABP-104 and LABP-111 to Landos’ Founder Transaction Solidifies Company’s Near-Term Strategic Focus on Advancing Clinical Development of NX-13 Company Remains On-Track to In

Exhibit 99.2 Landos Biopharma Announces Transfer of LANCL Portfolio, including Omilancor, LABP-104 and LABP-111 to Landos’ Founder Transaction Solidifies Company’s Near-Term Strategic Focus on Advancing Clinical Development of NX-13 Company Remains On-Track to Initiate the NX-13 Phase 2 Proof-of-Concept Trial in Ulcerative Colitis in the Second Quarter of 2023 NEW YORK, February 28, 2023 – Landos

February 28, 2023 EX-99

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED ASSET PURCHASE AND REDEMPTION AGREEMENT

Exhibit 99.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED ASSET PURCHASE AND REDEMPTION AGREEMENT This Asset Purchase and Redemption Agreement (this “Agreement”) dated as of February 28, 2023 between Landos Biopharma, Inc. (“Landos” or “Seller”),

February 14, 2023 SC 13G/A

LABP / Landos Biopharma Inc / Bassaganya-Riera Josep Passive Investment

SC 13G/A 1 formsc13ga.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Landos Biopharma, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 515069102 (CUSIP Number) December 31, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the

January 13, 2023 EX-10.1

Amendment No. 1 to the Amended and Restated Investor’s Rights Agreement, dated January 10, 2023, by and between the Company and the investors that are a party thereto (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K (File No. 001-39971), filed with the Securities and Exchange Commission on January 13, 2023).

Exhibit 10.1 AMENDMENT NO. 1 TO THE AMENDED AND RESTATED INVESTOR’S RIGHTS AGREEMENT This AMENDMENT NO. 1 TO THE AMENDED AND RESTATED INVESTOR’S RIGHTS AGREEMENT (this “Amendment”) is made and entered into as of January 10, 2023 by and among Landos Biopharma, Inc., a Delaware corporation (the “Company”) and the Investors listed on the signature pages hereto, and amends that certain Amended and Res

January 13, 2023 SC 13D/A

LABP / Landos Biopharma Inc / PERCEPTIVE ADVISORS LLC - SC 13D/A Activist Investment

SC 13D/A 1 d361670dsc13da.htm SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 515069 102 (CUSIP Number) Alexander Rakitin Perceptive Advisors LLC 51 Astor Place, 10th Floor New York, NY 10003 (646) 205-53

January 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 10, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

January 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 05, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

January 5, 2023 EX-99.2

Corporate Overview January 5, 2023

Corporate Overview January 5, 2023 This presentation contains forward-looking statements that involve substantial risks and uncertainties.

January 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 04, 2023 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

January 5, 2023 EX-4.1

Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K (File No. 001-39971), filed with the Securities and Exchange Commission on January 5, 2023).

EX-4.1 2 labp-ex41.htm EX-4.1 Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PU

January 5, 2023 EX-99.1

Landos Biopharma Provides Comprehensive Update on Clinical Development Plans Advancing NX-13 Clinical Development for Treatment of Ulcerative Colitis On Track to Initiate Phase 2 Proof-of-Concept Trial for NX-13 in the Second Quarter of 2023 and Repo

Exhibit 99.1 Landos Biopharma Provides Comprehensive Update on Clinical Development Plans Advancing NX-13 Clinical Development for Treatment of Ulcerative Colitis On Track to Initiate Phase 2 Proof-of-Concept Trial for NX-13 in the Second Quarter of 2023 and Report Topline Data by the Fourth Quarter of 2024 Broader, Novel Pipeline Poised for Partnering and Continued Development in the Future; Sign

January 5, 2023 EX-99.1

Landos Biopharma Announces $16.7 Million Private Placement Financing

Exhibit 99.1 Landos Biopharma Announces $16.7 Million Private Placement Financing NEW YORK, January 5, 2023 ? Landos Biopharma, Inc. (NASDAQ: LABP) (?Landos? or the ?Company?), a clinical-stage biopharmaceutical company developing novel, oral medicines for patients with autoimmune diseases, today announced a $16.7 million private placement financing from the sale of pre-funded warrants to purchase

January 5, 2023 EX-10.1

Securities Purchase Agreement by and between the Company and the investors that are a party thereto, dated January 4, 2023 (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K (File No. 001-39971), filed with the Securities and Exchange Commission on January 5, 2023).

EX-10.1 3 labp-ex101.htm EX-10.1 Exhibit 10.1 SECURITIES Purchase AGREEMENT THIS SECURITIES PURCHASE AGREEMENT (the “Agreement”), dated as of January 4, 2023, by and between Landos Biopharma, Inc., a Delaware corporation (the “Company”), and the Purchasers identified on Schedule 1 attached hereto (together, the “Purchasers”). Capitalized terms used herein but not otherwise defined shall have the m

December 16, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 13, 2022 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissio

November 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

November 10, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2022 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissio

November 10, 2022 EX-99.1

Landos Biopharma Reports Third Quarter 2022 Results and Provides Business Update On Track to Complete Comprehensive Review of Clinical Development Plans in the Coming Weeks

Exhibit 99.1 Landos Biopharma Reports Third Quarter 2022 Results and Provides Business Update On Track to Complete Comprehensive Review of Clinical Development Plans in the Coming Weeks NEW YORK, November 10, 2022 –– Landos Biopharma, Inc. (NASDAQ: LABP), a clinical-stage biopharmaceutical company developing novel, oral medicines for patients with autoimmune diseases, today announced financial res

November 3, 2022 SC 13D/A

LABP / Landos Biopharma Inc / RTW INVESTMENTS, LP - LANDOS BIOPHARMA, INC. Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) Under the Securities Exchange Act of 1934 (Amendment No. 3) Landos Biopharma, Inc. (Name of Issuer) Common Stock, par value $0.01 per share (Title of Class of Securities) 515069102 (CUSIP Number) Ele

October 31, 2022 SC 13D/A

LABP / Landos Biopharma Inc / RTW INVESTMENTS, LP - LANDOS BIOPHARMA, INC. Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) Under the Securities Exchange Act of 1934 (Amendment No. 2) Landos Biopharma, Inc. (Name of Issuer) Common Stock, par value $0.01 per share (Title of Class of Securities) 515069102 (CUSIP Number) Ele

October 6, 2022 SC 13D/A

LABP / Landos Biopharma Inc / RTW INVESTMENTS, LP - LANDOS BIOPHARMA, INC. Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) Under the Securities Exchange Act of 1934 (Amendment No. 1) Landos Biopharma, Inc. (Name of Issuer) Common Stock, par value $0.01 per share (Title of Class of Securities) 515069102 (CUSIP Number) Ele

August 11, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2022 Landos Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

August 11, 2022 EX-99.2

Forward Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation, including statements regardi

NX-13 Phase 1b Clinical Trial Data AUGUST 2022 Exhibit 99.2 Forward Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation, including statements regarding our strategy, future operations, prospects, plans and objectives of management, are for

August 11, 2022 EX-10.2

Employment Agreement by and between the Company and Gregory Oakes, effective as of June 20, 2022 (incorporated by reference to Exhibit 10.2 to the Company’s Quarterly Report on Form 10-Q (File No. 001-39971), filed with the Securities and Exchange Commission on August 11, 2022).

Exhibit 10.2 EXECUTIVE EMPLOYMENT AGREEMENT This Executive Employment Agreement (the ?Agreement?) is entered into effective June 20, 2022 (the ?Effective Date?), by and between Gregory Oakes (the ?Executive?) and Landos Biopharma, Inc. (the ?Company?). The Company desires to employ the Executive and, in connection therewith, to compensate the Executive for Executive?s personal services to the Comp

August 11, 2022 EX-10.1

Separation and Release of Claims Agreement by and between the Company and Jyoti Chauhan, dated May 4, 2022.

Exhibit 10.1 Revised May 4, 2022 Jyoti Chauhan 42562 Magellan Square Brambleton, VA 20148 Re: Separation Agreement Dear Jyoti: This letter revises the letter sent to you on February 28, 2022, as initially revised on April 25, 2022, and sets forth the substance of the Separation Agreement (the ?Agreement?) which Landos Biopharma, Inc. (the ?Company?) is offering to you. 1. Separation. Your last day

August 11, 2022 EX-99.1

Landos Biopharma Reports Second Quarter 2022 Results and Provides Business Update Positive Top-Line Results From NX-13 Phase 1b Trial in Ulcerative Colitis Demonstrate a Favorable Safety and Tolerability Profile Across Range of Once-Daily Oral Doses,

Exhibit 99.1 Landos Biopharma Reports Second Quarter 2022 Results and Provides Business Update Positive Top-Line Results From NX-13 Phase 1b Trial in Ulcerative Colitis Demonstrate a Favorable Safety and Tolerability Profile Across Range of Once-Daily Oral Doses, as well as Promising Early Efficacy Signals Phase 2 Proof of Concept Clinical Trial for NX-13 in Ulcerative Colitis Planned On Track to

August 11, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

August 11, 2022 S-3/A

As filed with the Securities and Exchange Commission on August 11, 2022

As filed with the Securities and Exchange Commission on August 11, 2022 Registration No.

August 11, 2022 CORRESP

August 11, 2022

August 11, 2022 VIA EDGAR Michael Davis U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Landos Biopharma, Inc. Registration Statement on Form S-3 (File No. 333-263836), as amended by Amendment No. 1 Request for Acceleration of Effective Date Acceleration Request Requested Date: Monday, August 15, 2022 Requested Time: 8:00 a.m. E

August 9, 2022 SC 13D/A

LABP / Landos Biopharma Inc / Xontogeny, LLC - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 515069 102 (CUSIP Number) Christopher Garabedian Xontogeny, LLC 240 Newbury Street, Suite 201 Boston, MA 02116 (857) 891-0017 (Name, Address and Telephone Number of

August 9, 2022 EX-99.3

JOINT FILING AGREEMENT

Exhibit 3 JOINT FILING AGREEMENT The persons below hereby agree that the Schedule 13D to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13D, shall be filed jointly on behalf of each of them.

August 9, 2022 SC 13D/A

LABP / Landos Biopharma Inc / PERCEPTIVE ADVISORS LLC - SC 13D/A Activist Investment

SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 515069 102 (CUSIP Number) Alexander Rakitin Perceptive Advisors LLC 51 Astor Place, 10th Floor New York, NY 10003 (646) 205-5340 (Name, Address and Telephon

August 3, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2022 Landos Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission F

August 3, 2022 EX-99.1

Landos Biopharma Reports Positive Top-Line Results From NX-13 Phase 1b Trial NX-13 Demonstrated Favorable Safety and Tolerability Profile Across Range of Once-Daily Doses Results Indicate Promising Early Signals Regarding the Efficacy of NX-13 Phase

Exhibit 99.1 Landos Biopharma Reports Positive Top-Line Results From NX-13 Phase 1b Trial NX-13 Demonstrated Favorable Safety and Tolerability Profile Across Range of Once-Daily Doses Results Indicate Promising Early Signals Regarding the Efficacy of NX-13 Phase 2 Proof of Concept Clinical Trial in Ulcerative Colitis Planned NEW YORK, August 3, 2022— Landos Biopharma, Inc. (NASDAQ: LABP), a clinic

June 21, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 17, 2022 Landos Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fi

June 17, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2022 Landos Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fi

June 13, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2022 Landos Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 19, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2022 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 18, 2022 CORRESP

May 18, 2022

May 18, 2022 VIA EDGAR Michael Davis U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Request to Withdraw Acceleration Request of Landos Biopharma, Inc., (the ?Company?), dated May 16, 2022 for the Registration Statement on Form S-3 (File No. 333-263836) Dear Mr. Davis, On behalf of the Company, I hereby formally request the with

May 16, 2022 CORRESP

May 16, 2022

CORRESP 1 filename1.htm May 16, 2022 VIA EDGAR Michael Davis Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Landos Biopharma, Inc. Registration Statement on Form S-3; File No. 333-263836 Acceleration Request Requested Date: Wednesday, May 18, 2022 Requested Time: 4:00 p.m. Eastern Time Dear Mr. Davis: In accordance with Rule 461 under

May 12, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

May 12, 2022 EX-99.1

Landos Biopharma Reports First Quarter 2022 Results and Provides Business Update On Track to Complete Review of Clinical Development Plans by Mid-2022 Top-Line Results for NX-13 Phase 1b and LABP-104 Phase 1 Trials Remain On Track for Mid-2022 Plans

Exhibit 99.1 FOR IMMEDIATE RELEASE Landos Biopharma Reports First Quarter 2022 Results and Provides Business Update On Track to Complete Review of Clinical Development Plans by Mid-2022 Top-Line Results for NX-13 Phase 1b and LABP-104 Phase 1 Trials Remain On Track for Mid-2022 Plans to Announce Timing of Phase 2b Trial of Omilancor Later this Year NEW YORK, May 12, 2022 ?? Landos Biopharma, Inc.

May 12, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2022 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

April 28, 2022 DEFA14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 28, 2022 DEF 14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 26, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 20, 2022 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission F

April 6, 2022 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 5, 2022 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fi

March 24, 2022 EX-99.1

Landos Biopharma Reports Fourth Quarter and Full Year 2021 Results and Provides Business Update Continued Progress Towards Optimizing Clinical Development Plans On Track to Initiate Phase 2b Study of Omilancor in Ulcerative Colitis Later this Year Co

Exhibit 99.1 Landos Biopharma Reports Fourth Quarter and Full Year 2021 Results and Provides Business Update Continued Progress Towards Optimizing Clinical Development Plans On Track to Initiate Phase 2b Study of Omilancor in Ulcerative Colitis Later this Year Completed Enrollment of Phase 1b Trial of NX-13 in Ulcerative Colitis and Phase 1a Trial of LABP-104 in Normal Healthy Volunteers; Top Line

March 24, 2022 EX-4.4

Form of Common Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.4 LANDOS BIOPHARMA, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF LANDOS BIOPHARMA, INC. FORM OF COMMON STOCK WARRANT AGREEMENT THIS COMMON STOCK WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between LANDOS BIOPHARMA, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking association] organized and existing under

March 24, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

March 24, 2022 EX-10.8

Employment Agreement by and between the Company and Tim M. Mayleben, effective as of December 17, 2021.

Exhibit 10.8 EMPLOYMENT AGREEMENT This Employment Agreement (this ?Agreement?) is made as of December 17, 2021 (the ?Effective Date?) by and between Landos Biopharma, Inc. (the ?Company?) and Tim M. Mayleben (the ?Executive?). 1. Employment. The Company and the Executive desire that the Executive be employed as the Company?s Chief Executive Officer on an interim basis. The employment relationship

March 24, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 24, 2022 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission F

March 24, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Registration Statement on Form S-8 LANDOS BIOPHARMA, INC.

March 24, 2022 EX-10.9

EX-10.9

March 24, 2022 EX-10.8

EX-10.8

March 24, 2022 S-8

As filed with the Securities and Exchange Commission on March 24, 2022

As filed with the Securities and Exchange Commission on March 24, 2022 Registration No.

March 24, 2022 EX-99.3

2022 Inducement Plan and Forms of Stock Option Grant Notice and Option Agreements thereunder

Exhibit 99.3 LANDOS BIOPHARMA, INC. 2022 INDUCEMENT PLAN 1. Purposes of the Plan. The only persons eligible to receive grants of Awards under this Plan are individuals who satisfy the standards for inducement grants under NASDAQ Marketplace Rule 5635(c)(4) or 5635(c)(3), if applicable, and the related guidance under NASDAQ IM 5635-1. A person who previously served as an Employee or Director will n

March 24, 2022 EX-4.6

Form of Debt Securities Warrant Agreement and Warrant Certificate.

Exhibit 4.6 LANDOS BIOPHARMA, INC. AND [], AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OF [] LANDOS BIOPHARMA, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT THIS DEBT SECURITIES WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between LANDOS BIOPHARMA, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking association] organized and

March 24, 2022 EX-4.5

Form of Preferred Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.5 LANDOS BIOPHARMA, INC. AND [], AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF LANDOS BIOPHARMA, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT THIS PREFERRED STOCK WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between LANDOS BIOPHARMA, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking association] organized and exi

March 24, 2022 EX-FILING FEES

Calculation of Filing Fee Tables

Exhibit 107 Calculation of Filing Fee Tables Registration Statement on Form S-3 LANDOS BIOPHARMA, INC.

March 24, 2022 EX-10.7

Separation and Release of Claims Agreement by and between the Company and Josep Bassaganya-Riera, dated November 6, 2021.

Exhibit 10.7 SEPARATION AND RELEASE OF CLAIMS AGREEMENT This Separation and Release of Claims Agreement (the ?Agreement?) is entered into by and between Landos Biopharma, Inc. (the ?Company?) and Josep Bassaganya-Riera (?Executive?) (together, the ?Parties?). WHEREAS, the Company and Executive are parties to the Employment Agreement dated as of January 1, 2020 (the ?Employment Agreement?); WHEREAS

March 24, 2022 EX-10.7

EX-10.7

March 24, 2022 EX-10.9

Employment Agreement by and between the Company and Patricia L. Bitar, effective as of December 17, 2021.

Exhibit 10.9 EMPLOYMENT AGREEMENT This Employment Agreement (this ?Agreement?) is made as of December 17, 2021 (the ?Effective Date?) by and between Landos Biopharma, Inc. (the ?Company?) and Patricia Bitar (the ?Executive?). 1. Employment. The Company and the Executive desire that the Executive be employed as the Company?s Chief Financial Officer on an interim basis. The employment relationship b

March 24, 2022 S-3

As filed with the Securities and Exchange Commission on March 24, 2022

Table of Contents As filed with the Securities and Exchange Commission on March 24, 2022 Registration No.

March 24, 2022 EX-4.2

Form of Indenture, between the Registrant and one or more trustees to be named.

Table of Contents Exhibit 4.2 LANDOS BIOPHARMA, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [?], 20 Debt Securities Table of Contents TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.01 Designation and Terms of Securities 4 Section 2.02 Form of Securit

March 10, 2022 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 8, 2022 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fi

March 10, 2022 EX-99.1

Landos Biopharma Appoints Roger Adsett to its Board of Directors

Exhibit 99.1 FOR IMMEDIATE RELEASE Landos Biopharma Appoints Roger Adsett to its Board of Directors BLACKSBURG, Va., March 10, 2022 ? Landos Biopharma, Inc. (NASDAQ: LABP), a clinical-stage biopharmaceutical company developing novel, oral medicines for patients with autoimmune diseases, today announced that it has appointed Roger Adsett to the Company?s Board of Directors, effective March 8, 2022.

February 14, 2022 SC 13G

LABP / Landos Biopharma Inc / Bassaganya-Riera Josep Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Landos Biopharma, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 515069102 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this S

February 3, 2022 SC 13G

LABP / Landos Biopharma Inc / Osage University GP III, LLC - SC 13G Passive Investment

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* LANDOS BIOPHARMA, INC. (Name of Issuer) Common Stock, $0.01 par value per share (Title of Class of Securities) 515069 102 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designat

February 3, 2022 EX-99.1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned, and any amendments thereto executed by the undersigned shall be filed on behalf of each of the undersigned without the necessity of filing any additional joint filing agreement.

January 13, 2022 8-K

Regulation FD Disclosure, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2022 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

December 21, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 17, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissio

November 15, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 15, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissio

November 15, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

November 15, 2021 EX-99.1

Landos Biopharma Reports Third Quarter 2021 Financial Results and Provides Corporate Update Enhancing Focus on High-Impact Clinical-Stage Programs to Ensure Optimal Path to Commercialization Refining Ulcerative Colitis Clinical Development Plans for

Exhibit 99.1 Landos Biopharma Reports Third Quarter 2021 Financial Results and Provides Corporate Update Enhancing Focus on High-Impact Clinical-Stage Programs to Ensure Optimal Path to Commercialization Refining Ulcerative Colitis Clinical Development Plans for Omilancor to Generate Additional Phase 2b Data Prior to Initiating Pivotal Phase 3 Program Determining Optimal Enrollment for Phase 2 Cli

November 10, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 6, 2021 Landos Biopharma, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

November 3, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported) November 2, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

November 3, 2021 EX-99.1

Landos Biopharma Announces FDA Clearance of its IND for

Exhibit 99.1 Landos Biopharma Announces FDA Clearance of its IND for LABP-104 for the Treatment of Rheumatoid Arthritis Phase 1 trial is underway with topline results expected in the first half of 2022 Represents Landos? seventh IND cleared overall and the second IND cleared for LABP-104, a potentially first-in-class therapeutic candidate for systemic lupus erythematosus and rheumatoid arthritis B

October 28, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported) October 28, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

October 28, 2021 EX-99.1

Topline results are expected in the first half of 2022 A whole blood LABP-104 precision medicine signature will be assessed during the trial

Exhibit 99.1 Landos Biopharma Announces First Subject Dosed in a Phase 1 Study of LABP-104 for Systemic Lupus Erythematosus October 28, 2021 Topline results are expected in the first half of 2022 A whole blood LABP-104 precision medicine signature will be assessed during the trial BLACKSBURG, Va., Oct. 28, 2021 (GLOBE NEWSWIRE) ? Landos Biopharma, Inc. (NASDAQ: LABP), a late-clinical-stage biophar

October 12, 2021 EX-99.1

Phase 1 trial initiation expected before yearend with topline results in 1H 2022

Exhibit 99.1 Landos Biopharma Announces FDA Clearance of its IND for LABP-104 for the Treatment of Systemic Lupus Erythematosus October 11, 2021 Phase 1 trial initiation expected before yearend with topline results in 1H 2022 BLACKSBURG, Va., Oct. 11, 2021 (GLOBE NEWSWIRE) ? Landos Biopharma, Inc. (NASDAQ: LABP), a late clinical-stage biopharmaceutical company utilizing its LANCE? Advanced A.I. pl

October 12, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported) October 11, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

October 8, 2021 EX-99.1

Landos Biopharma Announces Publication in Scientific Reports of Novel Preclinical Findings Demonstrating Omilancor’s Therapeutic Potential in Models of Psoriasis and Further Validating the LANCL2 Mechanism

Exhibit 99.1 Landos Biopharma Announces Publication in Scientific Reports of Novel Preclinical Findings Demonstrating Omilancor?s Therapeutic Potential in Models of Psoriasis and Further Validating the LANCL2 Mechanism BLACKSBURG, Va., Oct. 06, 2021 ? Landos Biopharma, Inc. (NASDAQ: LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE? Advanced A.I. platform to discover and d

October 8, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported) October 6, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission f

September 22, 2021 EX-99.1

Landos Biopharma to Collaborate on a Phase 2 Study of Omilancor in Crohn’s Disease with the Icahn School of Medicine at Mount Sinai Second Phase 2 trial of omilancor in Crohn’s disease (CD), expected to initiate in 2021 Awarded a $3 million NIH R01 g

Exhibit 99.1 Landos Biopharma to Collaborate on a Phase 2 Study of Omilancor in Crohn?s Disease with the Icahn School of Medicine at Mount Sinai Second Phase 2 trial of omilancor in Crohn?s disease (CD), expected to initiate in 2021 Awarded a $3 million NIH R01 grant from the U.S. National Institute of Diabetes and Digestive and Kidney Diseases to fund this study BLACKSBURG, Va., September 20, 202

September 22, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported) September 20, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissio

September 17, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported) September 15, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commissio

September 17, 2021 EX-99.1

Landos Biopharma to Present Results of LABP-104 in Lupus at the American College of Rheumatology Convergence 2021 Oral treatment with LABP-104 in preclinical models of Systemic Lupus Erythematosus (SLE) resulted in enhanced Treg function, decreased k

EX-99.1 2 d202757dex991.htm EX-99.1 Exhibit 99.1 Landos Biopharma to Present Results of LABP-104 in Lupus at the American College of Rheumatology Convergence 2021 Oral treatment with LABP-104 in preclinical models of Systemic Lupus Erythematosus (SLE) resulted in enhanced Treg function, decreased kidney inflammation and reduced interferon gamma signaling; Phase 1 clinical trial anticipated to begi

August 27, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 27, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

August 26, 2021 EX-99.1

Landos Biopharma Announces Research Collaboration into the NLRX1 Pathway in Multiple Sclerosis with Johns Hopkins University School of Medicine

Exhibit 99.1 Landos Biopharma Announces Research Collaboration into the NLRX1 Pathway in Multiple Sclerosis with Johns Hopkins University School of Medicine BLACKSBURG, Va., August 26, 2021 ? Landos Biopharma, Inc. (NASDAQ: LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE? Advanced A.I. platform to develop novel oral therapeutics for patients with autoimmune diseases, tod

August 26, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 26, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission

August 2, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 29, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fi

August 2, 2021 EX-99.1

Landos Biopharma Reports Second Quarter 2021 Financial Results and Provides Business Updates Following the recent positive End-of-Phase 2 meeting with the FDA, Landos initiated global pivotal Phase 3 clinical trial site feasibility studies of omilanc

EX-99.1 2 d209827dex991.htm EX-99.1 Exhibit 99.1 Landos Biopharma Reports Second Quarter 2021 Financial Results and Provides Business Updates Following the recent positive End-of-Phase 2 meeting with the FDA, Landos initiated global pivotal Phase 3 clinical trial site feasibility studies of omilancor in ulcerative colitis (UC) Initiated enrollment of Phase 2 trial of omilancor in Crohn’s Disease (

July 29, 2021 EX-1.1

Exclusive Collaboration and License Agreement by and between the Company and Lian Respiratory Limited, dated May 14, 2021 (incorporated by reference to Exhibit 1.1 to the Company’s Quarterly Report on Form 10-Q (File No. 001-39971), filed with the Securities and Exchange Commission on July 29, 2021).

Exhibit 1.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED LICENSE AND COLLABORATION AGREEMENT THIS LICENSE AND COLLABORATION AGREEMENT (this ?Agreement?), entered into as of May 14, 2021 (the ?Effective Date?), is entered into by and between LianB

July 29, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

July 22, 2021 EX-99.1

Landos Biopharma’s Phase 2 Data of Omilancor in Ulcerative Colitis Accepted for Oral Presentation at the United European Gastroenterology Week 2021 Omilancor shows efficacy and tolerability as a potential once-daily, oral, gut-restricted therapy for

Exhibit 99.1 Landos Biopharma?s Phase 2 Data of Omilancor in Ulcerative Colitis Accepted for Oral Presentation at the United European Gastroenterology Week 2021 Omilancor shows efficacy and tolerability as a potential once-daily, oral, gut-restricted therapy for mild-to-moderate UC patients Following the recent positive End-of-Phase 2 meeting with the FDA, Landos initiated clinical trial site feas

July 22, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 22, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fi

June 14, 2021 EX-99.1

Landos Biopharma Announces Positive Outcome of

Exhibit 99.1 Landos Biopharma Announces Positive Outcome of End-of-Phase 2 Meeting with the FDA for Omilancor in Mild-to-Moderate Active Ulcerative Colitis (UC) Patients The FDA clears the path to initiate the PACIFY I and II global registration studies in Mild-to-Moderate Active UC patients representing the potential for a broad product label for Omilancor BLACKSBURG, Va., June 14, 2021 (GLOBE NE

June 14, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 19, 2021 EX-99.1

Landos Biopharma Announces the Appointment of Tim M. Mayleben to its Board of Directors

Exhibit 99.1 Landos Biopharma Announces the Appointment of Tim M. Mayleben to its Board of Directors BLACKSBURG, Va., May 19 2021 ? Landos Biopharma, Inc (NASDAQ: LABP), a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutics for patients with autoimmune diseases, today announced the appointment of Tim M. Mayleben to its Board of Directors. Mr. Mayleben

May 19, 2021 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 17, 2021 EX-99.2

Landos Biopharma and LianBio Announce Exclusive Collaboration and License Agreement to Develop and Commercialize Omilancor and NX-13 in Greater China and Select Asian Markets

Exhibit 99.2 Landos Biopharma and LianBio Announce Exclusive Collaboration and License Agreement to Develop and Commercialize Omilancor and NX-13 in Greater China and Select Asian Markets Blacksburg, Va., & Shanghai, China and Princeton, N.J., May 17, 2021 - Landos Biopharma, Inc (NASDAQ: LABP), a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutics for

May 17, 2021 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 17, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

May 17, 2021 S-8

Form S-8

S-8 1 d137526ds8.htm S-8 As filed with the Securities and Exchange Commission on May 17, 2021 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Landos Biopharma, Inc. (Exact name of Registrant as specified in its charter) Delaware 81-5085535 (State or other jurisdiction of incorporation or

May 17, 2021 EX-99.1

Landos Biopharma Reports First Quarter 2021 Financial Results and Provides Business Updates Completed initial public offering of common stock, raising approximately $100 million in gross proceeds Following positive Phase 2 results of omilancor in ulc

Exhibit 99.1 Landos Biopharma Reports First Quarter 2021 Financial Results and Provides Business Updates Completed initial public offering of common stock, raising approximately $100 million in gross proceeds Following positive Phase 2 results of omilancor in ulcerative colitis, including statistically significant immunological and biomarker results, end-of-Phase 2 Meeting with FDA planned for Q2

May 7, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 6, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission File

May 7, 2021 EX-99.1

Landos Biopharma Announces First Patient Dosed in a Phase 2 Study of Omilancor for Moderate-to-Severe Crohn’s Disease Company’s second omilancor program entering a Phase 2 study with plans to pursue at least five autoimmune indications Topline result

EX-99.1 2 d146305dex991.htm EX-99.1 Exhibit 99.1 Landos Biopharma Announces First Patient Dosed in a Phase 2 Study of Omilancor for Moderate-to-Severe Crohn’s Disease Company’s second omilancor program entering a Phase 2 study with plans to pursue at least five autoimmune indications Topline results are expected in the second quarter of 2022 BLACKSBURG, VA., May 6, 2021 – Landos Biopharma (NASDAQ:

April 29, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 29, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission F

April 29, 2021 EX-99.1

Landos Biopharma Announces First Patient Dosed in a Phase 1b Study of NX-13 for Ulcerative Colitis Landos’ second first-in-class product candidate designed to provide a safer and more convenient treatment for ulcerative colitis patients Topline resul

Exhibit 99.1 Landos Biopharma Announces First Patient Dosed in a Phase 1b Study of NX-13 for Ulcerative Colitis Landos? second first-in-class product candidate designed to provide a safer and more convenient treatment for ulcerative colitis patients Topline results are expected in the first quarter of 2022 BLACKSBURG, Va., April 29, 2021- Landos Biopharma (NASDAQ: LABP), a clinical-stage biopharma

April 13, 2021 EX-99.1

Landos Biopharma Announces the Appointment of Tiago Girão to its Board of Directors

EX-99.1 2 d127292dex991.htm EX-99.1 EXHIBIT 99.1 Landos Biopharma Announces the Appointment of Tiago Girão to its Board of Directors BLACKSBURG, Va., April 13, 2021 — Landos Biopharma (NASDAQ: LABP), a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutics for patients with autoimmune diseases, today announced the appointment of Tiago Girão to its Board o

April 13, 2021 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 8, 2021 Landos Biopharma, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commission Fi

April 6, 2021 SC 13D/A

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) (CUSIP Number)

SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 515069 102 (CUSIP Number) Alexander Rakitin Perceptive Advisors LLC 51 Astor Place, 10th Floor New York, NY 10003 (646) 205-5340 (Name, Address and Telephon

March 31, 2021 EX-10.6

Non-Employee Director Compensation Policy (incorporated by reference to Exhibit 10.6 to the Company’s Annual Report on Form 10-K (File No. 001-39971), filed with the Securities and Exchange Commission on March 31, 2021).

Exhibit 10.6 LANDOS BIOPHARMA, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY APPROVED BY THE BOARD OF DIRECTORS ON March 30, 2021 Each member of the Board of Directors (the ?Board?) of Landos Biopharma, Inc. (the ?Company?) who is a non-employee director of the Company (each such member, a ?Non-Employee Director?) will receive the compensation described in this Non-Employee Director Compensation

March 31, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39971 Landos Biopharma, Inc.

March 31, 2021 EX-4.2

Description of the Company’s Common Stock (incorporated by reference to Exhibit 4.2 to the Company’s Annual Report on Form 10-K (File No. 001-39971), filed with the Securities and Exchange Commission on March 31, 2021).

Exhibit 4.2 DESCRIPTION OF LANDOS BIOPHARMA, INC. COMMON STOCK The following description of the common stock of Landos Biopharma, Inc., or the Company, and certain provisions of the Company?s amended and restated certificate of incorporation, or the restated certificate, and amended and restated bylaws, or restated bylaws, are summaries. These summaries are qualified in the entirety by reference t

February 18, 2021 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 Exhibit 1 JOINT FILING AGREEMENT The persons below hereby agree that the Schedule 13D to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13D, shall be filed jointly on behalf of each of them. This agreement is intended to satisfy the requirements of Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934. Dated: February 18, 2021 PE

February 18, 2021 SC 13D

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment )* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) (CUSIP Number) Alexand

SC 13D SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment )* Landos Biopharma, Inc. (Name of Issuer) Common Stock, $0.01 par value (Title of Class of Securities) 515069 102 (CUSIP Number) Alexander Rakitin Perceptive Advisors LLC 51 Astor Place, 10th Floor New York, NY 10003 (646) 205-5340 (Name, Address and Telephone Number

February 16, 2021 SC 13D

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. N/A)* LANDOS BIOPHARMA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) (CUSIP Number) RTW

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. N/A)* LANDOS BIOPHARMA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 515069102 (CUSIP Number) RTW Investments, LP Attn: Roderick Wong 40 10th Avenue, Floor 7, New York, New York 10014 (Name, Address and Telephone Number of Person Authori

February 16, 2021 EX-2

Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities and Exchange Act of 1934, as amended.

Exhibit 2 Joint Filing Statement Pursuant to Rule 13d-1(k)(1) The undersigned hereby consent and agree to the joint filing of Schedule 13D under the Securities Exchange Act of 1934, as amended, with respect to the Common Stock of Landos Biopharma, Inc.

February 8, 2021 EX-3.1

Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K (File No. 00139971), filed with the Securities and Exchange Commission on February 8, 2021).

EX-3.1 Exhibit 3.1 LANDOS BIOPHARMA, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION Landos Biopharma, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Company”), does hereby certify as follows: FIRST: The name of the Company is Landos Biopharma, Inc. SECOND: The Company was originally formed as a corporation organized under the jurisdiction of the St

February 8, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 8, 2021 Landos Biopharma, Inc. (Exact name of registrant as specified in its Charter) Delaware 001-39971 81-5085535 (State or Other Jurisdiction of Incorporation) (Commis

February 4, 2021 424B4

Raymond James

424B4 Table of Contents Filed Pursuant to Rule 424(b)(4) Registration No. 333-252083 Prospectus 6,250,000 shares Common stock This is an initial public offering of shares of common stock Landos Biopharma, Inc. We are offering 6,250,000 shares of our common stock. The initial public offering price is $16.00 per share. Prior to this offering, there has been no public market for our common stock. Our

February 1, 2021 CORRESP

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VIA EDGAR February 1, 2021 Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

February 1, 2021 8-A12B

- 8-A12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Landos Biopharma, Inc. (Exact name of registrant as specified in its charter) Delaware 81-5085535 (State of incorporation or organization) (I.R.S. Employer Identification No.) 1800 Kraft Drive, Sui

February 1, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant, as amended (currently in effect)

Exhibit 3.1 Execution Version AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF LANDOS BIOPHARMA INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Landos Biopharma Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation Law”), DOES HEREBY CERTI

February 1, 2021 CORRESP

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LANDOS BIOPHARMA, INC. 1800 Kraft Drive, Suite 216 Blacksburg, VA 24060 Februaruy 1, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Jenn Do Kevin Kuhar Christopher Edwards Alan Campbell RE: Landos Biopharma, Inc. Registration Statement on Form S-1 File No. 333-252083 Acceleration Request Requested Date

February 1, 2021 CORRESP

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Eric Blanchard +1 212 479 6565 [email protected] February 1, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attn: Jenn Do Kevin Kuhar Christopher Edwards Alan Campbell Re: Landos Biopharma, Inc. Amendment No. 1 to Registration Statement on Form S-1 Filed January 28, 2021 File No. 333-252083 Ladies and Gentlemen: On behalf of

February 1, 2021 S-1/A

- S-1/A

S-1/A Table of Contents As filed with the Securities and Exchange Commission on February 1, 2021 Registration No.

January 28, 2021 EX-10.3

Form of Indemnification Agreement with Executive Officers and Directors (incorporated by reference to Exhibit 10.3 to the Company’s Registration Statement on Form S-1 (File No. 333-252083), filed with the Securities and Exchange Commission on January 28, 2021).

EX-10.3 Exhibit 10.3 LANDOS BIOPHARMA, INC. INDEMNIFICATION AGREEMENT This Indemnification Agreement (this “Agreement”) is dated as of , 2021, and is between Landos Biopharma, Inc., a Delaware corporation (the “Company”), and [ ] (“Indemnitee”). RECITALS A. Indemnitee’s service to the Company substantially benefits the Company. B. Individuals are reluctant to serve as directors or officers of corp

January 28, 2021 EX-1.1

Form of Underwriting Agreement

EX-1.1 Exhibit 1.1 UNDERWRITING AGREEMENT Landos Biopharma, Inc. Shares of Common Stock Underwriting Agreement [ 🌑 ], 2021 J.P. MORGAN SECURITIES LLC JEFFERIES LLC SVB LEERINK LLC As Representatives of the several Underwriters listed in Schedule 1 hereto c/o J.P. Morgan Securities LLC 383 Madison Avenue New York, New York 10179 c/o Jefferies LLC 520 Madison Avenue New York, New York 10022 c/o SVB

January 28, 2021 EX-10.2

2019 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.2 to the Company’s Registration Statement on Form S-1 (File No. 333-252083), filed with the Securities and Exchange Commission on January 28, 2021).

EX-10.2 Exhibit 10.2 Privileged and Confidential FINAL LANDOS BIOPHARMA, INC. 2019 EQUITY INCENTIVE PLAN 1. Purposes of the Plan. The purposes of the Plan are to attract and retain the best available personnel, to provide additional incentives to Employees, Directors, and Consultants and to promote the success of the business of the Company. 2. Definitions. The following definitions shall apply as

January 28, 2021 S-1/A

- S-1/A

S-1/A Table of Contents As filed with the Securities and Exchange Commission on January 28, 2021 Registration No.

January 28, 2021 CORRESP

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CORRESP 1 filename1.htm Eric Blanchard +1 212 479 6565 [email protected] January 28, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attn: Jenn Do Kevin Kuhar Christopher Edwards Alan Campbell Re: Landos Biopharma, Inc. Registration Statement on Form S-1 Filed January 13, 2021 File No. 333-252083 Ladies and Gentlemen: On beha

January 28, 2021 EX-10.5

2021 Employee Stock Purchase Plan

EX-10.5 Exhibit 10.5 LANDOS BIOPHARMA, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN ADOPTED BY THE BOARD OF DIRECTORS: [], 2021 APPROVED BY THE STOCKHOLDERS: [], 2021 1. GENERAL; PURPOSE. (a) The Plan provides a means by which Eligible Employees of the Company and certain designated Related Corporations may be given an opportunity to purchase shares of Common Stock. The Plan permits the Company to grant

January 28, 2021 EX-3.4

Amended and Restated Bylaws (incorporated by reference to Exhibit 3.4 to the Company’s to the Company’s Registration Statement on Form S-1 (File No. 333-252083), filed with the Securities and Exchange Commission on January 28, 2021).

EX-3.4 Exhibit 3.4 LANDOS BIOPHARMA, INC. AMENDED AND RESTATED BYLAWS ARTICLE I OFFICES Section 1. Registered Office. The registered office shall be established and maintained at the office of Corporation Trust Center, 1209 Orange Street, in the City of Wilmington, in the County of New Castle, in the State of Delaware, 19801 and said corporation, or other such person or entity as the Board of Dire

January 28, 2021 EX-3.3

Form of Amended and Restated Certificate of Incorporation of the Registrant (to be effective upon the closing of this offering)

EX-3.3 Exhibit 3.3 LANDOS BIOPHARMA, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION Landos Biopharma, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Company”), does hereby certify as follows: FIRST: The name of the Company is Landos Biopharma, Inc. SECOND: The Company was originally formed as a corporation organized under the jurisdiction of the St

January 13, 2021 CORRESP

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CORRESP 1 filename1.htm Eric Blanchard +1 212 479 6565 [email protected] January 13, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attn: Jenn Do Kevin Kuhar Christopher Edwards Alan Campbell Re: Landos Biopharma, Inc. Amendment No. 2 to Draft Registration Statement on Form S-1 Submitted November 30, 2020 CIK No. 0001785345

January 13, 2021 EX-10.1

Amended and Restated Investors’ Rights Agreement, by and among the Company and certain of its stockholders, dated August 9, 2019 (incorporated by reference to Exhibit 10.1 to the Company’s Registration Statement on Form S-1 (File No. 333-252083), filed with the Securities and Exchange Commission on January 13, 2021).

EX-10.1 Exhibit 10.1 Execution Version AMENDED AND RESTATED INVESTOR’S RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTOR’S RIGHTS AGREEMENT (this “Agreement”), is made as of the 9th day of August, 2019, by and among Landos Biopharma, Inc., a Delaware corporation (the “Company”), and each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an “Investor”

January 13, 2021 EX-3.2

Bylaws of the Registrant (currently in effect)

EX-3.2 Exhibit 3.2 LANDOS BIOPHARMA, INC. BYLAWS (the “Corporation”) These Bylaws have been approved by the Board of Directors of the Corporation. ARTICLE I Stockholders 1. Annual Meeting. The annual meeting of stockholders shall be held each year at the place, date and time determined by the Board of Directors or the President. The purposes for which the annual meeting is to be held, in addition

January 13, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant (currently in effect)

EX-3.1 Exhibit 3.1 Execution Version AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF LANDOS BIOPHARMA INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Landos Biopharma Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation Law”), DOES HEREB

January 13, 2021 S-1

Power of Attorney (included on signature page)

S-1 Table of Contents As filed with the Securities and Exchange Commission on January 13, 2021 Registration No.

January 13, 2021 EX-10.4

Employment Agreement by and between the Registrant and Dr. Josep Bassaganya-Riera, effective as of January 1, 2020 (incorporated by reference to Exhibit 10.4 to the Company’s Registration Statement on Form S-1 (File No. 333-252083), filed with the Securities and Exchange Commission on January 13, 2021).

EX-10.4 Exhibit 10.4 EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”), made effective as of January 1, 2020 (“Effective Date”), by and between Landos Biopharma, Inc. (the “Company”), and Dr. Josep Bassaganya-Riera (“Employee”) provides: Employee founded the Company on January 6th of 2017 and has been serving as the Chairman of the Board, President, and Chief Executive Officer (“CEO

December 1, 2020 EX-10.4

EMPLOYMENT AGREEMENT

Exhibit 10.4 EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?), made effective as of January 1, 2020 (?Effective Date?), by and between Landos Biopharma, Inc. (the ?Company?), and Dr. Josep Bassaganya-Riera (?Employee?) provides: Employee founded the Company on January 6th of 2017 and has been serving as the Chairman of the Board, President, and Chief Executive Officer (?CEO?) of th

December 1, 2020 EX-10.1

AMENDED AND RESTATED INVESTOR’S RIGHTS AGREEMENT

Exhibit 10.1 Execution Version AMENDED AND RESTATED INVESTOR?S RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTOR?S RIGHTS AGREEMENT (this ?Agreement?), is made as of the 9th day of August, 2019, by and among Landos Biopharma, Inc., a Delaware corporation (the ?Company?), and each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an ?Investor?. RECITA

December 1, 2020 EX-10.2

LANDOS BIOPHARMA, INC. 2019 EQUITY INCENTIVE PLAN

EX-10.2 5 filename5.htm Exhibit 10.2 Privileged and Confidential FINAL LANDOS BIOPHARMA, INC. 2019 EQUITY INCENTIVE PLAN 1. Purposes of the Plan. The purposes of the Plan are to attract and retain the best available personnel, to provide additional incentives to Employees, Directors, and Consultants and to promote the success of the business of the Company. 2. Definitions. The following definition

December 1, 2020 DRS/A

As submitted to the Securities and Exchange Commission confidentially on November 30, 2020 as Amendment No. 2 to the initial confidential submission

Table of Contents As submitted to the Securities and Exchange Commission confidentially on November 30, 2020 as Amendment No.

December 1, 2020 EX-3.2

LANDOS BIOPHARMA, INC. (the “Corporation”) These Bylaws have been approved by the Board of Directors of the Corporation. ARTICLE I

Exhibit 3.2 LANDOS BIOPHARMA, INC. BYLAWS (the ?Corporation?) These Bylaws have been approved by the Board of Directors of the Corporation. ARTICLE I Stockholders 1. Annual Meeting. The annual meeting of stockholders shall be held each year at the place, date and time determined by the Board of Directors or the President. The purposes for which the annual meeting is to be held, in addition to thos

December 1, 2020 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION LANDOS BIOPHARMA INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware)

Exhibit 3.1 Execution Version AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF LANDOS BIOPHARMA INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Landos Biopharma Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the ?General Corporation Law?), DOES HEREBY CERTI

November 30, 2020 DRSLTR

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Eric Blanchard +1 212 479 6565 [email protected] November 30, 2020 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attn: Jenn Do Kevin Kuhar Christopher Edwards Alan Campbell Re: Landos Biopharma, Inc. Amendment No. 1 to Draft Registration Statement on Form S-1 Submitted September 1, 2020 CIK No. 0001785345 Ladies and Gentlemen: O

September 1, 2020 DRSLTR

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Eric Blanchard +1 212 479 6565 [email protected] September 1, 2020 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attn: Jenn Do Kevin Kuhar Christopher Edwards Alan Campbell Re: Landos Biopharma, Inc. Draft Registration Statement on Form F-1 Submitted July 24, 2020 CIK No. 0001785345 Ladies and Gentlemen: On behalf of Landos Biop

September 1, 2020 DRS/A

As submitted to the Securities and Exchange Commission confidentially on September 1, 2020 as Amendment No. 1 to the initial confidential submission

Table of Contents As submitted to the Securities and Exchange Commission confidentially on September 1, 2020 as Amendment No.

July 24, 2020 DRS

As submitted to the Securities and Exchange Commission confidentially on July 24, 2020

Table of Contents As submitted to the Securities and Exchange Commission confidentially on July 24, 2020 Registration No.

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