NSPH / Nanosphere, Inc. - Документы SEC, Годовой отчет, Доверенное заявление

Наносфера, ООО
US ˙ NASDAQ
ЭТОТ СИМВОЛ БОЛЬШЕ НЕ АКТИВЕН

Основная статистика
CIK 1105184
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Nanosphere, Inc.
SEC Filings (Chronological Order)
На этой странице представлен полный хронологический список документов SEC, за исключением документов о собственности, которые мы предоставляем в других местах.
July 19, 2016 15-12B

Nanosphere 15-12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-33775 NANOSPHERE, INC. (Exact name of registrant as specified in its cha

June 30, 2016 POS AM

Nanosphere POS AM

As filed with the Securities and Exchange Commission on June 30, 2016 Registration No.

June 30, 2016 SC 14D9/A

Nanosphere SC 14D9/A

SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(D)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 4) NANOSPHERE, INC. (Name of Subject Company) Nanosphere, Inc. (Names of Persons Filing Statement) Common Stock (Title of Class of Securities) 63009F204 (CUSIP Number of Class of Securitie

June 30, 2016 POS AM

Nanosphere POS AM

As filed with the Securities and Exchange Commission on June 30, 2016 Registration No.

June 30, 2016 SC TO-T/A

Luminex SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO AMENDMENT NO. 3 (RULE 14d-100) Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Nanosphere, Inc. (Name of Subject Company) Commodore Acquisition, Inc. (Offeror) Luminex Corporation (Parent of Offeror) (Names of Filing Persons) COMMON STOCK, PAR VALUE $0.01 PER S

June 30, 2016 8-K

Regulation FD Disclosure, Changes in Control of Registrant, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

8-K 1 d221627d8k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 30, 2016 (June 30, 2016) NANOSPHERE, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-33775 36-4339870 (State or Other Jurisdiction

June 30, 2016 S-8 POS

Nanosphere S-8 POS

As filed with the Securities and Exchange Commission on June 30, 2016 Registration Nos.

June 30, 2016 S-8 POS

Nanosphere S-8 POS

S-8 POS 1 d176572ds8pos.htm S-8 POS As filed with the Securities and Exchange Commission on June 30, 2016 Registration Nos. 333-148989, 333-163634, 333-179543, 333-207244 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-148989 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-16

June 30, 2016 S-8 POS

Nanosphere S-8 POS

As filed with the Securities and Exchange Commission on June 30, 2016 Registration Nos.

June 30, 2016 S-8 POS

Nanosphere S-8 POS

S-8 POS As filed with the Securities and Exchange Commission on June 30, 2016 Registration Nos.

June 30, 2016 EX-3.1

STATE OF DELAWARE CERTIFICATE OF MERGER

EX-3.1 Exhibit 3.1 STATE OF DELAWARE CERTIFICATE OF MERGER Pursuant to Title 8, Section 251 of the Delaware General Corporation Law (the ?DGCL?), the undersigned corporation executed the following Certificate of Merger. 1. The name of each constituent corporation is ?Nanosphere, Inc.?, a Delaware corporation, and ?Commodore Acquisition, Inc.?, a Delaware corporation. 2. The Agreement and Plan of M

June 30, 2016 EX-99.(A)(5)(H)

Luminex Corporation Completes Acquisition of Nanosphere, Inc.

EX-99.(A)(5)(H) Exhibit (a)(5)(H) Luminex Corporation Completes Acquisition of Nanosphere, Inc. Austin, Texas, June 30, 2016 /PRNewswire/ ? Luminex Corporation (NASDAQ: LMNX) today announced that Luminex has completed its previously announced acquisition of Nanosphere, Inc. (NASDAQ: NSPH) ?We are pleased to announce the completion of this transaction and welcome the Nanosphere team to the Luminex

June 27, 2016 8-K

Regulation FD Disclosure

Document UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 27, 2016 (June 24, 2016) NANOSPHERE, INC.

June 27, 2016 SC 14D9/A

Nanosphere SC 14D9/A

SC 14D9/A 1 a14d-9a.htm SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(D)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) NANOSPHERE, INC. (Name of Subject Company) Nanosphere, Inc. (Names of Persons Filing Statement) Common Stock (Title of Class of Securities) 63009F204 (CUSIP Numb

June 27, 2016 SC TO-T/A

Nanosphere SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO AMENDMENT NO. 2 (RULE 14d-100) Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Nanosphere, Inc. (Name of Subject Company) Commodore Acquisition, Inc. (Offeror) Luminex Corporation (Parent of Offeror) (Names of Filing Persons) COMMON STOCK, PAR VALUE $0.01 PER S

June 10, 2016 SC 14D9/A

Nanosphere SC 14D9/A

SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(D)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) NANOSPHERE, INC. (Name of Subject Company) Nanosphere, Inc. (Names of Persons Filing Statement) Common Stock (Title of Class of Securities) 63009F204 (CUSIP Number of Class of Securitie

June 10, 2016 CORRESP

Nanosphere ESP

CORRESP June 10, 2016 Mr. Daniel F. Duchovny Special Counsel Office of Mergers and Acquisitions United States Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: Nanosphere, Inc. Schedule 14D-9 Filed June 2, 2016 SEC File No. 005-83365 Dear Mr. Duchovny: Reference is hereby made to comments from the Staff of the Division of Corporation Finance (the ?Staff?) of the Secu

June 3, 2016 SC 14D9/A

Nanosphere SC 14D9/A

SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(D)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) NANOSPHERE, INC. (Name of Subject Company) Nanosphere, Inc. (Names of Persons Filing Statement) Common Stock (Title of Class of Securities) 63009F204 (CUSIP Number of Class of Securitie

June 3, 2016 SC TO-T/A

Nanosphere SC TO-T/A

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO AMENDMENT NO. 1 (RULE 14d-100) Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Nanosphere, Inc. (Name of Subject Company) Commodore Acquisition, Inc. (Offeror) Luminex Corporation (Parent of Offeror) (Names of Filing Persons) COMMON STOCK, PAR VALUE $

June 2, 2016 EX-2.1

Second Amendment to the Agreement and Plan of Merger, dated as of June 1, 2016, among Luminex Corporation, Commodore Acquisition, Inc., and Nanosphere, Inc. (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed by Nanosphere, Inc. with the Securities and Exchange Commission on June 2, 2016).

EX-2.1 2 d190525dex21.htm EX-2.1 Exhibit 2.1 SECOND AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER BETWEEN LUMINEX CORPORATION, COMMODORE ACQUISITION, INC. AND NANOSPHERE, INC. This Second Amendment to the Agreement and Plan of Merger (this “Second Amendment”) is entered into as of June 1, 2016, by and among Nanosphere, Inc., a Delaware corporation, Luminex Corporation, a Delaware corporation, and

June 2, 2016 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 1, 2016 Nanosphere, Inc. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other jurisdiction of incorporation) (Commission File Numb

June 2, 2016 SC 14D9

Nanosphere SC 14D9

SC 14D9 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(D)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 NANOSPHERE, INC. (Name of Subject Company) Nanosphere, Inc. (Names of Persons Filing Statement) Common Stock (Title of Class of Securities) 63009F204 (CUSIP Number of Class of Securities) Michael K. McGarr

June 2, 2016 EX-99.E.2

2

EX-99.E.2 Exhibit (e)(2) Luminex Corporation 12212 Technology Blvd. Austin, TX 78727 Attn: Harriss Currie,, Chief Financial Officer Ladies and Gentlemen: This confidentiality agreement (this “Agreement”) is entered into as of the 6th day of November, 2015, by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Luminex Corporation (“you” or “your”). In connection with your con

June 2, 2016 EX-99.E.3

Nachum “Homi” Shamir

EX-99.E.3 3 d194989dex99e3.htm EX-99.E.3 Exhibit (e)(3) Nachum “Homi” Shamir President and Chief Executive Officer Luminex Confidential Via Email April 18, 2016 Mr. Michael McGarrity President & Chief Executive Officer Nanosphere, Inc. 4088 Commercial Avenue, Northbrook, IL 60062 Re: Project Commodore Dear Mr. McGarrity: The purpose of this non-binding letter of intent (“LOI”) is to set forth, in

June 2, 2016 EX-99.E.10

Terms of Agreement

EX-99.E.10 Exhibit (e)(10) Nanosphere, Inc. 4088 Commercial Avenue Northbrook, IL 60062 Agreement In consideration of my employment and the compensation paid to me by Nanosphere, Inc., a Delaware corporation headquartered in Illinois, any of its affiliated companies, successors or assigns (together, ?Nanosphere?), I acknowledge and agree as follows: Background A. Nanosphere has offered me a positi

June 2, 2016 EX-99.(A)(1)(D)

Offer to Purchase for Cash All Outstanding Shares of Common Stock Nanosphere, Inc. $1.70 Net Per Share Commodore Acquisition, Inc. a wholly-owned subsidiary of Luminex Corporation

EX-99.(a)(1)(D) Exhibit (a)(1)(D) Offer to Purchase for Cash All Outstanding Shares of Common Stock of Nanosphere, Inc. at $1.70 Net Per Share by Commodore Acquisition, Inc. a wholly-owned subsidiary of Luminex Corporation THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT 12:00 MIDNIGHT, EASTERN DAYLIGHT TIME, AT THE END OF JUNE 29, 2016, UNLESS THE OFFER IS EXTENDED OR EARLIER TERMINATED. June 2, 20

June 2, 2016 SC TO-T

Nanosphere SC TO-T

SC TO-T UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (RULE 14d-100) Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Nanosphere, Inc. (Name of Subject Company) Commodore Acquisition, Inc. (Offeror) Luminex Corporation (Parent of Offeror) (Names of Filing Persons) COMMON STOCK, PAR VALUE $0.01 PER SHARE (Ti

June 2, 2016 EX-99.(A)(1)(C)

Notice of Guaranteed Delivery Offer to Purchase for Cash All Outstanding Shares of Common Stock Nanosphere, Inc. $1.70 Net Per Share Commodore Acquisition, Inc. a wholly-owned subsidiary of Luminex Corporation

EX-99.(A)(1)(C) 4 d191531dex99a1c.htm EX-99.(A)(1)(C) Exhibit (a)(1)(C) Notice of Guaranteed Delivery for Offer to Purchase for Cash All Outstanding Shares of Common Stock of Nanosphere, Inc. at $1.70 Net Per Share by Commodore Acquisition, Inc. a wholly-owned subsidiary of Luminex Corporation THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT 12:00 MIDNIGHT, EASTERN DAYLIGHT TIME, AT THE END OF JUNE

June 2, 2016 EX-99.(D)(5)

2

EX-99.(d)(5) Exhibit (d)(5) Luminex Corporation 12212 Technology Blvd. Austin, TX 78727 Attn: Harriss Currie,, Chief Financial Officer Ladies and Gentlemen: This confidentiality agreement (this ?Agreement?) is entered into as of the 6th day of November, 2015, by and between Nanosphere, Inc., a Delaware corporation (the ?Company?), and Luminex Corporation (?you? or ?your?). In connection with your

June 2, 2016 EX-99.(A)(1)(A)

Offer to Purchase for Cash All Outstanding Shares of Common Stock Nanosphere, Inc. $1.70 Net Per Share Commodore Acquisition, Inc., a wholly-owned subsidiary of Luminex Corporation

EX-99.(a)(1)(A) Table of Contents Exhibit (a)(1)(A) Offer to Purchase for Cash All Outstanding Shares of Common Stock of Nanosphere, Inc. at $1.70 Net Per Share by Commodore Acquisition, Inc., a wholly-owned subsidiary of Luminex Corporation THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT 12:00 MIDNIGHT, EASTERN DAYLIGHT TIME, AT THE END OF JUNE 29, 2016, UNLESS THE OFFER IS EXTENDED OR EARLIER TER

June 2, 2016 EX-99.(D)(6)

Nachum “Homi” Shamir

EX-99.(d)(6) Exhibit (d)(6) Nachum ?Homi? Shamir President and Chief Executive Officer Luminex Confidential Via Email April 18, 2016 Mr. Michael McGarrity President & Chief Executive Officer Nanosphere, Inc. 4088 Commercial Avenue, Northbrook, IL 60062 Re: Project Commodore Dear Mr. McGarrity: The purpose of this non-binding letter of intent (?LOI?) is to set forth, in general terms, certain preli

June 2, 2016 EX-99.(A)(1)(E)

Offer to Purchase for Cash All Outstanding Shares of Common Stock Nanosphere, Inc. $1.70 Net Per Share Commodore Acquisition, Inc. a wholly-owned subsidiary of Luminex Corporation

EX-99.(a)(1)(E) Exhibit (a)(1)(E) Offer to Purchase for Cash All Outstanding Shares of Common Stock of Nanosphere, Inc. at $1.70 Net Per Share by Commodore Acquisition, Inc. a wholly-owned subsidiary of Luminex Corporation THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT 12:00 MIDNIGHT, EASTERN DAYLIGHT TIME, AT THE END OF JUNE 29, 2016, UNLESS THE OFFER IS EXTENDED OR EARLIER TERMINATED. June 2, 20

June 2, 2016 EX-99.(D)(3)

SECOND AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER LUMINEX CORPORATION, COMMODORE ACQUISITION, INC. NANOSPHERE, INC.

EX-99.(D)(3) 9 d191531dex99d3.htm EX-99.(D)(3) Exhibit (d)(3) SECOND AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER BETWEEN LUMINEX CORPORATION, COMMODORE ACQUISITION, INC. AND NANOSPHERE, INC. This Second Amendment to the Agreement and Plan of Merger (this “Second Amendment”) is entered into as of June 1, 2016, by and among Nanosphere, Inc., a Delaware corporation, Luminex Corporation, a Delaware

June 2, 2016 EX-99.(A)(1)(B)

THIS DOCUMENT IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION. Letter of Transmittal To Tender Shares of Common Stock Nanosphere, Inc. $1.70 Net Per Share Pursuant to the Offer to Purchase dated June 2, 2016 Commodore Acquisition, Inc. a wholly-ow

EX-99.(a)(1)(B) Exhibit (a)(1)(B) THIS DOCUMENT IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION. Letter of Transmittal To Tender Shares of Common Stock of Nanosphere, Inc. at $1.70 Net Per Share Pursuant to the Offer to Purchase dated June 2, 2016 by Commodore Acquisition, Inc. a wholly-owned subsidiary of Luminex Corporation THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT 12:00 MIDNIGHT, EASTER

June 2, 2016 EX-99.(A)(5)(G)

Luminex Corporation Announces Commencement of Tender Offer for All Outstanding Shares of Nanosphere, Inc. Common Stock

EX-99.(a)(5)(G) Exhibit (a)(5)(G) Luminex Corporation Announces Commencement of Tender Offer for All Outstanding Shares of Nanosphere, Inc. Common Stock Austin, Texas, June 2, 2016 /PRNewswire/ ? Luminex Corporation (NASDAQ: LMNX) announced today that its wholly-owned subsidiary Commodore Acquisition, Inc. has commenced its previously announced tender offer to purchase all outstanding shares of co

June 2, 2016 EX-99.(A)(5)(F)

Notice of Offer to Purchase for Cash All Outstanding Shares of Common Stock Nanosphere, Inc. $1.70 Net Per Share Commodore Acquisition, Inc. a wholly-owned subsidiary of Luminex Corporation

EX-99.(a)(5)(F) Exhibit (a)(5)(F) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below). The Offer (as defined below) is made solely by the Offer to Purchase, dated June 2, 2016, and the related Letter of Transmittal and any amendments or supplements thereto. Purchaser (as defined below) is not aware of any state where the making of the

May 31, 2016 EX-1.01

Nanosphere, Inc. Conflict Minerals Report For the Year Ended December 31, 2015

Exhibit Exhibit 1.02 Nanosphere, Inc. Conflict Minerals Report For the Year Ended December 31, 2015 This Conflict Minerals Report (the ?Report?) of Nanosphere, Inc. (the ?Company?) has been prepared in accordance with Rule 13p-1 under the Securities Exchange Act of 1934, as amended (the ?Rule?), for the reporting period January 1, 2015 to December 31, 2015. The Rule requires disclosure of certain

May 31, 2016 SD

Nanosphere SD CONFLICT MINERAL

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM SD Specialized Disclosure Report Nanosphere, Inc. (Name of Registrant) Delaware 001-33775 36-4339870 (State or other jurisdiction of incorporation or organization) (Commission File Number) (IRS Employer Identification No.) 4088 Commercial Avenue, Northbrook, IL 60062 (Address of principal executive offices) Farzana Moinud

May 31, 2016 SC 13G/A

NSPH / Nanosphere, Inc. / MMCAP International Inc. SPC Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 AMENDMENT NO.

May 24, 2016 8-K

Regulation FD Disclosure

8-K 1 a8ksharesoutstanding5.htm 8-K SHARES OUTSTANDING 5 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 24, 2016 (May 24, 2016) NANOSPHERE, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-33775 36-4339870 (St

May 24, 2016 SC 13G

NSPH / Nanosphere, Inc. / MMCAP International Inc. SPC Passive Investment

SC 13G 1 mmcap-nanosphere13g051916.htm SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 NANOSPHERE, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 63009F105 (CUSIP Number) May 16, 2016 (Date of Event Which Requires Filing of This Statement) Check the Appropriate

May 23, 2016 8-K

Regulation FD Disclosure

8-K 1 a8ksharesoutstanding4.htm 8-K SHARES OUTSTANDING 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 23, 2016 (May 23, 2016) NANOSPHERE, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-33775 36-4339870 (St

May 23, 2016 EX-9.1

Luminex Corporation and Nanosphere, Inc. Provide Update on Acquisition Agreement

EX-9.1 3 a424b3exhibit991-pressrele.htm EXHIBIT 9.1 424B3 MERGER AMEND Luminex Corporation and Nanosphere, Inc. Provide Update on Acquisition Agreement Austin, Texas and Northbrook, Illinois, May 23, 2016 /PRNewswire/ - Luminex Corporation (NASDAQ: LMNX) and Nanosphere, Inc. (NASDAQ: NSPH) announced today that they have entered into an amendment to the definitive agreement under which Luminex will

May 23, 2016 424B3

NANOSPHERE, INC. Common Stock

424B3 1 a424b38kmergeramend.htm 424B3 MERGER AMEND Filed Pursuant to Rule 424(b)(3) under the Securities Act of 1933 in connection with Registration Statement No. 333-207460 PROSPECTUS SUPPLEMENT NO. 2 (TO PROSPECTUS DATED APRIL 14, 2016) NANOSPHERE, INC. Common Stock This Prospectus Supplement No. 2 supplements and amends the prospectus (the “Prospectus”) of Nanosphere, Inc. (“we,” “us,” or the “

May 23, 2016 EX-2.1

FIRST AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER LUMINEX CORPORATION, COMMODORE ACQUISITION, INC. NANOSPHERE, INC.

SEC Exhibit FIRST AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER BETWEEN LUMINEX CORPORATION, COMMODORE ACQUISITION, INC.

May 23, 2016 EX-2.1

FIRST AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER LUMINEX CORPORATION, COMMODORE ACQUISITION, INC. NANOSPHERE, INC.

Exhibit 2.1 Exhibit 2.1 FIRST AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER BETWEEN LUMINEX CORPORATION, COMMODORE ACQUISITION, INC. AND NANOSPHERE, INC. This First Amendment to the Agreement and Plan of Merger (this ?First Amendment?) is entered into as of May 22, 2016, by and among Nanosphere, Inc., a Delaware corporation, Luminex Corporation, a Delaware corporation, and Commodore Acquisition, I

May 23, 2016 EX-99.1

Luminex Corporation and Nanosphere, Inc. Provide Update on Acquisition Agreement

EX-99.1 3 d126945dex991.htm EXHIBIT 99.1 Exhibit 99.1 Luminex Corporation and Nanosphere, Inc. Provide Update on Acquisition Agreement Austin, Texas and Northbrook, Illinois, May , 2016 /PRNewswire/ — Luminex Corporation (NASDAQ: LMNX) and Nanosphere, Inc. (NASDAQ: NSPH) announced today that they have entered into an amendment to the definitive agreement under which Luminex will acquire Nanosphere

May 23, 2016 SC TO-C

Nanosphere FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2016 (May 22, 2016) Luminex Corporation (Exact name of registrant as specified in its charter) Delaware 000-30109 74-2747608 (State or other jurisdiction of incorporation) (Co

May 23, 2016 EX-99.2

1

EX-99.2 4 d126945dex992.htm EXHIBIT 99.2 Exhibit 99.2 Dear Colleague, Please see the attached press release we released early this morning. As you can see, we raised our offer price to acquire Nanosphere due to their receipt of an unsolicited bid from another party. The Boards of each of our companies support the revised offer and we are still on track to launch the tender offer on schedule and cl

May 23, 2016 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2016 (May 22, 2016) Nanosphere, Inc. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other jurisdiction of incorporation) (Commi

May 23, 2016 EX-99.1

Luminex Corporation and Nanosphere, Inc. Provide Update on Acquisition Agreement

SEC Exhibit Luminex Corporation and Nanosphere, Inc. Provide Update on Acquisition Agreement Austin, Texas and Northbrook, Illinois, May 23, 2016 /PRNewswire/ - Luminex Corporation (NASDAQ: LMNX) and Nanosphere, Inc. (NASDAQ: NSPH) announced today that they have entered into an amendment to the definitive agreement under which Luminex will acquire Nanosphere, a leader in the molecular microbiology

May 23, 2016 EX-2.1

FIRST AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER LUMINEX CORPORATION, COMMODORE ACQUISITION, INC. NANOSPHERE, INC.

SEC Exhibit FIRST AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER BETWEEN LUMINEX CORPORATION, COMMODORE ACQUISITION, INC.

May 20, 2016 8-K

Regulation FD Disclosure

SEC Document UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 20, 2016 (May 20, 2016) NANOSPHERE, INC.

May 18, 2016 8-K

Regulation FD Disclosure

SEC Document UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 18, 2016 (May 18, 2016) NANOSPHERE, INC.

May 17, 2016 8-K

Regulation FD Disclosure

SEC Document UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 17, 2016 (May 17, 2016) NANOSPHERE, INC.

May 16, 2016 424B3

NANOSPHERE, INC. Common Stock

SEC Document Filed Pursuant to Rule 424(b)(3) under the Securities Act of 1933 in connection with Registration Statement No.

May 16, 2016 424B3

NANOSPHERE, INC. Common Stock

424B3 1 a424b38kmerger.htm 424B3 - 8K MERGER Filed Pursuant to Rule 424(b)(3) under the Securities Act of 1933 in connection with Registration Statement No. 333-207460 PROSPECTUS SUPPLEMENT NO. 1 (TO PROSPECTUS DATED APRIL 14, 2016) NANOSPHERE, INC. Common Stock This Prospectus Supplement No. 1 supplements and amends the prospectus (the “Prospectus”) of Nanosphere, Inc. (“we,” “us,” or the “Compan

May 16, 2016 EX-99.2

Luminex Corporation Signs Definitive Agreement to Acquire Nanosphere, Inc. - Acquisition Creates Premier Portfolio of Molecular Testing Solutions - Expands Access to the High-growth Molecular Microbiology Market - Immediately accelerates growth, accr

SEC Exhibit Exhibit 99.2 Luminex Corporation Signs Definitive Agreement to Acquire Nanosphere, Inc. - Acquisition Creates Premier Portfolio of Molecular Testing Solutions - Expands Access to the High-growth Molecular Microbiology Market - Immediately accelerates growth, accretive to adjusted earnings by end of 2017 Austin, Texas and Northbrook, Illinois, May 16, 2016 /PRNewswire/ - Luminex Corpora

May 16, 2016 EX-2.1

AGREEMENT AND PLAN OF MERGER LUMINEX CORPORATION COMMODORE ACQUISITION, INC. NANOSPHERE, INC. dated as of May 15, 2016

SEC Exhibit Exhibit 2.1 AGREEMENT AND PLAN OF MERGER among LUMINEX CORPORATION and COMMODORE ACQUISITION, INC. and NANOSPHERE, INC. dated as of May 15, 2016 26995100v.1 TABLE OF CONTENTS Page ARTICLE I THE OFFER 2 Section 1.01 The Offer 2 Section 1.02 Company Actions 5 Section 1.03 Directors 6 ARTICLE II THE MERGER 7 Section 2.01 The Merger 7 Section 2.02 Closing 7 Section 2.03 Effective Time 7 Se

May 16, 2016 EX-99.1

SUPPORT AGREEMENT

EX-99.1 3 exhibit991-other1.htm EXHIBIT 99.1 424 MERGER Exhibit 99.1 SUPPORT AGREEMENT THIS SUPPORT AGREEMENT (this “Agreement”) is made and entered into as of May 15, 2016 by and between Luminex Corporation, a Delaware corporation (“Parent”), and the undersigned stockholder (“Stockholder”) of Nanosphere, Inc., a Delaware corporation (the “Company”). W I T N E S S E T H: WHEREAS, concurrently with

May 16, 2016 EX-99.1

Dear Nanosphere Employees,

EX-99.1 3 d175206dex991.htm EX-99.1 Exhibit 99.1 Dear Nanosphere Employees, We are thrilled at the prospect of you joining our Luminex team. You have created exciting products and brand awareness and we are excited at the prospect of including you as part of our family. While this is a big change for both companies, I understand it is a bigger change for each of you. I know that change creates unc

May 16, 2016 EX-99.4

FORM OF SUPPORT AGREEMENT

EX-99.4 Exhibit 99.4 FORM OF SUPPORT AGREEMENT THIS SUPPORT AGREEMENT (this ?Agreement?) is made and entered into as of May 15, 2016 by and between Luminex Corporation, a Delaware corporation (?Parent?), and the undersigned stockholder (?Stockholder?) of Nanosphere, Inc., a Delaware corporation (the ?Company?). W I T N E S S E T H: WHEREAS, concurrently with the execution of this Agreement, Parent

May 16, 2016 EX-99.3

Luminex Corporation Signs Definitive Agreement to Acquire Nanosphere, Inc. - Acquisition Creates Premier Portfolio of Molecular Testing Solutions - Expands Access to the High-Growth Molecular Microbiology Market - Immediately Accelerates Growth, Accr

EX-99.3 5 d175206dex993.htm EX-99.3 Exhibit 99.3 Luminex Corporation Signs Definitive Agreement to Acquire Nanosphere, Inc. - Acquisition Creates Premier Portfolio of Molecular Testing Solutions - Expands Access to the High-Growth Molecular Microbiology Market - Immediately Accelerates Growth, Accretive to Adjusted Earnings by End of 2017 Austin, Texas and Northbrook, Illinois, May 16, 2016 /PRNew

May 16, 2016 EX-99.2

2

EX-99.2 Exhibit 99.2 Dear Colleagues, I am very excited to share some important news with you. As you can see from the attached press release from early this morning, Luminex and Nanoshpere, Inc. entered into a merger agreement for Luminex to acquire Nanosphere in an all-cash transaction. This transaction has the full support of the boards of directors of each company. For those of you less famili

May 16, 2016 EX-2.1

AGREEMENT AND PLAN OF MERGER LUMINEX CORPORATION COMMODORE ACQUISITION, INC. NANOSPHERE, INC. dated as of May 15, 2016 TABLE OF CONTENTS Page ARTICLE I THE OFFER 2 Section 1.01 The Offer 2 Section 1.02 Company Actions 5 Section 1.03 Directors 6 ARTIC

EX-2.1 Exhibit 2.1 AGREEMENT AND PLAN OF MERGER among LUMINEX CORPORATION and COMMODORE ACQUISITION, INC. and NANOSPHERE, INC. dated as of May 15, 2016 TABLE OF CONTENTS Page ARTICLE I THE OFFER 2 Section 1.01 The Offer 2 Section 1.02 Company Actions 5 Section 1.03 Directors 6 ARTICLE II THE MERGER 7 Section 2.01 The Merger 7 Section 2.02 Closing 7 Section 2.03 Effective Time 7 Section 2.04 Effect

May 16, 2016 SC TO-C

Nanosphere FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2016 (May 15, 2016) Luminex Corporation (Exact name of registrant as specified in its charter) Delaware 000-30109 74-2747608 (State or other jurisdiction of incorpora

May 16, 2016 10-Q

Nanosphere 10-Q Q1-2016 (Quarterly Report)

SEC Document UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2016 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-337

May 16, 2016 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2016 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commission File Numb

May 16, 2016 EX-99.1

Nanosphere Announces First Quarter results

EX-99.1 2 exhibit991q1-2016.htm EXHIBIT 99.1 Q1-16 EARNINGS RELEASE Exhibit 99.1 Nanosphere Announces First Quarter results NORTHBROOK, IL - May 16, 2016 - Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, today reported financial results for the first quarter March 31, 2016. Nanosphere achieved record revenues for the first quarter of 2016. Reve

May 16, 2016 EX-99.2

Luminex Corporation Signs Definitive Agreement to Acquire Nanosphere, Inc. - Acquisition Creates Premier Portfolio of Molecular Testing Solutions - Expands Access to the High-growth Molecular Microbiology Market - Immediately accelerates growth, accr

SEC Exhibit Exhibit 99.2 Luminex Corporation Signs Definitive Agreement to Acquire Nanosphere, Inc. - Acquisition Creates Premier Portfolio of Molecular Testing Solutions - Expands Access to the High-growth Molecular Microbiology Market - Immediately accelerates growth, accretive to adjusted earnings by end of 2017 Austin, Texas and Northbrook, Illinois, May 16, 2016 /PRNewswire/ - Luminex Corpora

May 16, 2016 EX-2.1

AGREEMENT AND PLAN OF MERGER LUMINEX CORPORATION COMMODORE ACQUISITION, INC. NANOSPHERE, INC. dated as of May 15, 2016

EX-2.1 2 exhibit21merger.htm EXHIBIT 2.1 MERGER AGMNT Exhibit 2.1 AGREEMENT AND PLAN OF MERGER among LUMINEX CORPORATION and COMMODORE ACQUISITION, INC. and NANOSPHERE, INC. dated as of May 15, 2016 26995100v.1 TABLE OF CONTENTS Page ARTICLE I THE OFFER 2 Section 1.01 The Offer 2 Section 1.02 Company Actions 5 Section 1.03 Directors 6 ARTICLE II THE MERGER 7 Section 2.01 The Merger 7 Section 2.02

May 16, 2016 EX-99.1

SUPPORT AGREEMENT

SEC Exhibit Exhibit 99.1 SUPPORT AGREEMENT THIS SUPPORT AGREEMENT (this ? Agreement ?) is made and entered into as of May 15, 2016 by and between Luminex Corporation, a Delaware corporation (? Parent ?), and the undersigned stockholder (? Stockholder ?) of Nanosphere, Inc., a Delaware corporation (the ? Company ?). W I T N E S S E T H: WHEREAS, concurrently with the execution of this Agreement, Pa

May 16, 2016 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2016 (May 15, 2016) Nanosphere, Inc. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other jurisdiction of incorporation) (Commi

April 22, 2016 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 22, 2016 (April 20, 2016) NANOSPHERE, INC.

April 12, 2016 POS AM

Nanosphere POS AM

Table of Contents As filed with the Securities and Exchange Commission on April 12, 2016 Registration No.

April 12, 2016 S-3/A

Nanosphere S-3/A

S-3/A Table of Contents As filed with the Securities and Exchange Commission on April 12, 2016 Registration No.

April 12, 2016 CORRESP

Nanosphere ESP

Acceleration Request April 12, 2016 Securities and Exchange Commission 100 F Street, N.

April 12, 2016 CORRESP

Nanosphere ESP

Acceleration Request April 12, 2016 Securities and Exchange Commission 100 F Street, N.

April 8, 2016 10-K/A

Nanosphere 2015 10-K/A (Annual Report)

10-K/A 1 nsph-20151231x10ka.htm 2015 10-K/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K/A (Amendment No. 1) (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2015 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition

March 2, 2016 SC 13G/A

NSPH / Nanosphere, Inc. / Perella Weinberg Partners Capital Management LP - SC 13G/A Passive Investment

SC 13G/A 1 a16-51611sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment No. 1 Nanosphere, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 63009F204 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate t

February 24, 2016 S-3

Nanosphere FORM S-3

Table of Contents As filed with the Securities and Exchange Commission on February 24, 2016 Registration No.

February 24, 2016 POS AM

Nanosphere POS AM

Table of Contents As filed with the Securities and Exchange Commission on February 24, 2016 Registration No.

February 24, 2016 10-K

Nanosphere 10-K YEAR END 2015 (Annual Report)

10-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2015 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-33775 Nanosphere

February 24, 2016 EX-99.1

Nanosphere Announces Fourth Quarter and Full Year 2015 Results, 2016 Guidance and Next Generation Verigene Progress

Exhibit Exhibit 99.1 Nanosphere Announces Fourth Quarter and Full Year 2015 Results, 2016 Guidance and Next Generation Verigene Progress Corporate Highlights and Guidance: ? Record fourth quarter and fiscal year revenues of $6.8 million and $21.1million, respectively ? Revenue guidance for 2016 set at $28 million to $30 million ? Next Generation Platform progress targeting third quarter 2016 regul

February 24, 2016 8-K

Nanosphere 8-K 2015 YEAR END EARNINGS RELEASE (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 24, 2016 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commission

February 24, 2016 EX-10.9

EX-10.9

nsph-exh109kenbahk

February 16, 2016 SC 13G

NSPH / Nanosphere, Inc. / Perella Weinberg Partners Capital Management LP - SC 13G Passive Investment

SC 13G 1 a16-38861sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Nanosphere, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 63009F204 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to w

January 29, 2016 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 29, 2016 (January 25, 2016) NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation

January 6, 2016 EX-99.1

Nanosphere Announces Record Preliminary Q4 and full year 2015 Results

Exhibit Nanosphere Announces Record Preliminary Q4 and full year 2015 Results ? Preliminary Fourth Quarter Revenue of $6.

January 6, 2016 8-K

Nanosphere 8-K Q4-15 PRE-RELEASE (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 6, 2016 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commission Fi

December 22, 2015 EX-99.1

NANOSPHERE, INC. ANNOUNCES COMPLETION OF $10 MILLION REGISTERED PUBLIC OFFERING

EX-99.1 Exhibit 99.1 NANOSPHERE, INC. ANNOUNCES COMPLETION OF $10 MILLION REGISTERED PUBLIC OFFERING NORTHBROOK, Ill ? December 22, 2015 ? Nanosphere, Inc. (NSPH), a company enhancing medicine through targeted and flexible molecular diagnostics, today announced the completion of its previously announced public offering of the company?s common stock for total gross proceeds of approximately $10 mil

December 22, 2015 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 22, 2015 (December 22, 2015) NANOSPHERE, INC.

December 22, 2015 EX-10.1

SECURITIES PURCHASE AGREEMENT

EX-10.1 2 d100759dex101.htm EX-10.1 Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of December 17, between Nanosphere, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject t

December 18, 2015 8-K

Nanosphere 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 18, 2015 (December 17, 2015) NANOSPHERE, INC.

December 18, 2015 EX-99.1

NANOSPHERE, INC. ANNOUNCES $10 MILLION REGISTERED PUBLIC OFFERING

EX-99.1 Exhibit 99.1 NANOSPHERE, INC. ANNOUNCES $10 MILLION REGISTERED PUBLIC OFFERING NORTHBROOK, Ill ? December 17, 2015 ? Nanosphere, Inc. (NSPH), a company enhancing medicine through targeted and flexible molecular diagnostics, today announced the pricing of a public offering of the company?s common stock with expected total gross proceeds of approximately $10 million. The offering is expected

December 18, 2015 EX-10.1

SECURITIES PURCHASE AGREEMENT

EX-10.1 Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of December 17, between Nanosphere, Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively the ?Purchasers?). WHEREAS, subject to the terms and conditions s

December 18, 2015 EX-4.1

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: Initial Exercise Date: December 22, 2015

EX-4.1 Exhibit 4.1 COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: Initial Exercise Date: December 22, 2015 THIS COMMON STOCK PURCHASE WARRANT (the ?Warrant?) certifies that, for value received, or its assigns (the ?Holder?) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the ?I

December 18, 2015 EX-4.3

JT 13351/2

EX-4.3 5 d103588dex43.htm EX-4.3 Exhibit 4.3 JT 13351/2 COPYRIGHT, 1930 BY DWIGHT & M. H. JACKSON CHICAGO PATENT PENDING NUMBER SHARES Incorporated under the laws of the State of Delaware NANOSPHERE, INC. [ ] Authorized Series C Convertible Preferred Shares $0.01 Par Value Per Share THIS CERTIFIES THAT is the owner of full paid and non-assessable SHARES OF THE SERIES C CONVERTIBLE PREFERRED STOCK

December 18, 2015 EX-3.1

NANOSPHERE, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS SERIES C CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW

EX-3.1 Exhibit 3.1 NANOSPHERE, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES C CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW The undersigned, Michael K. McGarrity and Farzana Moinuddin, do hereby certify that: 1. They are the President and Chief Executive Officer, and Secretary, respectively, of Nanaosphere, Inc., a D

December 18, 2015 424B4

2,298,744 Class A Units consisting of Common Stock and Warrants and 8,919.59044 Class B Units consisting of Series C Convertible Preferred Stock and Warrants (37,955,704 shares of Common Stock underlying the Series C Convertible Preferred Stock and W

424B4 Table of Contents Filed Pursuant to Rule 424(b)(4) under the Securities Act of 1933 in connection with Registration Statement Nos.

December 18, 2015 EX-4.2

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: Initial Exercise Date: December 22, 2015

EX-4.2 Exhibit 4.2 COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: Initial Exercise Date: December 22, 2015 THIS COMMON STOCK PURCHASE WARRANT (the ?Warrant?) certifies that, for value received, or its assigns (the ?Holder?) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the ?I

December 16, 2015 CORRESP

Nanosphere ESP

Acceleration Request December 16, 2015 Securities and Exchange Commission 100 F Street, N.

December 11, 2015 CORRESP

Nanosphere ESP

Correspondence December 11, 2015 Securities and Exchange Commission 100 F Street, N.

December 11, 2015 CORRESP

Nanosphere ESP

Correspondence H.C. Wainwright & Co., LLC 430 Park Avenue New York, New York 10022 December 11, 2015 Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: Nanosphere, Inc. Registration Statement on Form S-1 (File No. 333-207460) Withdrawal of Concurrence in Acceleration Request Ladies and Gentlemen: Reference is made to the letter of H.C. Wainwright & Co., LLC (?Wainwrig

December 11, 2015 CORRESP

Nanosphere ESP

Correspondence December 11, 2015 VIA FACSIMILE AND EDGAR U.S. Securities and Exchange Commission Division of Corporate Finance Washington, DC 20549 Re: NANOSPHERE, INC. Registration Statement on Form S-1 (Registration No. 333-207460) - Concurrence in Acceleration Request Ladies and Gentlemen: H.C. Wainwright & Co., LLC (?Wainwright?), as placement agent for the referenced offering, hereby concurs

December 11, 2015 CORRESP

Nanosphere ESP

Correspondence December 11, 2015 Securities and Exchange Commission 100 F Street, N.

December 10, 2015 EX-3.7

NANOSPHERE, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS SERIES C CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW

EX-3.7 2 d95890dex37.htm EX-3.7 EXHIBIT 3.7 NANOSPHERE, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES C CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW The undersigned, Michael K. McGarrity and Farzana Moinuddin, do hereby certify that: 1. They are the President and Chief Executive Officer, and Secretary, respectively,

December 10, 2015 FWP

Issuer Free Writing Prospectus

FWP Issuer Free Writing Prospectus Filed pursuant to Rule 433 Registration No. 333-207460 December 10, 2015 NANOSPHERE COMPANY OVERVIEW Nanosphere, Inc. (the ?Company?) has filed a registration statement (including a preliminary prospectus) with the U.S. Securities and Exchange Commission (the ?SEC?) for the offering to which this presentation relates. Before you invest, you should read the prospe

December 10, 2015 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

8-K 1 d88768d8k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 10, 2015 (December 10, 2015) NANOSPHERE, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-33775 36-4339870 (State or Other Juris

December 10, 2015 EX-4.1

SECURITIES PURCHASE AGREEMENT

EX-4.1 3 d95890dex41.htm EX-4.1 EXHIBIT 4.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of [ ], 2015, between Nanosphere, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the t

December 10, 2015 EX-99.1

Issuer Free Writing Prospectus

EX-99.1 Exhibit 99.1 Issuer Free Writing Prospectus Filed pursuant to Rule 433 Registration No. 333-207460 December 10, 2015 NANOSPHERE COMPANY OVERVIEW Nanosphere, Inc. (the ?Company?) has filed a registration statement (including a preliminary prospectus) with the U.S. Securities and Exchange Commission (the ?SEC?) for the offering to which this presentation relates. Before you invest, you shoul

December 10, 2015 S-1/A

Nanosphere AMENDMENT NO.2 TO FORM S-1

S-1/A 1 d95890ds1a.htm AMENDMENT NO.2 TO FORM S-1 Table of Contents As filed with the Securities and Exchange Commission on December 10, 2015 Registration No. 333-207460 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A (Amendment No. 2) REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Nanosphere, Inc. (Exact name of registrant as specified in its Charter) D

December 10, 2015 EX-4.2

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: Initial Exercise Date:

EX-4.2 Exhibit 4.2 COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: Initial Exercise Date: THIS COMMON STOCK PURCHASE WARRANT (the ?Warrant?) certifies that, for value received, or its assigns (the ?Holder?) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the ?Initial Exercise Da

December 8, 2015 EX-10.2

REGISTRATION RIGHTS AGREEMENT

EX-10.2 Exhibit 10.2 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this ?Agreement?) is made and entered into as of December 7, 2015, by and among Nanosphere, Inc., a Delaware corporation (the ?Company?), and the holders signatory hereto (each a ?Lender? and collectively, the ?Lenders?). This Agreement is made in connection with that certain Second Amendment dated as of Decembe

December 8, 2015 EX-4.1

WARRANT TO PURCHASE STOCK Company: Nanosphere, Inc. Number of Shares: Type/Series of Stock: Common Stock, par value $0.01 per share Warrant Price: $0.01 per share Issue Date: [Second Amendment Effective Date] Expiration Date: [10 year anniversary of

EX-4.1 Exhibit 4.1 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND

December 8, 2015 EX-10.1

SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT

EX-10.1 Exhibit 10.1 SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (this ?Second Amendment?), dated as of December 7, 2015, is made among NANOSPHERE, INC., a Delaware corporation (the ?Borrower?), NSPH FUNDING LLC, a Delaware limited liability company (?NSPH?), in its capacity as collateral agent (in such capacity, ?Collateral Agent?) and the

December 8, 2015 8-K

Nanosphere FORM 8-K (Current Report/Significant Event)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 8, 2015 (December 7, 2015) NANOSPHERE, INC.

November 20, 2015 CORRESP

Nanosphere ESP

November 20, 2015 Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: Nanosphere, Inc. (the ?Company?) Registration Statement on Form S-3 (File No. 333-207461) Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended, the Company hereby requests that the effective date of the above-captioned Registrati

November 20, 2015 S-1/A

Nanosphere AMENDMENT NO.1 TO FORM S-1

Amendment No.1 to Form S-1 Table of Contents As filed with the Securities and Exchange Commission on November 20, 2015 Registration No. 333-207460 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A (Amendment No. 1) REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Nanosphere, Inc. (Exact name of registrant as specified in its Charter) Delaware 3841 36-4339870

November 13, 2015 S-3/A

Nanosphere AMENDMENT NO. 1 TO FORM S-3

Amendment No. 1 to Form S-3 Table of Contents As filed with the Securities and Exchange Commission on November 13, 2015. Registration No. 333-207461 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-3/A (Amendment No. 1) REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NANOSPHERE, INC. (Exact Name of Registrant as Specified in Its Charter) DELAWARE 36-4339870 (S

November 13, 2015 EX-12.1

Ratios of Combined Fixed Charges and Preference Dividends to Earnings (Dollars in Thousands) Year ended December 31, Nine Months Ended September 30, 2014 2013 2012 2011 2010 2015 Earnings (1) Loss before income taxes $ (39,070 ) $ (34,647 ) $ (32,872

EX-12.1 Exhibit 12.1 Ratios of Combined Fixed Charges and Preference Dividends to Earnings (Dollars in Thousands) Year ended December 31, Nine Months Ended September 30, 2014 2013 2012 2011 2010 2015 Earnings (1) Loss before income taxes $ (39,070 ) $ (34,647 ) $ (32,872 ) $ (35,419 ) $ (40,612 ) $ (31,861 ) Fixed charges 1,617 1,108 211 231 472 2,187 $ (37,453 ) $ (33,539 ) $ (32,661 ) $ (35,188

November 9, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2015 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-33775 Nanosp

November 9, 2015 8-K

Nanosphere 8-K Q3-15 EARNINGS RELEASE (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2015 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commission F

November 9, 2015 EX-99.1

Nanosphere Announces Record Q3 2015 Results

Exhibit Exhibit 99.1 Nanosphere Announces Record Q3 2015 Results NORTHBROOK, IL - November 9, 2015 - Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, today reported financial and operating results for the third quarter ended September 30, 2015. Nanosphere achieved record revenues for the third quarter of 2015 of $4.9 million compared to $3.7 mil

October 16, 2015 S-1

Nanosphere FORM S-1

Table of Contents As filed with the Securities and Exchange Commission on October 16, 2015 Registration No.

October 16, 2015 S-3

Nanosphere S-3

S-3 1 d78076ds3.htm S-3 Table of Contents As filed with the Securities and Exchange Commission on October 16, 2015. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NANOSPHERE, INC. (Exact Name of Registrant as Specified in Its Charter) DELAWARE 36-4339870 (State or Other Jurisdiction of I

October 16, 2015 EX-12.1

Ratios of Combined Fixed Charges and Preference Dividends to Earnings (Dollars in Thousands) Year ended December 31, Six Months Ended June 30, 2014 2013 2012 2011 2010 2015 Earnings (1) Loss before income taxes $ (39,070 ) $ (34,647 ) $ (32,872 ) $ (

EX-12.1 Exhibit 12.1 Ratios of Combined Fixed Charges and Preference Dividends to Earnings (Dollars in Thousands) Year ended December 31, Six Months Ended June 30, 2014 2013 2012 2011 2010 2015 Earnings (1) Loss before income taxes $ (39,070 ) $ (34,647 ) $ (32,872 ) $ (35,419 ) $ (40,612 ) $ (21,930 ) Fixed charges 1,617 1,108 211 231 472 1,406 $ (37,453 ) $ (33,539 ) $ (32,661 ) $ (35,188 ) $ (4

October 2, 2015 S-8

Nanosphere FORM S-8

Form S-8 As filed with the Securities and Exchange Commission on October 2, 2015 Registration No.

October 2, 2015 SC 13D/A

NSPH / Nanosphere, Inc. / A&B Equity Holdings, LLC - AMENDMENT NO. 12 TO SCHEDULE 13D Activist Investment

SC 13D/A 1 d54549dsc13da.htm AMENDMENT NO. 12 TO SCHEDULE 13D SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13D Under the Securities Exchange Act of 1934 (Amendment No. 12)* Nanosphere, Inc. (Name of Issuer) Common Stock, $0.01 par value per share (Title of Class of Securities) 63009F105 (CUSIP Number) Theodore J. Theophilos Chief Administrative Officer Lurie Investments, Inc.

October 2, 2015 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Other Events, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 2, 2015 (September 30, 2015) NANOSPHERE, INC.

August 19, 2015 DEF 14A

Nanosphere DEF 14A

DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Definitive Pro

August 11, 2015 EX-10.15

RETENTION AGREEMENT

Exhibit 10.15 RETENTION AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Kenneth Bahk (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the continued employment of key management personnel; and NOW, THEREFORE, in considera

August 11, 2015 EX-10.12

SEVERANCE AGREEMENT

Exhibit 10.12 SEVERANCE AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Kenneth Bahk (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the continued employment of key management personnel; and WHEREAS, the Board recognize

August 11, 2015 EX-10.13

SEVERANCE AGREEMENT

Exhibit 10.13 SEVERANCE AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the ?Effective Date?), is made by and between Nanosphere, Inc., a Delaware corporation (the ?Company?), and Farzana Moinuddin (the ?Executive?). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the continued employment of key management personnel; and WHEREAS, the Board reco

August 11, 2015 EX-10.16

RETENTION AGREEMENT

EX-10.16 7 nsph-exh10162015630xq210qa.htm EXHIBIT 10.16 RETENTION 10Q/A Exhibit 10.16 RETENTION AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Farzana Moinuddin (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the conti

August 11, 2015 EX-10.11

SEVERANCE AGREEMENT

EX-10.11 2 nsph-exh10112015630xq210qa.htm EXHIBIT 10.11 SEVERANCE 10Q/A Exhibit 10.11 SEVERANCE AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Michael K. McGarrity (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the co

August 11, 2015 EX-10.14

RETENTION AGREEMENT

EX-10.14 5 nsph-exh10142015630xq210qa.htm EXHIBIT 10.14 RETENTION 10Q/A Exhibit 10.14 RETENTION AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Michael K. McGarrity (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the co

August 11, 2015 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1)

10-Q/A 1 nsph-2015630x10qa.htm 10-Q/A Q2-2015 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q/A (Amendment No. 1) (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2015 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the tran

August 10, 2015 EX-10.11

SEVERANCE AGREEMENT

EX-10.11 2 nsph-exh10112015630xq2.htm EXHIBIT 10.11 SEVERANCE Exhibit 10.11 SEVERANCE AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Michael K. McGarrity (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the continued em

August 10, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2015 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-33775 Nanosphere,

August 10, 2015 EX-99.1

Nanosphere Announces Record Q2 2015 Results

Exhibit 99.1 Q2-2015 Exhibit 99.1 Nanosphere Announces Record Q2 2015 Results NORTHBROOK, IL - August 10, 2015 - Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, today reported financial and operating results for the second quarter ended June 30, 2015. Nanosphere achieved record revenues for the second quarter 2015, of $4.7 million compared to $

August 10, 2015 EX-10.12

SEVERANCE AGREEMENT

EX-10.12 3 nsph-exh10122015630xq2.htm EXHIBIT 10.12 SEVERANCE Exhibit 10.12 SEVERANCE AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Kenneth Bahk (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the continued employment

August 10, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

Earnings Release Q2-2015 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

August 10, 2015 EX-10.14

RETENTION AGREEMENT

EX-10.14 5 nsph-exh10142015630xq2.htm EXHIBIT 10.14 RETENTION Exhibit 10.14 RETENTION AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Michael K. McGarrity (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the continued em

August 10, 2015 EX-10.16

RETENTION AGREEMENT

Exhibit 10.16 RETENTION AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Farzana Moinuddin (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the continued employment of key management personnel; and NOW, THEREFORE, in cons

August 10, 2015 EX-10.15

RETENTION AGREEMENT

Exhibit 10.15 RETENTION AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the “Effective Date”), is made by and between Nanosphere, Inc., a Delaware corporation (the “Company”), and Kenneth Bahk (the “Executive”). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the continued employment of key management personnel; and NOW, THEREFORE, in considera

August 10, 2015 EX-10.13

SEVERANCE AGREEMENT

Exhibit 10.13 SEVERANCE AGREEMENT THIS AGREEMENT, dated as of August 5, 2015 (the ?Effective Date?), is made by and between Nanosphere, Inc., a Delaware corporation (the ?Company?), and Farzana Moinuddin (the ?Executive?). WHEREAS, the Company considers it essential to the best interests of its stockholders to foster the continued employment of key management personnel; and WHEREAS, the Board reco

July 31, 2015 EX-10.1

FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT

EX-10.1 2 ex101.htm EXHIBIT 10.1 Exhibit 10.1 FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “First Amendment”), dated as of July 29, 2015 (the “First Amendment Effective Date”), is made among Nanosphere, Inc., a Delaware corporation (the “Borrower”), NSPH Funding LLC, a Delaware limited liability company, in its capacity as collateral agen

July 31, 2015 EX-99.1

Nanosphere Announces Amendment to $30 million term loan facility, Release of Q2 2015 results and Conference Call and Schedules 2015 Annual Meeting of Stockholders

EX-99.1 3 ex991pressrelease7-31x15.htm EXHIBIT 99.1 Exhibit 99.1 Nanosphere Announces Amendment to $30 million term loan facility, Release of Q2 2015 results and Conference Call and Schedules 2015 Annual Meeting of Stockholders NORTHBROOK, IL - July 31, 2015 - Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, announced today that it has amended c

July 31, 2015 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 31, 2015 (July 29, 2015) NANOSPHERE, INC.

July 20, 2015 CORRESP

Nanosphere ESP

July 20, 2015 Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: Nanosphere, Inc. (the ?Company?) Registration Statement on Form S-3 (File No. 333-205575) Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended, the Company hereby requests that the effective date of the above-captioned Registration S

July 9, 2015 S-3

Nanosphere FORM S-3

FORM S-3 Table of Contents As filed with the Securities and Exchange Commission on July 9, 2015 Registration No.

July 2, 2015 SC 13G/A

NSPH / Nanosphere, Inc. / BLAIR WILLIAM & CO/IL - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. 2)* NANOSPHERE, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 63009F105 (CUSIP Number) December 31, 2014 (Date of Event Whi

June 11, 2015 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

8-K 1 d941771d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 11, 2015 (June 8, 2015) NANOSPHERE, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-33775 36-4339870 (State or Other Jurisdiction of In

June 11, 2015 EX-4.7

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 723 Initial Exercise Date: December 11, 2015 Issue Date: June 11, 2015

EX-4.7 9 d941771dex47.htm EX-4.7 EXHIBIT 4.7 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT

June 11, 2015 EX-4.8

JT 13351/2

EX-4.8 Exhibit 4.8 JT 13351/2 COPYRIGHT 1930 BY DWIGHT & M. H. JACKSON CHICAGO PATENT PENDING NUMBER SHARES Incorporated under the Laws of the State of Delaware NANOSPHERE, INC. 4,400 Authorized Series B Convertible Preferred Shares $0.01 Par Value Per Share This Certifies that is the owner of full paid and non-assessable SHARES OF THE SERIES B CONVERTIBLE PREFERRED STOCK OF NANOSPHERE, INC. trans

June 11, 2015 EX-4.2

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 481,600 Initial Exercise Date: December 11, 2015 Issue Date: June 11, 2015

EX-4.2 EXHIBIT 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

June 11, 2015 EX-10.1

SECURITIES PURCHASE AGREEMENT

EX-10.1 EXHIBIT 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of June 8, 2015, between Nanosphere, Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively the ?Purchasers?). WHEREAS, subject to the terms and conditions

June 11, 2015 EX-4.5

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 24,919 Initial Exercise Date: December 11, 2015 Issue Date: June 11, 2015

EX-4.5 EXHIBIT 4.5 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

June 11, 2015 EX-3.1

NANOSPHERE, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS SERIES B CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW

EX-3.1 2 d941771dex31.htm EX-3.1 EXHIBIT 3.1 NANOSPHERE, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES B CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW The undersigned, Michael K. McGarrity and Ann Wallin, do hereby certify that: 1. They are the President and Chief Executive Officer, and Secretary, respectively, of Nan

June 11, 2015 EX-10.2

REGISTRATION RIGHTS AGREEMENT

EX-10.2 EXHIBIT 10.2 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this ?Agreement?) is made and entered into as of June 8, 2015, between Nanosphere, Inc., a Delaware corporation (the ?Company?), and each of the several purchasers signatory hereto (each such purchaser, a ?Purchaser? and, collectively, the ?Purchasers?). This Agreement is made pursuant to the Securities Purchase

June 11, 2015 EX-4.1

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 722,200 Initial Exercise Date: December 11, 2015 Issue Date: June 11, 2015

EX-4.1 EXHIBIT 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

June 11, 2015 EX-4.3

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 21,669 Initial Exercise Date: December 11, 2015 Issue Date: June 11, 2015

EX-4.3 EXHIBIT 4.3 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

June 11, 2015 EX-4.6

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 2,167 Initial Exercise Date: December 11, 2015 Issue Date: June 11, 2015

EX-4.6 8 d941771dex46.htm EX-4.6 EXHIBIT 4.6 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT

June 11, 2015 EX-4.4

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 22,752 Initial Exercise Date: December 11, 2015 Issue Date: June 11, 2015

EX-4.4 EXHIBIT 4.4 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

June 10, 2015 424B5

4,400 Shares of Series B Convertible Preferred Stock

424B5 1 d939844d424b5.htm 424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-183916 PROSPECTUS SUPPLEMENT (To Prospectus dated November 5, 2012) 4,400 Shares of Series B Convertible Preferred Stock Pursuant to this prospectus supplement and the accompanying prospectus, we are offering 4,400 shares of our Series B Convertible Preferred Stock, which we refer to as our Seri

June 8, 2015 EX-99.1

Nanosphere Announces $4.4 Million At The Market Registered Direct Offering

EX-99.1 Exhibit 99.1 Nanosphere Announces $4.4 Million At The Market Registered Direct Offering NORTHBROOK, IL ? June 8, 2015 ? Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, today announced today that it has entered into a definitive agreement with a dedicated healthcare institutional investor in a registered direct offering for $4.4 million

June 8, 2015 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2015 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commission

June 2, 2015 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 1, 2015 (June 2, 2015) NANOSPHERE, INC.

June 2, 2015 EX-10.1

LETTER OF AGREEMENT Date: June 2, 2015

EX-10.1 2 d936485dex101.htm EX-10.1 Exhibit 10.1 LETTER OF AGREEMENT Date: June 2, 2015 Section 1. Services to be Rendered. The purpose of this letter is to set forth the terms and conditions on which Chord Advisors, LLC (“Chord”) agrees to provide Nanosphere, Inc. (the “Company”) comprehensive outsourced CFO support, accounting policy and financial reporting services. These services may include,

June 1, 2015 SD

Nanosphere SD

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM SD Specialized Disclosure Report Nanosphere, Inc. (Name of Registrant) Delaware 001-33775 36-4339870 (State or other jurisdiction of incorporation or organization) (Commission File Number) (IRS Employer Identification No.) 4088 Commercial Avenue, Northbrook, IL 60062 (Address of principal executive offices) Ann Wallin Tit

June 1, 2015 EX-1.01

Nanosphere, Inc. Conflict Minerals Report For the Year Ended December 31, 2014

EX-1.01 2 d937488dex101.htm EX-1.01 Exhibit 1.01 Nanosphere, Inc. Conflict Minerals Report For the Year Ended December 31, 2014 This Conflict Minerals Report (the “Report”) of Nanosphere, Inc. (the “Company”) has been prepared in accordance with Rule 13p-1 under the Securities Exchange Act of 1934, as amended (the “Rule”), for the reporting period January 1, 2014 to December 31, 2014. The Rule req

May 26, 2015 SC 13G

NSPH / Nanosphere, Inc. / Perella Weinberg Partners Capital Management LP - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Nanosphere, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 63009F105 (CUSIP Number) May 14, 2015 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: o Rule 13d-

May 26, 2015 SC 13G

Nanosphere 3G (Passive Acquisition of More Than 5% of Shares)

SC 13G 1 e00243swk-sc13g.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Nanosphere, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 63009F105 (CUSIP Number) May 14, 2015 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this S

May 14, 2015 EX-4.3

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 701,200 Initial Exercise Date: November 14, 2015 Issue Date: May 14, 2015

EX-4.3 Exhibit 4.3 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

May 14, 2015 EX-4.4

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 467,459 Initial Exercise Date: November 14, 2015 Issue Date: May 14, 2015

EX-4.4 Exhibit 4.4 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

May 14, 2015 EX-10.1

LOAN AND SECURITY AGREEMENT

EX-10.1 Exhibit 10.1 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (as the same may be amended, restated, modified, or supplemented from time to time, this “Agreement”) dated as of May 14, 2015 (the “Effective Date”) among NSPH FUNDING LLC, a Delaware limited liability company, as collateral agent (in such capacity, together with its successors and assigns in such capacity, “Collate

May 14, 2015 EX-10.5

REGISTRATION RIGHTS AGREEMENT

Exhibit 10.5 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this ?Agreement?) is made and entered into as of May 11, 2015, between Nanosphere, Inc., a Delaware corporation (the ?Company?), and each of the several purchasers signatory hereto (each such purchaser, a ?Purchaser? and, collectively, the ?Purchasers?). This Agreement is made pursuant to the Securities Purchase Agreeme

May 14, 2015 EX-3.1

NANOSPHERE, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS SERIES A CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW

EX-3.1 Exhibit 3.1 NANOSPHERE, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES A CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151 OF THE DELAWARE GENERAL CORPORATION LAW The undersigned, Michael K. McGarry and Ann Wallin, do hereby certify that: 1. They are the President and Chief Executive Officer, and Secretary, respectively, of Nanaosphere, Inc., a Delaware c

May 14, 2015 EX-4.6

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 22,088 Initial Exercise Date: November 14, 2015 Issue Date: May 14, 2015

EX-4.6 8 d926475dex46.htm EX-4.6 Exhibit 4.6 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT

May 14, 2015 EX-4.2

WARRANT TO PURCHASE STOCK

EX-4.2 4 d926475dex42.htm EX-4.2 Exhibit 4.2 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF

May 14, 2015 EX-10.2

INTELLECTUAL PROPERTY SECURITY AGREEMENT

EX-10.2 15 d926475dex102.htm EX-10.2 Exhibit 10.2 INTELLECTUAL PROPERTY SECURITY AGREEMENT THIS INTELLECTUAL PROPERTY SECURITY AGREEMENT (“Agreement”) dated as of May 14, 2015, is made by Nanosphere, Inc., a Delaware corporation (“Grantor”), in favor of NSPH Funding LLC (“Collateral Agent”) in its capacity as collateral agent for the Lenders (as defined below). RECITALS A. Grantor has entered into

May 14, 2015 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Triggering Events That Accelerate or Increase a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

8-K 1 d926475d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 14, 2015 (May 11, 2015) NANOSPHERE, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-33775 36-4339870 (State or Other Jurisdiction of Inc

May 14, 2015 EX-4.7

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 24,191 Initial Exercise Date: November 14, 2015 Issue Date: May 14, 2015

EX-4.7 9 d926475dex47.htm EX-4.7 Exhibit 4.7 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT

May 14, 2015 EX-4.1

WARRANT TO PURCHASE STOCK Company: Nanosphere, Inc. Number of Shares: 600,000 Type/Series of Stock: Common Stock, par value $0.01 per share Warrant Price: $0.01 per share Issue Date: May 14, 2015 Expiration Date: May 14, 2025 (See also Section 5.1(b)

EX-4.1 3 d926475dex41.htm EX-4.1 Exhibit 4.1 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF

May 14, 2015 EX-10.3

REGISTRATION RIGHTS AGREEMENT

Exhibit 10.3 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this ?Agreement?) is made and entered into as of May 14, 2015, by and among Nanosphere, Inc., a Delaware corporation (the ?Company?), and the holders signatory hereto (each a ?Lender? and collectively, the ?Lenders?). This Agreement is made in connection with that certain Loan and Security Agreement, dated as of May 14,

May 14, 2015 EX-4.9

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 701 Initial Exercise Date: November 14, 2015 Issue Date: May 14, 2015

EX-4.9 11 d926475dex49.htm EX-4.9 Exhibit 4.9 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEP

May 14, 2015 EX-99.1

Nanosphere Announces Closing of New and Expanded Debt Facility and $4.4 Million At The Market Registered Direct Offering

Exhibit 99.1 Nanosphere Announces Closing of New and Expanded Debt Facility and $4.4 Million At The Market Registered Direct Offering NORTHBROOK, IL – May 14, 2015 – Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, announced today the closing of its previously announced registered direct offering of $4,400,000 of Series A Convertible Preferred S

May 14, 2015 EX-4.8

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 2,104 Initial Exercise Date: November 14, 2015 Issue Date: May 14, 2015

EX-4.8 10 d926475dex48.htm EX-4.8 Exhibit 4.8 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEP

May 14, 2015 EX-10.4

SECURITIES PURCHASE AGREEMENT

EX-10.4 17 d926475dex104.htm EX-10.4 EXHIBIT 10.4 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of May 11, 2015, between Nanosphere, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject

May 14, 2015 EX-4.10

JT 1335 ½

EX-4.10 Exhibit 4.10 JT 1335 ½ COPYRIGHT 1930 BY DWIGHT & M.H JACKSON CHICAGO PATENT PENOING NUMBER SHARES Incorporated under the Laws of the State of Delaware NANOSPHERE, INC. 4,400 Authorized Series A Convertible Preferred Shares $0.01 Par Value Per Share This Certifies that is the owner of full paid and non-assessable SHARES OF THE SERIES A CONVERTIBLE PREFERRED STOCK OF NANOSPHERE, INC. transf

May 14, 2015 EX-4.5

COMMON STOCK PURCHASE WARRANT NANOSPHERE, INC. Warrant Shares: 21,036 Initial Exercise Date: November 14, 2015 Issue Date: May 14, 2015

EX-4.5 Exhibit 4.5 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

May 13, 2015 424B5

4,400 Shares of Series A Convertible Preferred Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-183916 PROSPECTUS SUPPLEMENT (To Prospectus dated November 5, 2012) 4,400 Shares of Series A Convertible Preferred Stock Pursuant to this prospectus supplement and the accompanying prospectus, we are offering 4,400 shares of our Series A Convertible Preferred Stock, which we refer to as our Series A Preferred Stock, and

May 12, 2015 NT 10-Q

Nanosphere NT 10-Q

SEC FILE NUMBER 001-33775 CUSIP NUMBER 63009F204 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

May 12, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

10-Q 1 nsph-2015331x10q.htm 10-Q Q1-2015 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2015 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Co

May 12, 2015 EX-10.1

Nanosphere, Inc. $30,000,000 Secured Senior Credit Facilities Commitment Letter

EX-10.1 2 nsph-exh1012015331xq1.htm EXHIBIT 10.1 Exhibit 10.1 May 7, 2015 Nanosphere, Inc. $30,000,000 Secured Senior Credit Facilities Commitment Letter Nanosphere, Inc. 4088 Commercial Avenue Northbrook, IL 60062 Attention: Michael K. McGarrity, Chief Executive Officer Dear Michael: You have advised NSPH Funding LLC (in its capacity as agent, “Agent”, and in its capacity as a lender, “NSPH Lende

May 11, 2015 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2015 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commission File Numb

May 11, 2015 EX-99.1

Nanosphere Announces Record Q1 2015 Results, New and Expanded Debt Facility, $4.4 Million At The Market Registered Direct Offering and Next Generation Verigene System Progress

Exhibit 99.1 Exhibit 99.1 Nanosphere Announces Record Q1 2015 Results, New and Expanded Debt Facility, $4.4 Million At The Market Registered Direct Offering and Next Generation Verigene System Progress Corporate Highlights: ? Record Q1 revenues of $4.6 million confirming full year guidance ? New and Expanded Debt Facility ? Pricing of $4.4 million at the market registered direct offering ? Next Ge

April 7, 2015 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Other Events, Submission of Matters to a Vote of Security Holders

8-K 1 d905854d8k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 7, 2015 (April 7, 2015) NANOSPHERE, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-33775 36-4339870 (State or Other Jurisdiction

April 7, 2015 EX-3.1

CERTIFICATE OF AMENDMENT CERTIFICATE OF INCORPORATION NANOSPHERE, INC.

EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT OF CERTIFICATE OF INCORPORATION OF NANOSPHERE, INC. The undersigned, being the duly elected President and Chief Executive Officer of Nanosphere, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY: FIRST: That Article Four, Section A of the Eighth Amended and Restated

April 7, 2015 EX-99.1

Nanosphere Announces Reverse Split of Common Stock

EX-99.1 3 d905854dex991.htm EX-99.1 Exhibit 99.1 Nanosphere Announces Reverse Split of Common Stock NORTHBROOK, IL – April 7, 2015 – Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, announced today that a 20-to-1 reverse split of its common stock will be effective at 5:00 p.m. EDT on April 8, 2015, and commencing at the open of trading on Thursd

April 2, 2015 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K/A (Amendment No. 1) (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2014 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-3

March 3, 2015 DEF 14A

NSPH / Nanosphere, Inc. DEF 14A - - DEF 14A

DEF 14A 1 d877398ddef14a.htm DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule

February 20, 2015 PRE 14A

NSPH / Nanosphere, Inc. PRE 14A - - PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: x Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ¨ Definitive Proxy State

February 17, 2015 SC 13G/A

NSPH / Nanosphere, Inc. / Flynn James E Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No.

February 11, 2015 EX-99.1

Nanosphere Announces Fourth Quarter and Full Year 2014 Results, 2015 Guidance and Next Generation Verigene Progress

Exhibit 99.1 Nanosphere Announces Fourth Quarter and Full Year 2014 Results, 2015 Guidance and Next Generation Verigene Progress Corporate Highlights and Guidance: • Record fourth quarter and fiscal year revenues of $4.6 million, and $14.3 million, respectively • 47 new customer placements in the fourth quarter • Revenue guidance for 2015 set at $18 million to $20 million • Next Generation Platfor

February 11, 2015 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2014 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-33775 Nanosphere, Inc

February 11, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 11, 2015 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commission File

February 4, 2015 SC 13G/A

NSPH / Nanosphere, Inc. / BLAIR WILLIAM & CO/IL - SC 13G/A Passive Investment

SC 13G/A 1 v399877sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. 1)* NANOSPHERE, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 63009F105 (CUSIP Number

January 28, 2015 EX-99.2

January 21, 2015 WARNING LETTER

EX-99.2 Exhibit 99.2 DEPARTMENT OF HEALTH & HUMAN SERVICES Food and Drug Administration Chicago District 550 West Jackson Blvd., 15th Floor Chicago, Illinois 60661 Telephone: 312-353-5863 January 21, 2015 WARNING LETTER CHI-1-15 VIA UPS NEXT DAY – SIGNATURE REQUIRED Michael K. McGarrity President and Chief Executive Officer Nanosphere, Inc. 4088 Commercial Avenue Northbrook, Illinois 60062 Dear Mr

January 28, 2015 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) January 28, 2015 (January 22, 2015) NANOSPHERE, INC.

January 28, 2015 EX-99.1

Nanosphere Announces Fourth Quarter and Full Year 2014 Preliminary Top Line Results, Director and Management Changes and Receipt of FDA Warning Letter

EX-99.1 Exhibit 99.1 Nanosphere Announces Fourth Quarter and Full Year 2014 Preliminary Top Line Results, Director and Management Changes and Receipt of FDA Warning Letter Corporate Highlights: • Record fourth quarter and fiscal year preliminary revenue of $4.6 million and $14.3 million, respectively • 47 new customer placements in fourth quarter • Roger Moody steps down as Chief Financial Officer

November 5, 2014 EX-99.1

Nanosphere Announces Third Quarter Financial and Operating Results

EX-99.1 Exhibit 99.1 Nanosphere Announces Third Quarter Financial and Operating Results Corporate Highlights and Business Guidance: • Q3 2014 revenues of $3.7 million, a 56% increase over Q3 2013, and 30 new customer placements. • Received FDA clearance of Verigene® Enteric Pathogens Nucleic Acid Test (EP). NORTHBROOK, IL – November 5, 2014 – Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing me

November 5, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2014 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commission File

November 5, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2014 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Numbe

October 27, 2014 EX-99.1

Nanosphere, Inc. Announces the Closing of Common Stock Offering

EX-99.1 Exhibit 99.1 Nanosphere, Inc. 4088 Commercial Avenue Northbrook, IL 60062 NEWS For Immediate Release Nanosphere, Inc. Announces the Closing of Common Stock Offering NORTHBROOK, IL—October 27, 2014—Nanosphere, Inc. (the “Company”) (NASDAQ:NSPH), a company enhancing medicine through targeted molecular diagnostics, today announced the closing of its previously announced underwritten public of

October 27, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 27, 2014 (October 22, 2014) NANOSPHERE, INC.

October 27, 2014 EX-1.1

NANOSPHERE, INC. 40,000,000 Shares of Common Stock, $0.01 par value. UNDERWRITING AGREEMENT

EX-1.1 2 d810068dex11.htm EX-1.1 Exhibit 1.1 NANOSPHERE, INC. 40,000,000 Shares of Common Stock, $0.01 par value. UNDERWRITING AGREEMENT October 22, 2014 Chardan Capital Markets LLC As Representative of the several Underwriters c/o Chardan Capital Markets LLC 17 State Street, Suite 1600 New York, NY 10004 Ladies and Gentlemen: Nanosphere, Inc., a Delaware corporation (the “Company”), proposes, sub

October 24, 2014 424B5

Prospectus Supplement (To Prospectus dated November 5, 2012) 40,000,000 Shares of Common Stock

424B5 1 d807786d424b5.htm 424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-183916 Prospectus Supplement (To Prospectus dated November 5, 2012) 40,000,000 Shares of Common Stock Pursuant to this prospectus supplement and the accompanying prospectus, we are offering up to 40,000,000 shares of our common stock. Our common stock is listed on the NASDAQ Global Market under

October 22, 2014 EX-99.1

5

EX-99.1 2 d809471dex991.htm EX-99.1 EXHIBIT 99.1 Nanosphere, Inc. 4088 Commercial Avenue Northbrook, IL 60062 NEWS For Immediate Release Nanosphere Prices $20 million Public Offering of Common Stock Northbrook, Ill—October 22, 2014—Nanosphere, Inc. (the “Company”) (Nasdaq:NSPH), a leader in the development and commercialization of advanced molecular diagnostics systems, today announced the pricing

October 22, 2014 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

8-K 1 d809471d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 22, 2014 NANOSPHERE, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-33775 36-4339870 (State or Other Jurisdiction of Incorporation

October 21, 2014 424B3

Supplement No. 1 To Prospectus Supplement, dated March 18, 2014 To Prospectus, dated November 5, 2012 NANOSPHERE, INC. Relating to Up to $30 million of Shares of Common Stock

424B3 Filed Pursuant to Rule 424(b)(3) Registration No. 333-183916 Supplement No. 1 To Prospectus Supplement, dated March 18, 2014 To Prospectus, dated November 5, 2012 of NANOSPHERE, INC. Relating to Up to $30 million of Shares of Common Stock This supplement, dated October 21, 2014 (this “Supplement”), supplements our prospectus supplement dated March 18, 2014 and its accompanying prospectus dat

October 21, 2014 EX-99.2

COMPANY OVERVIEW

EX-99.2 COMPANY OVERVIEW OCTOBER 2014 Exhibit 99.2 NANOSPHERE This presentation contains forward-looking statements about us and our industry that involve substantial risks and uncertainties. We intend such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27

October 21, 2014 424B2

Subject to Completion Preliminary Prospectus Supplement Dated October 21, 2014 (To Prospectus dated November 5, 2012) Shares of Common Stock

Preliminary Prospectus Supplement Table of Contents Filed Pursuant to Rule 424(b)(2) Registration No.

October 21, 2014 EX-99.1

2

Exhibit 99.1 Nanosphere, Inc. 4088 Commercial Avenue Northbrook, IL 60062 NEWS For Immediate Release Nanosphere Announces Commencement of Public Offering of Common Stock; Preliminary Third Quarter 2014 Top Line Results. NORTHBROOK, IL—October 21, 2014—Nanosphere, Inc. (the “Company” or “Nanosphere”) (NASDAQ:NSPH), a company enhancing medicine through targeted molecular diagnostics, today announced

October 21, 2014 8-K

Regulation FD Disclosure, Termination of a Material Definitive Agreement, Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 21, 2014 (October 20, 2014) NANOSPHERE, INC.

October 14, 2014 8-K

Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 14, 2014 (October 13, 2014) NANOSPHERE, INC.

October 14, 2014 EX-99.1

FDA Clears Additional Viral Targets on Verigene Enteric Pathogens Test

EX-99.1 2 d804068dex991.htm EX-99.1 Exhibit 99.1 FDA Clears Additional Viral Targets on Verigene Enteric Pathogens Test NORTHBROOK, IL – October 13, 2014 – Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, today announced it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its Verigene® Enteric Pathogens Nucleic

September 22, 2014 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 19, 2014 (September 19, 2014) NANOSPHERE, INC.

September 4, 2014 EX-99.1

Nanosphere Announces Review of Strategic Alternatives

Exhibit 99.1 Nanosphere Announces Review of Strategic Alternatives NORTHBROOK, IL – September 3, 2014 – Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, today announced that the Company has engaged Jefferies LLC as its financial advisor to assist it in the development and evaluation of a full range of potential strategic alternatives for the Com

September 4, 2014 8-K

Financial Statements and Exhibits, Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 4, 2014 (September 4, 2014) NANOSPHERE, INC.

August 20, 2014 EX-99.1

Nanosphere Appoints Kristopher Wood to its Board of Directors

EX-99.1 Exhibit 99.1 Nanosphere Appoints Kristopher Wood to its Board of Directors NORTHBROOK, IL – August 20, 2014 – Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing medicine through targeted molecular diagnostics, today announced the appointment of Kristopher Wood to its board of directors. Mr. Wood brings to Nanosphere extensive experience in finance, strategy and venture capital. “We are p

August 20, 2014 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 20, 2014 (August 18, 2014) NANOSPHERE, INC.

August 6, 2014 EX-99.1

Nanosphere Announces Second Quarter Financial and Operating Results

EX-99.1 Exhibit 99.1 Nanosphere Announces Second Quarter Financial and Operating Results Corporate Highlights and Business Guidance: • Added 37 new Verigene® System customer placements • Achieved Q2 2014 revenues of $2.7 million, a 44% increase over Q2 2013 • Increased consumable sales by 108% from prior year 2013 • Gross margin increased to 38% from 32% from prior year 2013 • Received FDA clearan

August 6, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 6, 2014 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commissio

August 6, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2014 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001

August 6, 2014 EX-3.1

CERTIFICATE OF AMENDMENT CERTIFICATE OF INCORPORATION NANOSPHERE, INC.

EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT OF CERTIFICATE OF INCORPORATION OF NANOSPHERE, INC. The undersigned, being the duly elected Chief Financial Officer, Vice President of Finance & Administration, Treasurer and Secretary of Nanosphere, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY: FIRST: That Art

June 25, 2014 EX-99.1

Verigene® Enteric Pathogens Test Receives FDA Clearance

EX-99.1 Exhibit 99.1 Verigene® Enteric Pathogens Test Receives FDA Clearance NORTHBROOK, IL – JUNE 24, 2014 – Nanosphere, Inc. (NASDAQ: NSPH), a company enhancing the practice of medicine through targeted molecular diagnostics, today announced it has received U.S. Food and Drug Administration (FDA) 510(k) clearance for the bacterial portion of its Verigene® Enteric Pathogens Nucleic Acid Test (EP)

June 25, 2014 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 25, 2014 NANOSPHERE, INC.

June 2, 2014 SD

- FORM SD

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM SD Specialized Disclosure Report Nanosphere, Inc. (Name of Registrant) Delaware 001-33775 36-4339870 (State or other jurisdiction of incorporation or organization) (Commission File Number) (IRS Employer Identification No.) 4088 Commercial Avenue, Northbrook, IL 60062 (Address of principal executive offices) Roger Moody Ti

June 2, 2014 EX-1.02

Nanosphere, Inc. Conflict Minerals Report For the Year Ended December 31, 2013

EX-1.02 2 d737675dex102.htm EX-1.02 Exhibit 1.02 Nanosphere, Inc. Conflict Minerals Report For the Year Ended December 31, 2013 This Conflict Minerals Report (the “Report”) of Nanosphere, Inc. (the “Company”) has been prepared in accordance with Rule 13p-1 under the Securities Exchange Act of 1934, as amended (the “Rule”), for the reporting period January 1, 2013 to December 31, 2013. The Rule req

May 29, 2014 8-K

Submission of Matters to a Vote of Security Holders - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 29, 2014 (May 28, 2014) NANOSPHERE, INC.

May 7, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2014 NANOSPHERE, INC. (Exact name of registrant as specified in its charter) Delaware 001-33775 36-4339870 (State or other Jurisdiction of Incorporation) (Commission F

May 7, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2014 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 00

May 7, 2014 EX-99.1

Nanosphere Announces First Quarter Financial and Operating Results

EX-99.1 Exhibit 99.1 Nanosphere Announces First Quarter Financial and Operating Results Corporate Highlights and Business Guidance: • Achieved 48 new Verigene customer placements • Achieved Q1 2014 revenues of $3.3 million, a 39% increase over Q1 2013 • Reaffirmed 2014 guidance of approximately 200 new customer placements and $19 million to $21 million in revenue • Received FDA clearance of Verige

April 17, 2014 DEF 14A

- DEF 14A

DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Definitive Pro

April 9, 2014 SC 13D/A

NSPH / Nanosphere, Inc. / Lurie Investment Fund, L.L.C. - SC 13D/A Activist Investment

SC 13D/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13D Under the Securities Exchange Act of 1934 (Amendment No. 11)* Nanosphere, Inc. (Name of Issuer) Common Stock, $0.01 par value per share (Title of Class of Securities) 63009F105 (CUSIP Number) Theodore J. Theophilos Chief Administrative Officer Lurie Investments, Inc. 2 N. Riverside Plaza, Suite 1240 Chicago, Illinois 6

April 7, 2014 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 4, 2014 (April 4, 2014) NANOSPHERE, INC.

April 7, 2014 EX-99.1

Nanosphere Clarifies Recent Transactions in Company’s Common Stock

EX-99.1 Exhibit 99.1 Nanosphere Clarifies Recent Transactions in Company’s Common Stock NORTHBROOK, IL – April 4, 2014 – Nanosphere, Inc. (NASDAQ: NSPH) today clarified recent transactions in Nanosphere’s common stock by certain of its directors and significant stockholders in response to false and misleading reports and web site postings about those transactions, which are detailed below. From Ma

April 2, 2014 PRE 14A

- PRE 14A

PRE 14A 1 d664871dpre14a.htm PRE 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: x Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule

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