SHPG / Shire Plc. - Документы SEC, Годовой отчет, Доверенное заявление

Компания Шайр.
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ЭТОТ СИМВОЛ БОЛЬШЕ НЕ АКТИВЕН

Основная статистика
CIK 936402
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Shire Plc.
SEC Filings (Chronological Order)
На этой странице представлен полный хронологический список документов SEC, за исключением документов о собственности, которые мы предоставляем в других местах.
February 15, 2019 SC 13G

SHPG / Shire Plc. / UBS Group AG - SC 13G Passive Investment

SC 13G 1 d709952dsc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Shire PLC (Name of Issuer) Common Stock (Title of Class of Securities) G8124V108 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pur

February 7, 2019 15-15D

BXLT / Baxalta Incorporated FORM 15-15D

15-15D 1 d705536d1515d.htm FORM 15-15D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Numbers 001-36782 001-37896 Baxalta Incorpor

February 7, 2019 15-12B

SHPG / Shire Plc. FORM 15

15-12B 1 d641654d1512b.htm FORM 15 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-37896 Shire plc (Exact name of regist

February 4, 2019 POS AM

SHPG / Shire Plc. FORM POS AM

Form POS AM As filed with the Securities and Exchange Commission on February 4, 2019 Registration No.

February 4, 2019 S-8 POS

SHPG / Shire Plc. FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on February 4, 2019 Registration Statement No.

February 4, 2019 S-8 POS

SHPG / Shire Plc. FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on February 4, 2019 Registration Statement No.

February 4, 2019 S-8 POS

SHPG / Shire Plc. FORM S-8 POS

S-8 POS 1 d705509ds8pos.htm FORM S-8 POS As filed with the Securities and Exchange Commission on February 4, 2019 Registration Statement No. 333-151142 Registration Statement No. 333-151145 Registration Statement No. 333-202302 Registration Statement No. 333-211941 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO Form S-8 Registration Statem

February 4, 2019 S-8 POS

SHPG / Shire Plc. FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on February 4, 2019 Registration Statement No.

January 11, 2019 EX-99.1

Shire and SAIIDAC announce planned delisting of notes from the New York Stock Exchange

EXHIBIT 99.1 Exhibit 99.1 Shire and SAIIDAC announce planned delisting of notes from the New York Stock Exchange Dublin, Ireland – January 11, 2019 – Shire plc (“Shire”) and Shire Acquisitions Investments Ireland DAC, an Irish designated activity company and wholly-owned subsidiary of Shire (“SAIIDAC”), announced today that they have notified the New York Stock Exchange (the “NYSE”) of their inten

January 11, 2019 8-K

Financial Statements and Exhibits, Other Events

8-K 1 d685331d8k.htm FORM 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 11, 2019 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or

January 9, 2019 8-K

Financial Statements and Exhibits, Other Events

8-K 1 dp1007958k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2019 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction

January 9, 2019 EX-99.1

Director/PDMR Shareholding

Exhibit 99.1 Director/PDMR Shareholding January 8, 2019 – Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) Notification of transactions by persons discharging managerial responsibilities 1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Flemming Ornskov 2. Reason for the notification a) Position / status Chief Executiv

January 8, 2019 EX-3.1

Articles of Association of Shire plc as amended and adopted by a special resolution on January 8, 2019.

EX-3.1 2 d673508dex31.htm EXHIBIT 3.1 Table of Contents Exhibit 3.1 Companies (Jersey) Law 1991 Company Limited by Shares EFFECTIVE: 8 JANUARY 2019 ARTICLES OF ASSOCIATION OF SHIRE PLC (ADOPTED BY A SPECIAL RESOLUTION DATED 8 JANUARY 2019) Table of Contents CONTENTS 1    Definitions, interpretation and exclusion of Standard Table 1 Definitions 1 Interpretation 3 Exclusion of Standard Table 3 2    

January 8, 2019 8-K

Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Termination of a Material Definitive Agreement, Material Modification to Rights of Security Holders, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2019 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Co

January 8, 2019 EX-99.1

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Exhibit 99.1 Press Release www.shire.com Holding(s) in Company January 7, 2019 – Shire plc (LSE: SHP, NASDAQ: SHPG) 1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire Plc JE00B2QKY057 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non-UK issuer X 2. Reason for the notification (please ma

January 8, 2019 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 7, 2019 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission

January 3, 2019 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 3, 2019 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission

January 3, 2019 EX-99.1

RECOMMENDED OFFER SHIRE PLC TAKEDA PHARMACEUTICAL COMPANY LIMITED Court sanction of the Scheme

Exhibit 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION

January 2, 2019 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 27, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commissio

January 2, 2019 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 31 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

January 2, 2019 EX-99.5

Total Voting Rights

EX-99.5 6 january22019-tvrxexhibit995.htm EXHIBIT 99.5 EXHIBIT 99.5 Total Voting Rights January 2, 2019 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), in accordance with 5.6.1R of the Financial Conduct Authority's (the “FCA”) Disclosure Guidance and Transparency Rules, notifies the market of the following: As at December 31, 2018, the Company’s issued ordinary share capital comprised 925,47

January 2, 2019 EX-99.2

1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire Plc JE00B2QKY057 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non-UK issuer X 2. Reas

EXHIBIT 99.2 Press Release www.shire.com Holding(s) in Company December 28, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) 1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire Plc JE00B2QKY057 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non-UK issuer X 2. Reason for the notification (please

January 2, 2019 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 28 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

January 2, 2019 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 27 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

January 2, 2019 EX-99.6

1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire Plc JE00B2QKY057 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non-UK issuer X 2. Reas

EX-99.6 7 january22019-holdingcoxexh.htm EXHIBIT 99.6 EXHIBIT 99.6 Press Release www.shire.com Holding(s) in Company January 2, 2019 - Shire plc (LSE: SHP, NASDAQ: SHPG) 1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire Plc JE00B2QKY057 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non

December 26, 2018 EX-99.4

1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire Plc JE00B2QKY057 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non-UK issuer X 2. Reas

EXHIBIT 99.4 Press Release www.shire.com Holding(s) in Company December 24, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) 1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire Plc JE00B2QKY057 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non-UK issuer X 2. Reason for the notification (please

December 26, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 21, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commissio

December 26, 2018 EX-99.2

Director Declaration

EXHIBIT 99.2 Press Release www.shire.com Director Declaration December 21, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that Ian Clark, Non-Executive Director of the Company, is a Non-Executive Director of Guardant Health, Inc which became publically quoted on October 4, 2018. This disclosure is made pursuant to LR 9.6.14 of the UK Listing Rules. Sarah Rixon Senior Company S

December 26, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 24 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

December 26, 2018 EX-99.1

1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire Plc JE00B2QKY057 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non-UK issuer X 2. Reas

EXHIBIT 99.1 Press Release www.shire.com Holding(s) in Company December 21, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) 1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire Plc JE00B2QKY057 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non-UK issuer X 2. Reason for the notification (please

December 20, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 18, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commissio

December 20, 2018 EX-99.9

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EX-99.9 10 dec202018-formddxexhibit999.htm EXHIBIT 99.9 EXHIBIT 99.9 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a) Full name of discloser: Steven Gillis (b) Owner or controller of interests and short posi

December 20, 2018 EX-99.10

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EX-99.10 11 dec202018-formddxexhibit9910.htm EXHIBIT 99.10 EXHIBIT 99.10 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a) Full name of discloser: Ian Clark (b) Owner or controller of interests and short posi

December 20, 2018 EX-99.6

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.6 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a) Full name of discloser: Susan Kilsby (b) Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of no

December 20, 2018 EX-99.8

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.8 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a) Full name of discloser: Sara Mathew (b) Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of nom

December 20, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 december182018-rule29xexhi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 18 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeover

December 20, 2018 EX-99.5

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.5 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a) Full name of discloser: David Ginsburg (b) Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of

December 20, 2018 EX-99.4

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.4 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a) Full name of discloser: Gail Fosler (b) Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of nom

December 20, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 20 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

December 20, 2018 EX-99.3

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.3 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a) Full name of discloser: Albert Stroucken (b) Owner or controller of interests and short positions disclosed, if different from 1(a): The naming o

December 20, 2018 EX-99.11

1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Susan Kilsby 2. Reason for the notification a) Position / status Chairman - PDMR b) Initial notification / amendment Initi

EX-99.11 12 december202018-pdmrxexhibi.htm EXHIBIT 99.11 EXHIBIT 99.11 Press Release www.shire.com Director/PDMR Shareholding 20 December, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) Notification of transactions by persons discharging managerial responsibilities 1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Susan Kilsb

December 20, 2018 EX-99.7

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.7 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a) Full name of discloser: Olivier Bohuon (b) Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of

December 14, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 14 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

December 14, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 11 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

December 14, 2018 EX-99.5

1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Bill Mordan 2. Reason for the notification a) Position / status General Counsel and Company Secretary - PDMR b) Initial no

EXHIBIT 99.5 Press Release www.shire.com Director/PDMR Shareholding December 14, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) 1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Bill Mordan 2. Reason for the notification a) Position / status General Counsel and Company Secretary - PDMR b) Initial notification

December 14, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 13 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

December 14, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 11, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commissio

December 14, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 december122018-rule29xexhi.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 12 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeover

December 10, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 december62018-rule29xexhib.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 6 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

December 10, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 december72018-rule29xexhib.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 7 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

December 10, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 december52018-rule29xexhib.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 5 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

December 10, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 5, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission

December 6, 2018 EX-99.2

Shire plc (LEI: 54930005LQRLI2UXRQ59)

EX-99.2 3 dp99334ex9902.htm EXHIBIT 99.2 Exhibit 99.2 Holding(s) in Company December 4, 2018 – Shire plc (LSE: SHP, NASDAQ: SHPG) 1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii: Shire plc (LEI: 54930005LQRLI2UXRQ59) 1b. Please indicate if the issuer is a non-UK issuer (please mark with an “X” if appropriate) Non-UK issuer 2. Reason for

December 6, 2018 8-K

Financial Statements and Exhibits, Other Events, Submission of Matters to a Vote of Security Holders

8-K 1 dp993348k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 4, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction

December 6, 2018 EX-99.1

RECOMMENDED OFFER SHIRE PLC TAKEDA PHARMACEUTICAL COMPANY LIMITED Results of Court Meeting and Shire General Meeting

EX-99.1 2 dp99334ex9901.htm EXHIBIT 99.1 Exhibit 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION FOR IMMEDIATE RELEASE DECEMBER 5, 2018 RECOMMENDED OFFER for SHIRE PLC by TAKEDA PHARMACEUTICAL COMPANY LIMITED Results of Court Meetin

December 4, 2018 EX-99.3

Investor Relations Christoph Brackmann [email protected] +41 41 288 41 29 Sun Kim [email protected] +1 617 588 8175 Scott Burrows [email protected] +41 41 288 4195 Media Katie Joyce [email protected] +1 781 482 2779

EXHIBIT 99.3 Press Release www.shire.com Total Voting Rights December 3, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), in accordance with 5.6.1R of the Financial Conduct Authority's (the “FCA”) Disclosure Guidance and Transparency Rules, notifies the market of the following: As at November 30, 2018, the Company’s issued ordinary share capital comprised 915,888,124 ordinary shares of 5

December 4, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 december32018-rule29xexhib.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 3 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

December 4, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 29, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commissio

December 4, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 november292018-rule29xexhi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 29 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeover

December 4, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.4 5 december42018-rule29xexhib.htm EXHIBIT 99.4 EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 4 December 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

November 27, 2018 EX-99.3

Name of applicant: Shire plc Name of scheme: Shire Sharesave Scheme Period of return: From: May 23, 2018 To: November 22, 2018 Balance of unallotted securities under scheme(s) from previous return: 159,388 Plus: The amount by which the block scheme(s

EX-99.3 4 november232018-blsmrxexhib.htm EXHIBIT 99.3 EXHIBIT 99.3 Press Release www.shire.com BLOCK LISTING SIX MONTHLY RETURN November 23, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) Name of applicant: Shire plc Name of scheme: Shire Sharesave Scheme Period of return: From: May 23, 2018 To: November 22, 2018 Balance of unallotted securities under scheme(s) from previous return: 159,388 Plus: The a

November 27, 2018 EX-99.4

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.4 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: Shire plc (b)Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of nominee

November 27, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 november222018-rule29xexhi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 22 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeover

November 27, 2018 EX-99.5

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.5 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 27 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

November 27, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 22, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commissio

November 27, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 23 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

November 21, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 november162018-rule29xexhi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 16 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeover

November 21, 2018 EX-99.3

RECOMMENDED OFFER SHIRE PLC TAKEDA PHARMACEUTICAL COMPANY LIMITED Phase I conditional clearance by the European Commission

EX-99.3 4 november202018-recommended.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. FOR IMMEDIATE RELEASE NOVEMBER 20, 2018 RECOMMENDED OFFER for SHIRE PLC by TAKEDA PHARMACEUTICAL COMPANY LIMITED Phase I conditional

November 21, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 16, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commissio

November 21, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 nov202018-rule29xexhibit992.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 20 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

November 14, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 november92018-rule29xexhib.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 9 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

November 14, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 november122018-rule29xexhi.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 12 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeover

November 14, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission

November 14, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 november142018-rule29xexhi.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 14 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeover

November 7, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 november22018-rule29xexhib.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 2 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

November 7, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 2, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission

November 7, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 november62018-rule29xexhib.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 6 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

November 7, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 november72018-rule29xexhib.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 7 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

November 1, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 30 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the clo

November 1, 2018 EX-99.5

1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Flemming Ornskov 2. Reason for the notification a) Position / status Chief Executive Officer - PDMR b) Initial notificatio

EXHIBIT 99.5 Press Release www.shire.com Director/PDMR Shareholding November 1, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) Notification of transactions by persons discharging managerial responsibilities 1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Flemming Ornskov 2. Reason for the notification a) Position / status C

November 1, 2018 EX-99.2

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EX-99.2 3 november12018-form8ddxexhi.htm EXHIBIT 99.2 EXHIBIT 99.2 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: Flemming Ornskov (b)Owner or controller of interests and short posit

November 1, 2018 EX-99.4

Press Release www.shire.com

EXHIBIT 99.4 Press Release www.shire.com Total Voting Rights November 1, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), in accordance with 5.6.1R of the Financial Conduct Authority's (the “FCA”) Disclosure Guidance and Transparency Rules, notifies the market of the following: As at October 31, 2018, the Company’s issued ordinary share capital comprised 914,818,708 ordinary shares of 5

November 1, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 30, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission

November 1, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 1 November 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the clo

November 1, 2018 EX-99.1

Q3 2018(1)

EX-99.1 2 erq32018-exhibit991.htm EXHIBIT 99.1 Exhibit 99.1 Press Release Shire Delivers Product Sales Growth of 6% and Continues to Execute Against Key Priorities in Q3 2018 Delivered product sales of $3.8 billion; growth driven by Immunology, recently-launched products, and international expansion Received U.S. Food and Drug Administration and Health Canada approval for TAKHZYRO (lanadelumab-fly

November 1, 2018 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 erq32018-form8xk.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 1, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdictio

November 1, 2018 10-Q

SHPG / Shire Plc. 10-Q (Quarterly Report)

10-Q 1 a10-qq3x2018.htm 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period ended September 30, 2018 Commission file number 0-29630 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey (Channel Islands) (State or other jurisdiction o

October 29, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 october242018-rule29xexhib.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 24 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 29, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 24, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission

October 29, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 october252018-rule29xexhib.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 25 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 29, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 october262018-rule29xexhib.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 26 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 23, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 22 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the clo

October 23, 2018 EX-99.5

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.5 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 23 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the clo

October 23, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission

October 23, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 october182018-rule29xexhib.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 18 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 23, 2018 EX-99.2

UK dial in: 0800 358 9473 or +44 333 300 0804 US dial in: 1 855 857 0686 or 1 631 913 1422 International Access Numbers: Click here Password/Conf ID: 28705371 # Live Webcast: Click here

EXHIBIT 99.2 Press Release www.shire.com Shire to announce third quarter 2018 results Dublin, Ireland - October 18, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG), will announce third quarter 2018 earnings on Thursday November 1, 2018. Results press release will be issued at: 12:00 GMT / 08:00 EDT Investor conference call time: 14:00 GMT / 10:00 EDT Live conference call for investors: Flemming Ornskov,

October 23, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 october192018-rule29xexhib.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 19 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 16, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 16 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the clo

October 16, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 15 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the clo

October 16, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 11, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission

October 16, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 11 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the clo

October 16, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 october122018-rule29xexhib.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 12 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 10, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 october82018-rule29xexhibi.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 8 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 10, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 october52018-rule29xexhibi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 5 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 10, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxoctober102018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 5, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisd

October 10, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 october102018-rule29xexhib.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 10 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 4, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxoctober42018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 1, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdi

October 4, 2018 EX-99.7

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EX-99.7 8 oct12018-form8ddxe997.htm EXHIBIT 99.7 EXHIBIT 99.7 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: Steven Gillis (b)Owner or controller of interests and short positions dis

October 4, 2018 EX-99.9

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.9 10 october22018-rule29xexhibi.htm EXHIBIT 99.9 EXHIBIT 99.9 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 2 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 4, 2018 EX-99.8

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.8 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: Susan Kilsby (b)Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of nomi

October 4, 2018 EX-99.2

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EX-99.2 3 oct12018-form8ddxe992.htm EXHIBIT 99.2 EXHIBIT 99.2 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: David Ginsburg (b)Owner or controller of interests and short positions di

October 4, 2018 EX-99.6

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.6 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: Sara Mathew (b)Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of nomin

October 4, 2018 EX-99.1

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EX-99.1 2 oct12018-form8ddxe991.htm EXHIBIT 99.1 EXHIBIT 99.1 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: Albert Stroucken (b)Owner or controller of interests and short positions

October 4, 2018 EX-99.12

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.12 13 october42018-rule29xexhibi.htm EXHIBIT 99.12 EXHIBIT 99.12 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 4 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeov

October 4, 2018 EX-99.3

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.3 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: Gail Fosler (b)Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of nomin

October 4, 2018 EX-99.4

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.4 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: Ian Clark (b)Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of nominee

October 4, 2018 EX-99.5

PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”)

EXHIBIT 99.5 FORM 8 (DD) PUBLIC DEALING DISCLOSURE BY A PARTY TO AN OFFER OR PERSON ACTING IN CONCERT (INCLUDING DEALINGS FOR THE ACCOUNT OF DISCRETIONARY INVESTMENT CLIENTS) Rules 8.1, 8.2 and 8.4 of the Takeover Code (the “Code”) 1. KEY INFORMATION (a)Full name of discloser: Olivier Bohuon (b)Owner or controller of interests and short positions disclosed, if different from 1(a): The naming of no

October 4, 2018 EX-99.11

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.11 12 october32018-rule29xexhibi.htm EXHIBIT 99.11 EXHIBIT 99.11 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 3 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeov

October 4, 2018 EX-99.10

1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Bill Mordan 2. Reason for the notification a) Position / status General Counsel and Company Secretary - PDMR b) Initial no

EX-99.10 11 october22018-pdmrxexhibit9.htm EXHIBIT 99.10 EXHIBIT 99.10 Press Release www.shire.com Director/PDMR Shareholding October 2, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) Notification of transactions by person discharging managerial responsibilities 1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Nam

October 1, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 october12018-rule29xexhibi.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 1 October 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

October 1, 2018 EX-99.4

Press Release www.shire.com

EX-99.4 5 october12018-tvrxexhibit994.htm EXHIBIT 99.4 EXHIBIT 99.4 Press Release www.shire.com Total Voting Rights October 1, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), in accordance with 5.6.1R of the Financial Conduct Authority's (the “FCA”) Disclosure Guidance and Transparency Rules, notifies the market of the following: As at September 30, 2018, the Company’s issued ordinary s

October 1, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 28 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the c

October 1, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 september262018-rule29xexh.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 26 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

October 1, 2018 EX-99.5

1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Susan Kilsby 2. Reason for the notification a) Position / status Chairman - PDMR b) Initial notification / amendment Initi

EXHIBIT 99.5 Press Release www.shire.com Director/PDMR Shareholding October 1, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) Notification of transactions by persons discharging managerial responsibilities 1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Susan Kilsby 2. Reason for the notification a) Position / status Chairm

October 1, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commissi

September 25, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 september242018-rule29xexh.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 24 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

September 25, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 september202018-rule29xexh.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 20 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

September 25, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 september212018-rule29xexh.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 21 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

September 25, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxseptember252018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 20, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other j

September 19, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 19 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the c

September 19, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 september172018-rule29xexh.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 17 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

September 19, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxseptember192018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 14, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other j

September 19, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 september142018-rule29xexh.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 14 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

September 19, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 september182018-rule29xexh.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 18 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

September 13, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 september112018-rule29xexh.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 11 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

September 13, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.4 5 september132018-rule29xexh.htm EXHIBIT 99.4 EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 13 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

September 13, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxseptember132018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 10, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other j

September 13, 2018 EX-99.1

Press Release www.shire.com

EXHIBIT 99.1 Press Release www.shire.com Elections for the interim dividend in respect of the six months to June 30, 2018 September 10, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announced on July 31, 2018, an interim dividend of 5.60 US cents per Ordinary Share payable on October 19, 2018, to shareholders on the register of members at the close of business on September 7, 2018. Hol

September 13, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 september122018-rule29xexh.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 12 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeove

September 10, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 dp955298k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 10, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdictio

September 10, 2018 EX-99.1

SHIRE ANNOUNCES THE PRICING TERMS AND INCREASE IN THE MAXIMUM TENDER AMOUNT OF THE PREVIOUSLY ANNOUNCED CASH TENDER OFFERS FOR CERTAIN OUTSTANDING NOTES

Press Release www.shire.com SHIRE ANNOUNCES THE PRICING TERMS AND INCREASE IN THE MAXIMUM TENDER AMOUNT OF THE PREVIOUSLY ANNOUNCED CASH TENDER OFFERS FOR CERTAIN OUTSTANDING NOTES Dublin, Ireland – September 10, 2018 –Shire plc (LSE: SHP and NASDAQ: SHPG) (“Shire”), Baxalta Incorporated, a Delaware corporation and wholly-owned subsidiary of Shire (“Baxalta”), and Shire Acquisitions Investments Ir

September 10, 2018 EX-99.1

SHIRE ANNOUNCES EARLY RESULTS OF THE PREVIOUSLY ANNOUNCED CASH TENDER OFFERS FOR CERTAIN OUTSTANDING NOTES

EX-99.1 2 dp95528ex9901.htm EXHIBIT 99.1 Exhibit 99.1 Press Release www.shire.com SHIRE ANNOUNCES EARLY RESULTS OF THE PREVIOUSLY ANNOUNCED CASH TENDER OFFERS FOR CERTAIN OUTSTANDING NOTES Dublin, Ireland – September 10, 2018 –Shire plc (LSE: SHP and NASDAQ: SHPG) (“Shire”), Baxalta Incorporated, a Delaware corporation and wholly-owned subsidiary of Shire (“Baxalta”), and Shire Acquisitions Invest

September 10, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 dp955288k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 10, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdictio

September 6, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.4 5 september62018-rule29xexhi.htm EXHIBIT 99.4 EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 6 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeover

September 6, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 3 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the cl

September 6, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxseptember62018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 3, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jur

September 6, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 september42018-rule29xexhi.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 4 September 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeover

September 6, 2018 EX-99.2

Investor Relations Christoph Brackmann [email protected] +41 41 288 41 29 Sun Kim [email protected] +1 617 588 8175 Scott Burrows [email protected] +41 41 288 4195 Media Katie Joyce [email protected] +1 781 482 2779

EX-99.2 3 september32018-tvrxexhibit.htm EXHIBIT 99.2 EXHIBIT 99.2 Press Release www.shire.com Total Voting Rights September 3, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), in accordance with 5.6.1R of the Financial Conduct Authority's (the “FCA”) Disclosure Guidance and Transparency Rules, notifies the market of the following: As at August 31, 2018, the Company’s issued ordinary sha

August 31, 2018 EX-99.1

Shire Completes Sale of Oncology Franchise

EX-99.1 2 dp95085ex9901.htm EXHIBIT 99.1 Exhibit 99.1 Press Release www.shire.com Shire Completes Sale of Oncology Franchise Dublin, Ireland – August 31, 2018 – Shire plc (LSE: SHP, NASDAQ: SHPG) announces today that it has completed the sale of its Oncology franchise to Servier S.A.S. for $2.4 billion. The franchise includes the global rights to ONCASPAR® and ex-US and ex-Taiwan rights to ONIVYDE

August 31, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 dp950858k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 31, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction o

August 31, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxaugust312018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 29, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdi

August 31, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 august312018-rule29xexhibi.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 31 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

August 31, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 august292018-rule29xexhibi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 29 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

August 31, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 august302018-rule29xexhibi.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 30 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

August 24, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 august232018-rule29xexhibi.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 23 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

August 24, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxaugust242018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 21, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdi

August 24, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 august242018-rule29xexhibi.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 24 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

August 24, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 august212018-rule29xexhibi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 21 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

August 24, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 dp947698k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 24, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction o

August 24, 2018 EX-99.1

SHIRE ANNOUNCES CASH TENDER OFFERS FOR UP TO $2,250,000,000 OUTSTANDING PRINCIPAL AMOUNT OF NOTES

EX-99.1 2 dp94769ex9901.htm EXHIBIT 99.1 Exhibit 99.1 Press Release www.shire.com SHIRE ANNOUNCES CASH TENDER OFFERS FOR UP TO $2,250,000,000 OUTSTANDING PRINCIPAL AMOUNT OF NOTES Dublin, Ireland – August 24, 2018 – Shire plc (LSE: SHP and NASDAQ: SHPG) (“Shire”), Baxalta Incorporated, a Delaware corporation and wholly-owned subsidiary of Shire (“Baxalta”), and Shire Acquisitions Investments Irela

August 24, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 dp948078k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 23, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction o

August 24, 2018 EX-99.1

2

EX-99.1 2 dp94807ex9901.htm EXHIBIT 99.1 Exhibit 99.1 Press Release www.shire.com Intended for Global Audience Regulatory Approval Shire Announces FDA Approval of TAKHZYRO™ (lanadelumab-flyo), a First-of-its-Kind mAb Preventive Treatment for Hereditary Angioedema - In the pivotal study, patients taking TAKHZYRO 300 mg every 2 weeks had an 87% reduction in mean monthly attacks vs. placebo (0.26 vs.

August 17, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 august142018-rule29xexhibi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 14 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

August 17, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 august172018-rule29xexhibi.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 17 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

August 17, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxaugust172018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdi

August 17, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 august152018-rule29xexhibi.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 15 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers

August 10, 2018 EX-99.2

1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Perry Sternberg 2. Reason for the notification a) Position / status Head of US Commercial - PDMR b) Initial notification /

EXHIBIT 99.2 Press Release www.shire.com Director/PDMR Shareholding August 7, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) Notification of transactions by persons discharging managerial responsibilities 1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Perry Sternberg 2. Reason for the notification a) Positi

August 10, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

Exhibit EXHIBIT 99.3 <

August 10, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 9 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close

August 10, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission F

August 10, 2018 EX-99.5

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.5 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 10 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the clos

August 10, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 august072018-rule29xexhibi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 7 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers a

August 6, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxaugust062018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 1, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdic

August 6, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 august012018-rule29xexhibi.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 1 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers a

August 6, 2018 EX-99.2

Investor Relations Christoph Brackmann [email protected] +41 41 288 41 29 Sun Kim [email protected] +1 617 588 8175 Scott Burrows [email protected] +41 41 288 4195 Media Katie Joyce [email protected] +1 781 482 2779

EX-99.2 3 august012018-tvrxexhibit992.htm EXHIBIT 99.2 EXHIBIT 99.2 Press Release www.shire.com Total Voting Rights August 1, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), in accordance with 5.6.1R of the Financial Conduct Authority's (the “FCA”) Disclosure Guidance and Transparency Rules, notifies the market of the following: As at July 31, 2018, the Company’s issued ordinary share c

August 6, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 2 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close

August 6, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.4 5 august032018-rule29xexhibi.htm EXHIBIT 99.4 EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 3 August 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers a

July 31, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 july262018-rule29xexhibit9.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 26 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

July 31, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 july302018-rule29xexhibit9.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 30 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

July 31, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxjuly312018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 26, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdictio

July 31, 2018 EX-99.1

Q2 2018

Exhibit 99.1 Press Release Shire Delivers Q2 2018 Product Sales Growth of 6% and Continued Regulatory and Pipeline Progress Product sales grew to $3.8 billion driven by Immunology, recently launched products, and international expansion Innovative pipeline continued to advance with 7 programs in registration and 16 in Phase 3 U.S. Food and Drug Administration (FDA) approval received for state-of-t

July 31, 2018 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission Fi

July 31, 2018 10-Q

SHPG / Shire Plc. 10-Q (Quarterly Report)

10-Q 1 a10-qq2x2018.htm 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period ended June 30, 2018 Commission file number 0-29630 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey (Channel Islands) (State or other jurisdiction of inc

July 25, 2018 EX-99.3

Press Release www.shire.com

EX-99.3 4 july242018-directordeclara.htm EXHIBIT 99.3 EXHIBIT 99.3 Press Release www.shire.com Director Declaration July 24, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that Ian Clark, Non-Executive Director of the Company, is a Non-Executive Director of Forty Seven, Inc. and AVROBIO, Inc which both became publically quoted in June 2018. This disclosure is made pursuant to

July 25, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 25 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close

July 25, 2018 EX-99.5

Investor Relations Christoph Brackmann [email protected] +41 41 288 41 29 Sun Kim [email protected] +1 617 588 8175 Scott Burrows [email protected] +41 41 288 4195 Media Katie Joyce [email protected] +1 781 482 2779

EXHIBIT 99.5 Press Release www.shire.com Director Declaration July 25, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that Steven Gillis, Non-Executive Director of the Company, is a Non-Executive Director of Homology Medicines, Inc., which became publicly quoted in March, 2018. This disclosure is made pursuant to LR 9.6.14 of the UK Listing Rules. Oliver Strawbridge Senior Ass

July 25, 2018 EX-99.2

UK dial in: 0800 358 9473 or +44 333 300 0804 US dial in: 1 855 857 0686 or 1 631 913 1422 International Access Numbers: Click here Password/Conf ID: 45131838 # Live Webcast: Click here

EXHIBIT 99.2 Press Release www.shire.com Shire to announce second quarter 2018 results Dublin, Ireland - July 23, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG), will announce second quarter 2018 earnings on Tuesday July 31, 2018. Results press release will be issued at: 12:00 BST / 07:00 EDT Investor conference call time: 14:00 BST / 09:00 EDT Live conference call for investors: Flemming Ornskov, MD,

July 25, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 20, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission Fi

July 25, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

Exhibit EXHIBIT 99.1 <

July 19, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 17 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close

July 19, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 july192018-rule29xexhibit9.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 19 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

July 19, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxjuly192018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 16, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdictio

July 19, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 july162018-rule29xexhibit9.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 16 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

July 12, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 10 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close

July 12, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 9, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission Fil

July 12, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 9 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

July 12, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.4 5 july122018-rule29xexhibit9.htm EXHIBIT 99.4 EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 12 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

July 12, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 july112018-rule29xexhibit9.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 11 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

July 5, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 3 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

July 5, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.4 5 july42018-rule29xexhibit994.htm EXHIBIT 99.4 EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 4 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

July 5, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 2, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission Fil

July 5, 2018 EX-99.1

Press Release www.shire.com

EXHIBIT 99.1 Press Release www.shire.com Total Voting Rights July 2, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), in accordance with 5.6.1R of the Financial Conduct Authority's (the “FCA”) Disclosure Guidance and Transparency Rules, notifies the market of the following: As at June 30, 2018, the Company’s issued ordinary share capital comprised 914,014,351 ordinary shares of 5 pence e

July 5, 2018 EX-99.5

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.5 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 5 July 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

July 5, 2018 EX-99.2

1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Susan Kilsby 2. Reason for the notification a) Position / status Chairman - PDMR b) Initial notification / amendment Initi

EXHIBIT 99.2 Press Release www.shire.com Director/PDMR Shareholding July 2, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) Notification of transactions by persons discharging managerial responsibilities 1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated with them (“PCA”) a) Name Susan Kilsby 2. Reason for the notification a) Position / status Chairman

June 29, 2018 11-K

SHPG / Shire Plc. FORM 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 11-K x ANNUAL REPORT PURSUANT TO SECTION 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the year ended December 31, 2017 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 1-4448 A. Full title of the plan and the address of the plan, if di

June 29, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 29 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close

June 29, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 june272018-rule29xexhibit9.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 27 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 29, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxjune292018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 26, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdictio

June 29, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 june262018-rule29xexhibit9.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 26 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 29, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 june282018-rule29xexhibit9.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 28 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 28, 2018 11-K

SHPG / Shire Plc. FORM 11-K

FORM 11-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2017 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 000-29630 Shire Holdings US AG 401(k) Savings Plan Full title of the plan and the address of the plan, if dif

June 22, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 june222018-rule29xexhibit9.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 22 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 22, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxjune222018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 19, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdictio

June 22, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 june192018-rule29xexhibit9.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 19 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 22, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 june202018-rule29xexhibit9.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 20 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 18, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 june132018-rule29xexhibit9.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 13 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 18, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 june152018-rule29xexhibit9.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 15 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 18, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.4 5 june182018-rule29xexhibit9.htm EXHIBIT 99.4 EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 18 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 18, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 june142018-rule29xexhibit9.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 14 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 18, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxjune182018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdictio

June 12, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 june82018-rule29xexhibit992.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 8 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 12, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.4 5 june122018-rule29xexhibit9.htm EXHIBIT 99.4 EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 12 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 12, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.3 4 june112018-rule29xexhibit9.htm EXHIBIT 99.3 EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 11 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 12, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission Fil

June 12, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 june72018-rule29xexhibit991.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 7 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 6, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 june12018-rule29xexhibit991.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 1 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

June 6, 2018 EX-99.4

1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated them (“PCA”) a) Name Joanne Cordeiro 2. Reason for the notification a) Position / status Chief Human Resources Officer - PDMR b) Initial notificatio

Exhibit 99.4 Press Release www.shire.com Director/PDMR Shareholding June 4, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) Notification of transactions by person discharging managerial responsibilities 1. Details of the person discharging managerial responsibilities (“PDMR”) / person closely associated them (“PCA”) a) Name Joanne Cordeiro 2. Reason for the notification a) Position / sta

June 6, 2018 EX-99.2

Investor Relations Christoph Brackmann [email protected] +41 795 432 359 Robert Coates [email protected] +44 203 549 0874 Sun Kim [email protected] +1 617 588 8175 Media Katie Joyce [email protected] +1 781 482 2779

Exhibit 99.2 Press Release www.shire.com Total Voting Rights June 1, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), in accordance with 5.6.1R of the Financial Conduct Authority's (the “FCA”) Disclosure Guidance and Transparency Rules, notifies the market of the following: As at May 31, 2018, the Company’s issued ordinary share capital comprised 913,925,158 ordinary shares of 5 pence ea

June 6, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 4 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

June 6, 2018 EX-99.5

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.5 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 6 June 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

June 6, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxjune62018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 1, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction

May 31, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 may302018-rule29xexhibit992.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 30 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

May 31, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxmay312018file.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 28, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction

May 31, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 may282018-rule29xexhibit991.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 28 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers an

May 31, 2018 EX-99.3

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.3 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 31 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

May 24, 2018 EX-99.3

Press Release www.shire.com

Exhibit 99.3 Press Release www.shire.com Director Declaration May 22, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that Olivier Bohuon, Senior Independent Director of the Company, is to be appointed as a Non-Executive Director of Smiths Group plc on July 1, 2018. This disclosure is made pursuant to LR 9.6.14 of the UK Listing Rules. Oliver Strawbridge Senior Assistant Compan

May 24, 2018 EX-99.4

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.4 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 23 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

May 24, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 21 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

May 24, 2018 EX-99.6

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.6 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 24 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

May 24, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 22 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

May 24, 2018 EX-99.5

Name of applicant: Shire plc Name of scheme: Shire Sharesave Scheme Period of return: From: November 23, 2017 To: May 22, 2018 Balance of unallotted securities under scheme(s) from previous return: 163,520 Plus: The amount by which the block scheme(s

Exhibit 99.5 Press Release www.shire.com BLOCK LISTING SIX MONTHLY RETURN May 23, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG) Name of applicant: Shire plc Name of scheme: Shire Sharesave Scheme Period of return: From: November 23, 2017 To: May 22, 2018 Balance of unallotted securities under scheme(s) from previous return: 163,520 Plus: The amount by which the block scheme(s) has been increased since

May 24, 2018 SD

SHPG / Shire Plc. SD

SD 1 a05242018sd.htm SD UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM SD Specialized Disclosure Report Shire plc (Exact name of the registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State of other jurisdiction of incorporation or organization) (Commission File Number) (IRS Employer Identification No.) Block 2, Miesian Plaza, 50-58 Ba

May 24, 2018 8-K

SHPG / Shire Plc. 8-K (Current Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 21, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of incorporation) (Commission Fil

May 18, 2018 EX-99.2

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.2 3 may182018-exhibit992.htm EXHIBIT 99.2 EXHIBIT 99.2 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 18 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Merge

May 18, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 may162018-exhibit991.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 16 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Merge

May 18, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 a8-kxmay182018file.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdic

May 15, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

Exhibit 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 15 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close o

May 15, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 dp910108k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of i

May 11, 2018 8-K

Financial Statements and Exhibits, Other Events

8-K 1 dp909348k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2018 SHIRE PLC (Exact name of registrant as specified in its charter) Jersey, Channel Islands 0-29630 98-0601486 (State or other jurisdiction of i

May 11, 2018 EX-99.1

Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement

EX-99.1 2 dp90934ex9901.htm EXHIBIT 99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. 11 May 2018 Shire plc (“Shire” or the “Company”) Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the

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