THAR / Tharimmune, Inc. - Документы SEC, Годовой отчет, Доверенное заявление

Тариммун, Инк.

Основная статистика
CIK 1861657
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Tharimmune, Inc.
SEC Filings (Chronological Order)
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September 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 5, 2025 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 5, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

September 5, 2025 EX-99.1

THARIMMUNE, INC. CONDENSED CONSOLIDATED BALANCE SHEETS

Exhibit 99.1 THARIMMUNE, INC. CONDENSED CONSOLIDATED BALANCE SHEETS August 31, 2025 (Unaudited) ASSETS Current assets Cash and cash equivalents $ 8,782,667 Prepaid expenses and other current assets 151,591 Deferred offering costs 92,168 Total current assets 9,026,426 Total assets $ 9,026,426 LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT) Current liabilities Accounts payable $ 870,296 Accrued expen

September 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 5, 2025 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 5, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

September 3, 2025 S-3/A

As filed with the U.S. Securities and Exchange Commission on September 3, 2025

As filed with the U.S. Securities and Exchange Commission on September 3, 2025 Registration No. 333-289869 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 84-2642541 (State or other jurisdiction of (I.R.S. Emplo

August 27, 2025 424B5

205,777 Shares of Common Stock 983,111 Pre-Funded Warrants to Purchase 983,111 Shares of Common Stock Tharimmune, Inc.

Filed Pursuant to Rule 424(b)(5) Registration Statement No.: 333-270684 PROSPECTUS SUPPLEMENT (To Prospectus dated March 24, 2023) 205,777 Shares of Common Stock 983,111 Pre-Funded Warrants to Purchase 983,111 Shares of Common Stock Tharimmune, Inc. Pursuant to this prospectus supplement and the accompanying prospectus, we are offering in a registered direct offering to certain purchasers 205,777

August 26, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 26, 2025 THARIMMUNE, INC. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 26, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Nu

August 26, 2025 EX-FILING FEES

Calculation of Filing Fee Tables FORM S-3 (Form Type) THARIMMUNE, INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

Exhibit 107 Calculation of Filing Fee Tables FORM S-3 (Form Type) THARIMMUNE, INC.

August 26, 2025 S-3

As filed with the U.S. Securities and Exchange Commission on August 26, 2025

As filed with the U.S. Securities and Exchange Commission on August 26, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 84-2642541 (State or other jurisdiction of (I.R.S. Employer incorporation or organi

August 26, 2025 EX-10.2

[Signature page follows]

Exhibit 10.2 August 26, 2025 Tharimmune, Inc. 34 Shrewsbury Avenue Suite 1C Red Bank, NJ 07701 Dear Mr. Sireesh Appajosyula, This agreement (the “Agreement”) constitutes the agreement between and among Tharimmune, Inc., a Delaware corporation (the “Company”), President Street Global, LLC (“President Street”) and RF Lafferty & Co., Inc. (“RF Lafferty” and together with President Street, the “Placem

August 26, 2025 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 26, 2025 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 26, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

August 26, 2025 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of August 26, 2025, between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions set f

August 26, 2025 EX-4.1

PRE-FUNDED COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.

Exhibit 4.1 PRE-FUNDED COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC. Warrant Shares: Issuance Date: THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exer

August 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 THARIMMUNE, INC. (Exact n

August 14, 2025 EX-10.4

Employment Agreement by and between the Company and Vincent LoPriore dated June 11, 2025

Exhibit 10.4 LOPRIORE (V) EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this “Agreement”) is made as of June 11, 2025 (the “Effective Date”) by and between Tharimmune Inc., a Delaware corporation with principal executive offices at 1200 Route 22 EastBridgewayer, New Jersey 08807 (“Company”), and Vincent Lopriore, residing at 21 Bruce Road Red Bank,NJ 07701 (“Executive”). Each of Company and Exec

August 14, 2025 EX-10.2

Amended and Restated Employment Agreement by and between the Company and Sireesh Appajosyula dated June 11, 2025

Exhibit 10.2 AMENDED AND RESTATED APPAJOSYULA EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this “Agreement”) is made as of June 11, 2025 (the “Effective Date”) by and between Tharimmune Inc., a Delaware corporation with principal executive offices at 1200 Route 22 EastBridgewayer, New Jersey 08807 (“Company”), and Sireesh Appajosyula, residing at 2 Linden Court, Holmdel, NJ 07733 (“Executive”).

August 14, 2025 EX-10.1

Settlement and General Release Agreement by and between the Company and Randy Milby dated June 11, 2025

Exhibit 10.1 CONFIDENTIAL CONFIDENTIAL SETTLEMENT AGREEMENT AND COMPLETE RELEASE OF ALL CLAIMS This CONFIDENTIAL SETTLEMENT AND GENERAL RELEASE AGREEMENT (the “Agreement”) is entered into by and between Randy Milby (“Executive”) and Tharimmune, Inc. (the “Company”) and collectively, the “Parties.” RECITALS A. Executive and the Company entered into an Amended and Restated Milby Employment Agreement

August 7, 2025 EX-99.1

Nancy Davis, Visionary Philanthropist and Founder of Race to Erase MS and Cure Addiction Now Appointed to the Tharimmune Board of Directors

Exhibit 99.1 Nancy Davis, Visionary Philanthropist and Founder of Race to Erase MS and Cure Addiction Now Appointed to the Tharimmune Board of Directors RED BANK, NJ / ACCESS Newswire / August 5, 2025 / Tharimmune, Inc. (NASDAQ:THAR), (“Tharimmune” or the “Company), a clinical-stage biotechnology company dedicated to developing innovative therapeutic candidates for inflammation, immunology, and cr

August 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 4, 2025 THARIMMUNE, INC. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 4, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Num

July 31, 2025 EX-4.1

Form of Pre-Funded Warrant

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

July 31, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 25, 2025 THARIMMUNE, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 25, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

July 31, 2025 EX-4.2

Form of Common Warrant

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

July 31, 2025 EX-10.1

Form of Securities Purchase Agreement

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of July 25, 2025, between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject to the terms and conditions set fo

July 28, 2025 424B5

DATED JULY 23, 2025

Filed Pursuant to Rule 424(b)(5) Registration Statement No.: 333-270684 DATED JULY 23, 2025 PROSPECTUS SUPPLEMENT (To Prospectus dated March 24, 2023) 974,241 Shares of Common Stock and/or Prefunded Warrants Tharimmune, Inc. Pursuant to this prospectus supplement and the accompanying prospectus, we are offering in a registered direct offering to certain purchasers 974,241 units (the “Units”), with

July 28, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities and Exchange Act of 1934 Date of Report (Date of earliest event reported): July 23, 2025 THARIMMUNE, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities and Exchange Act of 1934 Date of Report (Date of earliest event reported): July 23, 2025 THARIMMUNE, INC. (Exact name of Registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

July 28, 2025 EX-4.2

Form of Common Warrant

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

July 28, 2025 EX-99.1

Tharimmune Announces Pricing of $1.74 Million Registered Direct Public Offering of Common Stock and Warrants

Exhibit 99.1 Tharimmune Announces Pricing of $1.74 Million Registered Direct Public Offering of Common Stock and Warrants RED BANK, NJ / ACCESS Newswire / July 23, 2025 / Tharimmune, Inc. (the “Company” and “Tharimmune”) (Nasdaq Capital Market:THAR), a clinical-stage biotechnology company committed to pioneering therapies in immunology and inflammation, today announced the pricing of a registered

July 28, 2025 EX-10.2

Placement Agency Agreement dated July 23, 2025, by and between Tharimmune, Inc. and President Street Global, LLC

Exhibit 10.2 July 23, 2025 Tharimmune, Inc. 34 Shrewsbury Avenue Suite 1C Red Bank, NJ 07701 Dear Mr. Sireesh Appajosyula, This agreement (the “Agreement”) constitutes the agreement between Tharimmune, Inc., a Delaware corporation (the “Company”), and President Street Global, LLC (“President Street” or the “Placement Agent”), that President Street shall serve as the exclusive lead placement agent

July 28, 2025 EX-10.1

Form of Purchase Agreement

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of July 23, 2025, between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions set for

July 28, 2025 EX-4.1

Form of Pre-Funded Warrant

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

July 25, 2025 424B5

SUBJECT TO COMPLETION, DATED JULY 23, 2025

Filed Pursuant to Rule 424(b)(5) Registration Statement No.: 333-270684 The information contained in this preliminary prospectus supplement and the accompanying prospectus is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these securities and are not a solicitation of an offer to buy these securities in any jurisdict

July 11, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables FORM S-8 (Form Type) THARIMMUNE, INC.

July 11, 2025 S-8

As filed with the Securities and Exchange Commission on July 11, 2025

As filed with the Securities and Exchange Commission on July 11, 2025 Registration No.

July 8, 2025 CORRESP

Tharimmune, Inc. 34 Shrewsbury Avenue Red Bank, NJ 07701

Tharimmune, Inc. 34 Shrewsbury Avenue Red Bank, NJ 07701 July 8, 2025 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Daniel Crawford Re: Tharimmune, Inc. Registration Statement on Form S-3 File No. 333-288518 Filed July 3, 2025 Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulat

July 3, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables FORM S-3 (Form Type) THARIMMUNE, INC.

July 3, 2025 S-3

As filed with the U.S. Securities and Exchange Commission on July 3, 2025

As filed with the U.S. Securities and Exchange Commission on July 3, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 84-2642541 (State or other jurisdiction of (I.R.S. Employer incorporation or organizat

June 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 22, 2025 THARIMMUNE, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 22, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

June 20, 2025 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 13, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

June 20, 2025 EX-4.2

Form of Series A Warrant

Exhibit 4.2 FORM OF SERIES A COMMON WARRANT NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT

June 20, 2025 EX-4.1

Form of Pre-Funded Warrant

Exhibit 4.1 FORM OF PRE-FUNDED WARRANT NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSU

June 20, 2025 EX-10.1

Form of Securities Purchase Agreement

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of June 13, 2025 (the “Effective Date”), between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject to the term

June 20, 2025 EX-4.3

Form of Series B Warrant

Exhibit 4.3 FORM OF SERIES B COMMON WARRANT NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT

June 16, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 10, 2025 THARIMMUNE, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 10, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

June 11, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 11, 2025 THARIMMUNE, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 11, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

June 10, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 10, 2025 THARIMMUNE, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 10, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

May 12, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 THARIMMUNE, INC. (Exact

May 9, 2025 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 9, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Number

May 2, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

April 30, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

April 30, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

April 28, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 28, 2025 THARIMMUNE, INC. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 28, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Num

April 25, 2025 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 24, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Num

April 10, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 9, 2025 THARIMMUNE, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 9, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

April 4, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 1, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

March 26, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 THARIMMUNE, INC. (Exact name

February 27, 2025 EX-10.1

Consulting Agreement with Don Kim dated February 21, 2025

Exhibit 10.1 CONSULTING AGREEMENT This Consulting Agreement (the “Agreement”) by and between Tharimmune, Inc. (“Client”) and Don Kim (“Consultant”) is effective as of February 21, 2025 (the “Effective Date”). RECITALS WHEREAS the parties desire for the Client to engage Consultant to perform the services described herein and for Consultant to provide such services on the terms and conditions descri

February 27, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 21, 2025 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 21, 2025 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

December 30, 2024 424B3

1,442,167 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-283936 PROSPECTUS 1,442,167 Shares of Common Stock The selling stockholders named in this prospectus may use this prospectus to offer and resell from time to time up to 1,442,167 shares of our common stock, par value $0.0001 per share, which are comprised of (i) 470,289 shares (the “Shares”) of our common stock, par value $0.0001 issued in a pr

December 23, 2024 CORRESP

Tharimmune, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807

Tharimmune, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 December 23, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Tim Buchmiller Re: Tharimmune, Inc. Registration Statement on Form S-3 File No. 333-283936 Filed December 19, 2024 Ladies and Gentlemen: Pursuant to Rule 461 of the Gen

December 19, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables FORM S-3 (Form Type) THARIMMUNE, INC.

December 19, 2024 S-3

As filed with the U.S. Securities and Exchange Commission on December 19, 2024

As filed with the U.S. Securities and Exchange Commission on December 19, 2024 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 84-2642541 (State or other jurisdiction of (I.R.S. Employer incorporation or orga

December 6, 2024 EX-10.1

Form of Securities Purchase Agreement

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of December 5, 2024 (the “Effective Date”), between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject to the t

December 6, 2024 EX-4.2

Form of Common Warrant

Exhibit 4.2 FORM OF COMMON WARRANT NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT

December 6, 2024 EX-4.1

Form of Pre-Funded Warrant

Exhibit 4.1 FORM OF PRE-FUNDED WARRANT NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSU

December 6, 2024 EX-99.1

Tharimmune Announces $2.02 Million Private Placement to Advance Development Programs

Exhibit 99.1 Tharimmune Announces $2.02 Million Private Placement to Advance Development Programs BRIDGEWATER, N.J. / ACCESSWIRE / December 6, 2024 – Tharimmune, Inc. (Nasdaq: THAR) (“Tharimmune” or the “Company”), a clinical-stage biotechnology company committed to pioneering therapies in immunology and inflammation, today announced it has entered into a securities purchase agreement to raise gro

December 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 5, 2024 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 5, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File N

November 21, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 20, 2024 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 20, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

November 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 THARIMMUNE, INC. (Ex

November 7, 2024 EX-10.1

Patent License Agreement by and between the Company and Intract Pharma Limited dated September 11, 2024

Exhibit 10.1 [*] Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) is the type of information that the company treats as private or confidential. PATENT LICENSE AGREEMENT This Patent License Agreement (this “Agreement”) is entered into as of September 11, 2024 (the “Effective Date”) by and between Intract Pharma Limited, a company

September 30, 2024 EX-99.2

Tharimmune Signs Nonbinding Letter of Intent to Merge with Intract Pharma to Create Transformative Oral Biologic Therapeutics Company - Business combination to form a best-in-class, transformative oral biologics company - Synergies between Tharimmune

Exhibit 99.2 FINAL Tharimmune Signs Nonbinding Letter of Intent to Merge with Intract Pharma to Create Transformative Oral Biologic Therapeutics Company - Business combination to form a best-in-class, transformative oral biologics company - Synergies between Tharimmune’s clinical-stage assets and Intract’s delivery platform to drive pipeline growth - Merger anticipated to close in 1Q25 BRIDGEWATER

September 30, 2024 EX-99.1

Presentation Materials

Exhibit 99.1

September 30, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 30, 2024 THARIMMUNE, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 30, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

September 16, 2024 EX-99.1

Tharimmune Acquires Global License and Partners with Intract Pharma to Develop an Oral Formulation of Infliximab

Exhibit 99.1 Tharimmune Acquires Global License and Partners with Intract Pharma to Develop an Oral Formulation of Infliximab BRIDGEWATER, N.J. and LONDON / ACCESSWIRE / September 16, 2024 – Tharimmune, Inc. (NASDAQ: THAR) (“Tharimmune” or the “Company”), a clinical-stage biotechnology company developing a portfolio of therapeutic candidates in inflammation and immunology, announced today that it

September 16, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 11, 2024 THARIMMUNE, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 11, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

September 16, 2024 EX-99.2

Presentation Materials

Exhibit 99.2

August 9, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 THARIMMUNE, INC. (Exact n

July 23, 2024 424B3

1,009,102 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-280814 PROSPECTUS 1,009,102 Shares of Common Stock The selling stockholders named in this prospectus may use this prospectus to offer and resell from time to time up to 1,009,102 shares of our common stock, par value $0.0001 per share, which are comprised of (i) 207,292 shares (the “Shares”) of our common stock, par value $0.0001 issued in a pr

July 18, 2024 CORRESP

Tharimmune, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807

Tharimmune, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 July 18, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Tim Buchmiller Re: Tharimmune, Inc. Registration Statement on Form S-3 File No. 333- 280814 Filed July 15, 2024 Ladies and Gentlemen: Pursuant to Rule 461 of the General Ru

July 15, 2024 S-3

As filed with the U.S. Securities and Exchange Commission on July 15, 2024

As filed with the U.S. Securities and Exchange Commission on July 15, 2024 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 84-2642541 (State or other jurisdiction of (I.R.S. Employer incorporation or organiza

July 15, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables FORM S-3 (Form Type) THARIMMUNE, INC.

June 20, 2024 EX-99.1

Tharimmune Announces $2.08 Million Private Placement

Exhibit 99.1 Tharimmune Announces $2.08 Million Private Placement BRIDGEWATER, N.J. / ACCESSWIRE / June 20, 2024 – Tharimmune, Inc. (Nasdaq: THAR) (“Tharimmune” or the “Company”), a clinical-stage biotechnology company developing a portfolio of therapeutic candidates for inflammation and immunology, developing lead candidate, TH104 for chronic pruritus in primary biliary cholangitis announced toda

June 20, 2024 EX-10.1

Form of Securities Purchase Agreement, dated June 18, 2024, by and between Tharimmune, Inc. and the purchasers named therein (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on June 20, 2024)

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of June 18, 2024 (the “Effective Date”), between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject to the term

June 20, 2024 EX-4.1

Form of Pre-Funded Warrant

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

June 20, 2024 EX-4.2

Form of Common Warrant

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

June 20, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 18, 2024 THARIMMUNE, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 18, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

June 12, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables FORM S-8 (Form Type) THARIMMUNE, INC.

June 12, 2024 S-8

As filed with the Securities and Exchange Commission on June 12, 2024

As filed with the Securities and Exchange Commission on June 12, 2024 Registration No.

June 11, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 11, 2024 THARIMMUNE, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 11, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

June 7, 2024 424B5

Up to $1,650,000 Common Stock

Filed Pursuant to Rule 424(b)(5) Registration No. 333-270684 PROSPECTUS SUPPLEMENT (To prospectus dated March 24, 2023) Up to $1,650,000 Common Stock We have entered into an at the market offering agreement (the “ATM Agreement”) with Rodman & Renshaw LLC (the “sales agent”) relating to the sale of shares of our common stock, $0.0001 par value per share, offered by this prospectus supplement and th

June 7, 2024 EX-1.1

ATM Agreement between the Company and Rodman & Renshaw dated June 7, 2024

Exhibit 1.1 AT THE MARKET OFFERING AGREEMENT June 7, 2024 Rodman & Renshaw LLC 600 Lexington Avenue, 32nd Floor New York, NY 10022 Ladies and Gentlemen: Tharimmune, Inc., a corporation organized under the laws of Delaware (the “Company”), confirms its agreement (this “Agreement”) with Rodman & Renshaw LLC (the “Manager”) as follows: 1. Definitions. The terms that follow, when used in this Agreemen

June 7, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 7, 2024 THARIMMUNE, INC. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 7, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numbe

May 22, 2024 EX-99.1

Tharimmune Announces 1-for-15 Reverse Stock Split

Exhibit 99.1 Tharimmune Announces 1-for-15 Reverse Stock Split BRIDGEWATER, N.J., May 22, 2024 – Tharimmune, Inc. (Nasdaq: THAR) (“Tharimmune” or the “Company”), a clinical-stage biotechnology company developing a portfolio of therapeutic candidates for rare, inflammatory and oncologic conditions, announced today that it will effect a 1-for-15 reverse stock split of its issued and outstanding shar

May 22, 2024 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 22, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numbe

May 22, 2024 EX-3.1

Certificate of Amendment to Certificate of Incorporation, as amended dated May 22, 2024 (Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K filed with the SEC on May 22, 2024)

Exhibit 3.1 CERTIFICATE OF AMENDMENT to the CERTIFICATE OF INCORPORATION of THARIMMUNE, INC. THARIMMUNE, INC., a corporation organized and existing under the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify as follows: FIRST: The name of the Corporation is Tharimmune, Inc. The Certificate of Incorporation was filed with the Secretary of State of the State o

May 14, 2024 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 14, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numbe

May 9, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 THARIMMUNE, INC. (Exact

March 22, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

March 21, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

March 21, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

March 11, 2024 EX-3.1

Amendment to the Bylaws of Tharimmune, Inc.

Exhibit 3.1 AMENDMENT NO. 1 TO THE BYLAWS OF THARIMMUNE, INC. a Delaware Corporation Pursuant to the resolutions of the Board of Directors (the “Board”) of Tharimmune, Inc., a Delaware corporation (the “Corporation”) adopted on March 7, 2024 and in accordance with the authority provided to the directors pursuant to Article IX of the Company’s Bylaws (the “Bylaws”): 1. Article II, Section 2.6 of th

March 11, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

March 11, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) March 7, 2024 THARIMMUNE, INC. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) March 7, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File Numb

February 23, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 THARIMMUNE, INC. (Exact name

February 23, 2024 EX-97.1

Tharimmune, Inc. Clawback Policy

Exhibit 97.1 Tharimmune, Inc. CLAWBACK POLICY I. Purpose and Scope The Board of Directors (the “Board”) of the Company believes that it is in the best interests of the Company and its shareholders to create and maintain a culture that emphasizes integrity and accountability and that reinforces the Company’s pay-for-performance compensation philosophy. The Board has therefore adopted this Clawback

February 14, 2024 SC 13G/A

US4327052001 / THARIMMUNE INC / TANG CAPITAL PARTNERS LP - AMENDMENT NO. 1 Passive Investment

SC 13G/A 1 j117244sc13ga1.htm AMENDMENT NO. 1 Securities and Exchange Commission Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Tharimmune, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 432705200 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of This Statement) Check the approp

February 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 8, 2024 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 8, 2024 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File N

December 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 12, 2023 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 12, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

December 11, 2023 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 8, 2023 THARIMMUNE, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 8, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

December 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 8, 2023 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 8, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File N

December 7, 2023 EX-99.1

Presentation Materials

Exhibit 99.1

December 7, 2023 SC 13G

THAR / Tharimmune Inc / TANG CAPITAL PARTNERS LP Passive Investment

Securities and Exchange Commission Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

December 7, 2023 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 ex991.htm EXHIBIT 99.1 Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, the undersigned agree to the joint filing of a Statement on Schedule 13G (including any and all amendments thereto) with respect to the Common Stock, $0.0001 par value per share, of Tharimmune, Inc. and further agree to the filing of this a

December 7, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 6, 2023 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 6, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File N

November 29, 2023 424B5

The date of this prospectus is November 27, 2023 TABLE OF CONTENTS

Filed Pursuant to Rule 424(b)(5) Registration No. 333-275350 Prospectus 1,825,000 Shares of Common Stock 8,175,000 Pre-Funded Warrants to purchase up to 8,175,000 Shares of Common Stock Tharimmune, Inc. We are offering 1,825,000 shares of our common stock at a public offering price of $1.00 per share. We are also offering 8,175,000 pre-funded warrants (each a “Pre-funded Warrant”) to purchase up t

November 27, 2023 CORRESP

Tharimmune, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807

Tharimmune, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 November 27, 2023 VIA EDGAR United States Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Attention: Daniel Crawford Re: Tharimmune, Inc. Registration Statement on Form S-1 File No. 333-275350 Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of

November 27, 2023 CORRESP

ThinkEquity LLC 17 State Street, 41st Floor New York, NY 10004

ThinkEquity LLC 17 State Street, 41st Floor New York, NY 10004 November 27, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

November 27, 2023 EX-99.1

Tharimmune Reports Positive Phase 1 Data on TH104, its Lead Therapeutic Candidate, for Chronic Pruritis in Primary Biliary Cholangitis (PBC) Phase 1 ex-US trial achieved primary objective of predictable pharmacokinetic profiling with favorable safety

Exhibit 99.1 Tharimmune Reports Positive Phase 1 Data on TH104, its Lead Therapeutic Candidate, for Chronic Pruritis in Primary Biliary Cholangitis (PBC) Phase 1 ex-US trial achieved primary objective of predictable pharmacokinetic profiling with favorable safety and tolerability Company expects to engage FDA on Phase 2 trial design and expects topline data in 2024 for chronic pruritis First indic

November 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 27, 2023 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 27, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

November 24, 2023 CORRESP

ThinkEquity LLC 17 State Street, 41st Floor New York, NY 10004

ThinkEquity LLC 17 State Street, 41st Floor New York, NY 10004 November 24, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

November 24, 2023 CORRESP

Tharimmune, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807

Tharimmune, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 November 24, 2023 VIA EDGAR United States Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Attention: Daniel Crawford Re: Tharimmune, Inc. Registration Statement on Form S-1 File No. 333-275350 Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of

November 17, 2023 EX-4.4

Form of Pre-funded Warrant

Exhibit 4.4 FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC. Warrant Shares: Issue Date: [], 2023 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the Issue Date and u

November 17, 2023 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 UNDERWRITING AGREEMENT between THARIMMUNE, INC. and THINKEQUITY LLC as Representative of the Several Underwriters THARIMMUNE, INC. UNDERWRITING AGREEMENT New York, New York [], 2023 ThinkEquity LLC As Representative of the several Underwriters named on Schedule 1 attached hereto 17 State Street, 41st Floor New York, NY 10004 Ladies and Gentlemen: The undersigned, Tharimmune, Inc. (form

November 17, 2023 S-1/A

As filed with the Securities and Exchange Commission on November 17, 2023

As filed with the Securities and Exchange Commission on November 17, 2023 Registration Statement No.

November 17, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 17, 2023 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 17, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

November 17, 2023 EX-3.1

Certificate of Amendment to Certificate of Incorporation, as amended dated November 17, 2023 (Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K filed with the SEC on November 17, 2023)

Exhibit 3.1

November 17, 2023 EX-99.1

Tharimmune Announces 1-for-25 Reverse Stock Split

Exhibit 99.1 Tharimmune Announces 1-for-25 Reverse Stock Split BRIDGEWATER, N.J., November 17, 2023 (GLOBE NEWSWIRE) –Tharimmune, Inc. (Nasdaq: THAR) (“Tharimmune” or the “Company”), a clinical-stage biotechnology company developing a portfolio of therapeutic candidates for rare, inflammatory, and oncologic conditions announced today that it will effect a 1-for-25 reverse stock split of its issued

November 17, 2023 EX-4.3

Form of Representative’s Warrant

Exhibit 4.3 FORM OF REPRESENTATIVE’S WARRANT AGREEMENT Tharimmune, Inc. THE REGISTERED HOLDER OF THIS PURCHASE WARRANT BY ITS ACCEPTANCE HEREOF, AGREES THAT IT WILL NOT SELL, TRANSFER OR ASSIGN THIS PURCHASE WARRANT EXCEPT AS HEREIN PROVIDED AND THE REGISTERED HOLDER OF THIS PURCHASE WARRANT AGREES THAT IT WILL NOT SELL, TRANSFER, ASSIGN, PLEDGE OR HYPOTHECATE THIS PURCHASE WARRANT FOR A PERIOD OF

November 17, 2023 FWP

FWP

November 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 10, 2023 THARIMMUNE, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 10, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission File

November 7, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41210 THARIMMUNE, INC.

November 7, 2023 DEL AM

THARIMMUNE, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807

THARIMMUNE, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 November 7, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Delaying Amendment for Tharimmune, Inc. Registration Statement on Form S-1 (File No. 333-275350) Ladies and Gentlemen: Reference is made to the Registration Statement on Form S-1

November 7, 2023 EX-99.1

Tharimmune Executes Exclusive Global Licensing Agreement for Innovative Clinical Stage Asset for Chronic Pruritis Expects completion and topline data of a Phase 2 clinical trial in chronic pruritis over approximately 12 months after aligning with FDA

Exhibit 99.1 Tharimmune Executes Exclusive Global Licensing Agreement for Innovative Clinical Stage Asset for Chronic Pruritis Expects completion and topline data of a Phase 2 clinical trial in chronic pruritis over approximately 12 months after aligning with FDA on trial design Seeking first approval in an orphan disease, PBC, for the treatment of chronic pruritis in which more than 70% of patien

November 7, 2023 8-K

Entry into a Material Definitive Agreement, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 3, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction (Commission (I. R. S. Employer of in

November 7, 2023 CORRESP

THARIMMUNE, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807

THARIMMUNE, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 November 7, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Delaying Amendment for Tharimmune, Inc. Registration Statement on Form S-1 (File No. 333-275350) Ladies and Gentlemen: Reference is made to the Registration Statement on Form S-1

November 7, 2023 EX-10.1

Patent License Agreement by and between the Company and Avior Inc. dba Avior Bio dated November 3, 2023 (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed with the SEC on November 7, 2023)

Exhibit 10.1 [*] Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) is the type of information that the company treats as private or confidential. PATENT LICENSE AGREEMENT THIS PATENT LICENSE AGREEMENT (this “Agreement”) is entered into as of the 3rd day of November, 2023, (the “Effective Date”) by and between Avior Inc. dba Avior B

November 6, 2023 S-1

As filed with the Securities and Exchange Commission on November 6, 2023

As filed with the Securities and Exchange Commission on November 6, 2023 Registration Statement No.

November 6, 2023 EX-10.7

Patent License Agreement by and between the Company and Avior Inc. dba Avior Bio dated November 3, 2023

Exhibit 10.7 [*] Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) is the type of information that the company treats as private or confidential. PATENT LICENSE AGREEMENT THIS PATENT LICENSE AGREEMENT (this “Agreement”) is entered into as of the 3rd day of November, 2023, (the “Effective Date”) by and between Avior Inc. dba Avior B

November 6, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables FORM S-1 (Form Type) THARIMMUNE, INC.

November 2, 2023 EX-10.1

Tharimmune, Inc. 2023 Omnibus Equity Incentive Plan (Incorporated by reference to Exhibit 10.1 to the Company’s Registration Statement on Form S-8 filed with the SEC on November 2, 2023)

Exhibit 10.1 THARIMMUNE, INC. 2023 OMNIBUS EQUITY INCENTIVE PLAN Section 1. Purpose of Plan. The name of the Plan is the Tharimmune, Inc. 2023 Omnibus Equity Incentive Plan. The purposes of the Plan are to (i) provide an additional incentive to selected employees, directors, and independent contractors of the Company or its Affiliates whose contributions are essential to the growth and success of

November 2, 2023 S-8

As filed with the Securities and Exchange Commission on November 2, 2023

As filed with the Securities and Exchange Commission on November 2, 2023 Registration No.

November 2, 2023 EX-FILING FEES

Filing Fee Tables

Exhibit 107 Calculation of Filing Fee Tables FORM S-8 (Form Type) THARIMMUNE, INC.

October 24, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 23, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction (Commission (I. R. S. Employer of in

September 29, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

September 25, 2023 EX-99.1

Hillstream BioPharma progressing towards acquiring clinical stage asset and announces corporate name change to Tharimmune, Inc. Expects to launch and complete a Phase 1 trial in Q4 2023 Tharimmune to begin trading under new ticker, THAR, on Monday Se

Exhibit 99.1 Hillstream BioPharma progressing towards acquiring clinical stage asset and announces corporate name change to Tharimmune, Inc. Expects to launch and complete a Phase 1 trial in Q4 2023 Tharimmune to begin trading under new ticker, THAR, on Monday September 25, 2023 BRIDGEWATER, N.J., September 22, 2023 — Hillstream BioPharma Inc., (NASDAQ: HILS), a biotechnology company developing in

September 25, 2023 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 21, 2023 THARIMMUNE, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction (Commission (I. R. S. Employer of

September 25, 2023 EX-3.1

Certificate of Amendment to Certificate of Incorporation dated September 21, 2023 (Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K filed with the SEC on September 25, 2023)

Exhibit 3.1

September 12, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) September 12, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction (Commission (I. R. S. Em

September 12, 2023 EX-99.1

Presentation Materials

Exhibit 99.1

August 30, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

August 30, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

August 18, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

August 11, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41210 HILLSTREAM BIOPHARMA, INC.

July 17, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 12, 2023 HILLSTREAM BIOPHARMA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 12, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction (Commission (I. R. S. Employe

July 11, 2023 EX-10.3

Amended and Restated Employment Agreement by and between the Company and Randy Milby dated July 6, 2023 (Incorporated by reference to Exhibit 10.3 to the Company’s Current Report on Form 8-K filed with the SEC on July 11, 2023)

Exhibit 10.3 AMENDED and RESTATED MILBY EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this “Agreement”) is made as of July 6, 2023 (the “Effective Date”) by and between Hillstream BioPharma Inc., a Delaware corporation with principal executive offices at 245 Main Street, Suite 204, Chester, New Jersey 07930 (“Company”), and Randy D. Milby, residing at [ ] (“Executive”). Each of Company and Execu

July 11, 2023 EX-10.1

Research and Development Collaboration and License Agreement by and between the Company and Applied Biomedical Science Institute dated July 5, 2023 (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed with the SEC on July 11, 2023)

Exhibit 10.1 [*] CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH NOT MATERIAL AND IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. RESEARCH AND DEVELOPMENT COLLABORATION AND LICENSE AGREEMENT This Research and Development Collaboration and License Agreement (the “Agreement”) is entered into as of July 5, 2023 (the “Effective Date”) by and betw

July 11, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 5, 2023 HILLSTREAM BIOPHARMA,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 5, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction (Commission (I. R. S. Employer

July 11, 2023 EX-10.2

Employment Agreement by and between the Company and Sireesh Appajosyula dated July 11, 2023 (Incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K filed with the SEC on July 11, 2023)

Exhibit 10.2 EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this “Agreement”) is made as of July 11, 2023 (the “Effective Date”) by and between Hillstream BioPharma Inc., a Delaware corporation with principal executive offices at 1200 Route 22 East, Suite 2000, Bridgewater, NJ 08807 245 Main Street, Suite 204, Chester, New Jersey 07930 (“Company”), and Sireesh Appajosyula, residing at [ ] (“Execu

June 20, 2023 8-K

Changes in Registrant's Certifying Accountant, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 14, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission

June 20, 2023 EX-16.1

Letter of Mayer Hoffman McCann P.C. dated June 20, 2023 (Incorporated by reference to Exhibit 16.1 to the Company’s Current Report on Form 8-K filed with the SEC on June 20, 2023)

Exhibit 16.1 June 20, 2023 Securities and Exchange Commission 100 F Street N.E. Washington, D.C. 20549 Commissioners: We have read Item 4.01 of Hillstream BioPharma, Inc.’s Form 8-K dated June 20, 2023, and we agree with the statements set forth in Item 4.01, insofar as they relate to our firm. We have no basis to agree or disagree with other statements made by the registrant contained in Item 4.0

June 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 12, 2023 HILLSTREAM BIOPHARMA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 12, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission

May 22, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41210 HILLSTREAM BIOPHARMA, INC.

May 22, 2023 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1 ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 HILLSTREAM

May 22, 2023 8-K

Non-Reliance on Previously Issued Financial Statements or a Related Audit Report or Completed Interim Review

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 17, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission

May 16, 2023 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

SEC FILE NUMBER: 001-41210 CUSIP NUMBER: 432705101 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

May 15, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 9, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commission F

May 15, 2023 EX-99.1

Hillstream BioPharma Strengthens its Board of Directors with Appointment of Kelly Anderson Appointment to Enhance Board’s Expertise Across Investments, Business Development and Capital Markets

Exhibit 99.1 Hillstream BioPharma Strengthens its Board of Directors with Appointment of Kelly Anderson Appointment to Enhance Board’s Expertise Across Investments, Business Development and Capital Markets BRIDGEWATER, N.J., May 15, 2023 — Hillstream BioPharma, Inc. (Nasdaq: HILS) (“Hillstream” or the “Company”), a biotechnology company developing therapeutic candidates targeting drug resistant an

May 1, 2023 424B5

ThinkEquity The date of this prospectus supplement is April 27, 2023. TABLE OF CONTENTS PROSPECTUS SUPPLEMENT

Filed Pursuant to Rule 424(b)(5) Registration No. 333-270684 PROSPECTUS SUPPLEMENT (To Prospectus dated March 24, 2023) 5,300,000 Shares of Common Stock Hillstream BioPharma, Inc. We are offering 5,300,000 shares of our common stock, $0.0001 par value per share (the “common stock”), at an offering price of $0.50 per share, pursuant to this prospectus supplement and the accompanying base prospectus

May 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 27, 2023 HILLSTREAM BIOPHARM

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 27, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commissio

May 1, 2023 EX-1.1

Underwriting Agreement, dated April 27, 2023, by and between Hillstream BioPharma, Inc. and ThinkEquity LLC

Exhibit 1.1 UNDERWRITING AGREEMENT between HILLSTREAM BIOPHARMA, INC. and THINKEQUITY LLC as Representative of the Several Underwriters HILLSTREAM BIOPHARMA, INC. UNDERWRITING AGREEMENT New York, New York April 27, 2023 ThinkEquity LLC As Representative of the several Underwriters named on Schedule 1 attached hereto 17 State Street, 41st Floor New York, NY 10004 Ladies and Gentlemen: The undersign

May 1, 2023 EX-99.1

Hillstream BioPharma Announces Proposed Public Offering

EX-99.1 4 ex99-1.htm Exhibit 99.1 Hillstream BioPharma Announces Proposed Public Offering BRIDGEWATER, N.J., April 27, 2023 — Hillstream BioPharma, Inc. (Nasdaq: HILS) (“Hillstream” or the “Company”), a biotechnology company developing therapeutic candidates targeting drug resistant and devastating cancers using ferroptosis, an emerging new anti-cancer mechanism resulting in iron-mediated cell dea

May 1, 2023 EX-99.2

Hillstream BioPharma Announces Pricing of Public Offering

Exhibit 99.2 Hillstream BioPharma Announces Pricing of Public Offering BRIDGEWATER, N.J., April 27, 2023 — Hillstream BioPharma, Inc. (Nasdaq: HILS) (“Hillstream” or the “Company”), a biotechnology company developing therapeutic candidates targeting drug resistant and devastating cancers using ferroptosis, an emerging new anti-cancer mechanism resulting in iron-mediated cell death, and immuno-onco

April 27, 2023 FWP

FWP

FWP 1 formfwp.htm

April 27, 2023 424B5

ThinkEquity The date of this prospectus supplement is , 2023. TABLE OF CONTENTS PROSPECTUS SUPPLEMENT

Filed Pursuant to Rule 424(b)(5) Registration No. 333-270684 This preliminary prospectus supplement relates to an effective registration statement under the Securities Act of 1933, as amended, but the information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these securit

March 22, 2023 CORRESP

Hillstream BioPharma, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 March 22, 2023

Hillstream BioPharma, Inc. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 March 22, 2023 VIA EDGAR United States Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Attention: Arzhang Navai Re: Hillstream BioPharma, Inc. Registration Statement on Form S-3 File No. 333-270684 Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations under the Sec

March 17, 2023 S-3

As filed with the U.S. Securities and Exchange Commission on March 17, 2023

As filed with the U.S. Securities and Exchange Commission on March 17, 2023 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 84-2642541 (State or other jurisdiction (I.R.S. Employer of incorporation

March 17, 2023 EX-4.4

Form of Subordinated Indenture

Exhibit 4.4 HILLSTREAM BIOPHARMA, INC., ISSUER AND [TRUSTEE], TRUSTEE INDENTURE DATED AS OF , 20 SUBORDINATED DEBT SECURITIES TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.01 Designation and Terms of Securities 4 Section 2.02 Form of Securities and Trustee’s Cert

March 17, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables FORM S-3 (Form Type) HILLSTREAM BIOPHARMA, INC.

March 17, 2023 EX-4.3

Form of Senior Indenture

Exhibit 4.3 HILLSTREAM BIOPHARMA, INC., ISSUER AND [TRUSTEE], TRUSTEE INDENTURE DATED AS OF , 20 SENIOR DEBT SECURITIES TABLE OF CONTENTS Page ARTICLE I DEFINITIONS 1 Section 1.1 Definitions of Terms 1 ARTICLE II ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.1 Designation and Terms of Securities 4 Section 2.2 Form of Securities and Trustee’s Certificate

March 16, 2023 EX-21.1

Subsidiaries (Incorporated by reference to Exhibit 21.1 to the Company’s Annual Report on Form 10-K filed with the SEC on March 16, 2023)

Exhibit 21.1 List of Subsidiaries of Hillstream BioPharma, Inc. Name State/Country of Organization or Incorporation HB Pharma Corp. Delaware Farrington Therapeutics LLC (1) Delaware (1) On February 27, 2023, the Company filed a Certificate of Cancellation with the Delaware Secretary of State with respect to Farrington Therapeutics LLC.

March 16, 2023 EX-4.3

Exhibit 4.3

Exhibit 4.3 DESCRIPTION OF THE REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of December 31, 2022, Hillstream BioPharma, Inc. (the “Company”) had one class of security registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), its common stock, par value $0.0001 per share (the “Common Stock”). Descripti

March 16, 2023 10-K

Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 HILLSTREAM BIOPHARMA, INC. (E

February 14, 2023 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 14, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commis

February 7, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 7, 2023 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commiss

February 7, 2023 EX-99.1

Presentation Materials

Exhibit 99.1

November 14, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41210 HILLSTREAM BIOPHARMA, INC.

October 28, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 27, 2022 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commiss

August 11, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41210 HILLSTREAM BIOPHARMA, INC.

August 9, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 8, 2022 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commissio

June 23, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

June 17, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defin

June 17, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

May 16, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41210 HILLSTREAM BIOPHARMA, INC.

April 1, 2022 EX-21.1

List of Subsidiaries of Hillstream BioPharma, Inc.

EX-21.1 4 ex21-1.htm Exhibit 21.1 List of Subsidiaries of Hillstream BioPharma, Inc. Name State/Country of Organization or Incorporation HB Pharma Corp. Delaware Farrington Therapeutics LLC Delaware

April 1, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-41210 HILLSTREAM BIOPHARMA, INC. (E

April 1, 2022 NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 12b-25 Commission File Number: 001-41210 NOTIFICATION OF LATE FILING

NT 10-K 1 formnt10-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 12b-25 Commission File Number: 001-41210 NOTIFICATION OF LATE FILING [X] Form 10-K [ ] Form 20-F [ ] Form 11-K [ ] Form 10-Q [ ] Form 10-D [ ] Form N-SAR [ ] Form N-CSR For Period Ended: December 31, 2021 [ ] Transition Report on Form 10-K [ ] Transition Report on Form 10-Q [ ] Transition Report o

April 1, 2022 EX-4.3

Description of the Registrant’s Securities

Exhibit 4.3 DESCRIPTION OF THE REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of January 11, 2022, Hillstream BioPharma, Inc. (the ?Company?) had one class of security registered under Section 12 of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?), its common stock, par value $0.0001 per share (the ?Common Stock?). Descriptio

April 1, 2022 EX-14.1

Code of Business Conduct and Ethics (Incorporated by reference to Exhibit 14.1 to the Company’s Annual Report on Form 10-K filed with the SEC on April 1, 2022)

Exhibit 14.1 HILLSTREAM BIOPHARMA, INC. CODE OF BUSINESS CONDUCT AND ETHICS (Effective September 23, 2021) Hillstream BioPharma, Inc. (the ?Company?) has adopted the following Code of Business Conduct and Ethics (this ?Code?) for directors, executive officers and employees of the Company. This Code is intended to focus the directors, executive officers and employees on areas of ethical risk, provi

February 24, 2022 EX-99.1

Presentation Materials

Exhibit 99.1

February 24, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 24, 2022 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commis

February 22, 2022 EX-10.1

Hillstream BioPharma, Inc. 2019 Stock Incentive Plan (Incorporated by reference to Exhibit 10.1 to the Company’s Registration Statement on Form S-8 filed with the SEC on February 22, 2022)

Exhibit 10.1 Hillstream BioPharma Inc. 2019 STOCK INCENTIVE PLAN 1. Purpose The purpose of this 2019 Stock Incentive Plan (the ?Plan?) of Hillstream BioPharma, a Delaware corporation (the ?Company?), is to advance the interests of the Company?s stockholders by enhancing the Company?s ability to attract, retain and motivate persons who are expected to make important contributions to the Company and

February 22, 2022 S-8

As filed with the Securities and Exchange Commission on February 22, 2022

S-8 1 forms-8.htm As filed with the Securities and Exchange Commission on February 22, 2022 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organizat

February 22, 2022 EX-FILING FEES

Filing Fee Tables

Exhibit 107 Calculation of Filing Fee Tables FORM S-8 (Form Type) HILLSTREAM BIOPHARMA, INC.

January 20, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) January 20, 2022 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-41210 84-2642541 (State or other jurisdiction of incorporation) (Commiss

January 20, 2022 EX-99.1

Presentation Materials

EX-99.1 2 ex99-1.htm Exhibit 99.1

January 13, 2022 424B4

The date of this prospectus is January 11, 2022

424B4 1 form424b4.htm PROSPECTUS Filed Pursuant to Rule 424(b)(4) Registration No. 333-259821 3,750,000 Shares Common Stock Hillstream BioPharma, Inc. This is a firm commitment initial public offering of 3,750,000 shares of common stock of Hillstream BioPharma, Inc. Prior to this offering, there has been no public market for our common stock. The initial public offering price of our common stock i

January 10, 2022 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Hillstream BioPharma, Inc. (Exact name of registrant as specified in its charter) Delaware 84-2642541 (State or other jurisdiction of incorporation or organization (I.R.S. Employer Identification N

January 7, 2022 CORRESP

ThinkEquity LLC 17 State Street, 22nd Floor New York, NY 10004 January 7, 2022

CORRESP 1 filename1.htm ThinkEquity LLC 17 State Street, 22nd Floor New York, NY 10004 January 7, 2022 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F St., N.E. Washington, D.C. 20549 Re: Hillstream BioPharma Inc. Registration Statement on Form S-1 Registration No. 333-259821 Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securities Act of

January 7, 2022 CORRESP

HILLSTREAM BIOPHARMA, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 January 7, 2022

HILLSTREAM BIOPHARMA, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 January 7, 2022 VIA EDGAR United States Securities and Exchange Commission 100 F. Street, NE Washington, DC 20549 Attention: Jenn Do Daniel Gordon Abby Adams Christopher Edwards Re: Hillstream BioPharma, Inc. Registration Statement on Form S-1, as amended File No. 333-259821 Ladies and Gentlemen: Pursuant to Rule 461 o

January 5, 2022 S-1/A

As filed with the Securities and Exchange Commission on January 5, 2022

S-1/A 1 forms-1a.htm As filed with the Securities and Exchange Commission on January 5, 2022 Registration Statement No. 333-259821 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 Amendment No. 4 To FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 2834 84-2642541 (State

January 3, 2022 S-1/A

As filed with the Securities and Exchange Commission on January 3, 2022

As filed with the Securities and Exchange Commission on January 3, 2022 Registration Statement No.

December 20, 2021 FWP

FWP

December 10, 2021 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 HILLSTREAM BIOPHARMA, INC. UNDERWRITING AGREEMENT New York, New York [●], 2021 ThinkEquity LLC As Representative of the several Underwriters named on Schedule 1 attached hereto 17 State Street, 22nd Floor New York, NY 10004 Ladies and Gentlemen: The undersigned, Hillstream BioPharma, Inc., a corporation formed under the laws of the State of Delaware (collectively with its subsidiaries

December 10, 2021 S-1/A

As filed with the Securities and Exchange Commission on December 10, 2021

S-1/A 1 forms-1a.htm As filed with the Securities and Exchange Commission on December 10, 2021 Registration Statement No. 333-259821 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 Amendment No. 2 To FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 2834 84-2642541 (Sta

December 10, 2021 EX-4.2

Form of Underwriter Warrant (Incorporated by reference to Exhibit 4.2 to the Company’s Registration Statement on Form S-1/A filed with the SEC on December 10, 2021)

EX-4.2 3 ex4-2.htm Exhibit 4.2 Form of Representative’s Warrant Agreement THE REGISTERED HOLDER OF THIS PURCHASE WARRANT BY ITS ACCEPTANCE HEREOF, AGREES THAT IT WILL NOT SELL, TRANSFER OR ASSIGN THIS PURCHASE WARRANT EXCEPT AS HEREIN PROVIDED AND THE REGISTERED HOLDER OF THIS PURCHASE WARRANT AGREES THAT IT WILL NOT SELL, TRANSFER, ASSIGN, PLEDGE OR HYPOTHECATE THIS PURCHASE WARRANT FOR A PERIOD

October 15, 2021 S-1/A

As filed with the Securities and Exchange Commission on October 15, 2021

S-1/A 1 forms-1a.htm As filed with the Securities and Exchange Commission on October 15, 2021 Registration Statement No. 333-259821 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 Amendment No. 1 To FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 2834 84-2642541 (Stat

October 15, 2021 EX-3.5

Amendment to Certificate of Incorporation dated October 11, 2021 (Incorporated by reference to Exhibit 3.5 to the Company’s Registration Statement on Form S-1/A filed with the SEC on October 15, 2021)

Exhibit 3.5

October 15, 2021 CORRESP

HILLSTREAM BIOPHARMA, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807

HILLSTREAM BIOPHARMA, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 October 15, 2021 VIA EDGAR United States Securities and Exchange Commission 100 F. Street, NE Washington, DC 20549 Attention: Jenn Do Daniel Gordon Abby Adams Christopher Edwards Re: Hillstream BioPharma, Inc. Registration Statement on Form S-1 Filed September 27, 2021 File No. 333-259821 Dear Ladies and Gentlemen: Thi

September 27, 2021 EX-10.4

Form of Subordinated Convertible Promissory Note

Exhibit 10.4 THIS SUBORDINATED CONVERTIBLE PROMISSORY NOTE (THIS ?NOTE?) AND THE SECURITIES ISSUABLE UPON CONVERSION HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT, APPLICABLE STATE SECURITIES LAWS, OR APPLICABLE LAWS OF ANY FOREIGN JURISDICTION. THIS NOTE AND SUCH SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO DISTRIBUTION OR RESALE, AND MAY NOT BE OFFERED, SOLD, PL

September 27, 2021 EX-3.1

Certificate of Incorporation (Incorporated by reference to Exhibit 3.1 to the Company’s Registration Statement on Form S-1 filed with the SEC on September 27, 2021)

Exhibit 3.1

September 27, 2021 EX-3.4

Bylaws (Incorporated by reference to Exhibit 3.4 to the Company’s Registration Statement on Form S-1 filed with the SEC on September 27, 2021)

EX-3.4 5 ex3-4.htm Exhibit 3.4

September 27, 2021 EX-10.7

First Amendment to Amended and Restated Employment Agreement by and between the Company and Randy Milby dated June 1, 2021

Exhibit 10.7 FIRST AMENDMENT TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT This First Amendment (the ?Amendment?) to the Amended and Restated Milby Employment Agreement is dated as September 24, 2021 and is entered into by and between Hillstream BioPharma, Inc., a Delaware corporation (the ?Corporation?) and Randy D. Milby (the ?Executive?). All capitalized terms used herein but not otherwise defin

September 27, 2021 EX-10.2

Hillstream BioPharma, Inc. 2017 Stock Incentive Plan (Incorporated by reference to Exhibit 10.2 to the Company’s Registration Statement on Form S-1 filed with the SEC on September 27, 2021)

Exhibit 10.2 HILLSTREAM BIOSCIENCES INC. 2017 STOCK INCENTIVE PLAN 1. Purpose The purpose of this 2017 Stock Incentive Plan (the ?Plan?) of Hillstream Biosciences Inc., a Delaware corporation (the ?Company?), is to advance the interests of the Company?s stockholders by enhancing the Company?s ability to attract, retain and motivate persons who are expected to make important contributions to the Co

September 27, 2021 EX-10.3

Hillstream BioPharma, Inc. 2019 Stock Incentive Plan

Exhibit 10.3 Hillstream BioPharma Inc. 2019 STOCK INCENTIVE PLAN 1. Purpose The purpose of this 2019 Stock Incentive Plan (the ?Plan?) of Hillstream BioPharma, a Delaware corporation (the ?Company?), is to advance the interests of the Company?s stockholders by enhancing the Company?s ability to attract, retain and motivate persons who are expected to make important contributions to the Company and

September 27, 2021 EX-10.5

Form of Subordinated Convertible Promissory Note

Exhibit 10.5 THIS SUBORDINATED CONVERTIBLE PROMISSORY NOTE (THIS ?NOTE?) AND THE SECURITIES ISSUABLE UPON CONVERSION HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT, APPLICABLE STATE SECURITIES LAWS, OR APPLICABLE LAWS OF ANY FOREIGN JURISDICTION. THIS NOTE AND SUCH SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO DISTRIBUTION OR RESALE, AND MAY NOT BE OFFERED, SOLD, PL

September 27, 2021 EX-4.1

Specimen Stock Certificate Evidencing the Shares of Common Stock (Incorporated by reference to Exhibit 4.1 to the Company’s Registration Statement on Form S-1 filed with the SEC on September 27, 2021)

Exhibit 4.1

September 27, 2021 EX-3.2

Amendment to Certificate of Incorporation dated August 7, 2019 (Incorporated by reference to Exhibit 3.2 to the Company’s Registration Statement on Form S-1 filed with the SEC on September 27, 2021)

Exhibit 3.2

September 27, 2021 CORRESP

HILLSTREAM BIOPHARMA, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807

CORRESP 1 filename1.htm HILLSTREAM BIOPHARMA, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 September 27, 2021 VIA EDGAR United States Securities and Exchange Commission 100 F. Street, NE Washington, DC 20549 Attention: Jenn Do Daniel Gordon Abby Adams Christopher Edwards Re: Hillstream BioPharma, Inc. Amendment No. 2 to Draft Registration Statement Submitted August 4, 2021 File No. 37

September 27, 2021 EX-10.6

Form of Indemnification Agreement for Officers and Directors

Exhibit 10.6 HILLSTREAM BIOPHARMA, INC. INDEMNIFICATION AGREEMENT This INDEMNIFICATION AGREEMENT (?Agreement?) is made as of [ ], 2021 by and between Hillstream BioPharma, Inc., a Delaware corporation (the ?Company?), and [ ] (?Indemnitee?). This Agreement supersedes and replaces any and all previous Agreements between the Company and Indemnitee covering the subject matter of this Agreement. RECIT

September 27, 2021 S-1

Power of Attorney

As filed with the Securities and Exchange Commission on September 27, 2021 Registration Statement No.

September 27, 2021 EX-10.1

Amended and Restated Employment Agreement by and between the Company and Randy Milby dated June 1, 2021

Exhibit 10.1 AMENDED and RESTATED MILBY EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this “Agreement”) is made as of June 1, 2021 (the “Effective Date”) by and between Hillstream BioPharma Inc., a Delaware corporation with principal executive offices at 245 Main Street, Suite 204, Chester, New Jersey 07930 (“Company”), and Randy D. Milby, residing at (“Executive”). Each of Company and Executive

September 27, 2021 EX-3.3

Amendment to Certificate of Incorporation dated September 16, 2021 (Incorporated by reference to Exhibit 3.3 to the Company’s Registration Statement on Form S-1 filed with the SEC on September 27, 2021)

Exhibit 3.3

August 4, 2021 DRS/A

As confidentially submitted to the U.S. Securities and Exchange Commission on August 3, 2021 pursuant to the Jumpstart Our Business Startups Act of 2012, as Amendment No. 2 to the draft registration statement. This Amendment No. 2 to the draft regist

DRS/A 1 filename1.htm As confidentially submitted to the U.S. Securities and Exchange Commission on August 3, 2021 pursuant to the Jumpstart Our Business Startups Act of 2012, as Amendment No. 2 to the draft registration statement. This Amendment No. 2 to the draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains stri

August 3, 2021 DRSLTR

HILLSTREAM BIOPHARMA, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807

HILLSTREAM BIOPHARMA, INC. 1200 Route 22 East, Suite 2000 Bridgewater, NJ 08807 August 3, 2021 VIA EDGAR United States Securities and Exchange Commission 100 F. Street, NE Washington, DC 20549 Attention: Jenn Do Daniel Gordon Abby Adams Christopher Edwards Re: Hillstream BioPharma, Inc. Amendment No. 1 to Draft Registration Statement Submitted June 1, 2021 File No. 377-04884 Dear Ladies and Gentle

June 21, 2021 DRS/A

As confidentially submitted to the U.S. Securities and Exchange Commission on June 17, 2021 pursuant to the Jumpstart Our Business Startups Act of 2012

DRS/A 1 filename1.htm As confidentially submitted to the U.S. Securities and Exchange Commission on June 17, 2021 pursuant to the Jumpstart Our Business Startups Act of 2012 Registration Statement No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as s

May 17, 2021 DRS

As confidentially submitted to the U.S. Securities and Exchange Commission on May 17, 2021 pursuant to the Jumpstart Our Business Startups Act of 2012

As confidentially submitted to the U.S. Securities and Exchange Commission on May 17, 2021 pursuant to the Jumpstart Our Business Startups Act of 2012 Registration Statement No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in its charter

May 17, 2021 DRSLTR

Sheppard, Mullin, Richter & Hampton LLP

Sheppard, Mullin, Richter & Hampton LLP 30 Rockefeller Plaza New York, New York 10112-0015 212.

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